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Search term: YHR193C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name EGD2
SGD link S000001236
Alternative ID YHR193C
Description Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
Synonyms YHR193C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2239 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Transcription factor containing NAC and TS-N domains

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g33040 GI:18398710
Arabidopsis thaliana (Ath) At3g12390 GI:15230476
Arabidopsis thaliana (Ath) At3g49470 GI:15229149
Arabidopsis thaliana (Ath) At4g10480 GI:15235122
Arabidopsis thaliana (Ath) At5g13850 GI:15240731
Caenorhabditis elegans (Cel) CE22740
(WBGene00022042)		 GI:17510415 Q86S66
Drosophila melanogaster (Dme) 7296134 GI:20129139
Drosophila melanogaster (Dme) 7303400
(Nacalpha)		 GI:17137300
Homo sapiens (Hsa) Hs5031931 GI:5031931 Q13765
Homo sapiens (Hsa) Hs22044463 GI:22044463
Homo sapiens (Hsa) Hs17463799 GI:17463799
Homo sapiens (Hsa) Hs17472280 GI:17472280
Homo sapiens (Hsa) Hs18557511 GI:18557511
Homo sapiens (Hsa) Hs18559414_1 GI:18559414
Homo sapiens (Hsa) Hs18588424 GI:18588424
Homo sapiens (Hsa) Hs20541584 GI:20541584
Homo sapiens (Hsa) Hs14042953 GI:14042953
Saccharomyces cerevisiae (Sce) YHR193c
(S000001236)		 GI:6321987 P38879
Schizosaccharomyces pombe (Spo) SPBC25H2.05 GI:19113153 P87147
Encephalitozoon cuniculi (Ecu) ECU02g1050 GI:19074024 Q8SWB5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g10480
At1g33040
At3g49470
GO:0005829 cytosol C
IDA
SpoSPBC25H2.05
GO:0005854 nascent polypeptide-associated
complex		 C
IDA
SceS000001236
ISS
DmeNacalpha
SpoSPBC25H2.05
NAS
DmeNacalpha
GO:0022626 cytosolic ribosome C
IDA
AthAt5g13850
At3g12390
GO:0042788 polysomal ribosome C
IDA
SpoSPBC25H2.05
GO:0003674 molecular_function F
ND
AthAt4g10480
At5g13850
At3g49470
At1g33040
GO:0005515 protein binding F
IPI
DmeNacalpha
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000001236
GO:0051082 unfolded protein binding F
IMP
SceS000001236
ISS
SpoSPBC25H2.05
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001236
GO:0070300 phosphatidic acid binding F
IDA
SceS000001236
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001236
GO:0000003 reproduction P
IMP
CelWBGene00022042
GO:0002119 nematode larval development P
IMP
CelWBGene00022042
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001236
GO:0007317 regulation of pole plasm oskar mRNA
localization		 P
IMP
DmeNacalpha
GO:0008150 biological_process P
ND
AthAt3g49470
At4g10480
At1g33040
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00022042
GO:0009651 response to salt stress P
IEP
AthAt5g13850
At3g12390
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022042
GO:0010171 body morphogenesis P
IMP
CelWBGene00022042
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00022042
GO:0019915 lipid storage P
IMP
CelWBGene00022042
GO:0040007 growth P
IMP
CelWBGene00022042
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00022042
GO:0040011 locomotion P
IMP
CelWBGene00022042
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00022042
GO:0040039 inductive cell migration P
IMP
CelWBGene00022042
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00022042
GO:0048477 oogenesis P
IMP
DmeNacalpha
GO:0051083 'de novo' cotranslational protein
folding		 P
IPI
SceS000001236
ISS
SpoSPBC25H2.05

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55914

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NACA GI:163965366
Pan troglodytes (Ptr) NACA GI:114644223
Canis familiaris (Cfa) LOC474408 GI:73968420
Drosophila melanogaster (Dme) Nacalpha GI:17137300
Anopheles gambiae (Aga) AgaP_AGAP006766 GI:58378742
Caenorhabditis elegans (Cel) Y65B4BR.5
(CE22740;
WBGene00022042)		 GI:32564132
Schizosaccharomyces pombe (Spo) egd1 GI:19113153
Saccharomyces cerevisiae (Sce) EGD2
(S000001236)		 GI:6321987 P38879
Kluyveromyces lactis (Kla) KLLA0B04290g GI:50303563
Eremothecium gossypii (Ego) AGOS_AER168C GI:45190772
Magnaporthe grisea (Mgr) MGG_02660 GI:39970387
Neurospora crassa (Ncr) NCU00635.1 GI:32408669
Arabidopsis thaliana (Ath) NACA2 GI:15229149
Oryza sativa (Osa) Os03g0121700 GI:115450389
Oryza sativa (Osa) Os01g0698900 GI:115439393
Plasmodium falciparum (Pfa) PFF1050w GI:86171390


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthNACA2
GO:0005854 nascent polypeptide-associated
complex		 C
IDA
SceS000001236
ISS
DmeNacalpha
PfaPFF1050w
NAS
DmeNacalpha
TAS
HsaNACA
GO:0003674 molecular_function F
ND
AthNACA2
GO:0005515 protein binding F
IPI
DmeNacalpha
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000001236
GO:0051082 unfolded protein binding F
IMP
SceS000001236
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001236
GO:0070300 phosphatidic acid binding F
IDA
SceS000001236
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001236
GO:0000003 reproduction P
IMP
CelWBGene00022042
GO:0002119 nematode larval development P
IMP
CelWBGene00022042
GO:0006412 translation P
TAS
HsaNACA
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001236
GO:0007317 regulation of pole plasm oskar mRNA
localization		 P
IMP
DmeNacalpha
GO:0008150 biological_process P
ND
AthNACA2
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00022042
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022042
GO:0010171 body morphogenesis P
IMP
CelWBGene00022042
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00022042
GO:0019915 lipid storage P
IMP
CelWBGene00022042
GO:0040007 growth P
IMP
CelWBGene00022042
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00022042
GO:0040011 locomotion P
IMP
CelWBGene00022042
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00022042
GO:0040039 inductive cell migration P
IMP
CelWBGene00022042
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00022042
GO:0048477 oogenesis P
IMP
DmeNacalpha
GO:0051083 'de novo' cotranslational protein
folding		 P
IPI
SceS000001236
ISS
PfaPFF1050w

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_950

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2218 ENSANGP00000020323
Anopheles gambiae (Aga) aga2217 ENSANGP00000028147
Ashbya gossypii (Ago) ago2671 AER168C
Arabidopsis thaliana (Ath) ath3458 At1g33040.1
Arabidopsis thaliana (Ath) ath13376 At3g12390.1
Arabidopsis thaliana (Ath) ath16259 At3g49470.1
Arabidopsis thaliana (Ath) ath18781 At4g10480.1
Caenorhabditis elegans (Cel) cel20294 Y65B4BR.5a
(CE22740;
WBGene00022042)
Caenorhabditis elegans (Cel) cel20295 Y65B4BR.5b
(CE33239)
Candida glabrata (Cgl) cgl4969 CAGL0M07161g
Dictyostelium discoideum (Ddi) ddi6660 DDB0205559
Drosophila melanogaster (Dme) dme181 CG4415-PA
(FBgn0031296)
Drosophila melanogaster (Dme) dme4779 CG8759-PA
(FBgn0017565)
Drosophila melanogaster (Dme) dme4778 CG8759-PB
(FBgn0017565)
Drosophila melanogaster (Dme) dme4780 CG8759-PC
(FBgn0017565)
Danio rerio (Dre) dre7177 ENSDARP00000010986
(LOC562388)
Danio rerio (Dre) dre15253 ENSDARP00000025953
(naca)		 Q8JIU7
Encephalitozoon cuniculi (Ecu) ecu103 19074024
Takifugu rubripes (Fru) fru31160 SINFRUP00000127819
Takifugu rubripes (Fru) fru28452 SINFRUP00000136613
Gallus gallus (Gga) gga24661 ENSGALP00000000669
Gallus gallus (Gga) gga9314 ENSGALP00000008980
(NACAD)
Homo sapiens (Hsa) hsa7706 ENSP00000349212
(NACA)		 Q13765
Kluyveromyces lactis (Kla) kla721 KLLA0B04290g
Mus musculus (Mmu) mmu6084 ENSMUSP00000056225
Mus musculus (Mmu) mmu3000 ENSMUSP00000073532
(MGI:106095)		 Q60817
Neurospora crassa (Ncr) ncr616 NCU00635.2
Oryza sativa (Osa) osa13295 2863.m00144
Oryza sativa (Osa) osa13999 2876.m00151
Oryza sativa (Osa) osa14011 2876.m00185
Oryza sativa (Osa) osa32007 4444.m00084
Oryza sativa (Osa) osa32983 4496.m00168
Oryza sativa (Osa) osa39616 4997.m00105
Plasmodium falciparum (Pfa) pfa2949 PFF1050w
Rattus norvegicus (Rno) rno25986 ENSRNOP00000003550
(RGD:1308642)		 B2RYX0
Saccharomyces cerevisiae (Sce) sce2969 YHR193C
(S000001236)
Schizosaccharomyces pombe (Spo) spo639 SPBC25H2.05 P87147
Yarrowia lipolytica (Yli) yli1747 YALI0C00605g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g10480
At1g33040
At3g49470
GO:0005634 nucleus C
IDA
MmuMGI:106095
GO:0005737 cytoplasm C
IDA
MmuMGI:106095
GO:0005829 cytosol C
IDA
SpoSPBC25H2.05
GO:0005854 nascent polypeptide-associated
complex		 C
IDA
SceS000001236
ISS
DmeFBgn0031296
PfaPFF1050w
SpoSPBC25H2.05
GO:0022626 cytosolic ribosome C
IDA
AthAt3g12390
GO:0042788 polysomal ribosome C
IDA
SpoSPBC25H2.05
GO:0003674 molecular_function F
ND
AthAt4g10480
At3g49470
At1g33040
GO:0003713 transcription coactivator activity F
IDA
MmuMGI:106095
GO:0017025 TATA-binding protein binding F
IDA
MmuMGI:106095
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000001236
GO:0051082 unfolded protein binding F
IMP
SceS000001236
ISS
DmeFBgn0031296
SpoSPBC25H2.05
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001236
GO:0070300 phosphatidic acid binding F
IDA
SceS000001236
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001236
GO:0000003 reproduction P
IMP
CelWBGene00022042
GO:0002119 nematode larval development P
IMP
CelWBGene00022042
GO:0006605 protein targeting P
ISS
DmeFBgn0031296
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001236
GO:0008150 biological_process P
ND
AthAt3g49470
At4g10480
At1g33040
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00022042
GO:0009651 response to salt stress P
IEP
AthAt3g12390
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00022042
GO:0010171 body morphogenesis P
IMP
CelWBGene00022042
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00022042
GO:0019915 lipid storage P
IMP
CelWBGene00022042
GO:0040007 growth P
IMP
CelWBGene00022042
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00022042
GO:0040011 locomotion P
IMP
CelWBGene00022042
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00022042
GO:0040039 inductive cell migration P
IMP
CelWBGene00022042
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00022042
GO:0045941 positive regulation of transcription P
IDA
MmuMGI:106095
GO:0051083 'de novo' cotranslational protein
folding		 P
IPI
SceS000001236
ISS
PfaPFF1050w
SpoSPBC25H2.05

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC25H2.05
(P87147)		 YHR193C
(S000001236)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SpoSPBC25H2.05
GO:0005854 nascent polypeptide-associated
complex		 C
IDA
SceS000001236
ISS
SpoSPBC25H2.05
GO:0042788 polysomal ribosome C
IDA
SpoSPBC25H2.05
GO:0032266 phosphatidylinositol-3-phosphate
binding		 F
IDA
SceS000001236
GO:0051082 unfolded protein binding F
IMP
SceS000001236
ISS
SpoSPBC25H2.05
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001236
GO:0070300 phosphatidic acid binding F
IDA
SceS000001236
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001236
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001236
GO:0051083 'de novo' cotranslational protein
folding		 P
IPI
SceS000001236
ISS
SpoSPBC25H2.05

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