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Search term: YHR069C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RRP4
SGD link S000001111
Alternative ID YHR069C
Description Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
Synonyms YHR069C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3013 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Exosomal 3'-5' exoribonuclease complex, subunit Rrp4

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g03360 GI:15218790
Caenorhabditis elegans (Cel) CE27533
(WBGene00022232)		 GI:17544090 Q95XD0
Drosophila melanogaster (Dme) 7291605 GI:7291605 Q9W1M9
Homo sapiens (Hsa) Hs19923403
(EXOSC2)		 GI:19923403 Q13868
Saccharomyces cerevisiae (Sce) YHR069c
(S000001111)		 GI:6321860 P38792
Schizosaccharomyces pombe (Spo) SPAC2F7.14c GI:19113896 Q09704
Encephalitozoon cuniculi (Ecu) ECU10g1340 GI:19074743 Q8SUC4


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000176 nuclear exosome (RNase complex) C
IDA
SceS000001111
ISS
SpoSPAC2F7.14c
GO:0000177 cytoplasmic exosome (RNase complex) C
IDA
SceS000001111
ISS
SpoSPAC2F7.14c
GO:0005634 nucleus C
IDA
CelWBGene00022232
SpoSPAC2F7.14c
GO:0005737 cytoplasm C
IDA
CelWBGene00022232
GO:0005816 spindle pole body C
IDA
SpoSPAC2F7.14c
GO:0005829 cytosol C
IDA
SpoSPAC2F7.14c
GO:0000175 3'-5'-exoribonuclease activity F
TAS
HsaEXOSC2
GO:0003674 molecular_function F
ND
SceS000001111
GO:0004527 exonuclease activity F
ISS
AthAt1g03360
GO:0005515 protein binding F
IPI
HsaEXOSC2
GO:0008312 7S RNA binding F
TAS
HsaEXOSC2
GO:0000467 exonucleolytic trimming to generate mature 3'-end
of 5.8S rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA)		 P
IMP
SceS000001111
GO:0006364 rRNA processing P
ISS
SpoSPAC2F7.14c
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC2F7.14c
GO:0034427 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 3'-5'		 P
IMP
SceS000001111
GO:0034475 U4 snRNA 3'-end processing P
IMP
SceS000001111
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated
decay		 P
IC
SceS000001111
GO:0070481 nuclear-transcribed mRNA catabolic process,
non-stop decay		 P
IC
SceS000001111
GO:0070651 nonfunctional rRNA decay P
IC
SceS000001111
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic
process		 P
IMP
SceS000001111
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic
process		 P
IDA
SceS000001111
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic
process		 P
IC
SceS000001111
GO:0071049 nuclear retention of pre-mRNA with aberrant
3'-ends at the site of transcription		 P
IGI
SceS000001111
GO:0071051 polyadenylation-dependent snoRNA 3'-end
processing		 P
IMP
SceS000001111

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6095

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EXOSC2 GI:19923403 Q13868
Pan troglodytes (Ptr) EXOSC2 GI:114627214
Canis familiaris (Cfa) EXOSC2 GI:73967942
Mus musculus (Mmu) Exosc2
(MGI:2385133)		 GI:21450259 Q3TKQ3
Rattus norvegicus (Rno) Exosc2 GI:62644921
Gallus gallus (Gga) EXOSC2 GI:61098302
Drosophila melanogaster (Dme) Rrp4
(FBgn0034879)		 GI:24762324
Anopheles gambiae (Aga) AgaP_AGAP011211 GI:158287391
Caenorhabditis elegans (Cel) exos-2
(CE27533;
WBGene00022232)		 GI:17544090 Q95XD0
Schizosaccharomyces pombe (Spo) SPAC2F7.14c GI:19113896 Q09704
Saccharomyces cerevisiae (Sce) RRP4
(S000001111)		 GI:6321860 P38792
Kluyveromyces lactis (Kla) KLLA0E12771g GI:50309037
Eremothecium gossypii (Ego) AGOS_AAL034C GI:45184790
Magnaporthe grisea (Mgr) MGG_08100 GI:145612113
Neurospora crassa (Ncr) NCU04009.1 GI:32405430
Arabidopsis thaliana (Ath) ATRRP4 GI:15218790
Oryza sativa (Osa) Os04g0520000 GI:115459464
Plasmodium falciparum (Pfa) PFD0515w GI:124505351


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000176 nuclear exosome (RNase complex) C
IDA
SceS000001111
IPI
DmeFBgn0034879
ISS
DmeFBgn0034879
SpoSPAC2F7.14c
GO:0000177 cytoplasmic exosome (RNase complex) C
IDA
SceS000001111
ISS
DmeFBgn0034879
SpoSPAC2F7.14c
GO:0000178 exosome (RNase complex) C
ISO
MmuMGI:2385133
ISS
PfaPFD0515w
GO:0005634 nucleus C
IDA
CelWBGene00022232
SpoSPAC2F7.14c
GO:0005652 nuclear lamina C
IDA
DmeFBgn0034879
GO:0005737 cytoplasm C
IDA
CelWBGene00022232
DmeFBgn0034879
GO:0005816 spindle pole body C
IDA
SpoSPAC2F7.14c
GO:0005829 cytosol C
IDA
SpoSPAC2F7.14c
GO:0000175 3'-5'-exoribonuclease activity F
ISS
DmeFBgn0034879
PfaPFD0515w
TAS
HsaEXOSC2
GO:0003674 molecular_function F
ND
MmuMGI:2385133
SceS000001111
GO:0004527 exonuclease activity F
ISS
AthATRRP4
GO:0005515 protein binding F
IPI
HsaEXOSC2
GO:0008312 7S RNA binding F
TAS
HsaEXOSC2
GO:0000467 exonucleolytic trimming to generate mature 3'-end
of 5.8S rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA)		 P
IMP
SceS000001111
GO:0006364 rRNA processing P
ISS
PfaPFD0515w
SpoSPAC2F7.14c
GO:0006397 mRNA processing P
ISS
DmeFBgn0034879
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC2F7.14c
GO:0008150 biological_process P
ND
MmuMGI:2385133
GO:0034427 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 3'-5'		 P
IMP
SceS000001111
GO:0034475 U4 snRNA 3'-end processing P
IMP
SceS000001111
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated
decay		 P
IC
SceS000001111
GO:0070481 nuclear-transcribed mRNA catabolic process,
non-stop decay		 P
IC
SceS000001111
GO:0070651 nonfunctional rRNA decay P
IC
SceS000001111
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic
process		 P
IMP
SceS000001111
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic
process		 P
IDA
SceS000001111
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic
process		 P
IC
SceS000001111
GO:0071049 nuclear retention of pre-mRNA with aberrant
3'-ends at the site of transcription		 P
IGI
SceS000001111
GO:0071051 polyadenylation-dependent snoRNA 3'-end
processing		 P
IMP
SceS000001111

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2363

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8263 ENSANGP00000011203
Ashbya gossypii (Ago) ago153 AAL034C
Arabidopsis thaliana (Ath) ath275 At1g03360.1
Caenorhabditis elegans (Cel) cel20722 Y73B6BL.3
(CE27533;
WBGene00022232)
Candida glabrata (Cgl) cgl2377 CAGL0H07205g
Cryptococcus neoformans (Cne) cne1890 181.m07858
Dictyostelium discoideum (Ddi) ddi10571 DDB0183814
Debaryomyces hansenii (Dha) dha6524 DEHA0G18436g
Drosophila melanogaster (Dme) dme6770 CG3931-PA
(FBgn0034879)
Danio rerio (Dre) dre14006 ENSDARP00000028443
(zgc:110117)		 Q568S7
Encephalitozoon cuniculi (Ecu) ecu659 19074743
Takifugu rubripes (Fru) fru11447 SINFRUP00000155889
Gallus gallus (Gga) gga7999 ENSGALP00000006174
(EXOSC2)		 Q5ZHN8
Homo sapiens (Hsa) hsa32070 ENSP00000253010
Kluyveromyces lactis (Kla) kla3523 KLLA0E12771g
Mus musculus (Mmu) mmu14410 ENSMUSP00000043519
(MGI:2385133)		 Q8VBV3
Neurospora crassa (Ncr) ncr3889 NCU04009.2
Oryza sativa (Osa) osa79755 8144.m00159
Plasmodium falciparum (Pfa) pfa3226 PFD0515w
Rattus norvegicus (Rno) rno18394 ENSRNOP00000012311
(RGD:1306573)
Saccharomyces cerevisiae (Sce) sce2827 YHR069C
(S000001111)
Schizosaccharomyces pombe (Spo) spo335 SPAC2F7.14c Q09704
Yarrowia lipolytica (Yli) yli2930 YALI0D05511g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000176 nuclear exosome (RNase complex) C
IDA
SceS000001111
IPI
DmeFBgn0034879
ISS
DmeFBgn0034879
SpoSPAC2F7.14c
GO:0000177 cytoplasmic exosome (RNase complex) C
IDA
SceS000001111
ISS
DmeFBgn0034879
SpoSPAC2F7.14c
GO:0000178 exosome (RNase complex) C
ISO
MmuMGI:2385133
ISS
PfaPFD0515w
GO:0005634 nucleus C
IDA
CelWBGene00022232
SpoSPAC2F7.14c
GO:0005652 nuclear lamina C
IDA
DmeFBgn0034879
GO:0005737 cytoplasm C
IDA
CelWBGene00022232
DmeFBgn0034879
GO:0005816 spindle pole body C
IDA
SpoSPAC2F7.14c
GO:0005829 cytosol C
IDA
SpoSPAC2F7.14c
GO:0000175 3'-5'-exoribonuclease activity F
ISS
DmeFBgn0034879
PfaPFD0515w
GO:0003674 molecular_function F
ND
MmuMGI:2385133
SceS000001111
GO:0004527 exonuclease activity F
ISS
AthAt1g03360
GO:0000467 exonucleolytic trimming to generate mature 3'-end
of 5.8S rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA)		 P
IMP
SceS000001111
GO:0006364 rRNA processing P
ISS
PfaPFD0515w
SpoSPAC2F7.14c
GO:0006397 mRNA processing P
ISS
DmeFBgn0034879
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC2F7.14c
GO:0008150 biological_process P
ND
MmuMGI:2385133
GO:0034427 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 3'-5'		 P
IMP
SceS000001111
GO:0034475 U4 snRNA 3'-end processing P
IMP
SceS000001111
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated
decay		 P
IC
SceS000001111
GO:0070481 nuclear-transcribed mRNA catabolic process,
non-stop decay		 P
IC
SceS000001111
GO:0070651 nonfunctional rRNA decay P
IC
SceS000001111
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic
process		 P
IMP
SceS000001111
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic
process		 P
IDA
SceS000001111
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic
process		 P
IC
SceS000001111
GO:0071049 nuclear retention of pre-mRNA with aberrant
3'-ends at the site of transcription		 P
IGI
SceS000001111
GO:0071051 polyadenylation-dependent snoRNA 3'-end
processing		 P
IMP
SceS000001111

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC2F7.14c
(Q09704)		 YHR069C
(S000001111)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000176 nuclear exosome (RNase complex) C
IDA
SceS000001111
ISS
SpoSPAC2F7.14c
GO:0000177 cytoplasmic exosome (RNase complex) C
IDA
SceS000001111
ISS
SpoSPAC2F7.14c
GO:0005634 nucleus C
IDA
SpoSPAC2F7.14c
GO:0005816 spindle pole body C
IDA
SpoSPAC2F7.14c
GO:0005829 cytosol C
IDA
SpoSPAC2F7.14c
GO:0003674 molecular_function F
ND
SceS000001111
GO:0000467 exonucleolytic trimming to generate mature 3'-end
of 5.8S rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA)		 P
IMP
SceS000001111
GO:0006364 rRNA processing P
ISS
SpoSPAC2F7.14c
GO:0006402 mRNA catabolic process P
ISS
SpoSPAC2F7.14c
GO:0034427 nuclear-transcribed mRNA catabolic process,
exonucleolytic, 3'-5'		 P
IMP
SceS000001111
GO:0034475 U4 snRNA 3'-end processing P
IMP
SceS000001111
GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5'
exonucleolytic nonsense-mediated
decay		 P
IC
SceS000001111
GO:0070481 nuclear-transcribed mRNA catabolic process,
non-stop decay		 P
IC
SceS000001111
GO:0070651 nonfunctional rRNA decay P
IC
SceS000001111
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic
process		 P
IMP
SceS000001111
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic
process		 P
IDA
SceS000001111
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic
process		 P
IC
SceS000001111
GO:0071049 nuclear retention of pre-mRNA with aberrant
3'-ends at the site of transcription		 P
IGI
SceS000001111
GO:0071051 polyadenylation-dependent snoRNA 3'-end
processing		 P
IMP
SceS000001111

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