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Search term: YJL208C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NUC1
SGD link S000003744
Alternative ID YJL208C
Description Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
Synonyms YJL208C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3721 -CDHYP-

KOGs classification KOGs description
METABOLISM Mitochondrial endonuclease

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE29488
(WBGene00000787)		 GI:17505967 Q95NM6
Drosophila melanogaster (Dme) 7295984 GI:20129167
Drosophila melanogaster (Dme) 7299390 GI:7299390
Drosophila melanogaster (Dme) 7303509
(FBgn0033690)		 GI:20129899
Homo sapiens (Hsa) Hs4758270 GI:4758270
Homo sapiens (Hsa) Hs4826714_1 GI:4826714
Saccharomyces cerevisiae (Sce) YJL208c
(S000003744)		 GI:6322253 P08466
Schizosaccharomyces pombe (Spo) SPAC17C9.08 GI:19115510 Q10480


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003744
GO:0005739 mitochondrion C
IDA
CelWBGene00000787
SceS000003744
SpoSPAC17C9.08
ISS
DmeFBgn0033690
GO:0005743 mitochondrial inner membrane C
IDA
SceS000003744
ISS
DmeFBgn0033690
SpoSPAC17C9.08
GO:0004518 nuclease activity F
IMP
SpoSPAC17C9.08
GO:0004519 endonuclease activity F
IDA
CelWBGene00000787
GO:0004520 endodeoxyribonuclease activity F
IDA
CelWBGene00000787
DmeFBgn0033690
SceS000003744
ISS
DmeFBgn0033690
SpoSPAC17C9.08
GO:0004521 endoribonuclease activity F
IDA
DmeFBgn0033690
GO:0004529 exodeoxyribonuclease activity F
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0004540 ribonuclease activity F
IDA
SceS000003744
GO:0000737 DNA catabolic process, endonucleolytic P
IDA
CelWBGene00000787
GO:0006261 DNA-dependent DNA replication P
ISS
DmeFBgn0033690
GO:0006308 DNA catabolic process P
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0006309 DNA fragmentation involved in apoptotic nuclear
change		 P
IDA
CelWBGene00000787
GO:0006310 DNA recombination P
IMP
SceS000003744
ISS
SpoSPAC17C9.08
GO:0006401 RNA catabolic process P
IDA
SceS000003744
IMP
SpoSPAC17C9.08
GO:0006915 apoptosis P
IMP
CelWBGene00000787
SceS000003744
GO:0006995 cellular response to nitrogen starvation P
IMP
SpoSPAC17C9.08
GO:0008219 cell death P
IMP
CelWBGene00000787

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55823

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ENDOG GI:53759134
Canis familiaris (Cfa) ENDOG GI:73968076
Mus musculus (Mmu) Endog
(MGI:1261433)		 GI:6679647 O08600
Rattus norvegicus (Rno) Endog
(RGD:1310763)		 GI:77917570
Gallus gallus (Gga) ENDOG GI:118099296
Drosophila melanogaster (Dme) CG8862
(FBgn0033690)		 GI:20129899
Anopheles gambiae (Aga) AgaP_AGAP007845 GI:158297418
Caenorhabditis elegans (Cel) cps-6
(CE29488;
WBGene00000787)		 GI:17505967 Q95NM6
Schizosaccharomyces pombe (Spo) nuc1
(SPBC4C3.05c)		 GI:19115510 P15398
Saccharomyces cerevisiae (Sce) NUC1
(S000003744)		 GI:6322253 P08466
Kluyveromyces lactis (Kla) KLLA0D00440g GI:50306239
Eremothecium gossypii (Ego) AGOS_ADR144C GI:45188017
Magnaporthe grisea (Mgr) MGG_05324 GI:145601925
Neurospora crassa (Ncr) NCU00030.1 GI:32403006


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003744
GO:0005736 DNA-directed RNA polymerase I complex C
ISS
SpoSPBC4C3.05c
GO:0005739 mitochondrion C
IDA
CelWBGene00000787
MmuMGI:1261433
SceS000003744
ISS
DmeFBgn0033690
GO:0005743 mitochondrial inner membrane C
IDA
SceS000003744
ISS
DmeFBgn0033690
GO:0005829 cytosol C
IDA
SpoSPBC4C3.05c
GO:0003899 DNA-directed RNA polymerase activity F
ISS
SpoSPBC4C3.05c
GO:0004519 endonuclease activity F
IDA
CelWBGene00000787
GO:0004520 endodeoxyribonuclease activity F
IDA
CelWBGene00000787
DmeFBgn0033690
SceS000003744
ISS
DmeFBgn0033690
GO:0004521 endoribonuclease activity F
IDA
DmeFBgn0033690
GO:0004529 exodeoxyribonuclease activity F
IDA
SceS000003744
GO:0004540 ribonuclease activity F
IDA
SceS000003744
GO:0000737 DNA catabolic process, endonucleolytic P
IDA
CelWBGene00000787
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1261433
GO:0006261 DNA-dependent DNA replication P
ISS
DmeFBgn0033690
GO:0006308 DNA catabolic process P
IDA
SceS000003744
GO:0006309 DNA fragmentation involved in apoptotic nuclear
change		 P
IDA
CelWBGene00000787
IMP
MmuMGI:1261433
GO:0006310 DNA recombination P
IMP
SceS000003744
GO:0006360 transcription from RNA polymerase I
promoter		 P
ISS
SpoSPBC4C3.05c
GO:0006401 RNA catabolic process P
IDA
SceS000003744
GO:0006406 mRNA export from nucleus P
IMP
SpoSPBC4C3.05c
GO:0006915 apoptosis P
IMP
CelWBGene00000787
SceS000003744
GO:0007000 nucleolus organization P
IMP
SpoSPBC4C3.05c
GO:0008219 cell death P
IMP
CelWBGene00000787
GO:0034503 protein localization to nucleolar rDNA
repeats		 P
IMP
SpoSPBC4C3.05c
GO:0034612 response to tumor necrosis factor P
IMP
MmuMGI:1261433
GO:0043065 positive regulation of apoptosis P
IMP
MmuMGI:1261433
GO:0046677 response to antibiotic P
IMP
MmuMGI:1261433

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2895

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9767 ENSANGP00000018575
Ashbya gossypii (Ago) ago1885 ADR144C
Caenorhabditis elegans (Cel) cel3833 C41D11.8
(CE29488;
WBGene00000787)
Candida glabrata (Cgl) cgl2797 CAGL0I06336g
Cryptococcus neoformans (Cne) cne3145 167.m03481
Dictyostelium discoideum (Ddi) ddi7249 DDB0187526
Debaryomyces hansenii (Dha) dha1045 DEHA0B08195g
Drosophila melanogaster (Dme) dme353 CG32463-PA
(FBgn0052463)
Drosophila melanogaster (Dme) dme4614 CG8862-PA
(FBgn0033690)
Danio rerio (Dre) dre22379 ENSDARP00000012288
Takifugu rubripes (Fru) fru16135 SINFRUP00000146826
Gallus gallus (Gga) gga8052 ENSGALP00000007374
(ENDOG)
Gallus gallus (Gga) gga9387 ENSGALP00000009922
(ENDOGL1)
Homo sapiens (Hsa) hsa22266 ENSP00000287675
(EXOG)		 Q9Y2C4-1
Homo sapiens (Hsa) hsa32008 ENSP00000300491
Kluyveromyces lactis (Kla) kla2090 KLLA0D00440g
Mus musculus (Mmu) mmu14364 ENSMUSP00000015481
(MGI:1261433)		 O08600
Mus musculus (Mmu) mmu28464 ENSMUSP00000035094
(MGI:2143333)		 Q8C163
Neurospora crassa (Ncr) ncr30 NCU00030.2
Rattus norvegicus (Rno) rno29453 ENSRNOP00000020174
(RGD:1304628)
Rattus norvegicus (Rno) rno18346 ENSRNOP00000021531
(RGD:1310763)		 Q3V5X8
Saccharomyces cerevisiae (Sce) sce3474 YJL208C
(S000003744)
Schizosaccharomyces pombe (Spo) spo4714 SPAC17C9.08 Q10480
Yarrowia lipolytica (Yli) yli2914 YALI0D05071g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003744
GO:0005739 mitochondrion C
IDA
CelWBGene00000787
MmuMGI:1261433
MGI:2143333
SceS000003744
SpoSPAC17C9.08
ISS
DmeFBgn0033690
FBgn0052463
GO:0005743 mitochondrial inner membrane C
IDA
SceS000003744
ISS
DmeFBgn0033690
SpoSPAC17C9.08
GO:0003674 molecular_function F
ND
MmuMGI:2143333
GO:0004518 nuclease activity F
IMP
SpoSPAC17C9.08
GO:0004519 endonuclease activity F
IDA
CelWBGene00000787
GO:0004520 endodeoxyribonuclease activity F
IDA
CelWBGene00000787
DmeFBgn0033690
SceS000003744
ISS
DmeFBgn0033690
FBgn0052463
SpoSPAC17C9.08
GO:0004521 endoribonuclease activity F
IDA
DmeFBgn0033690
GO:0004529 exodeoxyribonuclease activity F
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0004540 ribonuclease activity F
IDA
SceS000003744
GO:0000737 DNA catabolic process, endonucleolytic P
IDA
CelWBGene00000787
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1261433
GO:0006261 DNA-dependent DNA replication P
ISS
DmeFBgn0033690
GO:0006308 DNA catabolic process P
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0006309 DNA fragmentation involved in apoptotic nuclear
change		 P
IDA
CelWBGene00000787
IMP
MmuMGI:1261433
GO:0006310 DNA recombination P
IMP
SceS000003744
ISS
SpoSPAC17C9.08
GO:0006401 RNA catabolic process P
IDA
SceS000003744
IMP
SpoSPAC17C9.08
GO:0006915 apoptosis P
IMP
CelWBGene00000787
SceS000003744
GO:0006995 cellular response to nitrogen starvation P
IMP
SpoSPAC17C9.08
GO:0008150 biological_process P
ND
MmuMGI:2143333
GO:0008219 cell death P
IMP
CelWBGene00000787
GO:0034612 response to tumor necrosis factor P
IMP
MmuMGI:1261433
GO:0043065 positive regulation of apoptosis P
IMP
MmuMGI:1261433
GO:0046677 response to antibiotic P
IMP
MmuMGI:1261433

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC17C9.08
(Q10480)		 YJL208C
(S000003744)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000003744
GO:0005739 mitochondrion C
IDA
SceS000003744
SpoSPAC17C9.08
GO:0005743 mitochondrial inner membrane C
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0004518 nuclease activity F
IMP
SpoSPAC17C9.08
GO:0004520 endodeoxyribonuclease activity F
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0004529 exodeoxyribonuclease activity F
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0004540 ribonuclease activity F
IDA
SceS000003744
GO:0006308 DNA catabolic process P
IDA
SceS000003744
ISS
SpoSPAC17C9.08
GO:0006310 DNA recombination P
IMP
SceS000003744
ISS
SpoSPAC17C9.08
GO:0006401 RNA catabolic process P
IDA
SceS000003744
IMP
SpoSPAC17C9.08
GO:0006915 apoptosis P
IMP
SceS000003744
GO:0006995 cellular response to nitrogen starvation P
IMP
SpoSPAC17C9.08

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GO info in one table:

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