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Search term: YHR072W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG7
SGD link S000001114
Alternative ID YHR072W
Description Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
Synonyms YHR072W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0497 A--HYP-

KOGs classification KOGs description
METABOLISM Oxidosqualene-lanosterol cyclase and related proteins

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g66960 GI:15219789
Arabidopsis thaliana (Ath) At1g78480 GI:15218386
Arabidopsis thaliana (Ath) At1g78500 GI:15218390
Arabidopsis thaliana (Ath) At1g78950 GI:15219239
Arabidopsis thaliana (Ath) At1g78960 GI:15219240
Arabidopsis thaliana (Ath) At1g78970 GI:15219261
Arabidopsis thaliana (Ath) At2g07050 GI:15225650
Arabidopsis thaliana (Ath) At3g45130 GI:15230611
Arabidopsis thaliana (Ath) At4g15340 GI:7447120
Arabidopsis thaliana (Ath) At4g15370 GI:15233798
Arabidopsis thaliana (Ath) At5g36150 GI:15239312
Arabidopsis thaliana (Ath) At5g42600 GI:15239009
Arabidopsis thaliana (Ath) At5g48010 GI:15238869
Homo sapiens (Hsa) Hs4505027 GI:4505027
Saccharomyces cerevisiae (Sce) YHR072w
(S000001114)		 GI:6321863
Schizosaccharomyces pombe (Spo) SPAC13G7.01c GI:19114615 Q10231
Schizosaccharomyces pombe (Spo) SPAC4G9.21c GI:19114614
Arabidopsis thaliana (Ath) At1g66960 GI:15219789
Arabidopsis thaliana (Ath) At1g78480 GI:15218386
Arabidopsis thaliana (Ath) At1g78500 GI:15218390
Arabidopsis thaliana (Ath) At1g78950 GI:15219239
Arabidopsis thaliana (Ath) At1g78960 GI:15219240
Arabidopsis thaliana (Ath) At1g78970 GI:15219261
Arabidopsis thaliana (Ath) At2g07050 GI:15225650
Arabidopsis thaliana (Ath) At3g45130 GI:15230611
Arabidopsis thaliana (Ath) At4g15340 GI:7447120
Arabidopsis thaliana (Ath) At4g15370 GI:15233798
Arabidopsis thaliana (Ath) At5g36150 GI:15239312
Arabidopsis thaliana (Ath) At5g42600 GI:15239009
Arabidopsis thaliana (Ath) At5g48010 GI:15238869
Homo sapiens (Hsa) Hs4505027 GI:4505027
Saccharomyces cerevisiae (Sce) YHR072w
(S000001114)		 GI:6321863
Schizosaccharomyces pombe (Spo) SPAC13G7.01c GI:19114615 Q10231
Schizosaccharomyces pombe (Spo) SPAC4G9.21c GI:19114614
Arabidopsis thaliana (Ath) At1g66960 GI:15219789
Arabidopsis thaliana (Ath) At1g78480 GI:15218386
Arabidopsis thaliana (Ath) At1g78500 GI:15218390
Arabidopsis thaliana (Ath) At1g78950 GI:15219239
Arabidopsis thaliana (Ath) At1g78960 GI:15219240
Arabidopsis thaliana (Ath) At1g78970 GI:15219261
Arabidopsis thaliana (Ath) At2g07050 GI:15225650
Arabidopsis thaliana (Ath) At3g45130 GI:15230611
Arabidopsis thaliana (Ath) At4g15340 GI:7447120
Arabidopsis thaliana (Ath) At4g15370 GI:15233798
Arabidopsis thaliana (Ath) At5g36150 GI:15239312
Arabidopsis thaliana (Ath) At5g42600 GI:15239009
Arabidopsis thaliana (Ath) At5g48010 GI:15238869
Homo sapiens (Hsa) Hs4505027 GI:4505027
Saccharomyces cerevisiae (Sce) YHR072w
(S000001114)		 GI:6321863
Schizosaccharomyces pombe (Spo) SPAC13G7.01c GI:19114615 Q10231
Schizosaccharomyces pombe (Spo) SPAC4G9.21c GI:19114614


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g45130
At1g78960
At1g78500
At5g36150
At1g78970
At5g48010
GO:0005773 vacuole C
IDA
AthAt2g07050
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC13G7.01c
TAS
SceS000001114
GO:0005811 lipid particle C
IDA
SceS000001114
GO:0005829 cytosol C
IDA
SpoSPAC13G7.01c
GO:0005886 plasma membrane C
TAS
SceS000001114
GO:0000250 lanosterol synthase activity F
IDA
AthAt3g45130
IMP
SceS000001114
ISS
SpoSPAC13G7.01c
GO:0003824 catalytic activity F
ISS
AthAt4g15370
At1g78500
At5g42600
At5g36150
At5g48010
GO:0004659 prenyltransferase activity F
RCA
SceS000001114
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
RCA
SceS000001114
GO:0016871 cycloartenol synthase activity F
IDA
AthAt2g07050
GO:0031559 oxidosqualene cyclase activity F
IDA
AthAt1g78500
GO:0034074 marneral synthase activity F
IDA
AthAt5g42600
GO:0034075 arabidiol synthase activity F
IDA
AthAt4g15340
GO:0042299 lupeol synthase activity F
IDA
AthAt1g78970
IGI
AthAt1g78960
At1g78970
ISS
AthAt1g66960
At5g36150
TAS
AthAt1g78500
GO:0042300 beta-amyrin synthase activity F
IDA
AthAt1g78960
At1g78970
At1g78950
GO:0051746 thalianol synthase activity F
IDA
AthAt5g48010
GO:0080011 baruol synthase activity F
IDA
AthAt4g15370
GO:0006066 alcohol metabolic process P
RCA
SceS000001114
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000001114
ISS
SpoSPAC13G7.01c
GO:0009555 pollen development P
IMP
AthAt2g07050
GO:0010027 thylakoid membrane organization P
IMP
AthAt2g07050
GO:0010263 tricyclic triterpenoid biosynthetic
process		 P
IDA
AthAt4g15340
At5g48010
GO:0010686 tetracyclic triterpenoid biosynthetic
process		 P
IDA
AthAt4g15370
GO:0016104 triterpenoid biosynthetic process P
IDA
AthAt5g42600
At1g78960
GO:0019745 pentacyclic triterpenoid biosynthetic
process		 P
IDA
AthAt2g07050
IGI
AthAt1g78960
At1g78970
ISS
AthAt4g15370
At1g78960
At5g36150
At5g42600
At3g45130
At1g78500
At1g66960
At2g07050
At5g48010
At1g78970
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001114
GO:0048364 root development P
IMP
AthAt5g48010
GO:0080003 thalianol metabolic process P
IMP
AthAt5g48010

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37408

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) LSS GI:47933397
Pan troglodytes (Ptr) LSS GI:114684821
Mus musculus (Mmu) Lss
(MGI:1336155)		 GI:22122469 Q8BLN5
Rattus norvegicus (Rno) Lss
(RGD:620955)		 GI:13591981
Gallus gallus (Gga) LSS GI:57529773
Schizosaccharomyces pombe (Spo) erg7
(SPAC13G7.01c)		 GI:63054562 Q10231
Saccharomyces cerevisiae (Sce) ERG7
(S000001114)		 GI:6321863
Kluyveromyces lactis (Kla) KLLA0B10175g GI:50304065
Eremothecium gossypii (Ego) AGOS_AGR351W GI:45201447
Magnaporthe grisea (Mgr) MGG_11702 GI:145605265
Neurospora crassa (Ncr) NCU01119.1 GI:32412264
Arabidopsis thaliana (Ath) CAS1 GI:15225650
Oryza sativa (Osa) Os02g0139700 GI:115444137


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthCAS1
GO:0005773 vacuole C
IDA
AthCAS1
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC13G7.01c
TAS
SceS000001114
GO:0005792 microsome C
ISO
MmuMGI:1336155
GO:0005811 lipid particle C
IDA
SceS000001114
GO:0005829 cytosol C
IDA
SpoSPAC13G7.01c
GO:0005886 plasma membrane C
TAS
SceS000001114
GO:0000250 lanosterol synthase activity F
IMP
SceS000001114
ISO
MmuMGI:1336155
ISS
SpoSPAC13G7.01c
GO:0003674 molecular_function F
ND
AthCAS1
GO:0004659 prenyltransferase activity F
RCA
SceS000001114
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
RCA
SceS000001114
GO:0016871 cycloartenol synthase activity F
IDA
AthCAS1
GO:0006066 alcohol metabolic process P
RCA
SceS000001114
GO:0006695 cholesterol biosynthetic process P
IMP
HsaLSS
ISO
MmuMGI:1336155
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000001114
ISS
SpoSPAC13G7.01c
GO:0008202 steroid metabolic process P
TAS
HsaLSS
GO:0009555 pollen development P
IMP
AthCAS1
GO:0010027 thylakoid membrane organization P
IMP
AthCAS1
GO:0016125 sterol metabolic process P
ISO
MmuMGI:1336155
GO:0016481 negative regulation of transcription P
IEP
AthCAS1
GO:0019745 pentacyclic triterpenoid biosynthetic
process		 P
IDA
AthCAS1
ISS
AthCAS1
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001114

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2482

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4662 AGR351W
Arabidopsis thaliana (Ath) ath8035 At2g07050.1
Arabidopsis thaliana (Ath) ath15792 At3g45130.1
Candida glabrata (Cgl) cgl3467 CAGL0J10824g
Cryptococcus neoformans (Cne) cne847 163.m06187
Dictyostelium discoideum (Ddi) ddi11508 DDB0191311
Debaryomyces hansenii (Dha) dha1722 DEHA0C06501g
Danio rerio (Dre) dre23934 ENSDARP00000006539
Danio rerio (Dre) dre23935 ENSDARP00000007437
Danio rerio (Dre) dre23937 ENSDARP00000044375
Danio rerio (Dre) dre23936 ENSDARP00000045359
Takifugu rubripes (Fru) fru3103 SINFRUP00000142634
Gallus gallus (Gga) gga21228 ENSGALP00000009986
Gallus gallus (Gga) gga21227 ENSGALP00000009987
Gallus gallus (Gga) gga21225 ENSGALP00000009988
(LSS)		 Q5ZIC3
Gallus gallus (Gga) gga21226 ENSGALP00000009989
Homo sapiens (Hsa) hsa21090 ENSP00000324649
Homo sapiens (Hsa) hsa21089 ENSP00000348762
(LSS)		 P48449
Kluyveromyces lactis (Kla) kla980 KLLA0B10175g
Mus musculus (Mmu) mmu2366 ENSMUSP00000046856
(MGI:1336155)		 Q8BLN5
Neurospora crassa (Ncr) ncr1083 NCU01119.2
Oryza sativa (Osa) osa38714 4906.m00153
Oryza sativa (Osa) osa38716 4906.m00155
Rattus norvegicus (Rno) rno17744 ENSRNOP00000001708
Rattus norvegicus (Rno) rno17743 ENSRNOP00000039946
(RGD:620955)		 P48450
Saccharomyces cerevisiae (Sce) sce2833 YHR072W
(S000001114)
Schizosaccharomyces pombe (Spo) spo4947 SPAC13G7.01c Q10231
Yarrowia lipolytica (Yli) yli5526 YALI0F04378g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g45130
GO:0005773 vacuole C
IDA
AthAt2g07050
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC13G7.01c
TAS
SceS000001114
GO:0005792 microsome C
ISO
MmuMGI:1336155
GO:0005811 lipid particle C
IDA
SceS000001114
GO:0005829 cytosol C
IDA
SpoSPAC13G7.01c
GO:0005886 plasma membrane C
TAS
SceS000001114
GO:0000250 lanosterol synthase activity F
IDA
AthAt3g45130
IMP
SceS000001114
ISO
MmuMGI:1336155
ISS
SpoSPAC13G7.01c
GO:0004659 prenyltransferase activity F
RCA
SceS000001114
GO:0016765 transferase activity, transferring alkyl or aryl
(other than methyl) groups		 F
RCA
SceS000001114
GO:0016871 cycloartenol synthase activity F
IDA
AthAt2g07050
GO:0006066 alcohol metabolic process P
RCA
SceS000001114
GO:0006695 cholesterol biosynthetic process P
ISO
MmuMGI:1336155
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000001114
ISS
SpoSPAC13G7.01c
GO:0009555 pollen development P
IMP
AthAt2g07050
GO:0010027 thylakoid membrane organization P
IMP
AthAt2g07050
GO:0016125 sterol metabolic process P
ISO
MmuMGI:1336155
GO:0019745 pentacyclic triterpenoid biosynthetic
process		 P
IDA
AthAt2g07050
ISS
AthAt3g45130
At2g07050
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001114