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Search term: YJR050W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ISY1
SGD link S000003811
Alternative ID YJR050W
Description Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
Synonyms YJR050W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3068 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING mRNA splicing factor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g18790 GI:15230193
Caenorhabditis elegans (Cel) CE05922
(WBGene00009966)		 GI:17561262 Q20716
Drosophila melanogaster (Dme) 7298990 GI:7298990
Homo sapiens (Hsa) Hs20149304
(ISY1)		 GI:20149304 Q9ULR0
Saccharomyces cerevisiae (Sce) YJR050w
(S000003811)		 GI:6322510 P21374
Schizosaccharomyces pombe (Spo) SPBC32F12.05c GI:19112940 O74370


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000974 Prp19 complex C
IDA
SceS000003811
GO:0005634 nucleus C
IDA
HsaISY1
SpoSPBC32F12.05c
GO:0005681 spliceosomal complex C
ISS
SpoSPBC32F12.05c
GO:0005737 cytoplasm C
IDA
HsaISY1
GO:0005829 cytosol C
IDA
SpoSPBC32F12.05c
GO:0009507 chloroplast C
IDA
AthAt3g18790
GO:0071006 U2-type catalytic step 1 spliceosome C
IDA
SceS000003811
GO:0071007 U2-type catalytic step 2 spliceosome C
IDA
SceS000003811
GO:0071014 post-mRNA release spliceosomal
complex		 C
IDA
SceS000003811
GO:0071020 post-spliceosomal complex C
IDA
SceS000003811
GO:0000384 first spliceosomal transesterification
activity		 F
IGI
SceS000003811
GO:0000386 second spliceosomal transesterification
activity		 F
IC
SceS000003811
GO:0003674 molecular_function F
ND
AthAt3g18790
SpoSPBC32F12.05c
GO:0000003 reproduction P
IMP
CelWBGene00009966
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IMP
SceS000003811
GO:0000389 nuclear mRNA 3'-splice site recognition P
IMP
SceS000003811
GO:0000398 nuclear mRNA splicing, via spliceosome P
ISS
SpoSPBC32F12.05c
GO:0002119 nematode larval development P
IMP
CelWBGene00009966
GO:0008150 biological_process P
ND
AthAt3g18790
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009966
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00009966
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00009966

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
101607

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) cwf12
(SPBC32F12.05c)		 GI:19112940 O74370
Saccharomyces cerevisiae (Sce) ISY1
(S000003811)		 GI:6322510 P21374
Kluyveromyces lactis (Kla) KLLA0F16841g GI:50311621
Eremothecium gossypii (Ego) AGOS_AFR363W GI:45198881
Magnaporthe grisea (Mgr) MGG_02820 GI:145609984
Neurospora crassa (Ncr) NCU00664.1 GI:32408727


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000974 Prp19 complex C
IDA
SceS000003811
GO:0005634 nucleus C
IDA
SpoSPBC32F12.05c
GO:0005681 spliceosomal complex C
ISS
SpoSPBC32F12.05c
GO:0005829 cytosol C
IDA
SpoSPBC32F12.05c
GO:0071006 U2-type catalytic step 1 spliceosome C
IDA
SceS000003811
GO:0071007 U2-type catalytic step 2 spliceosome C
IDA
SceS000003811
GO:0071014 post-mRNA release spliceosomal
complex		 C
IDA
SceS000003811
GO:0071020 post-spliceosomal complex C
IDA
SceS000003811
GO:0000384 first spliceosomal transesterification
activity		 F
IGI
SceS000003811
GO:0000386 second spliceosomal transesterification
activity		 F
IC
SceS000003811
GO:0003674 molecular_function F
ND
SpoSPBC32F12.05c
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IMP
SceS000003811
GO:0000389 nuclear mRNA 3'-splice site recognition P
IMP
SceS000003811
GO:0000398 nuclear mRNA splicing, via spliceosome P
ISS
SpoSPBC32F12.05c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2118

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6742 ENSANGP00000023854
Ashbya gossypii (Ago) ago3555 AFR363W
Arabidopsis thaliana (Ath) ath14151 At3g18790.1
Caenorhabditis elegans (Cel) cel9988 F53B7.3
(CE05922;
WBGene00009966)
Candida glabrata (Cgl) cgl2585 CAGL0I01364g
Cryptococcus neoformans (Cne) cne977 163.m06454
Dictyostelium discoideum (Ddi) ddi8707 DDB0186544
Debaryomyces hansenii (Dha) dha2074 DEHA0C14586g
Drosophila melanogaster (Dme) dme11462 CG9667-PA
(FBgn0037550)
Danio rerio (Dre) dre27887 ENSDARP00000041858
Takifugu rubripes (Fru) fru26403 SINFRUP00000164860
Gallus gallus (Gga) gga5113 ENSGALP00000008012
Gallus gallus (Gga) gga5112 ENSGALP00000008013
(ISY1)
Homo sapiens (Hsa) hsa23110 ENSP00000273541
(ISY1)		 Q9ULR0-2
Homo sapiens (Hsa) hsa23109 ENSP00000317477
Kluyveromyces lactis (Kla) kla4836 KLLA0F16841g
Mus musculus (Mmu) mmu22290 ENSMUSP00000032137
Neurospora crassa (Ncr) ncr644 NCU00664.2
Oryza sativa (Osa) osa22286 3699.m00146
Oryza sativa (Osa) osa37344 4978.m00207
Plasmodium falciparum (Pfa) pfa1551 PF14_0688
Rattus norvegicus (Rno) rno21804 ENSRNOP00000013571
(RGD:1307688)		 Q6AYB3
Rattus norvegicus (Rno) rno21803 ENSRNOP00000048655
Saccharomyces cerevisiae (Sce) sce3545 YJR050W
(S000003811)
Schizosaccharomyces pombe (Spo) spo4877 SPBC32F12.05c O74370
Yarrowia lipolytica (Yli) yli3159 YALI0D10901g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000974 Prp19 complex C
IDA
SceS000003811
GO:0005575 cellular_component C
ND
PfaPF14_0688
GO:0005634 nucleus C
IDA
SpoSPBC32F12.05c
GO:0005681 spliceosomal complex C
ISS
SpoSPBC32F12.05c
GO:0005829 cytosol C
IDA
SpoSPBC32F12.05c
GO:0009507 chloroplast C
IDA
AthAt3g18790
GO:0071006 U2-type catalytic step 1 spliceosome C
IDA
SceS000003811
GO:0071007 U2-type catalytic step 2 spliceosome C
IDA
SceS000003811
GO:0071011 precatalytic spliceosome C
IDA
DmeFBgn0037550
GO:0071013 catalytic step 2 spliceosome C
IDA
DmeFBgn0037550
GO:0071014 post-mRNA release spliceosomal
complex		 C
IDA
SceS000003811
GO:0071020 post-spliceosomal complex C
IDA
SceS000003811
GO:0000384 first spliceosomal transesterification
activity		 F
IGI
SceS000003811
GO:0000386 second spliceosomal transesterification
activity		 F
IC
SceS000003811
GO:0003674 molecular_function F
ND
AthAt3g18790
PfaPF14_0688
SpoSPBC32F12.05c
GO:0000003 reproduction P
IMP
CelWBGene00009966
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IMP
SceS000003811
GO:0000389 nuclear mRNA 3'-splice site recognition P
IMP
SceS000003811
GO:0000398 nuclear mRNA splicing, via spliceosome P
IC
DmeFBgn0037550
ISS
SpoSPBC32F12.05c
GO:0002119 nematode larval development P
IMP
CelWBGene00009966
GO:0008150 biological_process P
ND
AthAt3g18790
PfaPF14_0688
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009966
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00009966
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00009966

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC32F12.05c
(O74370)		 YJR050W
(S000003811)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000974 Prp19 complex C
IDA
SceS000003811
GO:0005634 nucleus C
IDA
SpoSPBC32F12.05c
GO:0005681 spliceosomal complex C
ISS
SpoSPBC32F12.05c
GO:0005829 cytosol C
IDA
SpoSPBC32F12.05c
GO:0071006 U2-type catalytic step 1 spliceosome C
IDA
SceS000003811
GO:0071007 U2-type catalytic step 2 spliceosome C
IDA
SceS000003811
GO:0071014 post-mRNA release spliceosomal
complex		 C
IDA
SceS000003811
GO:0071020 post-spliceosomal complex C
IDA
SceS000003811
GO:0000384 first spliceosomal transesterification
activity		 F
IGI
SceS000003811
GO:0000386 second spliceosomal transesterification
activity		 F
IC
SceS000003811
GO:0003674 molecular_function F
ND
SpoSPBC32F12.05c
GO:0000350 generation of catalytic spliceosome for second
transesterification step		 P
IMP
SceS000003811
GO:0000389 nuclear mRNA 3'-splice site recognition P
IMP
SceS000003811
GO:0000398 nuclear mRNA splicing, via spliceosome P
ISS
SpoSPBC32F12.05c

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GO info in one table:

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