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Search term: YIL042C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PKP1
SGD link S000001304
Alternative ID YIL042C
Description Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
Synonyms YIL042C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0787 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Dehydrogenase kinase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g06483 GI:15229463
Caenorhabditis elegans (Cel) CE00397
(WBGene00022719)		 GI:17556919 Q02332
Drosophila melanogaster (Dme) 7303893 GI:17137298 A8DY78
Homo sapiens (Hsa) Hs5031609 GI:5031609
Homo sapiens (Hsa) Hs4505689
(PDK1)		 GI:4505689 Q15118
Homo sapiens (Hsa) Hs4885545 GI:4885545 Q15120
Homo sapiens (Hsa) Hs4505693
(PDK4)		 GI:4505693 Q16654
Homo sapiens (Hsa) Hs11432626 GI:11432626
Homo sapiens (Hsa) Hs19923736
(PDK2)		 GI:19923736 Q15119
Saccharomyces cerevisiae (Sce) YGL059w
(S000003027)		 GI:6321379
Saccharomyces cerevisiae (Sce) YIL042c
(S000001304)		 GI:6322147 P40530
Schizosaccharomyces pombe (Spo) SPAC644.11c GI:19114791 Q9P6P9
Arabidopsis thaliana (Ath) At3g06483 GI:15229463
Caenorhabditis elegans (Cel) CE00397
(WBGene00022719)		 GI:17556919 Q02332
Drosophila melanogaster (Dme) 7303893 GI:17137298 A8DY78
Homo sapiens (Hsa) Hs5031609 GI:5031609
Homo sapiens (Hsa) Hs4505689
(PDK1)		 GI:4505689 Q15118
Homo sapiens (Hsa) Hs4885545 GI:4885545 Q15120
Homo sapiens (Hsa) Hs4505693
(PDK4)		 GI:4505693 Q16654
Homo sapiens (Hsa) Hs11432626 GI:11432626
Homo sapiens (Hsa) Hs19923736
(PDK2)		 GI:19923736 Q15119
Saccharomyces cerevisiae (Sce) YGL059w
(S000003027)		 GI:6321379
Saccharomyces cerevisiae (Sce) YIL042c
(S000001304)		 GI:6322147 P40530
Schizosaccharomyces pombe (Spo) SPAC644.11c GI:19114791 Q9P6P9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
HsaPDK2
GO:0005739 mitochondrion C
IDA
HsaPDK2
SceS000001304
S000003027
SpoSPAC644.11c
ISS
SpoSPAC644.11c
NAS
AthAt3g06483
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC644.11c
GO:0004672 protein kinase activity F
IDA
HsaPDK1
PDK4
SceS000001304
S000003027
TAS
HsaPDK2
GO:0004740 pyruvate dehydrogenase (acetyl-transferring)
kinase activity		 F
IMP
AthAt3g06483
SceS000001304
S000003027
ISS
SpoSPAC644.11c
GO:0005524 ATP binding F
IDA
AthAt3g06483
HsaPDK4
PDK2
ISS
AthAt3g06483
SpoSPAC644.11c
GO:0009927 histidine phosphotransfer kinase
activity		 F
IDA
AthAt3g06483
GO:0016887 ATPase activity F
ISS
SpoSPAC644.11c
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISS
SpoSPAC644.11c
GO:0006200 ATP catabolic process P
ISS
SpoSPAC644.11c
GO:0006468 protein amino acid phosphorylation P
IMP
SceS000001304
GO:0007264 small GTPase mediated signal transduction P
TAS
HsaPDK1
GO:0010510 regulation of acetyl-CoA biosynthetic process from
pyruvate		 P
EXP
HsaPDK4
PDK1
PDK2
GO:0015976 carbon utilization P
IGI
SceS000001304
S000003027
GO:0018105 peptidyl-serine phosphorylation P
IMP
SceS000003027
S000001304
GO:0043086 negative regulation of catalytic
activity		 P
IMP
SceS000003027
GO:0055114 oxidation reduction P
RCA
SceS000001304

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
37642

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) BCKDK GI:171906589
Pan troglodytes (Ptr) BCKDK GI:114662123
Canis familiaris (Cfa) BCKDK GI:57087819
Mus musculus (Mmu) Bckdk
(MGI:1276121)		 GI:6753164 O55028
Rattus norvegicus (Rno) Bckdk
(RGD:2198)		 GI:29789094
Saccharomyces cerevisiae (Sce) PKP1
(S000001304)		 GI:6322147 P40530
Kluyveromyces lactis (Kla) KLLA0E04455g GI:50308297
Eremothecium gossypii (Ego) AGOS_ADL116C GI:45187757
Magnaporthe grisea (Mgr) MGG_06200 GI:145603206
Neurospora crassa (Ncr) NCU04349.1 GI:32406178


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1276121
SceS000001304
TAS
HsaBCKDK
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase
complex		 C
ISO
MmuMGI:1276121
ISS
HsaBCKDK
TAS
HsaBCKDK
GO:0004672 protein kinase activity F
IDA
MmuMGI:1276121
SceS000001304
GO:0004674 protein serine/threonine kinase
activity		 F
ISO
MmuMGI:1276121
ISS
HsaBCKDK
GO:0004740 pyruvate dehydrogenase (acetyl-transferring)
kinase activity		 F
IMP
SceS000001304
GO:0005515 protein binding F
IPI
HsaBCKDK
GO:0005524 ATP binding F
ISO
MmuMGI:1276121
ISS
HsaBCKDK
GO:0016301 kinase activity F
TAS
HsaBCKDK
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase
(acetyl-transferring)] kinase activity		 F
ISO
MmuMGI:1276121
GO:0006468 protein amino acid phosphorylation P
IMP
SceS000001304
GO:0009063 cellular amino acid catabolic process P
NAS
HsaBCKDK
GO:0009083 branched chain family amino acid catabolic
process		 P
ISO
MmuMGI:1276121
ISS
HsaBCKDK
TAS
HsaBCKDK
GO:0015976 carbon utilization P
IGI
SceS000001304
GO:0016310 phosphorylation P
IDA
MmuMGI:1276121
ISO
MmuMGI:1276121
ISS
HsaBCKDK
TAS
HsaBCKDK
GO:0018105 peptidyl-serine phosphorylation P
IMP
SceS000001304
GO:0055114 oxidation reduction P
RCA
SceS000001304

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_746

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12592 ENSANGP00000014379
Ashbya gossypii (Ago) ago1625 ADL116C
Ashbya gossypii (Ago) ago2772 AER270W
Arabidopsis thaliana (Ath) ath12725 At3g06483.1
Caenorhabditis elegans (Cel) cel21861 ZK370.5
(CE00397;
WBGene00022719)
Candida glabrata (Cgl) cgl4116 CAGL0L00869g
Cryptococcus neoformans (Cne) cne335 162.m02927
Cryptococcus neoformans (Cne) cne2542 181.m08691
Cryptococcus neoformans (Cne) cne2543 181.m08692
Debaryomyces hansenii (Dha) dha793 DEHA0B02541g
Debaryomyces hansenii (Dha) dha2065 DEHA0C14366g
Drosophila melanogaster (Dme) dme4078 CG8808-PA
(FBgn0017558)
Danio rerio (Dre) dre16320 ENSDARP00000008413
Danio rerio (Dre) dre24182 ENSDARP00000015430
(LOC560068)
Danio rerio (Dre) dre20048 ENSDARP00000021993
(LOC554522)
Danio rerio (Dre) dre10571 ENSDARP00000022009
Takifugu rubripes (Fru) fru5184 SINFRUP00000146220
Takifugu rubripes (Fru) fru204 SINFRUP00000149477
Takifugu rubripes (Fru) fru1760 SINFRUP00000156939
Takifugu rubripes (Fru) fru28630 SINFRUP00000160918
Takifugu rubripes (Fru) fru1994 SINFRUP00000165203
Takifugu rubripes (Fru) fru1759 SINFRUP00000172861
Gallus gallus (Gga) gga26258 ENSGALP00000021580
(RCJMB04_4o20)		 Q5ZLT4
Gallus gallus (Gga) gga2321 ENSGALP00000026284
(PDK3)		 Q5ZLT2
Homo sapiens (Hsa) hsa13973 ENSP00000007708
(PDK2)		 Q15119
Homo sapiens (Hsa) hsa12056 ENSP00000219794
(BCKDK)		 O14874
Homo sapiens (Hsa) hsa18870 ENSP00000282077
(PDK1)		 Q15118
Homo sapiens (Hsa) hsa32567 ENSP00000322522
Homo sapiens (Hsa) hsa18871 ENSP00000350289
Kluyveromyces lactis (Kla) kla3149 KLLA0E04455g
Kluyveromyces lactis (Kla) kla5300 KLLA0F27423g
Mus musculus (Mmu) mmu14772 ENSMUSP00000006669
(MGI:1926119)		 Q3U5E5
Mus musculus (Mmu) mmu29298 ENSMUSP00000036604
(MGI:2384308)		 Q922H2
Mus musculus (Mmu) mmu4606 ENSMUSP00000041447
(MGI:1343087)		 Q8VC63
Mus musculus (Mmu) mmu25178 ENSMUSP00000070345
(MGI:1276121)		 O55028
Neurospora crassa (Ncr) ncr4225 NCU04349.2
Neurospora crassa (Ncr) ncr6574 NCU06760.2
Oryza sativa (Osa) osa19208 3473.m00134
Oryza sativa (Osa) osa26 385.m00218
Oryza sativa (Osa) osa54356 6075.m00100
Rattus norvegicus (Rno) rno18769 ENSRNOP00000002072
(RGD:69427)		 Q5FVT5
Rattus norvegicus (Rno) rno5923 ENSRNOP00000005641
(RGD:69428)		 Q64536
Rattus norvegicus (Rno) rno31551 ENSRNOP00000017370
(RGD:1593276)		 B5DFI9
Rattus norvegicus (Rno) rno3057 ENSRNOP00000026466
(RGD:2198)		 Q00972
Saccharomyces cerevisiae (Sce) sce3056 YIL042C
(S000001304)
Schizosaccharomyces pombe (Spo) spo4542 SPAC644.11c Q9P6P9
Yarrowia lipolytica (Yli) yli2578 YALI0C21582g
Yarrowia lipolytica (Yli) yli4675 YALI0E19679g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1276121
MGI:1926119
MGI:1343087
MGI:2384308
SceS000001304
SpoSPAC644.11c
ISO
MmuMGI:1343087
ISS
SpoSPAC644.11c
NAS
AthAt3g06483
GO:0005759 mitochondrial matrix C
ISS
DmeFBgn0017558
NAS
DmeFBgn0017558
GO:0005886 plasma membrane C
ISA
MmuMGI:1926119
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase
complex		 C
ISO
MmuMGI:1276121
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC644.11c
GO:0045254 pyruvate dehydrogenase complex C
ISO
MmuMGI:1926119
MGI:1343087
GO:0003674 molecular_function F
ND
MmuMGI:2384308
GO:0004672 protein kinase activity F
IDA
MmuMGI:1276121
SceS000001304
GO:0004674 protein serine/threonine kinase
activity		 F
ISO
MmuMGI:1276121
GO:0004740 pyruvate dehydrogenase (acetyl-transferring)
kinase activity		 F
IMP
AthAt3g06483
SceS000001304
ISO
MmuMGI:1343087
MGI:1926119
ISS
DmeFBgn0017558
SpoSPAC644.11c
NAS
DmeFBgn0017558
GO:0005515 protein binding F
IPI
MmuMGI:1343087
GO:0005524 ATP binding F
IDA
AthAt3g06483
ISO
MmuMGI:1926119
MGI:1343087
MGI:1276121
ISS
AthAt3g06483
SpoSPAC644.11c
GO:0009927 histidine phosphotransfer kinase
activity		 F
IDA
AthAt3g06483
GO:0016887 ATPase activity F
ISS
SpoSPAC644.11c
GO:0032403 protein complex binding F
ISO
MmuMGI:1343087
MGI:1926119
GO:0042803 protein homodimerization activity F
ISO
MmuMGI:1926119
MGI:1343087
GO:0046982 protein heterodimerization activity F
ISO
MmuMGI:1343087
MGI:1926119
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase
(acetyl-transferring)] kinase activity		 F
ISO
MmuMGI:1276121
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISS
SpoSPAC644.11c
GO:0006090 pyruvate metabolic process P
ISS
DmeFBgn0017558
GO:0006200 ATP catabolic process P
ISS
SpoSPAC644.11c
GO:0006468 protein amino acid phosphorylation P
IMP
SceS000001304
ISO
MmuMGI:1926119
MGI:1343087
GO:0007166 cell surface receptor linked signaling
pathway		 P
ISO
MmuMGI:1926119
GO:0008150 biological_process P
ND
MmuMGI:2384308
GO:0009083 branched chain family amino acid catabolic
process		 P
ISO
MmuMGI:1276121
GO:0015976 carbon utilization P
IGI
SceS000001304
GO:0016310 phosphorylation P
IDA
MmuMGI:1276121
ISO
MmuMGI:1276121
GO:0018105 peptidyl-serine phosphorylation P
IMP
SceS000001304
GO:0023034 intracellular signaling pathway P
ISA
MmuMGI:1926119
GO:0055114 oxidation reduction P
RCA
SceS000001304

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC644.11c
(Q9P6P9)		 YIL042C
(S000001304)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000001304
SpoSPAC644.11c
ISS
SpoSPAC644.11c
GO:0005967 mitochondrial pyruvate dehydrogenase
complex		 C
ISS
SpoSPAC644.11c
GO:0004672 protein kinase activity F
IDA
SceS000001304
GO:0004740 pyruvate dehydrogenase (acetyl-transferring)
kinase activity		 F
IMP
SceS000001304
ISS
SpoSPAC644.11c
GO:0005524 ATP binding F
ISS
SpoSPAC644.11c
GO:0016887 ATPase activity F
ISS
SpoSPAC644.11c
GO:0006086 acetyl-CoA biosynthetic process from
pyruvate		 P
ISS
SpoSPAC644.11c
GO:0006200 ATP catabolic process P
ISS
SpoSPAC644.11c
GO:0006468 protein amino acid phosphorylation P
IMP
SceS000001304
GO:0015976 carbon utilization P
IGI
SceS000001304
GO:0018105 peptidyl-serine phosphorylation P
IMP
SceS000001304
GO:0055114 oxidation reduction P
RCA
SceS000001304

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