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Search term: YJL030W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MAD2
SGD link S000003567
Alternative ID YJL030W
Description Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
Synonyms YJL030W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3285 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Spindle assembly checkpoint protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g25980 GI:15230956
Caenorhabditis elegans (Cel) CE26559
(WBGene00003161)		 GI:17544052
Drosophila melanogaster (Dme) 7295424 GI:7295424
Homo sapiens (Hsa) Hs4505067
(MAD2L1)		 GI:4505067 Q13257
Homo sapiens (Hsa) Hs20562718 GI:20562718
Saccharomyces cerevisiae (Sce) YJL030w
(S000003567)		 GI:6322430 P40958
Schizosaccharomyces pombe (Spo) SPBC20F10.06 GI:19113162 O14417


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
AthAt3g25980
HsaMAD2L1
MAD2L1
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003567
TAS
SpoSPBC20F10.06
GO:0005634 nucleus C
IDA
HsaMAD2L1
GO:0005643 nuclear pore C
IDA
HsaMAD2L1
SceS000003567
GO:0005829 cytosol C
EXP
HsaMAD2L1
IDA
HsaMAD2L1
GO:0010369 chromocenter C
IDA
AthAt3g25980
GO:0033597 mitotic checkpoint complex C
IDA
SceS000003567
SpoSPBC20F10.06
IPI
SceS000003567
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaMAD2L1
GO:0003674 molecular_function F
ND
SceS000003567
GO:0003677 DNA binding F
ISS
AthAt3g25980
GO:0005515 protein binding F
IPI
HsaMAD2L1
SpoSPBC20F10.06
GO:0010997 anaphase-promoting complex binding F
IPI
SpoSPBC20F10.06
GO:0042803 protein homodimerization activity F
IPI
HsaMAD2L1
GO:0000278 mitotic cell cycle P
RCA
SceS000003567
GO:0006461 protein complex assembly P
RCA
SceS000003567
GO:0006950 response to stress P
IMP
CelWBGene00003161
GO:0007093 mitotic cell cycle checkpoint P
IDA
HsaMAD2L1
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
AthAt3g25980
IGI
SceS000003567
IMP
CelWBGene00003161
SceS000003567
SpoSPBC20F10.06
ISS
AthAt3g25980
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003161
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaMAD2L1
GO:0040011 locomotion P
IMP
CelWBGene00003161
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00003161
GO:0045841 negative regulation of mitotic metaphase/anaphase
transition		 P
IPI
SpoSPBC20F10.06
GO:0051312 chromosome decondensation P
IMP
SceS000003567
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaMAD2L1
GO:0060565 inhibition of mitotic anaphase-promoting complex
activity		 P
IPI
SpoSPBC20F10.06
GO:0070683 decatenation checkpoint P
IGI
SceS000003567

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1768

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MAD2L1 GI:4505067 Q13257
Pan troglodytes (Ptr) MAD2L1 GI:114595850
Canis familiaris (Cfa) MAD2L1 GI:73983524
Mus musculus (Mmu) Mad2l1
(MGI:1860374)		 GI:31543218 Q3TV93
Rattus norvegicus (Rno) Mad2l1 GI:27711040
Gallus gallus (Gga) MAD2L1 GI:50746731
Drosophila melanogaster (Dme) mad2
(FBgn0035640)		 GI:21358301
Anopheles gambiae (Aga) AgaP_AGAP000751 GI:158289601
Caenorhabditis elegans (Cel) mdf-2
(CE26559;
WBGene00003161)		 GI:71999490
Schizosaccharomyces pombe (Spo) mad2
(SPBC20F10.06)		 GI:19113162 O14417
Saccharomyces cerevisiae (Sce) MAD2
(S000003567)		 GI:6322430 P40958
Kluyveromyces lactis (Kla) KLLA0D09438g GI:50307009
Eremothecium gossypii (Ego) AGOS_ACR043W GI:45185730
Magnaporthe grisea (Mgr) MGG_08269 GI:145613032
Neurospora crassa (Ncr) NCU05781.1 GI:32410311
Arabidopsis thaliana (Ath) AT3G25980 GI:15230956
Oryza sativa (Osa) Os04g0486500 GI:115459076


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
MmuMGI:1860374
GO:0000776 kinetochore C
IDA
AthAt3g25980
DmeFBgn0035640
HsaMAD2L1
MAD2L1
MmuMGI:1860374
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003567
TAS
SpoSPBC20F10.06
GO:0005634 nucleus C
IDA
HsaMAD2L1
ISS
DmeFBgn0035640
GO:0005635 nuclear envelope C
IDA
DmeFBgn0035640
GO:0005643 nuclear pore C
IDA
HsaMAD2L1
SceS000003567
GO:0005737 cytoplasm C
IDA
DmeFBgn0035640
GO:0005816 spindle pole body C
IDA
MmuMGI:1860374
GO:0005819 spindle C
IDA
DmeFBgn0035640
GO:0005828 kinetochore microtubule C
IDA
DmeFBgn0035640
GO:0005829 cytosol C
EXP
HsaMAD2L1
IDA
HsaMAD2L1
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0035640
GO:0010369 chromocenter C
IDA
AthAt3g25980
GO:0033597 mitotic checkpoint complex C
IDA
SceS000003567
SpoSPBC20F10.06
IPI
SceS000003567
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaMAD2L1
GO:0003674 molecular_function F
ND
MmuMGI:1860374
SceS000003567
GO:0003677 DNA binding F
ISS
AthAt3g25980
GO:0005515 protein binding F
IPI
HsaMAD2L1
SpoSPBC20F10.06
GO:0010997 anaphase-promoting complex binding F
IPI
SpoSPBC20F10.06
GO:0042803 protein homodimerization activity F
IPI
HsaMAD2L1
GO:0000070 mitotic sister chromatid segregation P
IMP
MmuMGI:1860374
GO:0000278 mitotic cell cycle P
RCA
SceS000003567
GO:0006461 protein complex assembly P
RCA
SceS000003567
GO:0006950 response to stress P
IMP
CelWBGene00003161
GO:0007049 cell cycle P
IMP
DmeFBgn0035640
GO:0007093 mitotic cell cycle checkpoint P
IDA
HsaMAD2L1
IMP
DmeFBgn0035640
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
AthAt3g25980
DmeFBgn0035640
IGI
SceS000003567
IMP
CelWBGene00003161
DmeFBgn0035640
MmuMGI:1860374
SceS000003567
SpoSPBC20F10.06
ISA
MmuMGI:1860374
ISS
AthAt3g25980
DmeFBgn0035640
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003161
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaMAD2L1
GO:0040011 locomotion P
IMP
CelWBGene00003161
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00003161
GO:0045841 negative regulation of mitotic metaphase/anaphase
transition		 P
IPI
SpoSPBC20F10.06
TAS
MmuMGI:1860374
GO:0051312 chromosome decondensation P
IMP
SceS000003567
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaMAD2L1
GO:0060565 inhibition of mitotic anaphase-promoting complex
activity		 P
IPI
SpoSPBC20F10.06
GO:0070683 decatenation checkpoint P
IGI
SceS000003567

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3426

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15415 ENSANGP00000017449
Ashbya gossypii (Ago) ago1091 ACR043W
Arabidopsis thaliana (Ath) ath14925 At3g25980.1
Caenorhabditis elegans (Cel) cel20432 Y69A2AR.30a
(CE26559;
WBGene00003161)
Candida glabrata (Cgl) cgl3040 CAGL0J01089g
Cryptococcus neoformans (Cne) cne5289 179.m00138
Dictyostelium discoideum (Ddi) ddi1910 DDB0168106
Dictyostelium discoideum (Ddi) ddi2165 DDB0217277
Debaryomyces hansenii (Dha) dha3099 DEHA0D17809g
Drosophila melanogaster (Dme) dme8144 CG17498-PA
(FBgn0035640)
Danio rerio (Dre) dre22023 ENSDARP00000003616
(zgc:112133)		 Q567E0
Takifugu rubripes (Fru) fru21945 SINFRUP00000148571
Gallus gallus (Gga) gga17859 ENSGALP00000019493
(MAD2L1)
Homo sapiens (Hsa) hsa24586 ENSP00000296509
(MAD2L1)		 Q13257
Kluyveromyces lactis (Kla) kla2481 KLLA0D09438g
Mus musculus (Mmu) mmu21992 ENSMUSP00000031968
Mus musculus (Mmu) mmu21991 ENSMUSP00000078504
(MGI:1860374)		 Q9Z1B5
Neurospora crassa (Ncr) ncr5619 NCU05781.2
Oryza sativa (Osa) osa76546 7264.m00059
Oryza sativa (Osa) osa84442 8270.m00120
Rattus norvegicus (Rno) rno21410 ENSRNOP00000007285
(RGD:1310889)
Saccharomyces cerevisiae (Sce) sce3286 YJL030W
(S000003567)
Schizosaccharomyces pombe (Spo) spo3386 SPBC20F10.06 O14417
Yarrowia lipolytica (Yli) yli4428 YALI0E13684g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
MmuMGI:1860374
GO:0000776 kinetochore C
IDA
AthAt3g25980
DmeFBgn0035640
MmuMGI:1860374
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003567
TAS
SpoSPBC20F10.06
GO:0005634 nucleus C
ISS
DmeFBgn0035640
GO:0005635 nuclear envelope C
IDA
DmeFBgn0035640
GO:0005643 nuclear pore C
IDA
SceS000003567
GO:0005737 cytoplasm C
IDA
DmeFBgn0035640
GO:0005816 spindle pole body C
IDA
MmuMGI:1860374
GO:0005819 spindle C
IDA
DmeFBgn0035640
GO:0005828 kinetochore microtubule C
IDA
DmeFBgn0035640
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0035640
GO:0010369 chromocenter C
IDA
AthAt3g25980
GO:0033597 mitotic checkpoint complex C
IDA
SceS000003567
SpoSPBC20F10.06
IPI
SceS000003567
GO:0003674 molecular_function F
ND
MmuMGI:1860374
SceS000003567
GO:0003677 DNA binding F
ISS
AthAt3g25980
GO:0005515 protein binding F
IPI
SpoSPBC20F10.06
GO:0010997 anaphase-promoting complex binding F
IPI
SpoSPBC20F10.06
GO:0000070 mitotic sister chromatid segregation P
IMP
MmuMGI:1860374
GO:0000278 mitotic cell cycle P
RCA
SceS000003567
GO:0006461 protein complex assembly P
RCA
SceS000003567
GO:0006950 response to stress P
IMP
CelWBGene00003161
GO:0007049 cell cycle P
IMP
DmeFBgn0035640
GO:0007093 mitotic cell cycle checkpoint P
IMP
DmeFBgn0035640
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IDA
AthAt3g25980
DmeFBgn0035640
IGI
SceS000003567
IMP
CelWBGene00003161
DmeFBgn0035640
MmuMGI:1860374
SceS000003567
SpoSPBC20F10.06
ISA
MmuMGI:1860374
ISS
AthAt3g25980
DmeFBgn0035640
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003161
GO:0040011 locomotion P
IMP
CelWBGene00003161
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00003161
GO:0045841 negative regulation of mitotic metaphase/anaphase
transition		 P
IPI
SpoSPBC20F10.06
TAS
MmuMGI:1860374
GO:0051312 chromosome decondensation P
IMP
SceS000003567
GO:0060565 inhibition of mitotic anaphase-promoting complex
activity		 P
IPI
SpoSPBC20F10.06
GO:0070683 decatenation checkpoint P
IGI
SceS000003567

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC20F10.06
(O14417)		 YJL030W
(S000003567)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000003567
TAS
SpoSPBC20F10.06
GO:0005643 nuclear pore C
IDA
SceS000003567
GO:0033597 mitotic checkpoint complex C
IDA
SceS000003567
SpoSPBC20F10.06
IPI
SceS000003567
GO:0003674 molecular_function F
ND
SceS000003567
GO:0005515 protein binding F
IPI
SpoSPBC20F10.06
GO:0010997 anaphase-promoting complex binding F
IPI
SpoSPBC20F10.06
GO:0000278 mitotic cell cycle P
RCA
SceS000003567
GO:0006461 protein complex assembly P
RCA
SceS000003567
GO:0007094 mitotic cell cycle spindle assembly
checkpoint		 P
IGI
SceS000003567
IMP
SceS000003567
SpoSPBC20F10.06
GO:0045841 negative regulation of mitotic metaphase/anaphase
transition		 P
IPI
SpoSPBC20F10.06
GO:0051312 chromosome decondensation P
IMP
SceS000003567
GO:0060565 inhibition of mitotic anaphase-promoting complex
activity		 P
IPI
SpoSPBC20F10.06
GO:0070683 decatenation checkpoint P
IGI
SceS000003567

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