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Search term: YJR078W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name BNA2
SGD link S000003839
Alternative ID YJR078W
Description Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2p
Synonyms YJR078W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


HomoloGene results:

HomoloGene cluster Phylogenetic pattern
48830

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) IDO2 GI:148539554
Pan troglodytes (Ptr) IDO2 GI:114619873
Canis familiaris (Cfa) IDO2 GI:73979259
Mus musculus (Mmu) Ido2
(MGI:2142489)
GI:22122379 A4UHF3
Rattus norvegicus (Rno) Ido2 GI:109503528
Gallus gallus (Gga) INDOL1 GI:118101384
Saccharomyces cerevisiae (Sce) BNA2
(S000003839)
GI:6322538
Eremothecium gossypii (Ego) AGOS_ACR188C GI:45185874
Magnaporthe grisea (Mgr) MGG_13773 GI:145602911
Neurospora crassa (Ncr) NCU05752.1 GI:32410253


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
MmuMGI:2142489
SceS000003839
ISS
HsaIDO2
GO:0004833 tryptophan 2,3-dioxygenase activity F
NAS
SceS000003839
GO:0033754 indoleamine 2,3-dioxygenase activity F
IDA
HsaIDO2
MmuMGI:2142489
IMP
MmuMGI:2142489
ISS
HsaIDO2
NAS
SceS000003839
GO:0019441 tryptophan catabolic process to
kynurenine
P
IDA
HsaIDO2
MmuMGI:2142489
IMP
MmuMGI:2142489
ISS
HsaIDO2
GO:0034354 de novo NAD biosynthetic process from
tryptophan
P
IGI
SceS000003839

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_6821

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Ashbya gossypii (Ago) ago1235 ACR188C
Cryptococcus neoformans (Cne) cne5557 179.m00416
Debaryomyces hansenii (Dha) dha6276 DEHA0G12947g
Takifugu rubripes (Fru) fru23431 SINFRUP00000143857
Takifugu rubripes (Fru) fru23432 SINFRUP00000143858
Gallus gallus (Gga) gga23964 ENSGALP00000005476
Gallus gallus (Gga) gga23965 ENSGALP00000005477
Homo sapiens (Hsa) hsa30213 ENSP00000253513
(IDO1)
P14902
Mus musculus (Mmu) mmu25760 ENSMUSP00000033953
(MGI:2142489)
Q8R0V5
Mus musculus (Mmu) mmu25761 ENSMUSP00000033956
(MGI:96416)
P28776
Neurospora crassa (Ncr) ncr5590 NCU05752.2
Rattus norvegicus (Rno) rno12656 ENSRNOP00000036799
(GI:684861)
Rattus norvegicus (Rno) rno12655 ENSRNOP00000050320
(RGD:619989)
Q9ERD9
Saccharomyces cerevisiae (Sce) sce3573 YJR078W
(S000003839)
Yarrowia lipolytica (Yli) yli6449 YALI0F26455g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:96416
GO:0005737 cytoplasm C
IDA
MmuMGI:2142489
MGI:96416
SceS000003839
GO:0005829 cytosol C
ISO
MmuMGI:96416
GO:0004833 tryptophan 2,3-dioxygenase activity F
IDA
MmuMGI:96416
NAS
SceS000003839
GO:0016597 amino acid binding F
ISO
MmuMGI:96416
GO:0019825 oxygen binding F
ISO
MmuMGI:96416
GO:0033754 indoleamine 2,3-dioxygenase activity F
IDA
MmuMGI:2142489
IMP
MmuMGI:2142489
ISO
MmuMGI:96416
NAS
SceS000003839
GO:0002534 cytokine production involved in inflammatory
response
P
IMP
MmuMGI:96416
GO:0002666 positive regulation of T cell tolerance
induction
P
IMP
MmuMGI:96416
GO:0002678 positive regulation of chronic inflammatory
response
P
IMP
MmuMGI:96416
GO:0002830 positive regulation of T-helper 2 type immune
response
P
IMP
MmuMGI:96416
GO:0006952 defense response P
TAS
MmuMGI:96416
GO:0006954 inflammatory response P
IMP
MmuMGI:96416
GO:0007610 behavior P
IMP
MmuMGI:96416
GO:0019441 tryptophan catabolic process to
kynurenine
P
IDA
MmuMGI:2142489
MGI:96416
IMP
MmuMGI:2142489
ISO
MmuMGI:96416
GO:0032496 response to lipopolysaccharide P
IMP
MmuMGI:96416
GO:0032693 negative regulation of interleukin-10
production
P
IMP
MmuMGI:96416
GO:0032735 positive regulation of interleukin-12
production
P
IMP
MmuMGI:96416
GO:0033555 multicellular organismal response to
stress
P
IMP
MmuMGI:96416
GO:0034276 kynurenic acid biosynthetic process P
IMP
MmuMGI:96416
GO:0034354 de novo NAD biosynthetic process from
tryptophan
P
IGI
SceS000003839
GO:0042130 negative regulation of T cell proliferation P
IMP
MmuMGI:96416
GO:0043065 positive regulation of apoptosis P
IMP
MmuMGI:96416
GO:0046007 negative regulation of activated T cell
proliferation
P
IMP
MmuMGI:96416
GO:0070233 negative regulation of T cell apoptosis P
IMP
MmuMGI:96416

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s.khadayate@ucl.ac.uk