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Search term: YHR166C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name CDC23
SGD link S000001209
Alternative ID YHR166C
Description Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
Synonyms YHR166C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1155 AC-HYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Anaphase-promoting complex (APC), Cdc23 subunit

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g48150 GI:15228343
Caenorhabditis elegans (Cel) CE26888
(WBGene00003134)		 GI:17552992 Q19294
Homo sapiens (Hsa) Hs4757948 GI:4757948
Saccharomyces cerevisiae (Sce) YHR166c
(S000001209)		 GI:6321960 P16522
Schizosaccharomyces pombe (Spo) SPAC6F12.14 GI:19114212 O94556
Encephalitozoon cuniculi (Ecu) ECU06g1430 GI:19074393 Q8SV73
Arabidopsis thaliana (Ath) At3g48150 GI:15228343
Caenorhabditis elegans (Cel) CE26888
(WBGene00003134)		 GI:17552992 Q19294
Homo sapiens (Hsa) Hs4757948 GI:4757948
Saccharomyces cerevisiae (Sce) YHR166c
(S000001209)		 GI:6321960 P16522
Schizosaccharomyces pombe (Spo) SPAC6F12.14 GI:19114212 O94556
Encephalitozoon cuniculi (Ecu) ECU06g1430 GI:19074393 Q8SV73


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC6F12.14
GO:0005680 anaphase-promoting complex C
IDA
SceS000001209
TAS
SpoSPAC6F12.14
GO:0005816 spindle pole body C
IDA
SpoSPAC6F12.14
GO:0004842 ubiquitin-protein ligase activity F
TAS
SceS000001209
GO:0005515 protein binding F
IPI
SpoSPAC6F12.14
TAS
SceS000001209
GO:0000003 reproduction P
IMP
CelWBGene00003134
GO:0000022 mitotic spindle elongation P
TAS
SceS000001209
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000001209
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00003134
GO:0002119 nematode larval development P
IMP
CelWBGene00003134
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003134
GO:0007049 cell cycle P
ISS
AthAt3g48150
GO:0007091 mitotic metaphase/anaphase transition P
TAS
SceS000001209
GO:0007126 meiosis P
IMP
CelWBGene00003134
GO:0008054 cyclin catabolic process P
TAS
SceS000001209
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003134
GO:0010171 body morphogenesis P
IMP
CelWBGene00003134
GO:0016567 protein ubiquitination P
IC
SpoSPAC6F12.14
IPI
SceS000001209
GO:0030071 regulation of mitotic metaphase/anaphase
transition		 P
IMP
SpoSPAC6F12.14
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPAC6F12.14
IDA
SceS000001209
IPI
SceS000001209
GO:0031329 regulation of cellular catabolic
process		 P
RCA
SceS000001209
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00003134
GO:0051130 positive regulation of cellular component
organization		 P
RCA
SceS000001209

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
3426

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) CDC23 GI:118402596
Pan troglodytes (Ptr) CDC23 GI:114601921
Canis familiaris (Cfa) CDC23 GI:73971484
Mus musculus (Mmu) Cdc23
(MGI:1098815)		 GI:30387632 Q3TEF0
Drosophila melanogaster (Dme) cdc23
(FBgn0032863)		 GI:24585440
Anopheles gambiae (Aga) AgaP_AGAP009880 GI:158298847
Schizosaccharomyces pombe (Spo) apc8 GI:19114212
Saccharomyces cerevisiae (Sce) CDC23
(S000001209)		 GI:6321960 P16522
Kluyveromyces lactis (Kla) KLLA0A05258g GI:50302593
Eremothecium gossypii (Ego) AGOS_ABR206W GI:119873841
Magnaporthe grisea (Mgr) MGG_08648 GI:145601763
Neurospora crassa (Ncr) NCU01174.1 GI:32412374
Arabidopsis thaliana (Ath) APC8 GI:15228343
Oryza sativa (Osa) Os02g0656300 GI:115447689
Oryza sativa (Osa) Os06g0679100 GI:115469534


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1098815
GO:0005622 intracellular C
IDA
HsaCDC23
GO:0005654 nucleoplasm C
EXP
HsaCDC23
GO:0005680 anaphase-promoting complex C
IDA
HsaCDC23
SceS000001209
ISS
DmeFBgn0032863
GO:0005829 cytosol C
EXP
HsaCDC23
GO:0003674 molecular_function F
ND
MmuMGI:1098815
GO:0004842 ubiquitin-protein ligase activity F
ISS
DmeFBgn0032863
TAS
HsaCDC23
SceS000001209
GO:0005515 protein binding F
TAS
SceS000001209
GO:0000022 mitotic spindle elongation P
TAS
SceS000001209
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000001209
GO:0000080 G1 phase of mitotic cell cycle P
IDA
HsaCDC23
GO:0000090 mitotic anaphase P
NAS
DmeFBgn0032863
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
HsaCDC23
GO:0006911 phagocytosis, engulfment P
IMP
DmeFBgn0032863
GO:0007049 cell cycle P
TAS
HsaCDC23
GO:0007067 mitosis P
IDA
HsaCDC23
GO:0007080 mitotic metaphase plate congression P
IDA
HsaCDC23
GO:0007091 mitotic metaphase/anaphase transition P
TAS
HsaCDC23
SceS000001209
GO:0007096 regulation of exit from mitosis P
TAS
HsaCDC23
GO:0007113 endomitotic cell cycle P
IMP
DmeFBgn0032863
GO:0008054 cyclin catabolic process P
TAS
SceS000001209
GO:0008150 biological_process P
ND
MmuMGI:1098815
GO:0016567 protein ubiquitination P
IPI
SceS000001209
GO:0030071 regulation of mitotic metaphase/anaphase
transition		 P
IDA
HsaCDC23
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaCDC23
IDA
SceS000001209
IPI
SceS000001209
GO:0031329 regulation of cellular catabolic
process		 P
RCA
SceS000001209
GO:0051130 positive regulation of cellular component
organization		 P
RCA
SceS000001209
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaCDC23
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaCDC23
GO:0070979 protein K11-linked ubiquitination P
IDA
HsaCDC23

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2976

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12166 ENSANGP00000014868
Ashbya gossypii (Ago) ago800 ABR206W
Arabidopsis thaliana (Ath) ath16114 At3g48150.1
Caenorhabditis elegans (Cel) cel5888 F10C5.1
(CE26888;
WBGene00003134)
Candida glabrata (Cgl) cgl2622 CAGL0I02288g
Cryptococcus neoformans (Cne) cne5640 179.m00502
Dictyostelium discoideum (Ddi) ddi2027 DDB0168974
Debaryomyces hansenii (Dha) dha3367 DEHA0E02805g
Drosophila melanogaster (Dme) dme3124 CG2508-PA
(FBgn0032863)
Drosophila melanogaster (Dme) dme3122 CG31687-PA
(FBgn0051687)
Danio rerio (Dre) dre13857 ENSDARP00000018344
Encephalitozoon cuniculi (Ecu) ecu1620 19074393
Takifugu rubripes (Fru) fru25719 SINFRUP00000159406
Gallus gallus (Gga) gga6128 ENSGALP00000012291
Homo sapiens (Hsa) hsa25790 ENSP00000209827
Kluyveromyces lactis (Kla) kla229 KLLA0A05258g
Mus musculus (Mmu) mmu12485 ENSMUSP00000025228
(MGI:1098815)		 Q8BGZ4-1
Neurospora crassa (Ncr) ncr1137 NCU01174.2
Oryza sativa (Osa) osa29729 4335.m00174
Rattus norvegicus (Rno) rno13933 ENSRNOP00000035675
(RGD:1304819)		 Q4G037
Saccharomyces cerevisiae (Sce) sce2938 YHR166C
(S000001209)
Schizosaccharomyces pombe (Spo) spo1389 SPAC6F12.14 O94556
Yarrowia lipolytica (Yli) yli2158 YALI0C10692g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1098815
GO:0005634 nucleus C
IDA
SpoSPAC6F12.14
GO:0005680 anaphase-promoting complex C
IDA
SceS000001209
ISS
DmeFBgn0032863
TAS
SpoSPAC6F12.14
GO:0005816 spindle pole body C
IDA
SpoSPAC6F12.14
GO:0003674 molecular_function F
ND
MmuMGI:1098815
GO:0004842 ubiquitin-protein ligase activity F
ISS
DmeFBgn0032863
TAS
SceS000001209
GO:0005515 protein binding F
IPI
SpoSPAC6F12.14
TAS
SceS000001209
GO:0000003 reproduction P
IMP
CelWBGene00003134
GO:0000022 mitotic spindle elongation P
TAS
SceS000001209
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000001209
GO:0000090 mitotic anaphase P
NAS
DmeFBgn0032863
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00003134
GO:0002119 nematode larval development P
IMP
CelWBGene00003134
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003134
GO:0006911 phagocytosis, engulfment P
IMP
DmeFBgn0032863
GO:0007049 cell cycle P
ISS
AthAt3g48150
DmeFBgn0051687
GO:0007091 mitotic metaphase/anaphase transition P
TAS
SceS000001209
GO:0007113 endomitotic cell cycle P
IMP
DmeFBgn0032863
GO:0007126 meiosis P
IMP
CelWBGene00003134
GO:0008054 cyclin catabolic process P
TAS
SceS000001209
GO:0008150 biological_process P
ND
MmuMGI:1098815
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003134
GO:0010171 body morphogenesis P
IMP
CelWBGene00003134
GO:0016567 protein ubiquitination P
IC
SpoSPAC6F12.14
IPI
SceS000001209
GO:0030071 regulation of mitotic metaphase/anaphase
transition		 P
IMP
SpoSPAC6F12.14
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPAC6F12.14
IDA
SceS000001209
IPI
SceS000001209
GO:0031329 regulation of cellular catabolic
process		 P
RCA
SceS000001209
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00003134
GO:0051130 positive regulation of cellular component
organization		 P
RCA
SceS000001209

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC6F12.14
(O94556)		 YHR166C
(S000001209)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC6F12.14
GO:0005680 anaphase-promoting complex C
IDA
SceS000001209
TAS
SpoSPAC6F12.14
GO:0005816 spindle pole body C
IDA
SpoSPAC6F12.14
GO:0004842 ubiquitin-protein ligase activity F
TAS
SceS000001209
GO:0005515 protein binding F
IPI
SpoSPAC6F12.14
TAS
SceS000001209
GO:0000022 mitotic spindle elongation P
TAS
SceS000001209
GO:0000070 mitotic sister chromatid segregation P
TAS
SceS000001209
GO:0007091 mitotic metaphase/anaphase transition P
TAS
SceS000001209
GO:0008054 cyclin catabolic process P
TAS
SceS000001209
GO:0016567 protein ubiquitination P
IC
SpoSPAC6F12.14
IPI
SceS000001209
GO:0030071 regulation of mitotic metaphase/anaphase
transition		 P
IMP
SpoSPAC6F12.14
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
IC
SpoSPAC6F12.14
IDA
SceS000001209
IPI
SceS000001209
GO:0031329 regulation of cellular catabolic
process		 P
RCA
SceS000001209
GO:0051130 positive regulation of cellular component
organization		 P
RCA
SceS000001209

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GO info in one table:

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