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Search term: YJL034W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name KAR2
SGD link S000003571
Alternative ID YJL034W
Description ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
Synonyms YJL034W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0100 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g09080 GI:15224035
Arabidopsis thaliana (Ath) At5g28540 GI:15241844
Arabidopsis thaliana (Ath) At5g42020 GI:15238264
Caenorhabditis elegans (Cel) CE07244
(WBGene00002008)		 GI:17534771 P20163
Caenorhabditis elegans (Cel) CE08177
(WBGene00002007)		 GI:17568549 P27420
Drosophila melanogaster (Dme) 7292698 GI:7292698
Homo sapiens (Hsa) Hs18546205 GI:18546205
Homo sapiens (Hsa) Hs18546285 GI:18546285
Homo sapiens (Hsa) Hs16507237
(HSPA5)		 GI:16507237 P11021
Saccharomyces cerevisiae (Sce) YJL034w
(S000003571)		 GI:6322426 P16474
Schizosaccharomyces pombe (Spo) SPAC22A12.15c GI:19114157 P36604
Arabidopsis thaliana (Ath) At1g09080 GI:15224035
Arabidopsis thaliana (Ath) At5g28540 GI:15241844
Arabidopsis thaliana (Ath) At5g42020 GI:15238264
Caenorhabditis elegans (Cel) CE07244
(WBGene00002008)		 GI:17534771 P20163
Caenorhabditis elegans (Cel) CE08177
(WBGene00002007)		 GI:17568549 P27420
Drosophila melanogaster (Dme) 7292698 GI:7292698
Homo sapiens (Hsa) Hs18546205 GI:18546205
Homo sapiens (Hsa) Hs18546285 GI:18546285
Homo sapiens (Hsa) Hs16507237
(HSPA5)		 GI:16507237 P11021
Saccharomyces cerevisiae (Sce) YJL034w
(S000003571)		 GI:6322426 P16474
Schizosaccharomyces pombe (Spo) SPAC22A12.15c GI:19114157 P36604
Arabidopsis thaliana (Ath) At1g09080 GI:15224035
Arabidopsis thaliana (Ath) At5g28540 GI:15241844
Arabidopsis thaliana (Ath) At5g42020 GI:15238264
Caenorhabditis elegans (Cel) CE07244
(WBGene00002008)		 GI:17534771 P20163
Caenorhabditis elegans (Cel) CE08177
(WBGene00002007)		 GI:17568549 P27420
Drosophila melanogaster (Dme) 7292698 GI:7292698
Homo sapiens (Hsa) Hs18546205 GI:18546205
Homo sapiens (Hsa) Hs18546285 GI:18546285
Homo sapiens (Hsa) Hs16507237
(HSPA5)		 GI:16507237 P11021
Saccharomyces cerevisiae (Sce) YJL034w
(S000003571)		 GI:6322426 P16474
Schizosaccharomyces pombe (Spo) SPAC22A12.15c GI:19114157 P36604


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt5g28540
GO:0005634 nucleus C
IDA
HsaHSPA5
GO:0005773 vacuole C
IDA
AthAt5g28540
GO:0005783 endoplasmic reticulum C
IDA
HsaHSPA5
SceS000003571
SpoSPAC22A12.15c
ISS
CelWBGene00002008
TAS
HsaHSPA5
GO:0005788 endoplasmic reticulum lumen C
IDA
SpoSPAC22A12.15c
ISS
CelWBGene00002007
TAS
AthAt1g09080
At5g28540
HsaHSPA5
GO:0005793 ER-Golgi intermediate compartment C
IDA
HsaHSPA5
GO:0005794 Golgi apparatus C
IDA
SpoSPAC22A12.15c
GO:0005886 plasma membrane C
IDA
AthAt5g28540
GO:0008303 caspase complex C
IDA
HsaHSPA5
GO:0009507 chloroplast C
IDA
AthAt5g28540
GO:0009986 cell surface C
IDA
HsaHSPA5
GO:0030176 integral to endoplasmic reticulum
membrane		 C
IDA
HsaHSPA5
GO:0031965 nuclear membrane C
IDA
SpoSPAC22A12.15c
GO:0034099 luminal surveillance complex C
IDA
SceS000003571
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaHSPA5
GO:0005509 calcium ion binding F
ISS
CelWBGene00002007
TAS
HsaHSPA5
GO:0005515 protein binding F
IPI
HsaHSPA5
SpoSPAC22A12.15c
ISS
CelWBGene00002007
GO:0005524 ATP binding F
IC
SpoSPAC22A12.15c
NAS
HsaHSPA5
GO:0016887 ATPase activity F
IDA
SceS000003571
ISS
CelWBGene00002007
SpoSPAC22A12.15c
GO:0030674 protein binding, bridging F
NAS
HsaHSPA5
GO:0031625 ubiquitin protein ligase binding F
IPI
HsaHSPA5
GO:0043027 caspase inhibitor activity F
IDA
HsaHSPA5
GO:0051082 unfolded protein binding F
IMP
SceS000003571
ISS
SpoSPAC22A12.15c
TAS
HsaHSPA5
GO:0051087 chaperone binding F
TAS
HsaHSPA5
GO:0000003 reproduction P
IMP
CelWBGene00002007
WBGene00002008
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IGI
SceS000003571
IMP
SceS000003571
GO:0002119 nematode larval development P
IMP
CelWBGene00002007
WBGene00002008
GO:0006200 ATP catabolic process P
ISS
SpoSPAC22A12.15c
GO:0006457 protein folding P
ISS
AthAt5g28540
At1g09080
CelWBGene00002008
RCA
SceS000003571
TAS
AthAt1g09080
At5g28540
GO:0006616 SRP-dependent cotranslational protein targeting to
membrane, translocation		 P
IMP
SceS000003571
GO:0006916 anti-apoptosis P
IMP
HsaHSPA5
TAS
HsaHSPA5
GO:0006950 response to stress P
IDA
CelWBGene00002008
ISS
CelWBGene00002007
WBGene00002008
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000003571
GO:0006986 response to unfolded protein P
IMP
SceS000003571
RCA
SceS000003571
GO:0009306 protein secretion P
ISS
CelWBGene00002007
GO:0009408 response to heat P
IDA
AthAt5g28540
At1g09080
GO:0009790 embryo development P
IMP
CelWBGene00002008
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002008
GO:0009860 pollen tube growth P
IEP
AthAt1g09080
GO:0010171 body morphogenesis P
IMP
CelWBGene00002007
GO:0010197 polar nucleus fusion P
IGI
AthAt5g28540
GO:0030433 ER-associated protein catabolic
process		 P
IMP
AthAt5g28540
SceS000003571
ISS
SpoSPAC22A12.15c
TAS
HsaHSPA5
GO:0030968 endoplasmic reticulum unfolded protein
response		 P
IEP
CelWBGene00002007
WBGene00002008
TAS
HsaHSPA5
GO:0031204 posttranslational protein targeting to membrane,
translocation		 P
IDA
SceS000003571
IMP
SceS000003571
GO:0034620 cellular response to unfolded protein P
ISS
SpoSPAC22A12.15c
GO:0040007 growth P
IMP
CelWBGene00002007
WBGene00002008
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002008
GO:0040011 locomotion P
IMP
CelWBGene00002007
GO:0042149 cellular response to glucose starvation P
IDA
HsaHSPA5
GO:0042221 response to chemical stimulus P
ISS
CelWBGene00002007
GO:0043066 negative regulation of apoptosis P
IMP
HsaHSPA5
GO:0043154 negative regulation of caspase
activity		 P
IDA
HsaHSPA5
GO:0051084 'de novo' posttranslational protein
folding		 P
IDA
SpoSPAC22A12.15c
GO:0060904 regulation of protein folding in endoplasmic
reticulum		 P
TAS
HsaHSPA5

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
3908

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HSPA5 GI:16507237 P11021
Pan troglodytes (Ptr) HSPA5 GI:114626690
Canis familiaris (Cfa) LOC480726 GI:73968072
Mus musculus (Mmu) Hspa5
(MGI:95835)		 GI:31981722 P20029
Rattus norvegicus (Rno) Hspa5
(RGD:2843)		 GI:25742763 44354
Gallus gallus (Gga) HSPA5 GI:45382769
Drosophila melanogaster (Dme) Hsc70-3
(FBgn0001218)		 GI:24641404
Anopheles gambiae (Aga) AgaP_AGAP004192 GI:118783568
Caenorhabditis elegans (Cel) hsp-3
(CE08177;
WBGene00002007)		 GI:17568549 P27420
Caenorhabditis elegans (Cel) hsp-4
(CE07244;
WBGene00002008)		 GI:17534771 P20163
Schizosaccharomyces pombe (Spo) bip
(SPAC22A12.15c)		 GI:19114157 P36604
Saccharomyces cerevisiae (Sce) KAR2
(S000003571)		 GI:6322426 P16474
Kluyveromyces lactis (Kla) KLLA0D09559g GI:50307021
Eremothecium gossypii (Ego) AGOS_ACR038W GI:45185725
Magnaporthe grisea (Mgr) MGG_02503 GI:39968821
Neurospora crassa (Ncr) NCU03982.1 GI:32405376
Arabidopsis thaliana (Ath) BIP2 GI:30693962
Arabidopsis thaliana (Ath) BIP1 GI:15241844
Oryza sativa (Osa) Os02g0115900 GI:115443791
Plasmodium falciparum (Pfa) PFI0875w GI:124506906