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Search term: YJL154C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VPS35
SGD link S000003690
Alternative ID YJL154C
Description Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
Synonyms YJL154C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1107 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Membrane coat complex Retromer, subunit VPS35

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g75850 GI:15222896
Arabidopsis thaliana (Ath) At2g17790 GI:15227901
Arabidopsis thaliana (Ath) At3g51310 GI:15230445
Caenorhabditis elegans (Cel) CE26372 GI:17534603
Caenorhabditis elegans (Cel) CE26373 GI:17534609
Drosophila melanogaster (Dme) 7291388 GI:7291388
Homo sapiens (Hsa) Hs14767017 GI:14767017
Homo sapiens (Hsa) Hs14778985 GI:14778985
Homo sapiens (Hsa) Hs17999541
(VPS35)		 GI:17999541 Q9NX80
Saccharomyces cerevisiae (Sce) YJL154c
(S000003690)		 GI:6322307 P34110
Schizosaccharomyces pombe (Spo) SPCC777.13 GI:19075760 O74552
Arabidopsis thaliana (Ath) At1g75850 GI:15222896
Arabidopsis thaliana (Ath) At2g17790 GI:15227901
Arabidopsis thaliana (Ath) At3g51310 GI:15230445
Caenorhabditis elegans (Cel) CE26372 GI:17534603
Caenorhabditis elegans (Cel) CE26373 GI:17534609
Drosophila melanogaster (Dme) 7291388 GI:7291388
Homo sapiens (Hsa) Hs14767017 GI:14767017
Homo sapiens (Hsa) Hs14778985 GI:14778985
Homo sapiens (Hsa) Hs17999541
(VPS35)		 GI:17999541 Q9NX80
Saccharomyces cerevisiae (Sce) YJL154c
(S000003690)		 GI:6322307 P34110
Schizosaccharomyces pombe (Spo) SPCC777.13 GI:19075760 O74552


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000322 storage vacuole C
RCA
SceS000003690
GO:0000323 lytic vacuole C
RCA
SceS000003690
GO:0000324 fungal-type vacuole C
RCA
SceS000003690
GO:0005575 cellular_component C
ND
AthAt2g17790
At1g75850
GO:0005768 endosome C
IDA
HsaVPS35
IMP
SpoSPCC777.13
IPI
SceS000003690
GO:0005771 multivesicular body C
IDA
AthAt3g51310
GO:0005773 vacuole C
RCA
SceS000003690
GO:0005774 vacuolar membrane C
RCA
SceS000003690
GO:0005792 microsome C
IDA
AthAt3g51310
GO:0005829 cytosol C
IDA
HsaVPS35
SpoSPCC777.13
GO:0016020 membrane C
IDA
AthAt3g51310
GO:0030904 retromer complex C
IDA
AthAt3g51310
IMP
SceS000003690
SpoSPCC777.13
IPI
SceS000003690
ISS
AthAt3g51310
SpoSPCC777.13
GO:0030906 retromer complex, inner shell C
IPI
SceS000003690
GO:0044437 vacuolar part C
RCA
SceS000003690
GO:0003674 molecular_function F
ND
AthAt3g51310
At2g17790
SpoSPCC777.13
GO:0005515 protein binding F
IGI
SceS000003690
IMP
SceS000003690
IPI
HsaVPS35
GO:0008565 protein transporter activity F
IMP
SceS000003690
IPI
SceS000003690
GO:0006886 intracellular protein transport P
IGI
AthAt2g17790
IMP
SpoSPCC777.13
ISS
AthAt1g75850
At3g51310
At2g17790
RCA
SceS000003690
GO:0008333 endosome to lysosome transport P
ISS
AthAt3g51310
GO:0030437 ascospore formation P
IMP
SpoSPCC777.13
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SpoSPCC777.13
IPI
SceS000003690
ISS
AthAt2g17790
At3g51310
At1g75850
NAS
HsaVPS35
GO:0045053 protein retention in Golgi apparatus P
IMP
SceS000003690
GO:0045184 establishment of protein localization P
RCA
SceS000003690
GO:0050801 ion homeostasis P
RCA
SceS000003690

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6221

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) VPS35 GI:17999541 Q9NX80
Pan troglodytes (Ptr) VPS35 GI:114662311
Canis familiaris (Cfa) VPS35 GI:73976907
Mus musculus (Mmu) Vps35
(MGI:1890467)		 GI:13928670 Q3TJ43
Rattus norvegicus (Rno) Vps35 GI:109507853
Gallus gallus (Gga) VPS35 GI:57524880
Drosophila melanogaster (Dme) CG5625
(FBgn0034708)		 GI:45550489
Anopheles gambiae (Aga) AgaP_AGAP007683 GI:158285212
Caenorhabditis elegans (Cel) vps-35
(CE39945;
WBGene00006933)		 GI:115533921
Schizosaccharomyces pombe (Spo) vps35
(SPCC777.13)		 GI:19075760 O74552
Saccharomyces cerevisiae (Sce) VPS35
(S000003690)		 GI:6322307 P34110
Kluyveromyces lactis (Kla) KLLA0B07535g GI:50303835
Eremothecium gossypii (Ego) AGOS_AEL107W GI:45190500
Magnaporthe grisea (Mgr) MGG_05089 GI:145602221
Neurospora crassa (Ncr) NCU06284.1 GI:32411317
Arabidopsis thaliana (Ath) VPS35B GI:145337595
Oryza sativa (Osa) Os03g0801600 GI:115455985


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000322 storage vacuole C
RCA
SceS000003690
GO:0000323 lytic vacuole C
RCA
SceS000003690
GO:0000324 fungal-type vacuole C
RCA
SceS000003690
GO:0005575 cellular_component C
ND
AthVPS35B
GO:0005768 endosome C
IDA
DmeFBgn0034708
HsaVPS35
IMP
SpoSPCC777.13
IPI
SceS000003690
GO:0005773 vacuole C
RCA
SceS000003690
GO:0005774 vacuolar membrane C
RCA
SceS000003690
GO:0005829 cytosol C
IDA
HsaVPS35
SpoSPCC777.13
GO:0016021 integral to membrane C
ISA
MmuMGI:1890467
GO:0030904 retromer complex C
IMP
SceS000003690
SpoSPCC777.13
IPI
SceS000003690
ISS
SpoSPCC777.13
GO:0030906 retromer complex, inner shell C
IPI
SceS000003690
GO:0044437 vacuolar part C
RCA
SceS000003690
GO:0003674 molecular_function F
ND
SpoSPCC777.13
GO:0005515 protein binding F
IGI
SceS000003690
IMP
SceS000003690
IPI
HsaVPS35
MmuMGI:1890467
GO:0008565 protein transporter activity F
IMP
SceS000003690
IPI
SceS000003690
GO:0000003 reproduction P
IMP
CelWBGene00006933
GO:0006624 vacuolar protein processing P
ISA
MmuMGI:1890467
GO:0006886 intracellular protein transport P
IMP
SpoSPCC777.13
ISS
AthVPS35B
RCA
SceS000003690
GO:0006897 endocytosis P
IMP
DmeFBgn0034708
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00006933
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006933
GO:0016192 vesicle-mediated transport P
ISS
DmeFBgn0034708
GO:0018991 oviposition P
IMP
CelWBGene00006933
GO:0030437 ascospore formation P
IMP
SpoSPCC777.13
GO:0040011 locomotion P
IMP
CelWBGene00006933
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00006933
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SpoSPCC777.13
IPI
SceS000003690
ISS
AthVPS35B
NAS
HsaVPS35
GO:0045053 protein retention in Golgi apparatus P
IMP
SceS000003690
GO:0045184 establishment of protein localization P
RCA
SceS000003690
GO:0050801 ion homeostasis P
RCA
SceS000003690

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1436

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3116 ENSANGP00000020747
Ashbya gossypii (Ago) ago2399 AEL107W
Arabidopsis thaliana (Ath) ath6900 At1g75850.1
Arabidopsis thaliana (Ath) ath8628 At2g17790.1
Arabidopsis thaliana (Ath) ath16448 At3g51310.1
Caenorhabditis elegans (Cel) cel11146 F59G1.3
(CE39945;
WBGene00006933)
Candida glabrata (Cgl) cgl2785 CAGL0I06072g
Cryptococcus neoformans (Cne) cne5436 179.m00288
Dictyostelium discoideum (Ddi) ddi10020 DDB0191828
Debaryomyces hansenii (Dha) dha2161 DEHA0C16489g
Drosophila melanogaster (Dme) dme6497 CG5625-PA
(FBgn0034708)
Drosophila melanogaster (Dme) dme6498 CG5625-PB
(FBgn0034708)
Danio rerio (Dre) dre21792 ENSDARP00000003960
(vps35)		 Q1ED30
Danio rerio (Dre) dre21794 ENSDARP00000027812
Danio rerio (Dre) dre21793 ENSDARP00000029530
Takifugu rubripes (Fru) fru16448 SINFRUP00000140765
Takifugu rubripes (Fru) fru16450 SINFRUP00000168949
Takifugu rubripes (Fru) fru16449 SINFRUP00000175527
Gallus gallus (Gga) gga4620 ENSGALP00000006965
(VPS35)		 Q5ZL51
Gallus gallus (Gga) gga4621 ENSGALP00000006966
Homo sapiens (Hsa) hsa12135 ENSP00000299138
(VPS35)		 Q96QK1
Homo sapiens (Hsa) hsa12136 ENSP00000346781
Kluyveromyces lactis (Kla) kla862 KLLA0B07535g
Mus musculus (Mmu) mmu26362 ENSMUSP00000034131
(MGI:1890467)		 Q9EQH3
Neurospora crassa (Ncr) ncr6107 NCU06284.2
Oryza sativa (Osa) osa64393 6706.m00182
Plasmodium falciparum (Pfa) pfa1057 PF11_0112
Rattus norvegicus (Rno) rno14686 ENSRNOP00000024020
(RGD:1589784)		 B5DFC1
Saccharomyces cerevisiae (Sce) sce3418 YJL154C
(S000003690)
Schizosaccharomyces pombe (Spo) spo2 SPCC777.13 O74552
Yarrowia lipolytica (Yli) yli4578 YALI0E17413g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000322 storage vacuole C
RCA
SceS000003690
GO:0000323 lytic vacuole C
RCA
SceS000003690
GO:0000324 fungal-type vacuole C
RCA
SceS000003690
GO:0005575 cellular_component C
ND
AthAt2g17790
At1g75850
GO:0005768 endosome C
IDA
DmeFBgn0034708
IMP
SpoSPCC777.13
IPI
SceS000003690
GO:0005771 multivesicular body C
IDA
AthAt3g51310
GO:0005773 vacuole C
RCA
SceS000003690
GO:0005774 vacuolar membrane C
RCA
SceS000003690
GO:0005792 microsome C
IDA
AthAt3g51310
GO:0005829 cytosol C
IDA
SpoSPCC777.13
GO:0016020 membrane C
IDA
AthAt3g51310
GO:0016021 integral to membrane C
ISA
MmuMGI:1890467
GO:0030117 membrane coat C
ISS
PfaPF11_0112
GO:0030904 retromer complex C
IDA
AthAt3g51310
IMP
SceS000003690
SpoSPCC777.13
IPI
SceS000003690
ISS
AthAt3g51310
SpoSPCC777.13
GO:0030906 retromer complex, inner shell C
IPI
SceS000003690
GO:0044437 vacuolar part C
RCA
SceS000003690
GO:0003674 molecular_function F
ND
AthAt3g51310
At2g17790
PfaPF11_0112
SpoSPCC777.13
GO:0005515 protein binding F
IGI
SceS000003690
IMP
SceS000003690
IPI
MmuMGI:1890467
GO:0008565 protein transporter activity F
IMP
SceS000003690
IPI
SceS000003690
GO:0000003 reproduction P
IMP
CelWBGene00006933
GO:0006624 vacuolar protein processing P
ISA
MmuMGI:1890467
GO:0006886 intracellular protein transport P
IGI
AthAt2g17790
IMP
SpoSPCC777.13
ISS
AthAt1g75850
At3g51310
At2g17790
RCA
SceS000003690
GO:0006897 endocytosis P
IMP
DmeFBgn0034708
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00006933
GO:0008333 endosome to lysosome transport P
ISS
AthAt3g51310
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006933
GO:0016192 vesicle-mediated transport P
ISS
DmeFBgn0034708
GO:0018991 oviposition P
IMP
CelWBGene00006933
GO:0030437 ascospore formation P
IMP
SpoSPCC777.13
GO:0040011 locomotion P
IMP
CelWBGene00006933
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00006933
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SpoSPCC777.13
IPI
SceS000003690
ISS
AthAt2g17790
At3g51310
At1g75850
PfaPF11_0112
GO:0045053 protein retention in Golgi apparatus P
IMP
SceS000003690
GO:0045184 establishment of protein localization P
RCA
SceS000003690
GO:0050801 ion homeostasis P
RCA
SceS000003690

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC777.13
(O74552)		 YJL154C
(S000003690)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000322 storage vacuole C
RCA
SceS000003690
GO:0000323 lytic vacuole C
RCA
SceS000003690
GO:0000324 fungal-type vacuole C
RCA
SceS000003690
GO:0005768 endosome C
IMP
SpoSPCC777.13
IPI
SceS000003690
GO:0005773 vacuole C
RCA
SceS000003690
GO:0005774 vacuolar membrane C
RCA
SceS000003690
GO:0005829 cytosol C
IDA
SpoSPCC777.13
GO:0030904 retromer complex C
IMP
SceS000003690
SpoSPCC777.13
IPI
SceS000003690
ISS
SpoSPCC777.13
GO:0030906 retromer complex, inner shell C
IPI
SceS000003690
GO:0044437 vacuolar part C
RCA
SceS000003690
GO:0003674 molecular_function F
ND
SpoSPCC777.13
GO:0005515 protein binding F
IGI
SceS000003690
IMP
SceS000003690
GO:0008565 protein transporter activity F
IMP
SceS000003690
IPI
SceS000003690
GO:0006886 intracellular protein transport P
IMP
SpoSPCC777.13
RCA
SceS000003690
GO:0030437 ascospore formation P
IMP
SpoSPCC777.13
GO:0042147 retrograde transport, endosome to
Golgi		 P
IMP
SpoSPCC777.13
IPI
SceS000003690
GO:0045053 protein retention in Golgi apparatus P
IMP
SceS000003690
GO:0045184 establishment of protein localization P
RCA
SceS000003690
GO:0050801 ion homeostasis P
RCA
SceS000003690

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GO info in one table:

s.khadayate@ucl.ac.uk