Search term: YJL101C

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG3754	-CDHYP-

KOGs classification	KOGs description
METABOLISM	Gamma-glutamylcysteine synthetase

Species	KOG link	NCBI link	UniProt link
Caenorhabditis elegans (Cel)	CE03290	GI:17533793
Drosophila melanogaster (Dme)	7290879	GI:7290879	A4V448
Homo sapiens (Hsa)	Hs4557625 (GCLC)	GI:4557625	P48506
Saccharomyces cerevisiae (Sce)	YJL101c (S000003637)	GI:6322360	P32477
Schizosaccharomyces pombe (Spo)	SPAC22F3.10c	GI:19113943	Q09768

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005622	intracellular	C	IDA Sce S000003637
GO:0005634	nucleus	C	IDA Spo SPAC22F3.10c
GO:0005829	cytosol	C	IDA Spo SPAC22F3.10c
GO:0017109	glutamate-cysteine ligase complex	C	ISS Spo SPAC22F3.10c
GO:0000287	magnesium ion binding	F	IDA Hsa GCLC
GO:0004357	glutamate-cysteine ligase activity	F	IDA Hsa GCLC Sce S000003637 IMP Hsa GCLC Sce S000003637 Spo SPAC22F3.10c
GO:0016595	glutamate binding	F	IDA Hsa GCLC
GO:0043531	ADP binding	F	IDA Hsa GCLC
GO:0046911	metal chelating activity	F	TAS Spo SPAC22F3.10c
GO:0050662	coenzyme binding	F	IPI Hsa GCLC
GO:0006534	cysteine metabolic process	P	IDA Hsa GCLC
GO:0006536	glutamate metabolic process	P	IDA Hsa GCLC
GO:0006750	glutathione biosynthetic process	P	IDA Hsa GCLC Sce S000003637 IMP Hsa GCLC Sce S000003637 Spo SPAC22F3.10c
GO:0006916	anti-apoptosis	P	IDA Hsa GCLC
GO:0006979	response to oxidative stress	P	IDA Hsa GCLC
GO:0009408	response to heat	P	IDA Hsa GCLC
GO:0009725	response to hormone stimulus	P	IDA Hsa GCLC
GO:0016481	negative regulation of transcription	P	IDA Hsa GCLC
GO:0042542	response to hydrogen peroxide	P	IMP Sce S000003637
GO:0045454	cell redox homeostasis	P	IDA Hsa GCLC
GO:0046686	response to cadmium ion	P	IDA Sce S000003637
GO:0050880	regulation of blood vessel size	P	IMP Hsa GCLC
GO:0071276	cellular response to cadmium ion	P	IMP Spo SPAC22F3.10c

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
1148

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	GCLC	GI:4557625	P48506
Pan troglodytes (Ptr)	GCLC	GI:114607912
Canis familiaris (Cfa)	GCLC	GI:73973063
Mus musculus (Mmu)	Gclc (MGI:104990)	GI:33468897	P97494
Rattus norvegicus (Rno)	Gclc (RGD:619868)	GI:25742748	41167
Gallus gallus (Gga)	GCLC	GI:118088958
Drosophila melanogaster (Dme)	Gclc (FBgn0040319)	GI:24640503
Anopheles gambiae (Aga)	AgaP_AGAP001512	GI:118794597
Caenorhabditis elegans (Cel)	gcs-1 (CE32886; WBGene00001527)	GI:32564021
Schizosaccharomyces pombe (Spo)	apd1	GI:19113943
Saccharomyces cerevisiae (Sce)	GSH1 (S000003637)	GI:6322360	P32477
Kluyveromyces lactis (Kla)	KLLA0F14058g	GI:50311373
Magnaporthe grisea (Mgr)	MGG_07317	GI:39972003
Neurospora crassa (Ncr)	NCU01157.1	GI:32412340
Plasmodium falciparum (Pfa)	PFI0925w	GI:124506926

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005622	intracellular	C	IDA Sce S000003637
GO:0005634	nucleus	C	IDA Dme FBgn0040319
GO:0005829	cytosol	C	IDA Mmu MGI:104990
GO:0017109	glutamate-cysteine ligase complex	C	IDA Mmu MGI:104990 IPI Dme FBgn0040319 ISO Mmu MGI:104990 ISS Dme FBgn0040319
GO:0048471	perinuclear region of cytoplasm	C	IDA Dme FBgn0040319
GO:0000287	magnesium ion binding	F	IDA Hsa GCLC
GO:0004357	glutamate-cysteine ligase activity	F	IDA Dme FBgn0040319 Hsa GCLC Mmu MGI:104990 Sce S000003637 IMP Hsa GCLC Mmu MGI:104990 Sce S000003637 ISO Mmu MGI:104990 ISS Dme FBgn0040319
GO:0005515	protein binding	F	IPI Dme FBgn0040319
GO:0016595	glutamate binding	F	IDA Hsa GCLC
GO:0043531	ADP binding	F	IDA Hsa GCLC
GO:0046982	protein heterodimerization activity	F	IPI Mmu MGI:104990 ISO Mmu MGI:104990
GO:0050662	coenzyme binding	F	IPI Hsa GCLC
GO:0006534	cysteine metabolic process	P	IDA Hsa GCLC
GO:0006536	glutamate metabolic process	P	IDA Hsa GCLC
GO:0006749	glutathione metabolic process	P	IDA Dme FBgn0040319 IMP Mmu MGI:104990
GO:0006750	glutathione biosynthetic process	P	IDA Dme FBgn0040319 Hsa GCLC Mmu MGI:104990 Sce S000003637 IMP Cel WBGene00001527 Hsa GCLC Mmu MGI:104990 Sce S000003637 ISO Mmu MGI:104990
GO:0006916	anti-apoptosis	P	IDA Hsa GCLC
GO:0006974	response to DNA damage stimulus	P	IMP Dme FBgn0040319
GO:0006979	response to oxidative stress	P	IDA Hsa GCLC ISO Mmu MGI:104990
GO:0009408	response to heat	P	IDA Hsa GCLC IEP Cel WBGene00001527
GO:0009410	response to xenobiotic stimulus	P	IMP Mmu MGI:104990
GO:0009635	response to herbicide	P	IEP Cel WBGene00001527
GO:0009725	response to hormone stimulus	P	IDA Hsa GCLC
GO:0016481	negative regulation of transcription	P	IDA Hsa GCLC
GO:0019852	L-ascorbic acid metabolic process	P	IMP Mmu MGI:104990
GO:0031397	negative regulation of protein ubiquitination	P	IMP Mmu MGI:104990
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	P	IMP Mmu MGI:104990
GO:0042542	response to hydrogen peroxide	P	IMP Sce S000003637
GO:0043066	negative regulation of apoptosis	P	IGI Mmu MGI:104990
GO:0043524	negative regulation of neuron apoptosis	P	ISO Mmu MGI:104990
GO:0045454	cell redox homeostasis	P	IDA Hsa GCLC
GO:0046685	response to arsenic	P	IMP Cel WBGene00001527 Mmu MGI:104990
GO:0046686	response to cadmium ion	P	IDA Sce S000003637
GO:0050880	regulation of blood vessel size	P	IMP Hsa GCLC
GO:0051409	response to nitrosative stress	P	ISO Mmu MGI:104990
GO:0051900	regulation of mitochondrial depolarization	P	IGI Mmu MGI:104990

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_2140

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga3607	ENSANGP00000011664
Anopheles gambiae (Aga)	aga3608	ENSANGP00000022484
Ashbya gossypii (Ago)	ago3278	AFR086C
Caenorhabditis elegans (Cel)	cel8392	F37B12.2 (CE32886; WBGene00001527)
Candida glabrata (Cgl)	cgl4235	CAGL0L03630g
Cryptococcus neoformans (Cne)	cne2681	183.m01615
Dictyostelium discoideum (Ddi)	ddi13072	DDB0231403
Debaryomyces hansenii (Dha)	dha5642	DEHA0F28072g
Drosophila melanogaster (Dme)	dme16939	CG2259-PA (FBgn0040319)
Drosophila melanogaster (Dme)	dme16940	CG2259-PB (FBgn0040319)
Danio rerio (Dre)	dre3385	ENSDARP00000017790 (gclc)	Q6NV35
Takifugu rubripes (Fru)	fru25036	SINFRUP00000164408
Takifugu rubripes (Fru)	fru25038	SINFRUP00000166412
Takifugu rubripes (Fru)	fru25037	SINFRUP00000167556
Takifugu rubripes (Fru)	fru25039	SINFRUP00000168806
Gallus gallus (Gga)	gga15879	ENSGALP00000026269
Gallus gallus (Gga)	gga15880	ENSGALP00000026270 (GCLC)
Homo sapiens (Hsa)	hsa27318	ENSP00000229416 (GCLC)	P48506
Kluyveromyces lactis (Kla)	kla4711	KLLA0F14058g
Mus musculus (Mmu)	mmu27964	ENSMUSP00000034905 (MGI:104990)	P97494
Neurospora crassa (Ncr)	ncr1121	NCU01157.2
Plasmodium falciparum (Pfa)	pfa4651	PFI0925w
Rattus norvegicus (Rno)	rno28958	ENSRNOP00000035540 (RGD:619868)	P19468
Saccharomyces cerevisiae (Sce)	sce3361	YJL101C (S000003637)
Schizosaccharomyces pombe (Spo)	spo1894	SPAC22F3.10c	Q09768
Yarrowia lipolytica (Yli)	yli5106	YALI0E30129g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005622	intracellular	C	IDA Sce S000003637
GO:0005634	nucleus	C	IDA Dme FBgn0040319 Spo SPAC22F3.10c
GO:0005829	cytosol	C	IDA Mmu MGI:104990 Spo SPAC22F3.10c
GO:0017109	glutamate-cysteine ligase complex	C	IDA Mmu MGI:104990 IPI Dme FBgn0040319 ISO Mmu MGI:104990 ISS Dme FBgn0040319 Spo SPAC22F3.10c
GO:0048471	perinuclear region of cytoplasm	C	IDA Dme FBgn0040319
GO:0004357	glutamate-cysteine ligase activity	F	IDA Dme FBgn0040319 Mmu MGI:104990 Sce S000003637 IMP Mmu MGI:104990 Sce S000003637 Spo SPAC22F3.10c ISO Mmu MGI:104990 ISS Dme FBgn0040319
GO:0005515	protein binding	F	IPI Dme FBgn0040319
GO:0046911	metal chelating activity	F	TAS Spo SPAC22F3.10c
GO:0046982	protein heterodimerization activity	F	IPI Mmu MGI:104990 ISO Mmu MGI:104990
GO:0006749	glutathione metabolic process	P	IDA Dme FBgn0040319 IMP Mmu MGI:104990
GO:0006750	glutathione biosynthetic process	P	IDA Dme FBgn0040319 Mmu MGI:104990 Sce S000003637 IMP Cel WBGene00001527 Mmu MGI:104990 Sce S000003637 Spo SPAC22F3.10c ISO Mmu MGI:104990
GO:0006974	response to DNA damage stimulus	P	IMP Dme FBgn0040319
GO:0006979	response to oxidative stress	P	ISO Mmu MGI:104990
GO:0009408	response to heat	P	IEP Cel WBGene00001527
GO:0009410	response to xenobiotic stimulus	P	IMP Mmu MGI:104990
GO:0009635	response to herbicide	P	IEP Cel WBGene00001527
GO:0019852	L-ascorbic acid metabolic process	P	IMP Mmu MGI:104990
GO:0031397	negative regulation of protein ubiquitination	P	IMP Mmu MGI:104990
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	P	IMP Mmu MGI:104990
GO:0042542	response to hydrogen peroxide	P	IMP Sce S000003637
GO:0043066	negative regulation of apoptosis	P	IGI Mmu MGI:104990
GO:0043524	negative regulation of neuron apoptosis	P	ISO Mmu MGI:104990
GO:0046685	response to arsenic	P	IMP Cel WBGene00001527 Mmu MGI:104990
GO:0046686	response to cadmium ion	P	IDA Sce S000003637
GO:0051409	response to nitrosative stress	P	ISO Mmu MGI:104990
GO:0051900	regulation of mitochondrial depolarization	P	IGI Mmu MGI:104990
GO:0071276	cellular response to cadmium ion	P	IMP Spo SPAC22F3.10c

Curated yeast ortholog results:

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC22F3.10c (Q09768)	YJL101C (S000003637)

GO terms for curated homolog results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005622	intracellular	C	IDA Sce S000003637
GO:0005634	nucleus	C	IDA Spo SPAC22F3.10c
GO:0005829	cytosol	C	IDA Spo SPAC22F3.10c
GO:0017109	glutamate-cysteine ligase complex	C	ISS Spo SPAC22F3.10c
GO:0004357	glutamate-cysteine ligase activity	F	IDA Sce S000003637 IMP Sce S000003637 Spo SPAC22F3.10c
GO:0046911	metal chelating activity	F	TAS Spo SPAC22F3.10c
GO:0006750	glutathione biosynthetic process	P	IDA Sce S000003637 IMP Sce S000003637 Spo SPAC22F3.10c
GO:0042542	response to hydrogen peroxide	P	IMP Sce S000003637
GO:0046686	response to cadmium ion	P	IDA Sce S000003637
GO:0071276	cellular response to cadmium ion	P	IMP Spo SPAC22F3.10c