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Search term: YJL074C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SMC3
SGD link S000003610
Alternative ID YJL074C
Description Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
Synonyms YJL074C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0964 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g27170 GI:15227262
Caenorhabditis elegans (Cel) CE25302 GI:17555958
Drosophila melanogaster (Dme) 7293243 GI:7293243
Homo sapiens (Hsa) Hs4885399
(SMC3)		 GI:4885399 Q9UQE7
Saccharomyces cerevisiae (Sce) YJL074c
(S000003610)		 GI:6322387 P47037
Schizosaccharomyces pombe (Spo) SPAC10F6.09c GI:19114172 O42649
Encephalitozoon cuniculi (Ecu) ECU09g1910 GI:19173313
Arabidopsis thaliana (Ath) At2g27170 GI:15227262
Caenorhabditis elegans (Cel) CE25302 GI:17555958
Drosophila melanogaster (Dme) 7293243 GI:7293243
Homo sapiens (Hsa) Hs4885399
(SMC3)		 GI:4885399 Q9UQE7
Saccharomyces cerevisiae (Sce) YJL074c
(S000003610)		 GI:6322387 P47037
Schizosaccharomyces pombe (Spo) SPAC10F6.09c GI:19114172 O42649
Encephalitozoon cuniculi (Ecu) ECU09g1910 GI:19173313


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000785 chromatin C
IDA
HsaSMC3
GO:0000790 nuclear chromatin C
IC
SpoSPAC10F6.09c
GO:0000794 condensed nuclear chromosome C
IC
SpoSPAC10F6.09c
GO:0000922 spindle pole C
IDA
HsaSMC3
GO:0005604 basement membrane C
TAS
HsaSMC3
GO:0005634 nucleus C
IDA
SceS000003610
SpoSPAC10F6.09c
ISS
AthAt2g27170
GO:0005737 cytoplasm C
IDA
HsaSMC3
GO:0005829 cytosol C
IDA
SpoSPAC10F6.09c
GO:0008278 cohesin complex C
ISS
AthAt2g27170
NAS
HsaSMC3
GO:0016363 nuclear matrix C
IDA
HsaSMC3
GO:0030892 mitotic cohesin complex C
TAS
SpoSPAC10F6.09c
GO:0034990 nuclear mitotic cohesin complex C
IDA
SceS000003610
GO:0000217 DNA secondary structure binding F
RCA
SceS000003610
GO:0003680 AT DNA binding F
RCA
SceS000003610
GO:0003777 microtubule motor activity F
NAS
HsaSMC3
GO:0005515 protein binding F
IPI
HsaSMC3
SpoSPAC10F6.09c
GO:0005524 ATP binding F
ISS
AthAt2g27170
GO:0016887 ATPase activity F
ISS
SceS000003610
SpoSPAC10F6.09c
GO:0043565 sequence-specific DNA binding F
RCA
SceS000003610
GO:0043566 structure-specific DNA binding F
RCA
SceS000003610
GO:0045502 dynein binding F
IDA
HsaSMC3
GO:0046982 protein heterodimerization activity F
IPI
HsaSMC3
SpoSPAC10F6.09c
GO:0006200 ATP catabolic process P
ISS
SpoSPAC10F6.09c
GO:0007052 mitotic spindle organization P
IEP
HsaSMC3
GO:0007059 chromosome segregation P
ISS
AthAt2g27170
GO:0007062 sister chromatid cohesion P
IMP
AthAt2g27170
HsaSMC3
NAS
HsaSMC3
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000003610
IMP
SpoSPAC10F6.09c
GO:0007126 meiosis P
IDA
HsaSMC3
GO:0007130 synaptonemal complex assembly P
IMP
SceS000003610
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000003610
GO:0007165 signal transduction P
IDA
HsaSMC3
GO:0009294 DNA mediated transformation P
TAS
HsaSMC3
GO:0016567 protein ubiquitination P
ISS
SpoSPAC10F6.09c
GO:0030437 ascospore formation P
IMP
SceS000003610
GO:0032876 negative regulation of DNA endoreduplication P
IMP
HsaSMC3
GO:0051177 meiotic sister chromatid cohesion P
IMP
SceS000003610

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
3974

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SMC3 GI:4885399 Q9UQE7
Pan troglodytes (Ptr) SMC3 GI:114632908
Canis familiaris (Cfa) SMC3 GI:73998561
Mus musculus (Mmu) Smc3
(MGI:1339795)		 GI:36031035 Q3TMK9
Rattus norvegicus (Rno) Smc3 GI:13928790
Gallus gallus (Gga) SMC3 GI:45383139
Drosophila melanogaster (Dme) Cap
(FBgn0015615)		 GI:24642555
Anopheles gambiae (Aga) AgaP_AGAP006388 GI:118787977
Caenorhabditis elegans (Cel) smc-3
(CE41472;
WBGene00004873)		 GI:193210872
Schizosaccharomyces pombe (Spo) psm3
(SPAC10F6.09c)		 GI:19114172 O42649
Saccharomyces cerevisiae (Sce) SMC3
(S000003610)		 GI:6322387 P47037
Kluyveromyces lactis (Kla) KLLA0A00286g GI:50302157
Eremothecium gossypii (Ego) AGOS_AAL182W GI:45184642
Magnaporthe grisea (Mgr) MGG_04988 GI:39940504
Neurospora crassa (Ncr) NCU07554.1 GI:32414721
Arabidopsis thaliana (Ath) TTN7 GI:145360381
Oryza sativa (Osa) Os02g0133300 GI:115444047
Plasmodium falciparum (Pfa) PFD0685c GI:124505413


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000228 nuclear chromosome C
ISS
PfaPFD0685c
GO:0000785 chromatin C
IDA
HsaSMC3
GO:0000790 nuclear chromatin C
IC
SpoSPAC10F6.09c
IDA
CelWBGene00004873
GO:0000793 condensed chromosome C
IDA
CelWBGene00004873
GO:0000794 condensed nuclear chromosome C
IC
SpoSPAC10F6.09c
IDA
CelWBGene00004873
GO:0000800 lateral element C
IDA
MmuMGI:1339795
GO:0000922 spindle pole C
IDA
HsaSMC3
GO:0005604 basement membrane C
ISO
MmuMGI:1339795
TAS
HsaSMC3
GO:0005634 nucleus C
IDA
MmuMGI:1339795
SceS000003610
SpoSPAC10F6.09c
ISS
AthTTN7
GO:0005737 cytoplasm C
IDA
HsaSMC3
GO:0005819 spindle C
IDA
CelWBGene00004873
GO:0005829 cytosol C
IDA
SpoSPAC10F6.09c
GO:0008278 cohesin complex C
IDA
CelWBGene00004873
ISS
AthTTN7
DmeFBgn0015615
NAS
DmeFBgn0015615
HsaSMC3
GO:0016363 nuclear matrix C
IDA
HsaSMC3
GO:0030892 mitotic cohesin complex C
TAS
SpoSPAC10F6.09c
GO:0034990 nuclear mitotic cohesin complex C
IDA
SceS000003610
GO:0000217 DNA secondary structure binding F
RCA
SceS000003610
GO:0003680 AT DNA binding F
RCA
SceS000003610
GO:0003777 microtubule motor activity F
NAS
HsaSMC3
GO:0004674 protein serine/threonine kinase
activity		 F
NAS
CelWBGene00004873
GO:0005515 protein binding F
IPI
HsaSMC3
MmuMGI:1339795
SpoSPAC10F6.09c
GO:0005524 ATP binding F
ISS
AthTTN7
GO:0016887 ATPase activity F
ISS
SceS000003610
SpoSPAC10F6.09c
GO:0043565 sequence-specific DNA binding F
RCA
SceS000003610
GO:0043566 structure-specific DNA binding F
RCA
SceS000003610
GO:0045502 dynein binding F
IDA
HsaSMC3
GO:0046982 protein heterodimerization activity F
IPI
HsaSMC3
SpoSPAC10F6.09c
GO:0000003 reproduction P
IMP
CelWBGene00004873
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004873
GO:0006200 ATP catabolic process P
ISS
SpoSPAC10F6.09c
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004873
GO:0007052 mitotic spindle organization P
IEP
HsaSMC3
GO:0007059 chromosome segregation P
IMP
CelWBGene00004873
ISS
AthTTN7
GO:0007062 sister chromatid cohesion P
IMP
AthTTN7
HsaSMC3
ISS
DmeFBgn0015615
NAS
HsaSMC3
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000003610
IMP
SpoSPAC10F6.09c
GO:0007109 cytokinesis, completion of separation P
IMP
CelWBGene00004873
GO:0007126 meiosis P
IDA
HsaSMC3
IPI
MmuMGI:1339795
GO:0007130 synaptonemal complex assembly P
IMP
SceS000003610
GO:0007131 reciprocal meiotic recombination P
IMP
SceS000003610
GO:0007165 signal transduction P
IDA
HsaSMC3
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00004873
GO:0009294 DNA mediated transformation P
TAS
HsaSMC3
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004873
GO:0016567 protein ubiquitination P
ISS
SpoSPAC10F6.09c
GO:0030261 chromosome condensation P
IMP
CelWBGene00004873
GO:0030437 ascospore formation P
IMP
SceS000003610
GO:0032876 negative regulation of DNA endoreduplication P
IMP
HsaSMC3
GO:0040002 collagen and cuticulin-based cuticle
development		 P
IMP
CelWBGene00004873
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004873
GO:0040011 locomotion P
IMP
CelWBGene00004873
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004873
GO:0051177 meiotic sister chromatid cohesion P
IMP
SceS000003610

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1445

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1830 ENSANGP00000020478
Ashbya gossypii (Ago) ago5 AAL182W
Arabidopsis thaliana (Ath) ath9658 At2g27170.1
Caenorhabditis elegans (Cel) cel19070 Y47D3A.26
(CE41472;
WBGene00004873)
Candida glabrata (Cgl) cgl2183 CAGL0H02805g
Cryptococcus neoformans (Cne) cne590 163.m06195
Dictyostelium discoideum (Ddi) ddi11847 DDB0219934
Debaryomyces hansenii (Dha) dha5786 DEHA0G01958g
Drosophila melanogaster (Dme) dme18204 CG9802-PA
(FBgn0015615)
Drosophila melanogaster (Dme) dme18205 CG9802-PB
(FBgn0015615)
Danio rerio (Dre) dre14760 ENSDARP00000024411
(LOC554965)		 Q1LVV8
Danio rerio (Dre) dre14761 ENSDARP00000039777
Danio rerio (Dre) dre14762 ENSDARP00000041221
Encephalitozoon cuniculi (Ecu) ecu1464 19173313
Takifugu rubripes (Fru) fru5226 SINFRUP00000127255
Takifugu rubripes (Fru) fru20692 SINFRUP00000145156
Gallus gallus (Gga) gga20850 ENSGALP00000013963
(SMC3)
Homo sapiens (Hsa) hsa4593 ENSP00000350226
Homo sapiens (Hsa) hsa4592 ENSP00000353180
Homo sapiens (Hsa) hsa4591 ENSP00000354720
(SMC3)		 Q9UQE7
Kluyveromyces lactis (Kla) kla9 KLLA0A00286g
Mus musculus (Mmu) mmu13913 ENSMUSP00000025930
(MGI:1339795)		 Q9CW03
Neurospora crassa (Ncr) ncr7355 NCU07554.2
Oryza sativa (Osa) osa78168 7372.m00115
Oryza sativa (Osa) osa78169 7372.m00116
Oryza sativa (Osa) osa78176 7372.m00119
Plasmodium falciparum (Pfa) pfa3258 PFD0685c
Rattus norvegicus (Rno) rno4274 ENSRNOP00000019560
(RGD:62006)
Saccharomyces cerevisiae (Sce) sce3332 YJL074C
(S000003610)
Schizosaccharomyces pombe (Spo) spo1023 SPAC10F6.09c O42649
Yarrowia lipolytica (Yli) yli21 YALI0A00616g