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Search term: YHR053C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CUP1-1
SGD link S000001095
Alternative ID YHR053C
Description Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
Synonyms YHR053C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4738 ACDHYP-

KOGs classification KOGs description
METABOLISM Predicted metallothionein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g07600 GI:15222468
Arabidopsis thaliana (Ath) At1g07610 GI:15222469
Arabidopsis thaliana (Ath) At3g09390 GI:15232661
Arabidopsis thaliana (Ath) At5g02380 GI:15241787
Caenorhabditis elegans (Cel) CE07379
(WBGene00003473)
GI:17562718 P17511
Caenorhabditis elegans (Cel) CE25109
(WBGene00003474)
GI:17562720 P17512
Drosophila melanogaster (Dme) 7299256 GI:17737877
Drosophila melanogaster (Dme) 7300608 GI:7300608 Q9VDN2
Drosophila melanogaster (Dme) 7300618 GI:17738061
Homo sapiens (Hsa) Hs10835085
(MT1H)
GI:10835085 P80294
Homo sapiens (Hsa) Hs10835230
(MT1G)
GI:10835230 P13640
Homo sapiens (Hsa) Hs14269578
(MT4)
GI:14269578 P47944
Homo sapiens (Hsa) Hs20558501_2 GI:20558501
Homo sapiens (Hsa) Hs20562874 GI:20562874
Homo sapiens (Hsa) Hs20562876 GI:20562876
Homo sapiens (Hsa) Hs20562890 GI:20562890
Homo sapiens (Hsa) Hs20562892 GI:20562892
Homo sapiens (Hsa) Hs22047206 GI:22047206
Homo sapiens (Hsa) Hs4505271 GI:4505271
Homo sapiens (Hsa) Hs5174762
(MT3)
GI:5174762 P25713
Homo sapiens (Hsa) Hs5174764
(MT2A)
GI:5174764 P02795
Saccharomyces cerevisiae (Sce) YHR053c
(S000001095)
GI:6321844 P07215
Saccharomyces cerevisiae (Sce) YHR055c
(S000001097)
GI:6321846 P07215
Saccharomyces cerevisiae (Sce) YOR031w
(S000005557)
GI:6324605 P41902
Schizosaccharomyces pombe (Spo) SPAC22H10.13 GI:19114655 Q9UTC0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g09390
At1g07600
At5g02380
GO:0005634 nucleus C
IDA
SpoSPAC22H10.13
GO:0005737 cytoplasm C
ISS
SceS000005557
NAS
HsaMT4
GO:0005829 cytosol C
IDA
SceS000001097
S000001095
SpoSPAC22H10.13
GO:0008021 synaptic vesicle C
ISS
HsaMT3
GO:0022626 cytosolic ribosome C
IDA
AthAt1g07610
GO:0004784 superoxide dismutase activity F
IMP
SceS000001095
S000001097
GO:0005507 copper ion binding F
IDA
AthAt5g02380
At1g07600
At3g09390
SceS000001097
S000001095
S000005557
IMP
SceS000005557
ISS
AthAt1g07610
SceS000005557
NAS
HsaMT4
TAS
HsaMT3
GO:0005515 protein binding F
IPI
HsaMT1H
MT2A
MT1G
GO:0008270 zinc ion binding F
IMP
SpoSPAC22H10.13
ISS
HsaMT3
NAS
HsaMT4
GO:0016209 antioxidant activity F
IDA
SceS000001095
S000001097
NAS
HsaMT3
GO:0046870 cadmium ion binding F
IDA
SceS000001097
S000001095
GO:0046872 metal ion binding F
TAS
AthAt1g07600
GO:0001666 response to hypoxia P
IDA
HsaMT3
GO:0006414 translational elongation P
RCA
SceS000001095
GO:0006875 cellular metal ion homeostasis P
NAS
HsaMT3
GO:0006878 cellular copper ion homeostasis P
ISS
AthAt3g09390
TAS
HsaMT2A
GO:0006882 cellular zinc ion homeostasis P
IMP
SpoSPAC22H10.13
GO:0008150 biological_process P
ND
AthAt5g02380
HsaMT4
GO:0008283 cell proliferation P
TAS
HsaMT3
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003473
WBGene00003474
GO:0009408 response to heat P
IEP
CelWBGene00003474
WBGene00003473
GO:0009644 response to high light intensity P
IEP
AthAt1g07600
GO:0010035 response to inorganic substance P
RCA
SceS000001095
S000005557
GO:0010038 response to metal ion P
IMP
SceS000005557
GO:0010273 detoxification of copper ion P
IMP
SceS000001097
S000001095
GO:0019430 removal of superoxide radicals P
IDA
HsaMT3
SceS000001095
S000001097
IGI
SceS000001097
S000001095
GO:0033554 cellular response to stress P
IEP
SpoSPAC22H10.13
GO:0040007 growth P
IMP
CelWBGene00003473
WBGene00003474
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003474
WBGene00003473
GO:0046686 response to cadmium ion P
IEP
CelWBGene00003473
WBGene00003474
GO:0046688 response to copper ion P
IEP
AthAt1g07600
IGI
AthAt1g07600
IMP
SceS000001095
S000001097
ISS
AthAt1g07610
GO:0071585 detoxification of cadmium ion P
IMP
SceS000001095
S000001097

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
101597

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) CUP1-1
(S000001095)
GI:6321844 P07215
Saccharomyces cerevisiae (Sce) CUP1-2
(S000001097)
GI:6321846 P07215


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SceS000001097
S000001095
GO:0004784 superoxide dismutase activity F
IMP
SceS000001095
S000001097
GO:0005507 copper ion binding F
IDA
SceS000001097
S000001095
GO:0016209 antioxidant activity F
IDA
SceS000001095
S000001097
GO:0046870 cadmium ion binding F
IDA
SceS000001097
S000001095
GO:0006414 translational elongation P
RCA
SceS000001095
GO:0010035 response to inorganic substance P
RCA
SceS000001095
GO:0010273 detoxification of copper ion P
IMP
SceS000001097
S000001095
GO:0019430 removal of superoxide radicals P
IDA
SceS000001095
S000001097
IGI
SceS000001097
S000001095
GO:0046688 response to copper ion P
IMP
SceS000001095
S000001097
GO:0071585 detoxification of cadmium ion P
IMP
SceS000001095
S000001097

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_43646

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Saccharomyces cerevisiae (Sce) sce2808 YHR053C
(S000001095)
Saccharomyces cerevisiae (Sce) sce2811 YHR055C
(S000001097)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SceS000001097
S000001095
GO:0004784 superoxide dismutase activity F
IMP
SceS000001095
S000001097
GO:0005507 copper ion binding F
IDA
SceS000001097
S000001095
GO:0016209 antioxidant activity F
IDA
SceS000001095
S000001097
GO:0046870 cadmium ion binding F
IDA
SceS000001097
S000001095
GO:0006414 translational elongation P
RCA
SceS000001095
GO:0010035 response to inorganic substance P
RCA
SceS000001095
GO:0010273 detoxification of copper ion P
IMP
SceS000001097
S000001095
GO:0019430 removal of superoxide radicals P
IDA
SceS000001095
S000001097
IGI
SceS000001097
S000001095
GO:0046688 response to copper ion P
IMP
SceS000001095
S000001097
GO:0071585 detoxification of cadmium ion P
IMP
SceS000001095
S000001097

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