Bahler Lab

Search term: YIL015W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name BAR1

SGD link S000001277

Alternative ID YIL015W

Description Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest

Synonyms YIL015W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG1339 ACDHYP-

KOGs classification KOGs description

CELLULAR PROCESSES AND SIGNALING Aspartyl protease

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
TAS
Sce S000006075

GO:0000328 fungal-type vacuole lumen C
TAS
Sce S000006075

GO:0005575 cellular_component C
ND
Ath At3g12700
At4g16560
Sce S000003228
YGL258w-a

GO:0005576 extracellular region C
NAS
Hsa CTSD

GO:0005615 extracellular space C
IDA
Hsa CTSD
REN
TAS
Hsa PGC

GO:0005618 cell wall C
IDA
Ath At1g03230
At1g03220
At1g09750
At3g52500
At3g54400
At5g07030
TAS
Spo SPCC1795.09

GO:0005634 nucleus C
IDA
Dme FBgn0003044
ISS
Dme FBgn0003044
NAS
Dme FBgn0003044

GO:0005737 cytoplasm C
IDA
Sce S000002757

GO:0005739 mitochondrion C
IDA
Sce S000006075

GO:0005764 lysosome C
IC
Cel WBGene00000217
NAS
Hsa CTSD

GO:0005768 endosome C
IDA
Hsa CTSE

GO:0005773 vacuole C
IDA
Ath At1g62290
At1g11910

GO:0005783 endoplasmic reticulum C
IDA
Ath At5g02190
Sce S000002757
Spo SPAC26A3.01
SPCC1795.09

GO:0005794 Golgi apparatus C
IDA
Hsa BACE2

GO:0005886 plasma membrane C
IDA
Ath At3g02740
At1g03220
At1g65240
Sce S000004111
Spo SPAC26A3.01
ISS
Sce S000004111

GO:0009277 fungal-type cell wall C
IDA
Sce S000002551
S000001478
S000004110

GO:0009505 plant-type cell wall C
IDA
Ath At1g08210
At1g01300
At1g44130
At1g03220
At1g03230
At1g09750
At3g61820
At3g52500
At3g54400
At5g07030

GO:0009507 chloroplast C
IDA
Ath At3g54400

GO:0009986 cell surface C
NAS
Spo SPCC1795.09
TAS
Spo SPAC26A3.01

GO:0016020 membrane C
IDA
Ath At3g52500
At1g01300
At1g03220

GO:0016021 integral to membrane C
NAS
Hsa BACE2

GO:0030287 cell wall-bounded periplasmic space C
TAS
Sce S000001277

GO:0031012 extracellular matrix C
IDA
Hsa CTSD

GO:0031225 anchored to membrane C
TAS
Ath At5g36260
At2g17760
At3g02740
At1g05840
At1g08210
At1g65240
At3g51330
At3g51350
At4g35880
At5g10080

GO:0046658 anchored to plasma membrane C
IDA
Ath At1g65240
At5g10080
Sce S000004111
IPI
Sce S000004111

GO:0048046 apoplast C
IDA
Ath At5g33340
At1g79720
At1g09750
At3g54400
At5g10760

GO:0003674 molecular_function F
ND
Sce YGL258w-a

GO:0003677 DNA binding F
IDA
Dme FBgn0003044
ISS
Ath At3g59080
At5g10770

GO:0003700 transcription factor activity F
IDA
Dme FBgn0003044

GO:0004175 endopeptidase activity F
IDA
Ath At1g11910
RCA
Sce S000006075

GO:0004190 aspartic-type endopeptidase activity F
IDA
Ath At5g33340
Hsa BACE2
CTSE
REN
Sce S000002551
S000004110
S000001277
S000004111
IMP
Sce S000001277
ISS
Ath At5g33340
At5g02190
Cel WBGene00000217
Dme FBgn0032304
FBgn0032049
Sce S000002757
S000003228
S000001478
S000004111
RCA
Sce S000006075
TAS
Spo SPAC26A3.01

GO:0005102 receptor binding F
IPI
Hsa REN

GO:0005199 structural constituent of cell
wall F
IPI
Sce S000004111

GO:0005515 protein binding F
IPI
Dme FBgn0003044

GO:0008233 peptidase activity F
IDA
Ath At5g02190
Hsa REN
Sce S000006075

GO:0070001 aspartic-type peptidase activity F
RCA
Sce S000006075

GO:0070011 peptidase activity, acting on L-amino acid
peptides F
RCA
Sce S000006075

GO:0000746 conjugation P
RCA
Sce S000001277

GO:0000747 conjugation with cellular fusion P
IMP
Spo SPAC26A3.01

GO:0000754 adaptation of signaling pathway by response to
pheromone involved in conjugation with cellular
fusion P
IDA
Sce S000001277
IMP
Sce S000001277

GO:0001822 kidney development P
IMP
Hsa REN

GO:0002003 angiotensin maturation P
IDA
Hsa REN

GO:0006414 translational elongation P
RCA
Sce S000004111

GO:0006508 proteolysis P
IDA
Ath At1g11910
Hsa REN
IMP
Cel WBGene00000217
Sce S000002551
ISS
Ath At2g03200
At5g45120
At1g64830
At2g42980
At3g18490
At3g42550
At2g28030
At1g08210
At1g31450
At2g28220
At5g33340
At2g28040
At1g66180
At1g79720
At1g05840
At2g28010
At1g25510
At3g02740
At1g01300
At2g36670
At2g39710
At1g69100
At2g17760
At1g62290
At1g65240
At1g49050
At1g11910
At3g12700
At3g51360
At3g20015
At5g22850
At3g50050
At3g51350
At3g52500
At3g51330
At3g51340
At4g04460
At5g37540
At3g54400
At5g36260
At5g24820
At5g43100
At4g12920
At3g61820
At4g30040
At4g22050
At4g30030
At4g35880
At5g10760
At5g07030
At5g10080
NAS
Hsa BACE2

GO:0006509 membrane protein ectodomain proteolysis P
IDA
Hsa BACE2

GO:0007039 vacuolar protein catabolic process P
IMP
Sce S000006075
RCA
Sce S000006075

GO:0007586 digestion P
TAS
Hsa CTSE

GO:0008150 biological_process P
ND
Sce S000003228
YGL258w-a

GO:0008217 regulation of blood pressure P
TAS
Hsa REN

GO:0008219 cell death P
IMP
Cel WBGene00000217
WBGene00000218
WBGene00000219
WBGene00000216

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00000216

GO:0009267 cellular response to starvation P
IMP
Sce S000006075

GO:0009651 response to salt stress P
IEP
Ath At1g03220
At1g03230
At1g11910

GO:0009793 embryo development ending in seed
dormancy P
IMP
Ath At5g02190

GO:0010310 regulation of hydrogen peroxide metabolic
process P
IDA
Ath At5g33340
IMP
Ath At5g33340

GO:0010337 regulation of salicylic acid metabolic
process P
IMP
Ath At5g33340

GO:0012501 programmed cell death P
IMP
Ath At5g02190

GO:0012502 induction of programmed cell death P
IMP
Cel WBGene00000217

GO:0016237 microautophagy P
IMP
Sce S000006075

GO:0016485 protein processing P
IDA
Sce S000004110
RCA
Sce S000002551

GO:0016486 peptide hormone processing P
NAS
Hsa BACE2

GO:0016568 chromatin modification P
IDA
Dme FBgn0003044

GO:0019236 response to pheromone P
RCA
Sce S000001277

GO:0019886 antigen processing and presentation of exogenous
peptide antigen via MHC class II P
IDA
Hsa CTSE

GO:0019953 sexual reproduction P
RCA
Sce S000001277

GO:0030435 sporulation resulting in formation of a cellular
spore P
IMP
Sce S000006075

GO:0031505 fungal-type cell wall organization P
IGI
Sce S000002551
S000002757
S000001478
S000004110
S000004111

GO:0040011 locomotion P
IMP
Cel WBGene00000218

GO:0042742 defense response to bacterium P
IMP
Ath At5g33340

GO:0042985 negative regulation of amyloid precursor protein
biosynthetic process P
IMP
Hsa BACE2

GO:0043171 peptide catabolic process P
IDA
Sce S000001277

GO:0043408 regulation of MAPKKK cascade P
IDA
Hsa REN

GO:0044267 cellular protein metabolic process P
IDA
Sce S000004111
ISS
Sce S000004111

GO:0045892 negative regulation of transcription,
DNA-dependent P
IDA
Dme FBgn0003044

GO:0046686 response to cadmium ion P
IEP
Ath At4g04460

GO:0051603 proteolysis involved in cellular protein catabolic
process P
IMP
Sce S000006075

GO:0051604 protein maturation P
RCA
Sce S000002551

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

39340

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) sxa1
(SPAC26A3.01) GI:68000198 P32834

Schizosaccharomyces pombe (Spo) yps1
(SPCC1795.09) GI:19075535 O59774

Saccharomyces cerevisiae (Sce) BAR1
(S000001277) GI:6322174 P12630

Kluyveromyces lactis (Kla) KLLA0D15917g GI:50307563

Magnaporthe grisea (Mgr) MGG_03014 GI:39971095

Neurospora crassa (Ncr) NCU03168.1 GI:32420321

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005618 cell wall C
TAS
Spo SPCC1795.09

GO:0005783 endoplasmic reticulum C
IDA
Spo SPAC26A3.01
SPCC1795.09

GO:0005886 plasma membrane C
IDA
Spo SPAC26A3.01

GO:0009986 cell surface C
NAS
Spo SPCC1795.09
TAS
Spo SPAC26A3.01

GO:0030287 cell wall-bounded periplasmic space C
TAS
Sce S000001277

GO:0004190 aspartic-type endopeptidase activity F
IDA
Sce S000001277
IMP
Sce S000001277
TAS
Spo SPAC26A3.01

GO:0000746 conjugation P
RCA
Sce S000001277

GO:0000747 conjugation with cellular fusion P
IMP
Spo SPAC26A3.01

GO:0000754 adaptation of signaling pathway by response to
pheromone involved in conjugation with cellular
fusion P
IDA
Sce S000001277
IMP
Sce S000001277

GO:0019236 response to pheromone P
RCA
Sce S000001277

GO:0019953 sexual reproduction P
RCA
Sce S000001277

GO:0043171 peptide catabolic process P
IDA
Sce S000001277

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_20666

Species OrthoMCL
sequence Model organism
protein page UniProt link

Ashbya gossypii (Ago) ago4551 AGR240W

Candida glabrata (Cgl) cgl3087 CAGL0J02288g

Kluyveromyces lactis (Kla) kla2760 KLLA0D15917g

Neurospora crassa (Ncr) ncr6873 NCU07063.2

Neurospora crassa (Ncr) ncr8923 NCU09155.2

Saccharomyces cerevisiae (Sce) sce3025 YIL015W
(S000001277)

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0030287 cell wall-bounded periplasmic space C
TAS
Sce S000001277

GO:0004190 aspartic-type endopeptidase activity F
IDA
Sce S000001277
IMP
Sce S000001277

GO:0000746 conjugation P
RCA
Sce S000001277

GO:0000754 adaptation of signaling pathway by response to
pheromone involved in conjugation with cellular
fusion P
IDA
Sce S000001277
IMP
Sce S000001277

GO:0019236 response to pheromone P
RCA
Sce S000001277

GO:0019953 sexual reproduction P
RCA
Sce S000001277

GO:0043171 peptide catabolic process P
IDA
Sce S000001277

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1339	ACDHYP-

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALING	Aspartyl protease

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g01300	GI:15223368
Arabidopsis thaliana (Ath)	At1g03220	GI:15218740
Arabidopsis thaliana (Ath)	At1g03230	GI:18379072
Arabidopsis thaliana (Ath)	At1g05840	GI:18390579
Arabidopsis thaliana (Ath)	At1g08210	GI:6579210
Arabidopsis thaliana (Ath)	At1g09750	GI:15218254
Arabidopsis thaliana (Ath)	At1g11910	GI:15221141
Arabidopsis thaliana (Ath)	At1g25510	GI:15222611
Arabidopsis thaliana (Ath)	At1g31450	GI:15222357
Arabidopsis thaliana (Ath)	At1g44130	GI:15219354
Arabidopsis thaliana (Ath)	At1g49050	GI:15222029
Arabidopsis thaliana (Ath)	At1g62290	GI:15220747
Arabidopsis thaliana (Ath)	At1g64830	GI:15217764
Arabidopsis thaliana (Ath)	At1g65240	GI:15217887
Arabidopsis thaliana (Ath)	At1g66180	GI:18408451
Arabidopsis thaliana (Ath)	At1g69100	GI:15222219
Arabidopsis thaliana (Ath)	At1g77480	GI:15223969
Arabidopsis thaliana (Ath)	At1g79720	GI:7715602
Arabidopsis thaliana (Ath)	At2g03200	GI:7487145
Arabidopsis thaliana (Ath)	At2g17760	GI:15227889
Arabidopsis thaliana (Ath)	At2g28010	GI:15226315
Arabidopsis thaliana (Ath)	At2g28030	GI:15226317
Arabidopsis thaliana (Ath)	At2g28040	GI:15226319
Arabidopsis thaliana (Ath)	At2g28220	GI:15226358
Arabidopsis thaliana (Ath)	At2g36670	GI:15228017
Arabidopsis thaliana (Ath)	At2g39710	GI:7487691
Arabidopsis thaliana (Ath)	At2g42980	GI:15228044
Arabidopsis thaliana (Ath)	At3g02740	GI:15232960
Arabidopsis thaliana (Ath)	At3g12700	GI:15230568
Arabidopsis thaliana (Ath)	At3g18490	GI:15229656
Arabidopsis thaliana (Ath)	At3g20015	GI:15231010
Arabidopsis thaliana (Ath)	At3g25700	GI:15230868
Arabidopsis thaliana (Ath)	At3g42550	GI:15228576
Arabidopsis thaliana (Ath)	At3g50050	GI:15229663
Arabidopsis thaliana (Ath)	At3g51330	GI:11281623
Arabidopsis thaliana (Ath)	At3g51340	GI:15230458
Arabidopsis thaliana (Ath)	At3g51350	GI:15230460
Arabidopsis thaliana (Ath)	At3g51360	GI:15230462
Arabidopsis thaliana (Ath)	At3g52500	GI:18409620
Arabidopsis thaliana (Ath)	At3g54400	GI:15232503
Arabidopsis thaliana (Ath)	At3g59080	GI:15231625
Arabidopsis thaliana (Ath)	At3g61820	GI:15228618
Arabidopsis thaliana (Ath)	At4g04460	GI:15233518
Arabidopsis thaliana (Ath)	At4g12920	GI:15235526
Arabidopsis thaliana (Ath)	At4g16560_1	GI:7485159
Arabidopsis thaliana (Ath)	At4g22050	GI:15234696
Arabidopsis thaliana (Ath)	At4g30030	GI:15234606
Arabidopsis thaliana (Ath)	At4g30040	GI:15234607
Arabidopsis thaliana (Ath)	At4g33490	GI:7484812
Arabidopsis thaliana (Ath)	At4g35880	GI:15233372
Arabidopsis thaliana (Ath)	At5g02190	GI:15241713
Arabidopsis thaliana (Ath)	At5g07030	GI:15240680
Arabidopsis thaliana (Ath)	At5g10080	GI:15238055
Arabidopsis thaliana (Ath)	At5g10760	GI:15238250
Arabidopsis thaliana (Ath)	At5g10770	GI:15238251
Arabidopsis thaliana (Ath)	At5g19100	GI:15239644
Arabidopsis thaliana (Ath)	At5g19110	GI:15239655
Arabidopsis thaliana (Ath)	At5g19120	GI:15239656
Arabidopsis thaliana (Ath)	At5g22850	GI:15237145
Arabidopsis thaliana (Ath)	At5g24820	GI:18420846
Arabidopsis thaliana (Ath)	At5g33340	GI:15242803
Arabidopsis thaliana (Ath)	At5g33350	GI:15242805
Arabidopsis thaliana (Ath)	At5g36260	GI:15239353
Arabidopsis thaliana (Ath)	At5g37540	GI:15240269
Arabidopsis thaliana (Ath)	At5g43100	GI:15239176
Arabidopsis thaliana (Ath)	At5g45120	GI:15242307
Arabidopsis thaliana (Ath)	At5g48430	GI:15238970
Caenorhabditis elegans (Cel)	CE03567 (WBGene00000217)	GI:17549909	Q21966
Caenorhabditis elegans (Cel)	CE03881_2	GI:17549964
Caenorhabditis elegans (Cel)	CE04749 (WBGene00019619)	GI:17568861	Q94271
Caenorhabditis elegans (Cel)	CE04971	GI:17557204
Caenorhabditis elegans (Cel)	CE05287 (WBGene00007605)	GI:17557992	Q18020
Caenorhabditis elegans (Cel)	CE09538	GI:17560022
Caenorhabditis elegans (Cel)	CE09539 (WBGene00000218)	GI:17557206	O01532
Caenorhabditis elegans (Cel)	CE09540 (WBGene00017678)	GI:17560024	O01531
Caenorhabditis elegans (Cel)	CE09541	GI:17560028
Caenorhabditis elegans (Cel)	CE09542 (WBGene00000219)	GI:17557208	O01530
Caenorhabditis elegans (Cel)	CE09738 (WBGene00017881)	GI:17560290	Q22972
Caenorhabditis elegans (Cel)	CE11478	GI:17561738
Caenorhabditis elegans (Cel)	CE11480 (WBGene00019105)	GI:17561740	O16338
Caenorhabditis elegans (Cel)	CE16843 (WBGene00015700)	GI:17538662	O45072
Caenorhabditis elegans (Cel)	CE19495 (WBGene00000216)	GI:17549907	P55956
Caenorhabditis elegans (Cel)	CE20430	GI:17566864
Caenorhabditis elegans (Cel)	CE21681	GI:17565564
Caenorhabditis elegans (Cel)	CE21683	GI:17565562
Caenorhabditis elegans (Cel)	CE21684	GI:17565560
Caenorhabditis elegans (Cel)	CE21685	GI:17565558
Drosophila melanogaster (Dme)	7290034 (FBgn0003044)	GI:17986011
Drosophila melanogaster (Dme)	7296074	GI:7296074	Q9VQ14
Drosophila melanogaster (Dme)	7296075	GI:7296075	Q9VQ13
Drosophila melanogaster (Dme)	7296076	GI:19920514
Drosophila melanogaster (Dme)	7296077	GI:7296077
Drosophila melanogaster (Dme)	7297427 (FBgn0032049)	GI:20129385
Drosophila melanogaster (Dme)	7297765	GI:7297765	Q9VKP7
Drosophila melanogaster (Dme)	7297766 (FBgn0032304)	GI:19921120
Drosophila melanogaster (Dme)	7300253	GI:7300253	Q9VEK5
Drosophila melanogaster (Dme)	7300254	GI:7300254
Drosophila melanogaster (Dme)	7300255	GI:7300255	Q9VEK3
Drosophila melanogaster (Dme)	7303185	GI:7303185	A1Z9Q9
Drosophila melanogaster (Dme)	7304149	GI:6685167
Homo sapiens (Hsa)	Hs18549644	GI:18549644
Homo sapiens (Hsa)	Hs19923395 (BACE2)	GI:19923395	Q9Y5Z0
Homo sapiens (Hsa)	Hs21040360	GI:21040360	Q9Y5Z0
Homo sapiens (Hsa)	Hs21040362	GI:21040362	Q9Y5Z0
Homo sapiens (Hsa)	Hs21040364	GI:21040364	P56817
Homo sapiens (Hsa)	Hs21040366	GI:21040366	P56817
Homo sapiens (Hsa)	Hs21040368	GI:21040368	P56817
Homo sapiens (Hsa)	Hs22040925	GI:22040925
Homo sapiens (Hsa)	Hs22050827	GI:22050827
Homo sapiens (Hsa)	Hs22063872	GI:22063872
Homo sapiens (Hsa)	Hs22063875	GI:22063875
Homo sapiens (Hsa)	Hs22063919	GI:22063919
Homo sapiens (Hsa)	Hs4503143 (CTSD)	GI:4503143	P07339
Homo sapiens (Hsa)	Hs4503145 (CTSE)	GI:4503145	P14091
Homo sapiens (Hsa)	Hs4505757 (PGC)	GI:4505757	P20142
Homo sapiens (Hsa)	Hs4506475 (REN)	GI:4506475	Q15296
Homo sapiens (Hsa)	Hs4758754 (NAPSA)	GI:4758754	O96009
Homo sapiens (Hsa)	Hs6912266 (BACE1)	GI:6912266	P56817
Saccharomyces cerevisiae (Sce)	YDR144c (S000002551)	GI:6320348	P53379
Saccharomyces cerevisiae (Sce)	YDR349c (S000002757)	GI:6320556	Q06325
Saccharomyces cerevisiae (Sce)	YGL258w-a	GI:13129168	Q3E740
Saccharomyces cerevisiae (Sce)	YGL259w (S000003228)	GI:6321178	P53057
Saccharomyces cerevisiae (Sce)	YIL015w (S000001277)	GI:6322174	P12630
Saccharomyces cerevisiae (Sce)	YIR039c (S000001478)	GI:6322230	P40583
Saccharomyces cerevisiae (Sce)	YLR120c (S000004110)	GI:6323149	P32329
Saccharomyces cerevisiae (Sce)	YLR121c (S000004111)	GI:6323150	Q12303
Saccharomyces cerevisiae (Sce)	YPL154c (S000006075)	GI:6325103	P07267
Schizosaccharomyces pombe (Spo)	SPAC26A3.01	GI:19115056	P32834
Schizosaccharomyces pombe (Spo)	SPCC1795.09	GI:19075535	O59774

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	sxa1 (SPAC26A3.01)	GI:68000198	P32834
Schizosaccharomyces pombe (Spo)	yps1 (SPCC1795.09)	GI:19075535	O59774
Saccharomyces cerevisiae (Sce)	BAR1 (S000001277)	GI:6322174	P12630
Kluyveromyces lactis (Kla)	KLLA0D15917g	GI:50307563
Magnaporthe grisea (Mgr)	MGG_03014	GI:39971095
Neurospora crassa (Ncr)	NCU03168.1	GI:32420321

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago4551	AGR240W
Candida glabrata (Cgl)	cgl3087	CAGL0J02288g
Kluyveromyces lactis (Kla)	kla2760	KLLA0D15917g
Neurospora crassa (Ncr)	ncr6873	NCU07063.2
Neurospora crassa (Ncr)	ncr8923	NCU09155.2
Saccharomyces cerevisiae (Sce)	sce3025	YIL015W (S000001277)