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Search term: YHR068W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DYS1
SGD link S000001110
Alternative ID YHR068W
Description Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
Synonyms YHR068W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2924 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Deoxyhypusine synthase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g05920 GI:15239290
Caenorhabditis elegans (Cel) CE19037
(WBGene00012460)		 GI:17536927 Q9XXJ0
Drosophila melanogaster (Dme) 7295142 GI:8928108
Homo sapiens (Hsa) Hs4503325
(DHPS)		 GI:4503325 P49366
Homo sapiens (Hsa) Hs7108338 GI:7108338 P49366
Homo sapiens (Hsa) Hs7108340 GI:7108340 P49366
Saccharomyces cerevisiae (Sce) YHR068w
(S000001110)		 GI:6321859 P38791
Schizosaccharomyces pombe (Spo) SPBC1271.04c GI:19111938 O94337
Encephalitozoon cuniculi (Ecu) ECU09g0910 GI:19173213


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g05920
GO:0005634 nucleus C
IDA
SpoSPBC1271.04c
GO:0005737 cytoplasm C
IDA
SceS000001110
ISS
SpoSPBC1271.04c
GO:0005829 cytosol C
EXP
HsaDHPS
IDA
SpoSPBC1271.04c
GO:0005515 protein binding F
IPI
HsaDHPS
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
IDA
SceS000001110
GO:0034038 deoxyhypusine synthase activity F
EXP
HsaDHPS
ISS
SpoSPBC1271.04c
GO:0006412 translation P
TAS
HsaDHPS
GO:0006448 regulation of translational elongation P
IC
SpoSPBC1271.04c
GO:0008284 positive regulation of cell proliferation P
TAS
HsaDHPS
GO:0008612 peptidyl-lysine modification to
hypusine		 P
EXP
HsaDHPS
IDA
SceS000001110
ISS
AthAt5g05920
SpoSPBC1271.04c
GO:0009553 embryo sac development P
IMP
AthAt5g05920
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012460
GO:0050983 spermidine catabolic process to deoxyhypusine,
using deoxyhypusine synthase		 P
IC
SpoSPBC1271.04c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1453

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) DHPS GI:4503325 P49366
Pan troglodytes (Ptr) DHPS GI:114675549
Canis familiaris (Cfa) DHPS GI:57101388
Mus musculus (Mmu) Dhps
(MGI:2683592)		 GI:87252720 Q3TXU5
Rattus norvegicus (Rno) Dhps
(RGD:1303326)		 GI:51948386
Drosophila melanogaster (Dme) CG8005
(FBgn0035854)		 GI:45550569
Anopheles gambiae (Aga) AgaP_AGAP006531 GI:158296006
Caenorhabditis elegans (Cel) Y17G7B.4
(CE19037;
WBGene00012460)		 GI:17536927 Q9XXJ0
Schizosaccharomyces pombe (Spo) SPBC1271.04c GI:19111938 O94337
Saccharomyces cerevisiae (Sce) DYS1
(S000001110)		 GI:6321859 P38791
Kluyveromyces lactis (Kla) KLLA0E12727g GI:50309033
Eremothecium gossypii (Ego) AGOS_AAL036W GI:45184788
Magnaporthe grisea (Mgr) MGG_09173 GI:145605573
Neurospora crassa (Ncr) NCU05418.1 GI:32409585
Arabidopsis thaliana (Ath) DHS GI:15239290
Oryza sativa (Osa) Os03g0740600 GI:115455235
Plasmodium falciparum (Pfa) PF14_0125 GI:124808382


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthDHS
MmuMGI:2683592
GO:0005634 nucleus C
IDA
SpoSPBC1271.04c
GO:0005737 cytoplasm C
IDA
SceS000001110
ISS
SpoSPBC1271.04c
GO:0005829 cytosol C
EXP
HsaDHPS
IDA
SpoSPBC1271.04c
GO:0009507 chloroplast C
TAS
AthDHS
GO:0003849 3-deoxy-7-phosphoheptulonate synthase
activity		 F
IDA
AthDHS
IGI
AthDHS
TAS
AthDHS
GO:0005515 protein binding F
IPI
AthDHS
HsaDHPS
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
IDA
SceS000001110
GO:0034038 deoxyhypusine synthase activity F
EXP
HsaDHPS
ISO
MmuMGI:2683592
ISS
SpoSPBC1271.04c
GO:0006412 translation P
NAS
PfaPF14_0125
TAS
HsaDHPS
GO:0006448 regulation of translational elongation P
IC
SpoSPBC1271.04c
GO:0008284 positive regulation of cell proliferation P
TAS
HsaDHPS
GO:0008612 peptidyl-lysine modification to
hypusine		 P
EXP
HsaDHPS
IDA
SceS000001110
ISS
AthDHS
DmeFBgn0035854
SpoSPBC1271.04c
GO:0009073 aromatic amino acid family biosynthetic
process		 P
TAS
AthDHS
GO:0009423 chorismate biosynthetic process P
IDA
AthDHS
IGI
AthDHS
GO:0009553 embryo sac development P
IMP
AthDHS
GO:0009611 response to wounding P
IEP
AthDHS
GO:0009617 response to bacterium P
IEP
AthDHS
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012460
GO:0050983 spermidine catabolic process to deoxyhypusine,
using deoxyhypusine synthase		 P
IC
SpoSPBC1271.04c
ISO
MmuMGI:2683592
NAS
DmeFBgn0035854
PfaPF14_0125
GO:0051289 protein homotetramerization P
ISO
MmuMGI:2683592

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_896

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1989 ENSANGP00000010024
Ashbya gossypii (Ago) ago151 AAL036W
Arabidopsis thaliana (Ath) ath22778 At5g05920.1
Caenorhabditis elegans (Cel) cel17874 Y17G7B.4
(CE19037;
WBGene00012460)
Candida glabrata (Cgl) cgl2379 CAGL0H07249g
Cryptococcus neoformans (Cne) cne4090 185.m02762
Dictyostelium discoideum (Ddi) ddi7056 DDB0186679
Debaryomyces hansenii (Dha) dha5823 DEHA0G02860g
Drosophila melanogaster (Dme) dme8512 CG8005-PA
(FBgn0035854)
Danio rerio (Dre) dre15054 ENSDARP00000006252
Encephalitozoon cuniculi (Ecu) ecu1364 19173213
Takifugu rubripes (Fru) fru21145 SINFRUP00000140381
Takifugu rubripes (Fru) fru21143 SINFRUP00000156605
Takifugu rubripes (Fru) fru21146 SINFRUP00000169511
Takifugu rubripes (Fru) fru21144 SINFRUP00000173047
Takifugu rubripes (Fru) fru21147 SINFRUP00000173938
Homo sapiens (Hsa) hsa15710 ENSP00000210060
(DHPS)		 P49366-1
Homo sapiens (Hsa) hsa15711 ENSP00000221303
(DHPS)		 P49366-2
Kluyveromyces lactis (Kla) kla3521 KLLA0E12727g
Mus musculus (Mmu) mmu26350 ENSMUSP00000077733
(MGI:2683592)		 Q3TXU5
Neurospora crassa (Ncr) ncr5261 NCU05418.2
Oryza sativa (Osa) osa26305 4117.m00177
Oryza sativa (Osa) osa40011 5007.m00056
Oryza sativa (Osa) osa45614 5686.m00189
Oryza sativa (Osa) osa63587 6740.m00164
Oryza sativa (Osa) osa63625 6740.m00189
Oryza sativa (Osa) osa63626 6740.m00190
Oryza sativa (Osa) osa85947 8753.m00208
Oryza sativa (Osa) osa85955 8753.m00218
Plasmodium falciparum (Pfa) pfa1453 PF14_0125
Rattus norvegicus (Rno) rno14728 ENSRNOP00000005656
(RGD:1303326)		 Q6AY53
Saccharomyces cerevisiae (Sce) sce2826 YHR068W
(S000001110)
Schizosaccharomyces pombe (Spo) spo470 SPBC1271.04c O94337
Yarrowia lipolytica (Yli) yli772 YALI0B00726g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g05920
MmuMGI:2683592
GO:0005634 nucleus C
IDA
SpoSPBC1271.04c
GO:0005737 cytoplasm C
IDA
SceS000001110
ISS
SpoSPBC1271.04c
GO:0005829 cytosol C
IDA
SpoSPBC1271.04c
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
IDA
SceS000001110
GO:0034038 deoxyhypusine synthase activity F
ISO
MmuMGI:2683592
ISS
SpoSPBC1271.04c
GO:0006412 translation P
NAS
PfaPF14_0125
GO:0006448 regulation of translational elongation P
IC
SpoSPBC1271.04c
GO:0008612 peptidyl-lysine modification to
hypusine		 P
IDA
SceS000001110
ISS
AthAt5g05920
DmeFBgn0035854
SpoSPBC1271.04c
GO:0009553 embryo sac development P
IMP
AthAt5g05920
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012460
GO:0050983 spermidine catabolic process to deoxyhypusine,
using deoxyhypusine synthase		 P
IC
SpoSPBC1271.04c
ISO
MmuMGI:2683592
NAS
DmeFBgn0035854
PfaPF14_0125
GO:0051289 protein homotetramerization P
ISO
MmuMGI:2683592

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1271.04c
(O94337)		 YHR068W
(S000001110)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC1271.04c
GO:0005737 cytoplasm C
IDA
SceS000001110
ISS
SpoSPBC1271.04c
GO:0005829 cytosol C
IDA
SpoSPBC1271.04c
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
IDA
SceS000001110
GO:0034038 deoxyhypusine synthase activity F
ISS
SpoSPBC1271.04c
GO:0006448 regulation of translational elongation P
IC
SpoSPBC1271.04c
GO:0008612 peptidyl-lysine modification to
hypusine		 P
IDA
SceS000001110
ISS
SpoSPBC1271.04c
GO:0050983 spermidine catabolic process to deoxyhypusine,
using deoxyhypusine synthase		 P
IC
SpoSPBC1271.04c

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Query species:

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GO info in one table:

s.khadayate@ucl.ac.uk