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Search term: YJL138C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TIF2
SGD link S000003674
Alternative ID YJL138C
Description Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
Synonyms YJL138C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0327 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g12690 GI:15222047
Arabidopsis thaliana (Ath) At1g12770_1 GI:15220990
Arabidopsis thaliana (Ath) At1g54270 GI:15221761
Arabidopsis thaliana (Ath) At1g72730 GI:15218574
Arabidopsis thaliana (Ath) At3g13920 GI:18400210
Arabidopsis thaliana (Ath) At5g19210 GI:15239683
Caenorhabditis elegans (Cel) CE01338
(WBGene00018997)		 GI:17553716 Q20935
Caenorhabditis elegans (Cel) CE01341
(WBGene00002083)		 GI:17553942
Drosophila melanogaster (Dme) 7297048 GI:7297048
Homo sapiens (Hsa) Hs17459025 GI:17459025
Homo sapiens (Hsa) Hs17475661 GI:17475661
Homo sapiens (Hsa) Hs17476177 GI:17476177
Homo sapiens (Hsa) Hs20479405 GI:20479405
Homo sapiens (Hsa) Hs20482355 GI:20482355
Homo sapiens (Hsa) Hs20538426_2 GI:20538426
Homo sapiens (Hsa) Hs20548087 GI:20548087
Homo sapiens (Hsa) Hs22057430 GI:22057430
Homo sapiens (Hsa) Hs4503529
(EIF4A1)		 GI:4503529 Q9NZR9
Homo sapiens (Hsa) Hs4503531 GI:4503531
Homo sapiens (Hsa) Hs4826688 GI:4826688
Saccharomyces cerevisiae (Sce) YJL138c
(S000003674)		 GI:6322323 P10081
Saccharomyces cerevisiae (Sce) YKR059w
(S000001767)		 GI:6322323 P10081
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Encephalitozoon cuniculi (Ecu) ECU09g1200 GI:19173239
Arabidopsis thaliana (Ath) At1g12690 GI:15222047
Arabidopsis thaliana (Ath) At1g12770_1 GI:15220990
Arabidopsis thaliana (Ath) At1g54270 GI:15221761
Arabidopsis thaliana (Ath) At1g72730 GI:15218574
Arabidopsis thaliana (Ath) At3g13920 GI:18400210
Arabidopsis thaliana (Ath) At5g19210 GI:15239683
Caenorhabditis elegans (Cel) CE01338
(WBGene00018997)		 GI:17553716 Q20935
Caenorhabditis elegans (Cel) CE01341
(WBGene00002083)		 GI:17553942
Drosophila melanogaster (Dme) 7297048 GI:7297048
Homo sapiens (Hsa) Hs17459025 GI:17459025
Homo sapiens (Hsa) Hs17475661 GI:17475661
Homo sapiens (Hsa) Hs17476177 GI:17476177
Homo sapiens (Hsa) Hs20479405 GI:20479405
Homo sapiens (Hsa) Hs20482355 GI:20482355
Homo sapiens (Hsa) Hs20538426_2 GI:20538426
Homo sapiens (Hsa) Hs20548087 GI:20548087
Homo sapiens (Hsa) Hs22057430 GI:22057430
Homo sapiens (Hsa) Hs4503529
(EIF4A1)		 GI:4503529 Q9NZR9
Homo sapiens (Hsa) Hs4503531 GI:4503531
Homo sapiens (Hsa) Hs4826688 GI:4826688
Saccharomyces cerevisiae (Sce) YJL138c
(S000003674)		 GI:6322323 P10081
Saccharomyces cerevisiae (Sce) YKR059w
(S000001767)		 GI:6322323 P10081
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Encephalitozoon cuniculi (Ecu) ECU09g1200 GI:19173239
Arabidopsis thaliana (Ath) At1g12690 GI:15222047
Arabidopsis thaliana (Ath) At1g12770_1 GI:15220990
Arabidopsis thaliana (Ath) At1g54270 GI:15221761
Arabidopsis thaliana (Ath) At1g72730 GI:15218574
Arabidopsis thaliana (Ath) At3g13920 GI:18400210
Arabidopsis thaliana (Ath) At5g19210 GI:15239683
Caenorhabditis elegans (Cel) CE01338
(WBGene00018997)		 GI:17553716 Q20935
Caenorhabditis elegans (Cel) CE01341
(WBGene00002083)		 GI:17553942
Drosophila melanogaster (Dme) 7297048 GI:7297048
Homo sapiens (Hsa) Hs17459025 GI:17459025
Homo sapiens (Hsa) Hs17475661 GI:17475661
Homo sapiens (Hsa) Hs17476177 GI:17476177
Homo sapiens (Hsa) Hs20479405 GI:20479405
Homo sapiens (Hsa) Hs20482355 GI:20482355
Homo sapiens (Hsa) Hs20538426_2 GI:20538426
Homo sapiens (Hsa) Hs20548087 GI:20548087
Homo sapiens (Hsa) Hs22057430 GI:22057430
Homo sapiens (Hsa) Hs4503529
(EIF4A1)		 GI:4503529 Q9NZR9
Homo sapiens (Hsa) Hs4503531 GI:4503531
Homo sapiens (Hsa) Hs4826688 GI:4826688
Saccharomyces cerevisiae (Sce) YJL138c
(S000003674)		 GI:6322323 P10081
Saccharomyces cerevisiae (Sce) YKR059w
(S000001767)		 GI:6322323 P10081
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Encephalitozoon cuniculi (Ecu) ECU09g1200 GI:19173239


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003674
GO:0005618 cell wall C
IDA
AthAt3g13920
GO:0005730 nucleolus C
IDA
AthAt3g13920
GO:0005737 cytoplasm C
IDA
SceS000003674
ISS
SceS000003674
GO:0005739 mitochondrion C
IDA
AthAt1g12770
GO:0005829 cytosol C
EXP
HsaEIF4A1
IDA
AthAt1g54270
At3g13920
At1g72730
SpoSPAC1006.07
GO:0005840 ribosome C
TAS
SceS000003674
S000001767
GO:0005886 plasma membrane C
IDA
AthAt1g54270
At1g72730
GO:0009505 plant-type cell wall C
IDA
AthAt1g72730
GO:0016020 membrane C
IDA
AthAt3g13920
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IGI
SceS000001767
S000003674
ISS
SceS000003674
S000001767
SpoSPAC1006.07
TAS
HsaEIF4A1
GO:0000339 RNA cap binding F
TAS
HsaEIF4A1
GO:0003724 RNA helicase activity F
ISS
AthAt1g12770
GO:0003729 mRNA binding F
TAS
HsaEIF4A1
GO:0003743 translation initiation factor activity F
IDA
SceS000003674
S000001767
IMP
SceS000001767
ISS
AthAt1g54270
At3g13920
SceS000003674
SpoSPAC1006.07
TAS
SceS000003674
GO:0004004 ATP-dependent RNA helicase activity F
IDA
SceS000001767
IMP
SceS000003674
S000001767
ISS
SpoSPAC1006.07
GO:0004386 helicase activity F
TAS
HsaEIF4A1
GO:0005515 protein binding F
IPI
AthAt3g13920
HsaEIF4A1
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0008026 ATP-dependent helicase activity F
ISS
AthAt1g54270
At5g19210
At1g72730
At3g13920
GO:0008135 translation factor activity, nucleic acid
binding		 F
TAS
HsaEIF4A1
GO:0000003 reproduction P
IMP
CelWBGene00002083
WBGene00018997
GO:0002119 nematode larval development P
IMP
CelWBGene00018997
WBGene00002083
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006413 translational initiation P
IDA
SceS000001767
IMP
SceS000001767
ISS
AthAt3g13920
SpoSPAC1006.07
TAS
SceS000003674
GO:0006417 regulation of translation P
RCA
SceS000001767
S000003674
GO:0006446 regulation of translational initiation P
ISS
SceS000003674
GO:0008150 biological_process P
ND
AthAt1g72730
At5g19210
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002083
WBGene00018997
GO:0009663 plasmodesma organization P
IMP
AthAt1g12770
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002083
WBGene00018997
GO:0009793 embryo development ending in seed
dormancy		 P
NAS
AthAt1g12770
GO:0010497 plasmodesmata-mediated intercellular
transport		 P
IMP
AthAt1g12770
GO:0019915 lipid storage P
IMP
CelWBGene00002083
WBGene00018997
GO:0040007 growth P
IMP
CelWBGene00018997
WBGene00002083
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002083
WBGene00018997
GO:0040011 locomotion P
IMP
CelWBGene00018997
WBGene00002083
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC1006.07
GO:0046686 response to cadmium ion P
IEP
AthAt1g54270
At3g13920

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
103998

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EIF4A1 GI:4503529 Q9NZR9
Canis familiaris (Cfa) EIF4A1 GI:73966209
Mus musculus (Mmu) Eif4a1
(MGI:95303)		 GI:21450625 A0N8T7
Rattus norvegicus (Rno) Eif4a1
(RGD:735141)		 GI:40786436
Caenorhabditis elegans (Cel) inf-1
(CE01341;
WBGene00002083)		 GI:71987143
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Saccharomyces cerevisiae (Sce) TIF2
(S000003674)		 GI:6322323 P10081
Saccharomyces cerevisiae (Sce) TIF1
(S000001767)		 GI:6322912
Kluyveromyces lactis (Kla) KLLA0A05731g GI:50302639
Eremothecium gossypii (Ego) AGOS_ACR253C GI:45185939
Magnaporthe grisea (Mgr) MGG_04400 GI:145603147
Neurospora crassa (Ncr) NCU07420.1 GI:32414453
Arabidopsis thaliana (Ath) AT1G72730 GI:15218574
Plasmodium falciparum (Pfa) PF14_0655 GI:124810293


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003674
GO:0005737 cytoplasm C
IDA
SceS000003674
ISS
SceS000003674
GO:0005829 cytosol C
EXP
HsaEIF4A1
IDA
AthAt1g72730
SpoSPAC1006.07
GO:0005840 ribosome C
TAS
SceS000003674
S000001767
GO:0005886 plasma membrane C
IDA
AthAt1g72730
GO:0009505 plant-type cell wall C
IDA
AthAt1g72730
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IGI
SceS000001767
S000003674
ISS
PfaPF14_0655
SceS000003674
S000001767
SpoSPAC1006.07
TAS
HsaEIF4A1
GO:0000339 RNA cap binding F
ISS
PfaPF14_0655
TAS
HsaEIF4A1
GO:0003729 mRNA binding F
ISS
PfaPF14_0655
TAS
HsaEIF4A1
GO:0003743 translation initiation factor activity F
IDA
SceS000003674
S000001767
IMP
SceS000001767
ISS
PfaPF14_0655
SceS000003674
SpoSPAC1006.07
TAS
SceS000003674
GO:0004004 ATP-dependent RNA helicase activity F
IDA
SceS000001767
IMP
SceS000003674
S000001767
ISS
SpoSPAC1006.07
GO:0004386 helicase activity F
TAS
HsaEIF4A1
GO:0005515 protein binding F
IPI
HsaEIF4A1
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0008026 ATP-dependent helicase activity F
ISS
AthAt1g72730
GO:0008135 translation factor activity, nucleic acid
binding		 F
TAS
HsaEIF4A1
GO:0000003 reproduction P
IMP
CelWBGene00002083
GO:0002119 nematode larval development P
IMP
CelWBGene00002083
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006413 translational initiation P
IDA
SceS000001767
IMP
SceS000001767
ISS
SpoSPAC1006.07
TAS
SceS000003674
GO:0006417 regulation of translation P
RCA
SceS000001767
S000003674
GO:0006446 regulation of translational initiation P
ISS
PfaPF14_0655
SceS000003674
GO:0008150 biological_process P
ND
AthAt1g72730
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002083
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002083
GO:0019915 lipid storage P
IMP
CelWBGene00002083
GO:0040007 growth P
IMP
CelWBGene00002083
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002083
GO:0040011 locomotion P
IMP
CelWBGene00002083
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC1006.07

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_455

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga12143 ENSANGP00000014802
Anopheles gambiae (Aga) aga12144 ENSANGP00000023201
Ashbya gossypii (Ago) ago1300 ACR253C
Arabidopsis thaliana (Ath) ath4407 At1g51380.1
Arabidopsis thaliana (Ath) ath4739 At1g54270.1
Arabidopsis thaliana (Ath) ath6564 At1g72730.1
Arabidopsis thaliana (Ath) ath13579 At3g13920.1
Caenorhabditis elegans (Cel) cel10735 F57B9.6
Candida glabrata (Cgl) cgl2709 CAGL0I04356g
Cryptococcus neoformans (Cne) cne2466 181.m08505
Dictyostelium discoideum (Ddi) ddi11375 DDB0191262
Debaryomyces hansenii (Dha) dha3036 DEHA0D16423g
Drosophila melanogaster (Dme) dme974 CG9075-PA
(FBgn0001942)
Drosophila melanogaster (Dme) dme976 CG9075-PB
(FBgn0001942)
Drosophila melanogaster (Dme) dme975 CG9075-PC
(FBgn0001942)
Drosophila melanogaster (Dme) dme977 CG9075-PD
(FBgn0001942)
Danio rerio (Dre) dre18873 ENSDARP00000018923
(eif4a1b)		 Q7ZU67
Danio rerio (Dre) dre21323 ENSDARP00000040225
Danio rerio (Dre) dre21328 ENSDARP00000042150
Escherichia coli (Eco) eco1306 16129304
Escherichia coli (Eco) eco3055 16131054
Encephalitozoon cuniculi (Ecu) ecu1390 19173239
Takifugu rubripes (Fru) fru28117 SINFRUP00000139907
Takifugu rubripes (Fru) fru16090 SINFRUP00000141871
Gallus gallus (Gga) gga23615 ENSGALP00000014119
(EIF4A2)		 Q8JFP1
Homo sapiens (Hsa) hsa12985 ENSP00000293831
(EIF4A1)		 P60842
Homo sapiens (Hsa) hsa23594 ENSP00000326381
(EIF4A2)		 Q14240-1
Kluyveromyces lactis (Kla) kla252 KLLA0A05731g
Mus musculus (Mmu) mmu4026 ENSMUSP00000018919
Mus musculus (Mmu) mmu10134 ENSMUSP00000023599
(MGI:106906)		 P10630-1
Mus musculus (Mmu) mmu420 ENSMUSP00000074886
Neurospora crassa (Ncr) ncr7222 NCU07420.2
Oryza sativa (Osa) osa3391 1970.m00150
Oryza sativa (Osa) osa20303 3408.m00127
Oryza sativa (Osa) osa22574 3711.m00175
Oryza sativa (Osa) osa38916 4912.m00054
Plasmodium falciparum (Pfa) pfa1482 PF14_0655
Rattus norvegicus (Rno) rno7523 ENSRNOP00000002484
(RGD:1309225)		 Q5RKI1
Rattus norvegicus (Rno) rno5353 ENSRNOP00000043538
Rattus norvegicus (Rno) rno5352 ENSRNOP00000049419
(RGD:735141)		 Q6P3V8
Saccharomyces cerevisiae (Sce) sce3402 YJL138C
(S000003674)
Saccharomyces cerevisiae (Sce) sce3958 YKR059W
(S000001767)
Schizosaccharomyces pombe (Spo) spo3502 SPAC1006.07 P47943
Yarrowia lipolytica (Yli) yli1613 YALI0B20922g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003674
GO:0005575 cellular_component C
ND
AthAt1g51380
GO:0005618 cell wall C
IDA
AthAt3g13920
GO:0005634 nucleus C
IC
DmeFBgn0001942
GO:0005730 nucleolus C
IDA
AthAt3g13920
GO:0005737 cytoplasm C
IDA
SceS000003674
ISS
SceS000003674
GO:0005829 cytosol C
IDA
AthAt1g54270
At3g13920
At1g72730
SpoSPAC1006.07
ISS
DmeFBgn0001942
NAS
DmeFBgn0001942
GO:0005840 ribosome C
TAS
SceS000003674
S000001767
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0001942
GO:0005886 plasma membrane C
IDA
AthAt1g54270
At1g72730
GO:0009505 plant-type cell wall C
IDA
AthAt1g72730
GO:0016020 membrane C
IDA
AthAt3g13920
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IGI
SceS000001767
S000003674
ISS
DmeFBgn0001942
PfaPF14_0655
SceS000003674
S000001767
SpoSPAC1006.07
GO:0000339 RNA cap binding F
ISS
PfaPF14_0655
NAS
DmeFBgn0001942
GO:0003724 RNA helicase activity F
ISS
DmeFBgn0001942
GO:0003729 mRNA binding F
ISS
PfaPF14_0655
NAS
DmeFBgn0001942
GO:0003743 translation initiation factor activity F
IDA
SceS000003674
S000001767
IMP
SceS000001767
ISS
AthAt1g54270
At3g13920
DmeFBgn0001942
PfaPF14_0655
SceS000003674
SpoSPAC1006.07
NAS
DmeFBgn0001942
TAS
SceS000003674
GO:0004004 ATP-dependent RNA helicase activity F
IDA
SceS000001767
IMP
SceS000003674
S000001767
ISS
SpoSPAC1006.07
GO:0005515 protein binding F
IPI
AthAt3g13920
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0008026 ATP-dependent helicase activity F
ISS
AthAt1g54270
At1g72730
At3g13920
At1g51380
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA
helicase activity		 F
NAS
DmeFBgn0001942
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0001942
GO:0000381 regulation of alternative nuclear mRNA splicing,
via spliceosome		 P
IMP
DmeFBgn0001942
GO:0002168 instar larval development P
TAS
DmeFBgn0001942
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006268 DNA unwinding involved in replication P
NAS
DmeFBgn0001942
GO:0006413 translational initiation P
IDA
SceS000001767
IMP
SceS000001767
ISS
AthAt3g13920
DmeFBgn0001942
SpoSPAC1006.07
NAS
DmeFBgn0001942
TAS
SceS000003674
GO:0006417 regulation of translation P
RCA
SceS000001767
S000003674
GO:0006446 regulation of translational initiation P
ISS
PfaPF14_0655
SceS000003674
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0001942
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0001942
GO:0007446 imaginal disc growth P
TAS
DmeFBgn0001942
GO:0008150 biological_process P
ND
AthAt1g72730
GO:0009950 dorsal/ventral axis specification P
IMP
DmeFBgn0001942
GO:0030718 germ-line stem cell maintenance P
IMP
DmeFBgn0001942
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC1006.07
GO:0046686 response to cadmium ion P
IEP
AthAt1g54270
At3g13920
GO:0048132 female germ-line stem cell division P
IGI
DmeFBgn0001942
IMP
DmeFBgn0001942
GO:0048477 oogenesis P
IGI
DmeFBgn0001942
GO:0051789 response to protein stimulus P
IDA
MmuMGI:106906

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1006.07
(P47943)		 YJL138C
(S000003674)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003674
GO:0005737 cytoplasm C
IDA
SceS000003674
ISS
SceS000003674
GO:0005829 cytosol C
IDA
SpoSPAC1006.07
GO:0005840 ribosome C
TAS
SceS000003674
GO:0016281 eukaryotic translation initiation factor 4F
complex		 C
IGI
SceS000003674
ISS
SceS000003674
SpoSPAC1006.07
GO:0003743 translation initiation factor activity F
IDA
SceS000003674
ISS
SceS000003674
SpoSPAC1006.07
TAS
SceS000003674
GO:0004004 ATP-dependent RNA helicase activity F
IMP
SceS000003674
ISS
SpoSPAC1006.07
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006413 translational initiation P
ISS
SpoSPAC1006.07
TAS
SceS000003674
GO:0006417 regulation of translation P
RCA
SceS000003674
GO:0006446 regulation of translational initiation P
ISS
SceS000003674
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC1006.07

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GO info in one table:

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