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Search term: YJL026W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RNR2
SGD link S000003563
Alternative ID YJL026W
Description Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
Synonyms YJL026W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1567 ACDHYPE

KOGs classification KOGs description
METABOLISM Ribonucleotide reductase, beta subunit

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g23580 GI:15229476
Arabidopsis thaliana (Ath) At3g27060 GI:15232077
Caenorhabditis elegans (Cel) CE00874
(WBGene00004392)		 GI:17551968 P42170
Caenorhabditis elegans (Cel) CE07085_2 GI:17567153 Q19599
Drosophila melanogaster (Dme) 7303545 GI:7303545
Homo sapiens (Hsa) Hs4557845
(RRM2)		 GI:4557845 P31350
Homo sapiens (Hsa) Hs14743689 GI:14743689
Homo sapiens (Hsa) Hs17435183 GI:17435183
Saccharomyces cerevisiae (Sce) YGR180c
(S000003412)		 GI:6321619 P49723
Saccharomyces cerevisiae (Sce) YJL026w
(S000003563)		 GI:6322434 P09938
Schizosaccharomyces pombe (Spo) SPBC25D12.04 GI:19113338 P36603
Encephalitozoon cuniculi (Ecu) ECU06g0730 GI:19074323 Q8SRR2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g27060
GO:0005634 nucleus C
IDA
SceS000003563
S000003412
SpoSPBC25D12.04
GO:0005737 cytoplasm C
IDA
SceS000003563
S000003412
SpoSPBC25D12.04
NAS
HsaRRM2
GO:0005829 cytosol C
IDA
SpoSPBC25D12.04
GO:0005971 ribonucleoside-diphosphate reductase
complex		 C
IDA
SceS000003412
S000003563
IPI
SceS000003412
ISS
AthAt3g23580
TAS
SpoSPBC25D12.04
GO:0004748 ribonucleoside-diphosphate reductase
activity		 F
IDA
AthAt3g23580
SceS000003412
S000003563
S000003563
IGI
SceS000003412
IMP
SceS000003412
S000003412
ISS
AthAt3g27060
At3g23580
HsaRRM2
NAS
HsaRRM2
TAS
SpoSPBC25D12.04
GO:0005515 protein binding F
IPI
SpoSPBC25D12.04
GO:0000003 reproduction P
IMP
CelWBGene00004392
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004392
GO:0006066 alcohol metabolic process P
RCA
SceS000003563
GO:0006213 pyrimidine nucleoside metabolic
process		 P
IC
SpoSPBC25D12.04
GO:0006260 DNA replication P
IMP
AthAt3g27060
NAS
HsaRRM2
GO:0006281 DNA repair P
TAS
AthAt3g27060
At3g23580
GO:0006414 translational elongation P
RCA
SceS000003412
S000003563
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004392
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00017610
GO:0007090 regulation of S phase of mitotic cell
cycle		 P
IC
SpoSPBC25D12.04
GO:0007275 multicellular organismal development P
IMP
AthAt3g27060
At3g23580
GO:0007276 gamete generation P
IMP
CelWBGene00004392
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004392
GO:0009186 deoxyribonucleoside diphosphate metabolic
process		 P
ISS
AthAt3g27060
At3g23580
GO:0009212 pyrimidine deoxyribonucleoside triphosphate
biosynthetic process		 P
IC
SpoSPBC25D12.04
GO:0009216 purine deoxyribonucleoside triphosphate
biosynthetic process		 P
IC
SpoSPBC25D12.04
GO:0009259 ribonucleotide metabolic process P
TAS
AthAt3g23580
GO:0009263 deoxyribonucleotide biosynthetic
process		 P
IDA
SceS000003412
S000003563
ISS
HsaRRM2
GO:0009790 embryo development P
IMP
CelWBGene00004392
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004392
GO:0012501 programmed cell death P
IMP
AthAt3g27060
GO:0019915 lipid storage P
IMP
CelWBGene00017610
GO:0030728 ovulation P
IMP
CelWBGene00004392
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004392
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004392
GO:0042278 purine nucleoside metabolic process P
IC
SpoSPBC25D12.04
GO:0051188 cofactor biosynthetic process P
IMP
SceS000003412
IPI
SceS000003412
GO:0051726 regulation of cell cycle P
IMP
AthAt3g27060
At3g23580
GO:0090329 regulation of DNA-dependent DNA
replication		 P
TAS
SpoSPBC25D12.04

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
20277

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RRM2 GI:4557845 P31350
Canis familiaris (Cfa) RRM2 GI:73979721
Mus musculus (Mmu) Rrm2
(MGI:98181)		 GI:7106399 P11157
Rattus norvegicus (Rno) Rrm2 GI:71043760
Gallus gallus (Gga) RRM2 GI:118089007
Drosophila melanogaster (Dme) RnrS
(FBgn0011704)		 GI:18079279
Anopheles gambiae (Aga) AgaP_AGAP006818 GI:158286793
Caenorhabditis elegans (Cel) rnr-2
(CE00874;
WBGene00004392)		 GI:17551968 P42170
Schizosaccharomyces pombe (Spo) suc22
(SPBC25D12.04)		 GI:19113338 P36603
Saccharomyces cerevisiae (Sce) RNR2
(S000003563)		 GI:6322434 P09938
Kluyveromyces lactis (Kla) KLLA0F15103g GI:50311465
Eremothecium gossypii (Ego) AGOS_AAL136C GI:45184688
Magnaporthe grisea (Mgr) MGG_06408 GI:39977011
Neurospora crassa (Ncr) NCU07887.1 GI:32416230
Arabidopsis thaliana (Ath) TSO2 GI:15232077
Oryza sativa (Osa) Os06g0127900 GI:115466138
Plasmodium falciparum (Pfa) PF14_0053 GI:124808087


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthTSO2
PfaPF14_0053
GO:0005634 nucleus C
IDA
SceS000003563
SpoSPBC25D12.04
GO:0005737 cytoplasm C
IDA
SceS000003563
SpoSPBC25D12.04
NAS
HsaRRM2
GO:0005829 cytosol C
IDA
SpoSPBC25D12.04
GO:0005971 ribonucleoside-diphosphate reductase
complex		 C
IDA
SceS000003563
ISS
DmeFBgn0011704
NAS
DmeFBgn0011704
TAS
SpoSPBC25D12.04
GO:0003674 molecular_function F
ND
AthTSO2
GO:0004748 ribonucleoside-diphosphate reductase
activity		 F
IDA
MmuMGI:98181
MGI:98181
SceS000003563
S000003563
IMP
MmuMGI:98181
ISS
AthTSO2
DmeFBgn0011704
HsaRRM2
NAS
HsaRRM2
TAS
SpoSPBC25D12.04
GO:0005515 protein binding F
IPI
MmuMGI:98181
SpoSPBC25D12.04
GO:0000003 reproduction P
IMP
CelWBGene00004392
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004392
GO:0006066 alcohol metabolic process P
RCA
SceS000003563
GO:0006213 pyrimidine nucleoside metabolic
process		 P
IC
SpoSPBC25D12.04
GO:0006260 DNA replication P
IMP
AthTSO2
ISS
PfaPF14_0053
NAS
DmeFBgn0011704
HsaRRM2
GO:0006281 DNA repair P
TAS
AthTSO2
GO:0006414 translational elongation P
RCA
SceS000003563
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004392
GO:0006919 activation of caspase activity P
IMP
DmeFBgn0011704
GO:0007090 regulation of S phase of mitotic cell
cycle		 P
IC
SpoSPBC25D12.04
GO:0007275 multicellular organismal development P
IMP
AthTSO2
GO:0007276 gamete generation P
IMP
CelWBGene00004392
GO:0008284 positive regulation of cell proliferation P
ISO
MmuMGI:98181
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004392
GO:0009186 deoxyribonucleoside diphosphate metabolic
process		 P
ISS
AthTSO2
GO:0009212 pyrimidine deoxyribonucleoside triphosphate
biosynthetic process		 P
IC
SpoSPBC25D12.04
GO:0009216 purine deoxyribonucleoside triphosphate
biosynthetic process		 P
IC
SpoSPBC25D12.04
GO:0009262 deoxyribonucleotide metabolic process P
IDA
MmuMGI:98181
GO:0009263 deoxyribonucleotide biosynthetic
process		 P
IDA
MmuMGI:98181
SceS000003563
ISS
HsaRRM2
GO:0009266 response to temperature stimulus P
IMP
AthTSO2
GO:0009790 embryo development P
IMP
CelWBGene00004392
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004392
GO:0012501 programmed cell death P
IMP
AthTSO2
GO:0030728 ovulation P
IMP
CelWBGene00004392
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004392
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004392
GO:0042278 purine nucleoside metabolic process P
IC
SpoSPBC25D12.04
GO:0051259 protein oligomerization P
IPI
MmuMGI:98181
GO:0051290 protein heterotetramerization P
IPI
MmuMGI:98181
GO:0051726 regulation of cell cycle P
IMP
AthTSO2
GO:0090329 regulation of DNA-dependent DNA
replication		 P
TAS
SpoSPBC25D12.04

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_490

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2274 ENSANGP00000013211
Anopheles gambiae (Aga) aga2275 ENSANGP00000023621
Ashbya gossypii (Ago) ago51 AAL136C
Arabidopsis thaliana (Ath) ath14676 At3g23580.1
Arabidopsis thaliana (Ath) ath15057 At3g27060.1
Arabidopsis thaliana (Ath) ath25873 At5g40942.1
Caenorhabditis elegans (Cel) cel917 C03C10.3
(CE00874;
WBGene00004392)
Candida glabrata (Cgl) cgl810 CAGL0D03432g
Cryptococcus neoformans (Cne) cne3556 176.m02292
Cryptococcus neoformans (Cne) cne3657 176.m02392
Dictyostelium discoideum (Ddi) ddi12045 DDB0185062
Dictyostelium discoideum (Ddi) ddi3771 DDB0217423
Debaryomyces hansenii (Dha) dha5914 DEHA0G04895g
Drosophila melanogaster (Dme) dme4579 CG8975-PA
(FBgn0011704)
Danio rerio (Dre) dre12640 ENSDARP00000008907
(rrm2)		 P79733
Danio rerio (Dre) dre10458 ENSDARP00000011095
Danio rerio (Dre) dre12639 ENSDARP00000029258
Danio rerio (Dre) dre10466 ENSDARP00000050749
(rrm2b)		 Q32PP6
Escherichia coli (Eco) eco2164 16130170
Encephalitozoon cuniculi (Ecu) ecu1550 19074323
Takifugu rubripes (Fru) fru20147 SINFRUP00000140270
Takifugu rubripes (Fru) fru18375 SINFRUP00000153067
Gallus gallus (Gga) gga11400 ENSGALP00000025808
(RRM2B)
Gallus gallus (Gga) gga15966 ENSGALP00000026474
(RRM2)
Homo sapiens (Hsa) hsa30597 ENSP00000251810
(RRM2B)		 Q7LG56-1
Homo sapiens (Hsa) hsa17459 ENSP00000302955
(RRM2)		 P31350
Kluyveromyces lactis (Kla) kla4757 KLLA0F15103g
Mus musculus (Mmu) mmu5552 ENSMUSP00000020980
(MGI:98181)		 P11157
Mus musculus (Mmu) mmu8906 ENSMUSP00000022901
(MGI:2155865)		 Q6PEE3
Neurospora crassa (Ncr) ncr7683 NCU07887.2
Oryza sativa (Osa) osa44698 5621.m00201
Oryza sativa (Osa) osa50018 5749.m00174
Oryza sativa (Osa) osa67018 6942.m00101
Plasmodium falciparum (Pfa) pfa375 PF10_0154
Plasmodium falciparum (Pfa) pfa1309 PF14_0053
Rattus norvegicus (Rno) rno14764 ENSRNOP00000011163
Rattus norvegicus (Rno) rno24937 ENSRNOP00000037227
(RGD:1598310)		 Q4KLN6
Rattus norvegicus (Rno) rno26980 ENSRNOP00000038047
(RGD:1306045)
Saccharomyces cerevisiae (Sce) sce3282 YJL026W
(S000003563)
Schizosaccharomyces pombe (Spo) spo1823 SPBC25D12.04 P36603
Yarrowia lipolytica (Yli) yli894 YALI0B03630g