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Search term: YIL094C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LYS12
SGD link S000001356
Alternative ID YIL094C
Description Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
Synonyms YIL094C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0785 ACDHYP-

KOGs classification KOGs description
METABOLISM Isocitrate dehydrogenase, alpha subunit

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g09805 GI:15232762
Arabidopsis thaliana (Ath) At5g03290 GI:11251553
Caenorhabditis elegans (Cel) CE10354 GI:17507307
Drosophila melanogaster (Dme) 7291785 GI:20130355
Drosophila melanogaster (Dme) 7293593 GI:7293593
Homo sapiens (Hsa) Hs5031777
(IDH3A)
GI:5031777 P50213
Saccharomyces cerevisiae (Sce) YIL094c
(S000001356)
GI:6322097 P40495
Saccharomyces cerevisiae (Sce) YOR136w
(S000005662)
GI:6324709 P28241
Schizosaccharomyces pombe (Spo) SPAC31G5.04 GI:19114916 O14104
Schizosaccharomyces pombe (Spo) SPBC902.05c GI:19111995 Q9USP8
Arabidopsis thaliana (Ath) At3g09805 GI:15232762
Arabidopsis thaliana (Ath) At5g03290 GI:11251553
Caenorhabditis elegans (Cel) CE10354 GI:17507307
Drosophila melanogaster (Dme) 7291785 GI:20130355
Drosophila melanogaster (Dme) 7293593 GI:7293593
Homo sapiens (Hsa) Hs5031777
(IDH3A)
GI:5031777 P50213
Saccharomyces cerevisiae (Sce) YIL094c
(S000001356)
GI:6322097 P40495
Saccharomyces cerevisiae (Sce) YOR136w
(S000005662)
GI:6324709 P28241
Schizosaccharomyces pombe (Spo) SPAC31G5.04 GI:19114916 O14104
Schizosaccharomyces pombe (Spo) SPBC902.05c GI:19111995 Q9USP8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.04
ISS
SpoSPAC31G5.04
GO:0005739 mitochondrion C
IDA
AthAt5g03290
SceS000005662
S000001356
SpoSPBC902.05c
ISS
SpoSPAC31G5.04
GO:0005759 mitochondrial matrix C
ISS
SpoSPBC902.05c
NAS
SceS000005662
GO:0005962 mitochondrial isocitrate dehydrogenase complex
(NAD+)
C
IDA
SceS000005662
GO:0009507 chloroplast C
IDA
AthAt5g03290
GO:0004449 isocitrate dehydrogenase (NAD+)
activity
F
IDA
SceS000005662
IMP
AthAt5g03290
SpoSPBC902.05c
ISS
AthAt5g03290
GO:0005524 ATP binding F
IDA
AthAt5g03290
GO:0008270 zinc ion binding F
IDA
AthAt5g03290
GO:0047046 homoisocitrate dehydrogenase activity F
IDA
SceS000001356
ISS
SpoSPAC31G5.04
GO:0005975 carbohydrate metabolic process P
NAS
HsaIDH3A
GO:0006082 organic acid metabolic process P
RCA
SceS000005662
GO:0006091 generation of precursor metabolites and
energy
P
NAS
SpoSPAC31G5.04
GO:0006099 tricarboxylic acid cycle P
IMP
SpoSPBC902.05c
TAS
AthAt5g03290
SceS000005662
GO:0006102 isocitrate metabolic process P
IMP
AthAt5g03290
SpoSPBC902.05c
TAS
SceS000005662
GO:0006537 glutamate biosynthetic process P
IMP
SpoSPBC902.05c
TAS
SceS000005662
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001356
GO:0008152 metabolic process P
ISS
AthAt5g03290
GO:0009085 lysine biosynthetic process P
IMP
SpoSPAC31G5.04
TAS
SceS000001356
GO:0051186 cofactor metabolic process P
RCA
SceS000005662
GO:0055114 oxidation reduction P
RCA
SceS000005662

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
56188

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPAC31G5.04 GI:19114916 O14104
Saccharomyces cerevisiae (Sce) LYS12
(S000001356)
GI:6322097 P40495
Kluyveromyces lactis (Kla) KLLA0E08305g GI:50308647
Magnaporthe grisea (Mgr) MGG_01566 GI:39951847
Neurospora crassa (Ncr) NCU02954.1 GI:32419397


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.04
ISS
SpoSPAC31G5.04
GO:0005739 mitochondrion C
IDA
SceS000001356
ISS
SpoSPAC31G5.04
GO:0047046 homoisocitrate dehydrogenase activity F
IDA
SceS000001356
ISS
SpoSPAC31G5.04
GO:0006091 generation of precursor metabolites and
energy
P
NAS
SpoSPAC31G5.04
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001356
GO:0009085 lysine biosynthetic process P
IMP
SpoSPAC31G5.04
TAS
SceS000001356

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_657

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga4947 ENSANGP00000010852
Ashbya gossypii (Ago) ago1527 ADL214C
Ashbya gossypii (Ago) ago3329 AFR137C
Arabidopsis thaliana (Ath) ath13063 At3g09810.1
Arabidopsis thaliana (Ath) ath22482 At5g03290.1
Caenorhabditis elegans (Cel) cel9034 F43G9.1
(CE34018;
WBGene00009664)
Candida glabrata (Cgl) cgl1736 CAGL0G02585g
Candida glabrata (Cgl) cgl2835 CAGL0I07227g
Cryptococcus neoformans (Cne) cne185 162.m02601
Cryptococcus neoformans (Cne) cne225 162.m02681
Cryptococcus neoformans (Cne) cne983 163.m06462
Cryptococcus neoformans (Cne) cne2198 181.m08214
Dictyostelium discoideum (Ddi) ddi12156 DDB0231288
Debaryomyces hansenii (Dha) dha2232 DEHA0C18106g
Debaryomyces hansenii (Dha) dha5987 DEHA0G06435g
Drosophila melanogaster (Dme) dme18631 CG12233-PA
(FBgn0027291)
Drosophila melanogaster (Dme) dme18632 CG12233-PB
(FBgn0027291)
Drosophila melanogaster (Dme) dme8646 CG32026-PA
(FBgn0052026)
Danio rerio (Dre) dre28282 ENSDARP00000039951
(idh3a)
Q6NV33
Escherichia coli (Eco) eco1100 16129099
Escherichia coli (Eco) eco1756 16129754
Takifugu rubripes (Fru) fru27055 SINFRUP00000129247
Takifugu rubripes (Fru) fru18430 SINFRUP00000173155
Gallus gallus (Gga) gga3733 ENSGALP00000005224
(IDH3A)
Q5ZI29
Homo sapiens (Hsa) hsa10997 ENSP00000299518
(IDH3A)
P50213-1
Kluyveromyces lactis (Kla) kla3085 KLLA0E03058g
Kluyveromyces lactis (Kla) kla3325 KLLA0E08305g
Mus musculus (Mmu) mmu27652 ENSMUSP00000034818
(MGI:1915084)
Q9D6R2-1
Neurospora crassa (Ncr) ncr2859 NCU02954.2
Neurospora crassa (Ncr) ncr7494 NCU07697.2
Oryza sativa (Osa) osa9529 2733.m00139
Rattus norvegicus (Rno) rno28627 ENSRNOP00000015102
(RGD:70889)
Q99NA5
Saccharomyces cerevisiae (Sce) sce3113 YIL094C
(S000001356)
Saccharomyces cerevisiae (Sce) sce5873 YOR136W
(S000005662)
Schizosaccharomyces pombe (Spo) spo2177 SPAC31G5.04 O14104
Schizosaccharomyces pombe (Spo) spo3714 SPBC902.05c Q9USP8
Yarrowia lipolytica (Yli) yli2963 YALI0D06303g
Yarrowia lipolytica (Yli) yli3146 YALI0D10593g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.04
ISS
SpoSPAC31G5.04
GO:0005739 mitochondrion C
IDA
AthAt5g03290
At3g09810
MmuMGI:1915084
SceS000005662
S000001356
SpoSPBC902.05c
ISS
DmeFBgn0027291
SpoSPAC31G5.04
GO:0005759 mitochondrial matrix C
ISS
DmeFBgn0027291
SpoSPBC902.05c
NAS
SceS000005662
GO:0005811 lipid particle C
IDA
DmeFBgn0027291
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0027291
FBgn0052026
GO:0005962 mitochondrial isocitrate dehydrogenase complex
(NAD+)
C
IDA
SceS000005662
ISS
DmeFBgn0052026
GO:0009507 chloroplast C
IDA
AthAt5g03290
GO:0004449 isocitrate dehydrogenase (NAD+)
activity
F
IDA
SceS000005662
IGI
AthAt3g09810
IMP
AthAt5g03290
SpoSPBC902.05c
ISO
MmuMGI:1915084
ISS
AthAt5g03290
At3g09810
DmeFBgn0052026
FBgn0027291
GO:0005524 ATP binding F
IDA
AthAt5g03290
GO:0008270 zinc ion binding F
IDA
AthAt5g03290
GO:0047046 homoisocitrate dehydrogenase activity F
IDA
SceS000001356
ISS
SpoSPAC31G5.04
GO:0000003 reproduction P
IMP
CelWBGene00009664
GO:0006082 organic acid metabolic process P
RCA
SceS000005662
GO:0006091 generation of precursor metabolites and
energy
P
NAS
SpoSPAC31G5.04
GO:0006099 tricarboxylic acid cycle P
IMP
SpoSPBC902.05c
ISO
MmuMGI:1915084
ISS
DmeFBgn0027291
TAS
AthAt5g03290
At3g09810
SceS000005662
GO:0006102 isocitrate metabolic process P
IGI
AthAt3g09810
IMP
AthAt5g03290
SpoSPBC902.05c
ISO
MmuMGI:1915084
TAS
SceS000005662
GO:0006103 2-oxoglutarate metabolic process P
ISO
MmuMGI:1915084
GO:0006537 glutamate biosynthetic process P
IMP
SpoSPBC902.05c
TAS
SceS000005662
GO:0006734 NADH metabolic process P
ISO
MmuMGI:1915084
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00009664
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001356
GO:0008152 metabolic process P
ISS
AthAt5g03290
At3g09810
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00009664
GO:0009085 lysine biosynthetic process P
IMP
SpoSPAC31G5.04
TAS
SceS000001356
GO:0009790 embryo development P
IMP
CelWBGene00009664
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00009664
GO:0010171 body morphogenesis P
IMP
CelWBGene00009664
GO:0016246 RNA interference P
IMP
CelWBGene00009664
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00009664
GO:0040011 locomotion P
IMP
CelWBGene00009664
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00009664
GO:0051186 cofactor metabolic process P
RCA
SceS000005662
GO:0055114 oxidation reduction P
RCA
SceS000005662

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC31G5.04
(O14104)
YIL094C
(S000001356)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SpoSPAC31G5.04
ISS
SpoSPAC31G5.04
GO:0005739 mitochondrion C
IDA
SceS000001356
ISS
SpoSPAC31G5.04
GO:0047046 homoisocitrate dehydrogenase activity F
IDA
SceS000001356
ISS
SpoSPAC31G5.04
GO:0006091 generation of precursor metabolites and
energy
P
NAS
SpoSPAC31G5.04
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000001356
GO:0009085 lysine biosynthetic process P
IMP
SpoSPAC31G5.04
TAS
SceS000001356

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk