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Search term: YHR079C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name IRE1
SGD link S000001121
Alternative ID YHR079C
Description Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
Synonyms YHR079C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1027 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g17520 GI:15227855
Arabidopsis thaliana (Ath) At3g11870 GI:15229885
Arabidopsis thaliana (Ath) At5g24360 GI:10177897
Caenorhabditis elegans (Cel) CE01519 GI:17532369
Drosophila melanogaster (Dme) 7300551 GI:7300551
Homo sapiens (Hsa) Hs10863929_2
(RNASEL)		 GI:10863929 Q05823
Homo sapiens (Hsa) Hs4557569 GI:4557569
Homo sapiens (Hsa) Hs15149482 GI:15149482
Saccharomyces cerevisiae (Sce) YHR079c
(S000001121)		 GI:6321870 P32361
Schizosaccharomyces pombe (Spo) SPAC167.01 GI:19114296 O94537
Arabidopsis thaliana (Ath) At2g17520 GI:15227855
Arabidopsis thaliana (Ath) At3g11870 GI:15229885
Arabidopsis thaliana (Ath) At5g24360 GI:10177897
Caenorhabditis elegans (Cel) CE01519 GI:17532369
Drosophila melanogaster (Dme) 7300551 GI:7300551
Homo sapiens (Hsa) Hs10863929_2
(RNASEL)		 GI:10863929 Q05823
Homo sapiens (Hsa) Hs4557569 GI:4557569
Homo sapiens (Hsa) Hs15149482 GI:15149482
Saccharomyces cerevisiae (Sce) YHR079c
(S000001121)		 GI:6321870 P32361
Schizosaccharomyces pombe (Spo) SPAC167.01 GI:19114296 O94537


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
HsaRNASEL
GO:0005634 nucleus C
IDA
SceS000001121
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC167.01
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC167.01
GO:0042406 extrinsic to endoplasmic reticulum
membrane		 C
IDA
AthAt2g17520
GO:0003723 RNA binding F
IDA
HsaRNASEL
GO:0004521 endoribonuclease activity F
IDA
SceS000001121
IMP
AthAt2g17520
ISS
SpoSPAC167.01
NAS
HsaRNASEL
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000001121
ISS
SpoSPAC167.01
TAS
SpoSPAC167.01
GO:0005524 ATP binding F
ISS
SpoSPAC167.01
GO:0016301 kinase activity F
ISS
AthAt3g11870
At5g24360
At2g17520
GO:0042803 protein homodimerization activity F
IDA
SceS000001121
GO:0051082 unfolded protein binding F
IDA
SceS000001121
IMP
SceS000001121
GO:0006020 inositol metabolic process P
IMP
SceS000001121
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000001121
ISS
SpoSPAC167.01
NAS
HsaRNASEL
GO:0006916 anti-apoptosis P
IGI
SpoSPAC167.01
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001121
GO:0006986 response to unfolded protein P
RCA
SceS000001121
GO:0006987 activation of signaling protein activity involved
in unfolded protein response		 P
IMP
AthAt2g17520
GO:0007165 signal transduction P
NAS
SpoSPAC167.01
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IMP
SceS000001121
ISS
SpoSPAC167.01
GO:0031505 fungal-type cell wall organization P
IGI
SceS000001121
IMP
SceS000001121

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
21868

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) ppk4 GI:19114296
Saccharomyces cerevisiae (Sce) IRE1
(S000001121)		 GI:6321870 P32361
Kluyveromyces lactis (Kla) KLLA0D13266g GI:50307351
Eremothecium gossypii (Ego) AGOS_ADR293C GI:45188166
Magnaporthe grisea (Mgr) MGG_01998 GI:145604959
Neurospora crassa (Ncr) NCU02202.1 GI:32421069


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000001121
GO:0004521 endoribonuclease activity F
IDA
SceS000001121
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000001121
GO:0042803 protein homodimerization activity F
IDA
SceS000001121
GO:0051082 unfolded protein binding F
IDA
SceS000001121
IMP
SceS000001121
GO:0006020 inositol metabolic process P
IMP
SceS000001121
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000001121
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001121
GO:0006986 response to unfolded protein P
RCA
SceS000001121
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IMP
SceS000001121
GO:0031505 fungal-type cell wall organization P
IGI
SceS000001121
IMP
SceS000001121

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1701

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6699 ENSANGP00000011285
Anopheles gambiae (Aga) aga6698 ENSANGP00000029215
Ashbya gossypii (Ago) ago2034 ADR293C
Arabidopsis thaliana (Ath) ath8595 At2g17520.1
Arabidopsis thaliana (Ath) ath24700 At5g24360.1
Caenorhabditis elegans (Cel) cel3819 C41C4.4
(CE35836;
WBGene00002147)
Candida glabrata (Cgl) cgl1369 CAGL0F03245g
Cryptococcus neoformans (Cne) cne4730 186.m03593
Dictyostelium discoideum (Ddi) ddi11557 DDB0231217
Debaryomyces hansenii (Dha) dha5630 DEHA0F27819g
Drosophila melanogaster (Dme) dme13418 CG4583-PA
(FBgn0038736)
Danio rerio (Dre) dre59 ENSDARP00000006301
Danio rerio (Dre) dre58 ENSDARP00000017704
(LOC567021)
Danio rerio (Dre) dre60 ENSDARP00000030060
Danio rerio (Dre) dre61 ENSDARP00000031583
Takifugu rubripes (Fru) fru25098 SINFRUP00000136357
Takifugu rubripes (Fru) fru11602 SINFRUP00000138363
Takifugu rubripes (Fru) fru11605 SINFRUP00000168077
Takifugu rubripes (Fru) fru11604 SINFRUP00000169022
Takifugu rubripes (Fru) fru11603 SINFRUP00000175679
Gallus gallus (Gga) gga8522 ENSGALP00000005493
Homo sapiens (Hsa) hsa14179 ENSP00000225768
(ERN1)		 C9IZV7
Homo sapiens (Hsa) hsa11828 ENSP00000256797
(ERN2)		 Q76MJ5
Homo sapiens (Hsa) hsa11829 ENSP00000343687
Kluyveromyces lactis (Kla) kla2653 KLLA0D13266g
Mus musculus (Mmu) mmu5015 ENSMUSP00000001059
(MGI:1930134)		 Q9EQY0-1
Mus musculus (Mmu) mmu25033 ENSMUSP00000033153
(MGI:1349436)		 Q32MS5
Neurospora crassa (Ncr) ncr2143 NCU02202.2
Oryza sativa (Osa) osa49181 5729.m00099
Rattus norvegicus (Rno) rno6312 ENSRNOP00000017371
(RGD:1559716)
Rattus norvegicus (Rno) rno2925 ENSRNOP00000025699
(RGD:1308743)
Saccharomyces cerevisiae (Sce) sce2843 YHR079C
(S000001121)
Schizosaccharomyces pombe (Spo) spo2164 SPAC167.01 O94537
Yarrowia lipolytica (Yli) yli482 YALI0A14839g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000001121
GO:0005637 nuclear inner membrane C
IDA
MmuMGI:1930134
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC167.01
GO:0005789 endoplasmic reticulum membrane C
IDA
MmuMGI:1930134
ISS
SpoSPAC167.01
GO:0042406 extrinsic to endoplasmic reticulum
membrane		 C
IDA
AthAt2g17520
GO:0004519 endonuclease activity F
IDA
MmuMGI:1930134
GO:0004521 endoribonuclease activity F
IDA
MmuMGI:1930134
SceS000001121
IMP
AthAt2g17520
ISS
SpoSPAC167.01
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000001121
ISS
SpoSPAC167.01
TAS
SpoSPAC167.01
GO:0005524 ATP binding F
ISS
SpoSPAC167.01
GO:0016301 kinase activity F
ISS
AthAt5g24360
At2g17520
GO:0042803 protein homodimerization activity F
IDA
SceS000001121
GO:0051082 unfolded protein binding F
IDA
SceS000001121
IMP
SceS000001121
GO:0000003 reproduction P
IMP
CelWBGene00002147
GO:0006020 inositol metabolic process P
IMP
SceS000001121
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000001121
ISS
SpoSPAC167.01
GO:0006916 anti-apoptosis P
IGI
SpoSPAC167.01
GO:0006917 induction of apoptosis P
IDA
MmuMGI:1349436
MGI:1930134
GO:0006950 response to stress P
IMP
MmuMGI:1349436
ISS
MmuMGI:1930134
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001121
GO:0006986 response to unfolded protein P
RCA
SceS000001121
GO:0006987 activation of signaling protein activity involved
in unfolded protein response		 P
IMP
AthAt2g17520
GO:0007050 cell cycle arrest P
IDA
MmuMGI:1349436
MGI:1930134
GO:0007165 signal transduction P
NAS
SpoSPAC167.01
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IDA
MmuMGI:1930134
IMP
CelWBGene00002147
SceS000001121
ISS
SpoSPAC167.01
GO:0031505 fungal-type cell wall organization P
IGI
SceS000001121
IMP
SceS000001121
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00002147
GO:0045449 regulation of transcription P
IDA
MmuMGI:1349436
GO:0046777 protein amino acid autophosphorylation P
IDA
MmuMGI:1930134

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC167.01
(O94537)		 YHR079C
(S000001121)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000001121
GO:0005783 endoplasmic reticulum C
IDA
SpoSPAC167.01
GO:0005789 endoplasmic reticulum membrane C
ISS
SpoSPAC167.01
GO:0004521 endoribonuclease activity F
IDA
SceS000001121
ISS
SpoSPAC167.01
GO:0004674 protein serine/threonine kinase
activity		 F
IDA
SceS000001121
ISS
SpoSPAC167.01
TAS
SpoSPAC167.01
GO:0005524 ATP binding F
ISS
SpoSPAC167.01
GO:0042803 protein homodimerization activity F
IDA
SceS000001121
GO:0051082 unfolded protein binding F
IDA
SceS000001121
IMP
SceS000001121
GO:0006020 inositol metabolic process P
IMP
SceS000001121
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000001121
ISS
SpoSPAC167.01
GO:0006916 anti-apoptosis P
IGI
SpoSPAC167.01
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001121
GO:0006986 response to unfolded protein P
RCA
SceS000001121
GO:0007165 signal transduction P
NAS
SpoSPAC167.01
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IMP
SceS000001121
ISS
SpoSPAC167.01
GO:0031505 fungal-type cell wall organization P
IGI
SceS000001121
IMP
SceS000001121

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GO info in one table:

s.khadayate@ucl.ac.uk