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Search term: YHR204W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MNL1
SGD link S000001247
Alternative ID YHR204W
Description alpha-1,2-specific exomannosidase of the endoplasmic reticulum that generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
Synonyms YHR204W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2429 ACDHYP-

KOGs classification KOGs description
METABOLISM Glycosyl hydrolase, family 47

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g27520 GI:15223538
Arabidopsis thaliana (Ath) At5g43710 GI:15239952
Caenorhabditis elegans (Cel) CE05447 GI:17539264
Caenorhabditis elegans (Cel) CE09309
(WBGene00008646)		 GI:17559490 P90830
Drosophila melanogaster (Dme) 7290228
(Edem1)		 GI:20128901
Homo sapiens (Hsa) Hs7662002
(EDEM1)		 GI:7662002 Q92611
Homo sapiens (Hsa) Hs8922667 GI:8922667
Homo sapiens (Hsa) Hs17487891 GI:17487891
Homo sapiens (Hsa) Hs18580560 GI:18580560
Saccharomyces cerevisiae (Sce) YHR204w
(S000001247)		 GI:6321998 P38888
Schizosaccharomyces pombe (Spo) SPAC23A1.04c GI:19115346 O94726


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC23A1.04c
GO:0005788 endoplasmic reticulum lumen C
IDA
SceS000001247
GO:0005829 cytosol C
IDA
SpoSPAC23A1.04c
GO:0004559 alpha-mannosidase activity F
ISS
AthAt5g43710
At1g27520
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase
activity		 F
IMP
SceS000001247
ISS
DmeEdem1
GO:0030246 carbohydrate binding F
IMP
SceS000001247
ISS
SceS000001247
SpoSPAC23A1.04c
GO:0006487 protein amino acid N-linked glycosylation P
ISS
AthAt1g27520
At5g43710
GO:0006516 glycoprotein catabolic process P
ISS
SpoSPAC23A1.04c
GO:0006517 protein deglycosylation P
ISS
SpoSPAC23A1.04c
GO:0008340 determination of adult lifespan P
IMP
DmeEdem1
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000001247
ISS
SpoSPAC23A1.04c
NAS
DmeEdem1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74703

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) MNL1
(S000001247)		 GI:6321998 P38888
Kluyveromyces lactis (Kla) KLLA0B03608g GI:50303507
Eremothecium gossypii (Ego) AGOS_ADL390W GI:45187483


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005788 endoplasmic reticulum lumen C
IDA
SceS000001247
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase
activity		 F
IMP
SceS000001247
GO:0030246 carbohydrate binding F
IMP
SceS000001247
ISS
SceS000001247
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000001247

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_5001

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1351 ADL390W
Arabidopsis thaliana (Ath) ath2878 At1g27520.1
Caenorhabditis elegans (Cel) cel4250 C47E12.3
(CE33766;
WBGene00008148)
Candida glabrata (Cgl) cgl1619 CAGL0F09053g
Debaryomyces hansenii (Dha) dha2636 DEHA0D07667g
Danio rerio (Dre) dre29751 ENSDARP00000018577
(edem1)		 Q7ZVP7
Takifugu rubripes (Fru) fru16989 SINFRUP00000147251
Takifugu rubripes (Fru) fru16990 SINFRUP00000147253
Gallus gallus (Gga) gga5504 ENSGALP00000013528
(EDEM1)		 Q5ZK76
Homo sapiens (Hsa) hsa22007 ENSP00000256497
(EDEM1)		 Q92611
Kluyveromyces lactis (Kla) kla693 KLLA0B03608g
Mus musculus (Mmu) mmu22454 ENSMUSP00000032195
Neurospora crassa (Ncr) ncr2033 NCU02091.2
Oryza sativa (Osa) osa78334 7489.m00107
Rattus norvegicus (Rno) rno21948 ENSRNOP00000010810
(RGD:1563633)
Saccharomyces cerevisiae (Sce) sce2982 YHR204W
(S000001247)
Schizosaccharomyces pombe (Spo) spo2553 SPAC23A1.04c O94726
Yarrowia lipolytica (Yli) yli3251 YALI0D12925g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC23A1.04c
GO:0005788 endoplasmic reticulum lumen C
IDA
SceS000001247
GO:0005829 cytosol C
IDA
SpoSPAC23A1.04c
GO:0004559 alpha-mannosidase activity F
ISS
AthAt1g27520
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase
activity		 F
IMP
SceS000001247
GO:0030246 carbohydrate binding F
IMP
SceS000001247
ISS
SceS000001247
SpoSPAC23A1.04c
GO:0006487 protein amino acid N-linked glycosylation P
ISS
AthAt1g27520
GO:0006516 glycoprotein catabolic process P
ISS
SpoSPAC23A1.04c
GO:0006517 protein deglycosylation P
ISS
SpoSPAC23A1.04c
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000001247
ISS
SpoSPAC23A1.04c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC23A1.04c
(O94726)		 YHR204W
(S000001247)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
ISS
SpoSPAC23A1.04c
GO:0005788 endoplasmic reticulum lumen C
IDA
SceS000001247
GO:0005829 cytosol C
IDA
SpoSPAC23A1.04c
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase
activity		 F
IMP
SceS000001247
GO:0030246 carbohydrate binding F
IMP
SceS000001247
ISS
SceS000001247
SpoSPAC23A1.04c
GO:0006516 glycoprotein catabolic process P
ISS
SpoSPAC23A1.04c
GO:0006517 protein deglycosylation P
ISS
SpoSPAC23A1.04c
GO:0030433 ER-associated protein catabolic
process		 P
IMP
SceS000001247
ISS
SpoSPAC23A1.04c

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