Bahler Lab

Search term: YHR205W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name SCH9

SGD link S000001248

Alternative ID YHR205W

Description Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB

Synonyms YHR205W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0598 ACDHYPE

KOGs classification KOGs description

POORLY CHARACTERIZEDCELLULAR PROCESSES AND SIGNALING Ribosomal protein S6 kinase and related proteins

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000329 fungal-type vacuole membrane C
IDA
Sce S000001248

GO:0000785 chromatin C
IDA
Sce S000001248

GO:0005575 cellular_component C
ND
Hsa SGK2
Spo SPCC162.10
SPCC24B10.07

GO:0005634 nucleus C
IDA
Ath At3g08720
Hsa RPS6KB1
Sce S000004710
S000001248

GO:0005635 nuclear envelope C
IDA
Spo SPAC22E12.14c

GO:0005737 cytoplasm C
IDA
Ath At3g08730
Hsa RPS6KB1
Sce YBR028c
S000004710
S000001248

GO:0005739 mitochondrion C
IDA
Hsa RPS6KB1

GO:0005829 cytosol C
EXP
Hsa RPS6KB1
IDA
Sce S000001609
Spo SPCC4G3.08
SPAC1B9.02c
SPAC22E12.14c

GO:0005886 plasma membrane C
IDA
Sce S000001609

GO:0005935 cellular bud neck C
IDA
Sce S000001609

GO:0004672 protein kinase activity F
IDA
Hsa RPS6KB1
ISS
Ath At3g08720
At3g08730
Sce YBR028c
S000004710
TAS
Hsa RPS6KB1

GO:0004674 protein serine/threonine kinase
activity F
IDA
Ath At3g08730
Sce S000001609
Spo SPCC24B10.07
IGI
Sce S000001248
IMP
Sce S000001609
ISS
Sce S000001248
S000001609
Spo SPAC22E12.14c
SPCC162.10
SPCC4G3.08
RCA
Sce YBR028c
S000004710
TAS
Spo SPAC1B9.02c
SPAC22E12.14c
SPCC162.10
SPCC4G3.08

GO:0005515 protein binding F
IPI
Ath At3g08730
Hsa RPS6KB1
Spo SPCC24B10.07

GO:0005524 ATP binding F
IC
Spo SPAC1B9.02c
SPCC24B10.07
ISS
Spo SPAC22E12.14c
SPCC162.10
SPCC4G3.08

GO:0015459 potassium channel regulator activity F
IDA
Hsa SGK2

GO:0016301 kinase activity F
EXP
Hsa RPS6KB1
IDA
Ath At3g08720
At3g08730
ISS
Ath At3g08720
At3g08730

GO:0017080 sodium channel regulator activity F
NAS
Hsa SGK2

GO:0000003 reproduction P
IMP
Cel WBGene00012929

GO:0000082 G1/S transition of mitotic cell
cycle P
IMP
Hsa RPS6KB1

GO:0001300 chronological cell aging P
IGI
Spo SPAC22E12.14c

GO:0001302 replicative cell aging P
IMP
Sce S000001248

GO:0001315 age-dependent response to reactive oxygen
species P
IGI
Spo SPAC22E12.14c
IMP
Spo SPAC22E12.14c

GO:0001324 age-dependent response to oxidative stress
involved in chronological cell
aging P
IMP
Sce S000001248

GO:0002119 nematode larval development P
IGI
Cel WBGene00012929
IMP
Cel WBGene00012929

GO:0006412 translation P
IMP
Cel WBGene00012929

GO:0006468 protein amino acid phosphorylation P
IDA
Ath At3g08720
At3g08730
Sce S000001609
Spo SPCC24B10.07
IGI
Sce S000001248
IMP
Sce S000001609
ISS
Sce S000004710
S000001248
S000001609
Spo SPAC22E12.14c
SPCC162.10
SPCC4G3.08
NAS
Hsa SGK2
TAS
Spo SPAC1B9.02c

GO:0006970 response to osmotic stress P
IDA
Ath At3g08730
IMP
Ath At3g08730

GO:0006979 response to oxidative stress P
TAS
Hsa SGK2

GO:0007039 vacuolar protein catabolic process P
RCA
Sce S000004710

GO:0007165 signal transduction P
IC
Spo SPCC4G3.08
NAS
Spo SPCC162.10

GO:0007243 intracellular protein kinase cascade P
TAS
Hsa SGK2

GO:0007346 regulation of mitotic cell cycle P
TAS
Spo SPCC24B10.07

GO:0008150 biological_process P
ND
Sce YBR028c

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00012929

GO:0008361 regulation of cell size P
IMP
Sce S000001248

GO:0009408 response to heat P
IEP
Ath At3g08720
IMP
Cel WBGene00012929

GO:0009409 response to cold P
IEP
Ath At3g08730
At3g08720

GO:0009651 response to salt stress P
IEP
Ath At3g08730
At3g08720

GO:0019933 cAMP-mediated signaling P
IMP
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0031137 regulation of conjugation with cellular
fusion P
IGI
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0031142 induction of conjugation upon nitrogen
starvation P
IGI
Spo SPCC24B10.07

GO:0031929 TOR signaling cascade P
IDA
Hsa RPS6KB1
TAS
Spo SPCC24B10.07

GO:0032880 regulation of protein localization P
IMP
Sce S000001248

GO:0040007 growth P
IMP
Cel WBGene00012929

GO:0040018 positive regulation of multicellular organism
growth P
IMP
Cel WBGene00012929

GO:0043066 negative regulation of apoptosis P
IMP
Hsa RPS6KB1

GO:0043619 regulation of transcription from RNA polymerase II
promoter in response to oxidative
stress P
IMP
Sce S000001248

GO:0045727 positive regulation of translation P
IMP
Hsa RPS6KB1
TAS
Ath At3g08720
At3g08730

GO:0045931 positive regulation of mitotic cell
cycle P
IMP
Hsa RPS6KB1

GO:0045943 positive regulation of transcription from RNA
polymerase I promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0045945 positive regulation of transcription from RNA
polymerase III promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0045948 positive regulation of translational
initiation P
IMP
Hsa RPS6KB1

GO:0046777 protein amino acid autophosphorylation P
IDA
Sce S000001609

GO:0047484 regulation of response to osmotic
stress P
IMP
Sce S000001248

GO:0048015 phosphoinositide-mediated signaling P
TAS
Hsa RPS6KB1

GO:0061093 negative regulation of phospholipid
translocation P
IMP
Sce S000001609

GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape P
IMP
Spo SPAC22E12.14c

GO:0070941 eisosome assembly P
IGI
Sce S000001609
S000004710

GO:0090062 regulation of trehalose metabolic
process P
IMP
Spo SPAC1B9.02c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

117461

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) sck1
(SPAC1B9.02c) GI:19114666 P50530

Saccharomyces cerevisiae (Sce) SCH9
(S000001248) GI:6321999 P11792

Kluyveromyces lactis (Kla) KLLA0B03586g GI:50303505

Eremothecium gossypii (Ego) AGOS_ADL389W GI:45187484

Magnaporthe grisea (Mgr) MGG_01251 GI:145616654

Neurospora crassa (Ncr) NCU03200.1 GI:32420385

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000329 fungal-type vacuole membrane C
IDA
Sce S000001248

GO:0000785 chromatin C
IDA
Sce S000001248

GO:0005634 nucleus C
IDA
Sce S000001248

GO:0005737 cytoplasm C
IDA
Sce S000001248

GO:0005829 cytosol C
IDA
Spo SPAC1B9.02c

GO:0004674 protein serine/threonine kinase
activity F
IGI
Sce S000001248
ISS
Sce S000001248
TAS
Spo SPAC1B9.02c

GO:0005524 ATP binding F
IC
Spo SPAC1B9.02c

GO:0001302 replicative cell aging P
IMP
Sce S000001248

GO:0001324 age-dependent response to oxidative stress
involved in chronological cell
aging P
IMP
Sce S000001248

GO:0006468 protein amino acid phosphorylation P
IGI
Sce S000001248
ISS
Sce S000001248
TAS
Spo SPAC1B9.02c

GO:0008361 regulation of cell size P
IMP
Sce S000001248

GO:0019933 cAMP-mediated signaling P
IMP
Spo SPAC1B9.02c

GO:0031137 regulation of conjugation with cellular
fusion P
IGI
Spo SPAC1B9.02c

GO:0032880 regulation of protein localization P
IMP
Sce S000001248

GO:0043619 regulation of transcription from RNA polymerase II
promoter in response to oxidative
stress P
IMP
Sce S000001248

GO:0045943 positive regulation of transcription from RNA
polymerase I promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0045945 positive regulation of transcription from RNA
polymerase III promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0047484 regulation of response to osmotic
stress P
IMP
Sce S000001248

GO:0090062 regulation of trehalose metabolic
process P
IMP
Spo SPAC1B9.02c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_1628

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga4285 ENSANGP00000019348

Ashbya gossypii (Ago) ago1352 ADL389W

Caenorhabditis elegans (Cel) cel1838 C12D8.10a
(CE15612;
WBGene00000102)

Caenorhabditis elegans (Cel) cel1839 C12D8.10b
(CE05274)

Candida glabrata (Cgl) cgl1620 CAGL0F09075g

Cryptococcus neoformans (Cne) cne2682 183.m01616

Dictyostelium discoideum (Ddi) ddi13295 DDB0220670

Debaryomyces hansenii (Dha) dha2633 DEHA0D07601g

Drosophila melanogaster (Dme) dme12879 CG4006-PA
(FBgn0010379)

Drosophila melanogaster (Dme) dme12880 CG4006-PB
(FBgn0010379)

Drosophila melanogaster (Dme) dme12881 CG4006-PC
(FBgn0010379)

Danio rerio (Dre) dre9512 ENSDARP00000023119
(akt2) Q8UUX0

Takifugu rubripes (Fru) fru32163 SINFRUP00000143131

Takifugu rubripes (Fru) fru6396 SINFRUP00000145101

Takifugu rubripes (Fru) fru24685 SINFRUP00000157275

Takifugu rubripes (Fru) fru24686 SINFRUP00000173187

Gallus gallus (Gga) gga19890 ENSGALP00000018962
(AKT1)

Homo sapiens (Hsa) hsa10195 ENSP00000270202
(AKT1) P31749

Homo sapiens (Hsa) hsa16392 ENSP00000309428
(AKT2) Q0VAN0

Homo sapiens (Hsa) hsa10194 ENSP00000311456

Homo sapiens (Hsa) hsa16391 ENSP00000351095
(AKT2) Q6P4H3

Kluyveromyces lactis (Kla) kla692 KLLA0B03586g

Mus musculus (Mmu) mmu6329 ENSMUSP00000001780
(MGI:87986) A4FUQ9

Mus musculus (Mmu) mmu23465 ENSMUSP00000052103
(MGI:104874) Q60823

Mus musculus (Mmu) mmu23464 ENSMUSP00000077843

Neurospora crassa (Ncr) ncr3101 NCU03200.2

Rattus norvegicus (Rno) rno1369 ENSRNOP00000025303
(RGD:2082) P47197

Rattus norvegicus (Rno) rno25721 ENSRNOP00000038369
(RGD:2081) P47196

Saccharomyces cerevisiae (Sce) sce2983 YHR205W
(S000001248)

Schizosaccharomyces pombe (Spo) spo1470 SPAC1B9.02c P50530

Schizosaccharomyces pombe (Spo) spo1173 SPAC22E12.14c Q10364

Yarrowia lipolytica (Yli) yli3310 YALI0D14542g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000329 fungal-type vacuole membrane C
IDA
Sce S000001248

GO:0000785 chromatin C
IDA
Sce S000001248

GO:0005622 intracellular C
IDA
Cel WBGene00000102

GO:0005625 soluble fraction C
ISO
Mmu MGI:87986
MGI:104874

GO:0005634 nucleus C
IDA
Sce S000001248

GO:0005635 nuclear envelope C
IDA
Spo SPAC22E12.14c

GO:0005737 cytoplasm C
IDA
Dme FBgn0010379
Mmu MGI:87986
Sce S000001248
ISO
Mmu MGI:87986

GO:0005739 mitochondrion C
ISO
Mmu MGI:104874

GO:0005792 microsome C
ISO
Mmu MGI:104874

GO:0005819 spindle C
IDA
Mmu MGI:87986

GO:0005829 cytosol C
EXP
Mmu MGI:87986
IDA
Spo SPAC1B9.02c
SPAC22E12.14c
ISO
Mmu MGI:87986
MGI:104874

GO:0005886 plasma membrane C
ISO
Mmu MGI:87986
MGI:104874
NAS
Dme FBgn0010379

GO:0009986 cell surface C
IDA
Dme FBgn0010379

GO:0030027 lamellipodium C
IDA
Mmu MGI:104874
MGI:87986

GO:0031982 vesicle C
ISO
Mmu MGI:104874

GO:0032593 insulin-responsive compartment C
ISO
Mmu MGI:104874

GO:0004672 protein kinase activity F
IDA
Dme FBgn0010379
Mmu MGI:87986
ISO
Mmu MGI:87986

GO:0004674 protein serine/threonine kinase
activity F
IDA
Cel WBGene00000102
Dme FBgn0010379
IGI
Sce S000001248
IMP
Dme FBgn0010379
ISO
Mmu MGI:87986
MGI:104874
ISS
Cel WBGene00000102
Dme FBgn0010379
Sce S000001248
Spo SPAC22E12.14c
NAS
Dme FBgn0010379
TAS
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0005515 protein binding F
IPI
Mmu MGI:87986
MGI:104874

GO:0005516 calmodulin binding F
IDA
Cel WBGene00000102
IPI
Cel WBGene00000102

GO:0005524 ATP binding F
IC
Spo SPAC1B9.02c
ISO
Mmu MGI:87986
MGI:104874
ISS
Spo SPAC22E12.14c

GO:0016301 kinase activity F
EXP
Mmu MGI:87986
ISO
Mmu MGI:87986

GO:0019899 enzyme binding F
ISO
Mmu MGI:87986

GO:0035091 phosphoinositide binding F
NAS
Dme FBgn0010379

GO:0001300 chronological cell aging P
IGI
Spo SPAC22E12.14c

GO:0001302 replicative cell aging P
IMP
Sce S000001248

GO:0001315 age-dependent response to reactive oxygen
species P
IGI
Spo SPAC22E12.14c
IMP
Spo SPAC22E12.14c

GO:0001324 age-dependent response to oxidative stress
involved in chronological cell
aging P
IMP
Sce S000001248

GO:0001893 maternal placenta development P
IMP
Mmu MGI:87986

GO:0001934 positive regulation of protein amino acid
phosphorylation P
ISO
Mmu MGI:104874

GO:0005977 glycogen metabolic process P
IMP
Mmu MGI:87986

GO:0005978 glycogen biosynthetic process P
ISO
Mmu MGI:87986

GO:0006412 translation P
ISO
Mmu MGI:87986

GO:0006468 protein amino acid phosphorylation P
IDA
Dme FBgn0010379
Mmu MGI:87986
IGI
Sce S000001248
ISO
Mmu MGI:87986
MGI:104874
ISS
Cel WBGene00000102
Sce S000001248
Spo SPAC22E12.14c
NAS
Dme FBgn0010379
TAS
Spo SPAC1B9.02c

GO:0006469 negative regulation of protein kinase
activity P
ISO
Mmu MGI:87986

GO:0006915 apoptosis P
IDA
Mmu MGI:87986

GO:0006916 anti-apoptosis P
IMP
Dme FBgn0010379
ISO
Mmu MGI:87986

GO:0006924 activation-induced cell death of T
cells P
ISO
Mmu MGI:87986

GO:0006954 inflammatory response P
IDA
Mmu MGI:87986

GO:0007165 signal transduction P
ISO
Mmu MGI:87986

GO:0007281 germ cell development P
IDA
Mmu MGI:87986

GO:0007424 open tracheal system development P
IMP
Dme FBgn0010379
TAS
Dme FBgn0010379

GO:0008286 insulin receptor signaling pathway P
IGI
Dme FBgn0010379
IMP
Cel WBGene00000102
Mmu MGI:87986
ISO
Mmu MGI:87986
NAS
Dme FBgn0010379
TAS
Dme FBgn0010379

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00000102

GO:0008360 regulation of cell shape P
IMP
Dme FBgn0010379

GO:0008361 regulation of cell size P
IMP
Sce S000001248
NAS
Dme FBgn0010379

GO:0008362 chitin-based embryonic cuticle biosynthetic
process P
IGI
Dme FBgn0010379

GO:0008637 apoptotic mitochondrial changes P
IDA
Mmu MGI:87986

GO:0009725 response to hormone stimulus P
IDA
Mmu MGI:87986

GO:0009967 positive regulation of signal transduction P
ISO
Mmu MGI:104874

GO:0010628 positive regulation of gene expression P
ISO
Mmu MGI:104874

GO:0010765 positive regulation of sodium ion
transport P
IDA
Mmu MGI:87986
IMP
Mmu MGI:87986
ISO
Mmu MGI:104874
MGI:87986

GO:0010975 regulation of neuron projection
development P
IDA
Mmu MGI:87986

GO:0015758 glucose transport P
IMP
Mmu MGI:87986

GO:0016310 phosphorylation P
EXP
Mmu MGI:87986

GO:0016567 protein ubiquitination P
IDA
Mmu MGI:87986

GO:0018105 peptidyl-serine phosphorylation P
IDA
Mmu MGI:87986
ISO
Mmu MGI:87986

GO:0019915 lipid storage P
IGI
Dme FBgn0010379
IMP
Cel WBGene00000102

GO:0019933 cAMP-mediated signaling P
IMP
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0023034 intracellular signaling pathway P
IGI
Dme FBgn0010379
ISO
Mmu MGI:87986

GO:0030030 cell projection organization P
ISO
Mmu MGI:87986

GO:0030163 protein catabolic process P
IDA
Mmu MGI:87986

GO:0030307 positive regulation of cell growth P
IMP
Dme FBgn0010379
ISO
Mmu MGI:87986
NAS
Dme FBgn0010379
TAS
Dme FBgn0010379

GO:0030334 regulation of cell migration P
ISO
Mmu MGI:87986

GO:0030335 positive regulation of cell migration P
ISO
Mmu MGI:104874

GO:0031137 regulation of conjugation with cellular
fusion P
IGI
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0032094 response to food P
IDA
Mmu MGI:87986

GO:0032270 positive regulation of cellular protein metabolic
process P
ISO
Mmu MGI:87986

GO:0032436 positive regulation of proteasomal
ubiquitin-dependent protein catabolic
process P
IMP
Mmu MGI:87986

GO:0032869 cellular response to insulin stimulus P
IDA
Mmu MGI:87986
IMP
Mmu MGI:87986
ISO
Mmu MGI:87986
MGI:104874

GO:0032880 regulation of protein localization P
IDA
Mmu MGI:87986
IMP
Sce S000001248
ISO
Mmu MGI:87986

GO:0033119 negative regulation of RNA splicing P
ISO
Mmu MGI:104874

GO:0033138 positive regulation of peptidyl-serine
phosphorylation P
ISO
Mmu MGI:104874

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00000102

GO:0040014 regulation of multicellular organism
growth P
IMP
Dme FBgn0010379
NAS
Dme FBgn0010379

GO:0040018 positive regulation of multicellular organism
growth P
TAS
Dme FBgn0010379

GO:0042306 regulation of protein import into
nucleus P
TAS
Dme FBgn0010379

GO:0042640 anagen P
IMP
Mmu MGI:87986

GO:0043053 dauer entry P
IMP
Cel WBGene00000102

GO:0043066 negative regulation of apoptosis P
IMP
Mmu MGI:87986
ISO
Mmu MGI:104874

GO:0043154 negative regulation of caspase
activity P
ISO
Mmu MGI:104874

GO:0043491 protein kinase B signaling cascade P
IGI
Mmu MGI:87986
ISO
Mmu MGI:104874

GO:0043619 regulation of transcription from RNA polymerase II
promoter in response to oxidative
stress P
IMP
Sce S000001248

GO:0045429 positive regulation of nitric oxide biosynthetic
process P
ISO
Mmu MGI:104874

GO:0045792 negative regulation of cell size P
ISO
Mmu MGI:87986

GO:0045793 positive regulation of cell size P
IMP
Dme FBgn0010379
NAS
Dme FBgn0010379
TAS
Dme FBgn0010379

GO:0045884 regulation of survival gene product
expression P
IDA
Mmu MGI:87986

GO:0045943 positive regulation of transcription from RNA
polymerase I promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0045944 positive regulation of transcription from RNA
polymerase II promoter P
ISO
Mmu MGI:104874

GO:0045945 positive regulation of transcription from RNA
polymerase III promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0046326 positive regulation of glucose
import P
ISO
Mmu MGI:104874

GO:0046328 regulation of JNK cascade P
IDA
Mmu MGI:104874

GO:0046329 negative regulation of JNK cascade P
ISO
Mmu MGI:87986

GO:0046620 regulation of organ growth P
NAS
Dme FBgn0010379

GO:0046622 positive regulation of organ growth P
IMP
Dme FBgn0010379
NAS
Dme FBgn0010379
TAS
Dme FBgn0010379

GO:0047484 regulation of response to osmotic
stress P
IMP
Sce S000001248

GO:0050773 regulation of dendrite development P
IMP
Dme FBgn0010379

GO:0050927 positive regulation of positive
chemotaxis P
ISO
Mmu MGI:104874

GO:0060709 glycogen cell development involved in embryonic
placenta development P
IMP
Mmu MGI:87986

GO:0060716 labyrinthine layer blood vessel
development P
IMP
Mmu MGI:87986

GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape P
IMP
Spo SPAC22E12.14c

GO:0090062 regulation of trehalose metabolic
process P
IMP
Spo SPAC1B9.02c

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC22E12.14c
(Q10364) YHR205W
(S000001248)

SPAC1B9.02c
(P50530) YHR205W
(S000001248)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000329 fungal-type vacuole membrane C
IDA
Sce S000001248

GO:0000785 chromatin C
IDA
Sce S000001248

GO:0005634 nucleus C
IDA
Sce S000001248

GO:0005635 nuclear envelope C
IDA
Spo SPAC22E12.14c

GO:0005737 cytoplasm C
IDA
Sce S000001248

GO:0005829 cytosol C
IDA
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0004674 protein serine/threonine kinase
activity F
IGI
Sce S000001248
ISS
Sce S000001248
Spo SPAC22E12.14c
TAS
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0005524 ATP binding F
IC
Spo SPAC1B9.02c
ISS
Spo SPAC22E12.14c

GO:0001300 chronological cell aging P
IGI
Spo SPAC22E12.14c

GO:0001302 replicative cell aging P
IMP
Sce S000001248

GO:0001315 age-dependent response to reactive oxygen
species P
IGI
Spo SPAC22E12.14c
IMP
Spo SPAC22E12.14c

GO:0001324 age-dependent response to oxidative stress
involved in chronological cell
aging P
IMP
Sce S000001248

GO:0006468 protein amino acid phosphorylation P
IGI
Sce S000001248
ISS
Sce S000001248
Spo SPAC22E12.14c
TAS
Spo SPAC1B9.02c

GO:0008361 regulation of cell size P
IMP
Sce S000001248

GO:0019933 cAMP-mediated signaling P
IMP
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0031137 regulation of conjugation with cellular
fusion P
IGI
Spo SPAC1B9.02c
SPAC22E12.14c

GO:0032880 regulation of protein localization P
IMP
Sce S000001248

GO:0043619 regulation of transcription from RNA polymerase II
promoter in response to oxidative
stress P
IMP
Sce S000001248

GO:0045943 positive regulation of transcription from RNA
polymerase I promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0045945 positive regulation of transcription from RNA
polymerase III promoter P
IGI
Sce S000001248
IMP
Sce S000001248

GO:0047484 regulation of response to osmotic
stress P
IMP
Sce S000001248

GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape P
IMP
Spo SPAC22E12.14c

GO:0090062 regulation of trehalose metabolic
process P
IMP
Spo SPAC1B9.02c

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s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0598	ACDHYPE

KOGs classification	KOGs description
POORLY CHARACTERIZEDCELLULAR PROCESSES AND SIGNALING	Ribosomal protein S6 kinase and related proteins

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At3g08720	GI:15231959
Arabidopsis thaliana (Ath)	At3g08730	GI:15231960
Caenorhabditis elegans (Cel)	CE03492 (WBGene00010838)	GI:17554256	Q21483
Caenorhabditis elegans (Cel)	CE07156 (WBGene00017898)	GI:17567363	Q19858
Caenorhabditis elegans (Cel)	CE14798	GI:17570293
Caenorhabditis elegans (Cel)	CE22045 (WBGene00012929)	GI:17555946	Q9NAH6
Caenorhabditis elegans (Cel)	CE28744	GI:17569233
Drosophila melanogaster (Dme)	7293512	GI:7293512
Drosophila melanogaster (Dme)	7295426	GI:5919226
Drosophila melanogaster (Dme)	7296853	GI:7296853
Homo sapiens (Hsa)	Hs20070247_2	GI:20070247
Homo sapiens (Hsa)	Hs20127541 (SGK2)	GI:20127541	Q9HBY8
Homo sapiens (Hsa)	Hs21450709	GI:20546299
Homo sapiens (Hsa)	Hs22065373	GI:22065373
Homo sapiens (Hsa)	Hs22065405	GI:22065405
Homo sapiens (Hsa)	Hs22066167	GI:22066167
Homo sapiens (Hsa)	Hs4506737 (RPS6KB1)	GI:4506737	P23443
Homo sapiens (Hsa)	Hs4506739	GI:4506739
Homo sapiens (Hsa)	Hs5032091	GI:5032091
Homo sapiens (Hsa)	Hs8923754 (STK32B)	GI:8923754	Q9NY57
Saccharomyces cerevisiae (Sce)	YBR028c	GI:6319502	P38070
Saccharomyces cerevisiae (Sce)	YHR205w (S000001248)	GI:6321999	P11792
Saccharomyces cerevisiae (Sce)	YKL126w (S000001609)	GI:6322723	P12688
Saccharomyces cerevisiae (Sce)	YMR104c (S000004710)	GI:6323751	P18961
Schizosaccharomyces pombe (Spo)	SPAC1B9.02c	GI:19114666	P50530
Schizosaccharomyces pombe (Spo)	SPAC22E12.14c	GI:19115752	Q10364
Schizosaccharomyces pombe (Spo)	SPCC162.10	GI:19075734	O74426
Schizosaccharomyces pombe (Spo)	SPCC24B10.07	GI:19075510	Q9P7J8
Schizosaccharomyces pombe (Spo)	SPCC4G3.08	GI:19075330	Q12706
Encephalitozoon cuniculi (Ecu)	ECU10g0570	GI:19074666	Q8SR57
Arabidopsis thaliana (Ath)	At3g08720	GI:15231959
Arabidopsis thaliana (Ath)	At3g08730	GI:15231960
Caenorhabditis elegans (Cel)	CE03492 (WBGene00010838)	GI:17554256	Q21483
Caenorhabditis elegans (Cel)	CE07156 (WBGene00017898)	GI:17567363	Q19858
Caenorhabditis elegans (Cel)	CE14798	GI:17570293
Caenorhabditis elegans (Cel)	CE22045 (WBGene00012929)	GI:17555946	Q9NAH6
Caenorhabditis elegans (Cel)	CE28744	GI:17569233
Drosophila melanogaster (Dme)	7293512	GI:7293512
Drosophila melanogaster (Dme)	7295426	GI:5919226
Drosophila melanogaster (Dme)	7296853	GI:7296853
Homo sapiens (Hsa)	Hs20070247_2	GI:20070247
Homo sapiens (Hsa)	Hs20127541 (SGK2)	GI:20127541	Q9HBY8
Homo sapiens (Hsa)	Hs21450709	GI:20546299
Homo sapiens (Hsa)	Hs22065373	GI:22065373
Homo sapiens (Hsa)	Hs22065405	GI:22065405
Homo sapiens (Hsa)	Hs22066167	GI:22066167
Homo sapiens (Hsa)	Hs4506737 (RPS6KB1)	GI:4506737	P23443
Homo sapiens (Hsa)	Hs4506739	GI:4506739
Homo sapiens (Hsa)	Hs5032091	GI:5032091
Homo sapiens (Hsa)	Hs8923754 (STK32B)	GI:8923754	Q9NY57
Saccharomyces cerevisiae (Sce)	YBR028c	GI:6319502	P38070
Saccharomyces cerevisiae (Sce)	YHR205w (S000001248)	GI:6321999	P11792
Saccharomyces cerevisiae (Sce)	YKL126w (S000001609)	GI:6322723	P12688
Saccharomyces cerevisiae (Sce)	YMR104c (S000004710)	GI:6323751	P18961
Schizosaccharomyces pombe (Spo)	SPAC1B9.02c	GI:19114666	P50530
Schizosaccharomyces pombe (Spo)	SPAC22E12.14c	GI:19115752	Q10364
Schizosaccharomyces pombe (Spo)	SPCC162.10	GI:19075734	O74426
Schizosaccharomyces pombe (Spo)	SPCC24B10.07	GI:19075510	Q9P7J8
Schizosaccharomyces pombe (Spo)	SPCC4G3.08	GI:19075330	Q12706
Encephalitozoon cuniculi (Ecu)	ECU10g0570	GI:19074666	Q8SR57

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	sck1 (SPAC1B9.02c)	GI:19114666	P50530
Saccharomyces cerevisiae (Sce)	SCH9 (S000001248)	GI:6321999	P11792
Kluyveromyces lactis (Kla)	KLLA0B03586g	GI:50303505
Eremothecium gossypii (Ego)	AGOS_ADL389W	GI:45187484
Magnaporthe grisea (Mgr)	MGG_01251	GI:145616654
Neurospora crassa (Ncr)	NCU03200.1	GI:32420385

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga4285	ENSANGP00000019348
Ashbya gossypii (Ago)	ago1352	ADL389W
Caenorhabditis elegans (Cel)	cel1838	C12D8.10a (CE15612; WBGene00000102)
Caenorhabditis elegans (Cel)	cel1839	C12D8.10b (CE05274)
Candida glabrata (Cgl)	cgl1620	CAGL0F09075g
Cryptococcus neoformans (Cne)	cne2682	183.m01616
Dictyostelium discoideum (Ddi)	ddi13295	DDB0220670
Debaryomyces hansenii (Dha)	dha2633	DEHA0D07601g
Drosophila melanogaster (Dme)	dme12879	CG4006-PA (FBgn0010379)
Drosophila melanogaster (Dme)	dme12880	CG4006-PB (FBgn0010379)
Drosophila melanogaster (Dme)	dme12881	CG4006-PC (FBgn0010379)
Danio rerio (Dre)	dre9512	ENSDARP00000023119 (akt2)	Q8UUX0
Takifugu rubripes (Fru)	fru32163	SINFRUP00000143131
Takifugu rubripes (Fru)	fru6396	SINFRUP00000145101
Takifugu rubripes (Fru)	fru24685	SINFRUP00000157275
Takifugu rubripes (Fru)	fru24686	SINFRUP00000173187
Gallus gallus (Gga)	gga19890	ENSGALP00000018962 (AKT1)
Homo sapiens (Hsa)	hsa10195	ENSP00000270202 (AKT1)	P31749
Homo sapiens (Hsa)	hsa16392	ENSP00000309428 (AKT2)	Q0VAN0
Homo sapiens (Hsa)	hsa10194	ENSP00000311456
Homo sapiens (Hsa)	hsa16391	ENSP00000351095 (AKT2)	Q6P4H3
Kluyveromyces lactis (Kla)	kla692	KLLA0B03586g
Mus musculus (Mmu)	mmu6329	ENSMUSP00000001780 (MGI:87986)	A4FUQ9
Mus musculus (Mmu)	mmu23465	ENSMUSP00000052103 (MGI:104874)	Q60823
Mus musculus (Mmu)	mmu23464	ENSMUSP00000077843
Neurospora crassa (Ncr)	ncr3101	NCU03200.2
Rattus norvegicus (Rno)	rno1369	ENSRNOP00000025303 (RGD:2082)	P47197
Rattus norvegicus (Rno)	rno25721	ENSRNOP00000038369 (RGD:2081)	P47196
Saccharomyces cerevisiae (Sce)	sce2983	YHR205W (S000001248)
Schizosaccharomyces pombe (Spo)	spo1470	SPAC1B9.02c	P50530
Schizosaccharomyces pombe (Spo)	spo1173	SPAC22E12.14c	Q10364
Yarrowia lipolytica (Yli)	yli3310	YALI0D14542g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC22E12.14c (Q10364)	YHR205W (S000001248)
SPAC1B9.02c (P50530)	YHR205W (S000001248)