YOGY Home YOGY Help

Search term: YJR090C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GRR1
SGD link S000003850
Alternative ID YJR090C
Description F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
Synonyms YJR090C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1947 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Leucine rich repeat proteins, some proteins contain F-box

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g12820 GI:18391439
Arabidopsis thaliana (Ath) At1g15740 GI:15218289
Arabidopsis thaliana (Ath) At1g21410 GI:18394987
Arabidopsis thaliana (Ath) At1g47056 GI:15220130
Arabidopsis thaliana (Ath) At1g55590 GI:15222749
Arabidopsis thaliana (Ath) At1g77000 GI:18411319
Arabidopsis thaliana (Ath) At1g80570 GI:18412871
Arabidopsis thaliana (Ath) At1g80630 GI:18412879
Arabidopsis thaliana (Ath) At2g06030 GI:15225041
Arabidopsis thaliana (Ath) At2g17020 GI:18398283
Arabidopsis thaliana (Ath) At2g25490 GI:18400846
Arabidopsis thaliana (Ath) At2g36370 GI:15227644
Arabidopsis thaliana (Ath) At2g39940 GI:18405209
Arabidopsis thaliana (Ath) At3g07550 GI:18397984
Arabidopsis thaliana (Ath) At3g26810 GI:18405102
Arabidopsis thaliana (Ath) At3g48880 GI:15229043
Arabidopsis thaliana (Ath) At3g50080 GI:18409012
Arabidopsis thaliana (Ath) At3g58530 GI:11357437
Arabidopsis thaliana (Ath) At3g62980 GI:18412567
Arabidopsis thaliana (Ath) At4g03190 GI:18412177
Arabidopsis thaliana (Ath) At4g03630 GI:15236356
Arabidopsis thaliana (Ath) At4g05460 GI:18412947
Arabidopsis thaliana (Ath) At4g05470 GI:7267307
Arabidopsis thaliana (Ath) At4g05480 GI:7267308
Arabidopsis thaliana (Ath) At4g05490 GI:18412951
Arabidopsis thaliana (Ath) At4g05500 GI:18412953
Arabidopsis thaliana (Ath) At4g07400 GI:18412996
Arabidopsis thaliana (Ath) At4g08980 GI:18413178
Arabidopsis thaliana (Ath) At4g11580 GI:15234238
Arabidopsis thaliana (Ath) At4g15470_2 GI:7485070
Arabidopsis thaliana (Ath) At4g24390 GI:18416337
Arabidopsis thaliana (Ath) At4g30640 GI:18417634
Arabidopsis thaliana (Ath) At4g33210 GI:7486446
Arabidopsis thaliana (Ath) At5g01720 GI:11357830
Arabidopsis thaliana (Ath) At5g07670 GI:15240836
Arabidopsis thaliana (Ath) At5g23340 GI:15237286
Arabidopsis thaliana (Ath) At5g25350 GI:15239399
Arabidopsis thaliana (Ath) At5g27920 GI:18421172
Arabidopsis thaliana (Ath) At5g40470 GI:15242713
Arabidopsis thaliana (Ath) At5g49980 GI:18423092
Arabidopsis thaliana (Ath) At5g51370 GI:15242063
Arabidopsis thaliana (Ath) At5g51380 GI:15242066
Arabidopsis thaliana (Ath) At5g52480 GI:15237166
Arabidopsis thaliana (Ath) At5g57900 GI:18424042
Arabidopsis thaliana (Ath) At5g67140 GI:15240225
Arabidopsis thaliana (Ath) At5g67250 GI:18425169
Caenorhabditis elegans (Cel) CE00856
(WBGene00007168)		 GI:17551858 Q17492
Caenorhabditis elegans (Cel) CE01883 GI:17532825
Caenorhabditis elegans (Cel) CE02305 GI:17535889
Caenorhabditis elegans (Cel) CE05180 GI:17538336
Caenorhabditis elegans (Cel) CE05182
(WBGene00007208)		 GI:17538340 Q17534
Caenorhabditis elegans (Cel) CE27215
(WBGene00020884)		 GI:17570119 Q968Y8
Caenorhabditis elegans (Cel) CE27216 GI:17570117 Q968Y8
Caenorhabditis elegans (Cel) CE28577
(WBGene00019294)		 GI:17568607
Drosophila melanogaster (Dme) 7291460
(FBgn0020257)		 GI:17647819
Drosophila melanogaster (Dme) 7292970 GI:7292970
Drosophila melanogaster (Dme) 7293460 GI:7293460
Drosophila melanogaster (Dme) 7294694 GI:7294694
Drosophila melanogaster (Dme) 7296905 GI:7296905
Drosophila melanogaster (Dme) 7298702 GI:20129655
Drosophila melanogaster (Dme) 7299136_2 GI:7299136
Drosophila melanogaster (Dme) 7299840 GI:7299840
Drosophila melanogaster (Dme) 7300083 GI:7300083
Drosophila melanogaster (Dme) 7300168 GI:7300168 Q8INB0
Drosophila melanogaster (Dme) 7301788 GI:7301788
Drosophila melanogaster (Dme) 7302418 GI:7302418 A1ZBR6
Drosophila melanogaster (Dme) 7303628 GI:7303628
Drosophila melanogaster (Dme) 7303992
(FBgn0033337)		 GI:19921840
Homo sapiens (Hsa) Hs13236573 GI:13236573
Homo sapiens (Hsa) Hs16306576
(FBXL6)		 GI:16306576 Q8N531
Homo sapiens (Hsa) Hs16306578 GI:16306578
Homo sapiens (Hsa) Hs16306580_2
(KDM2A)		 GI:16306580 Q9Y2K7
Homo sapiens (Hsa) Hs16306584_1
(FBXL3)		 GI:16306584 Q9UKT7
Homo sapiens (Hsa) Hs16306588
(FBXL4)		 GI:16306588 Q9UKA2
Homo sapiens (Hsa) Hs16306591 GI:16306591 Q8WV35
Homo sapiens (Hsa) Hs18585373 GI:18585373
Homo sapiens (Hsa) Hs20476897 GI:20476897
Homo sapiens (Hsa) Hs21450771 GI:20543007
Homo sapiens (Hsa) Hs22045361 GI:22045361
Homo sapiens (Hsa) Hs22052495 GI:22052495
Homo sapiens (Hsa) Hs22057112_2 GI:22057112
Homo sapiens (Hsa) Hs22061735 GI:20381419 Q8N1E6
Homo sapiens (Hsa) Hs22064590 GI:22064590
Homo sapiens (Hsa) Hs22069605 GI:22069605
Homo sapiens (Hsa) Hs6912466
(FBXL7)		 GI:6912466 Q9UJT9
Homo sapiens (Hsa) Hs8923179
(FBXL12)		 GI:8923179 Q9NXK8
Saccharomyces cerevisiae (Sce) YBR158w
(S000000362)		 GI:6319634 P38285
Saccharomyces cerevisiae (Sce) YJR052w
(S000003813)		 GI:6322512 P06779
Saccharomyces cerevisiae (Sce) YJR090c
(S000003850)		 GI:6322549 P24814
Schizosaccharomyces pombe (Spo) SPBC25B2.11 GI:19112871 O74783
Schizosaccharomyces pombe (Spo) SPCC330.02 GI:19075202 O74999


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000108 repairosome C
IDA
SceS000003813
GO:0000109 nucleotide-excision repair complex C
IPI
SpoSPCC330.02
GO:0000113 nucleotide-excision repair factor 4
complex		 C
IDA
SceS000003813
GO:0000142 cellular bud neck contractile ring C
IDA
SceS000003850
GO:0000151 ubiquitin ligase complex C
IDA
AthAt3g62980
ISS
SpoSPBC25B2.11
NAS
HsaFBXL7
FBXL3
TAS
HsaFBXL4
GO:0000152 nuclear ubiquitin ligase complex C
ISS
DmeFBgn0020257
GO:0005575 cellular_component C
ND
AthAt1g80630
At2g17020
At1g15740
At1g80570
At1g12820
At3g48880
At3g58530
At1g55590
At1g77000
At3g07550
At4g03630
At4g05470
At4g08980
At4g11580
At4g30640
At5g07670
At5g51370
At5g23340
At5g27920
At5g52480
At5g67140
GO:0005634 nucleus C
IDA
AthAt2g25490
At1g21410
At4g03190
At5g25350
SceS000000362
S000003850
SpoSPCC330.02
TAS
AthAt2g25490
At5g25350
GO:0005737 cytoplasm C
IDA
AthAt3g50080
At5g67250
SceS000000362
S000003850
GO:0005739 mitochondrion C
IDA
SpoSPBC25B2.11
GO:0005816 spindle pole body C
IDA
SpoSPCC330.02
GO:0005886 plasma membrane C
IDA
AthAt3g26810
GO:0005933 cellular bud C
IDA
SceS000000362
GO:0019005 SCF ubiquitin ligase complex C
IDA
AthAt3g62980
At5g57900
IMP
SceS000003850
IPI
AthAt2g39940
At1g21410
At5g25350
NAS
DmeFBgn0020257
GO:0031463 Cul3-RING ubiquitin ligase complex C
IDA
SceS000003813
GO:0043224 nuclear SCF ubiquitin ligase complex C
IPI
AthAt4g03190
GO:0003674 molecular_function F
ND
AthAt3g48880
At4g03630
At5g07670
At5g51370
At5g40470
At5g52480
At5g51380
GO:0003684 damaged DNA binding F
IDA
SceS000003813
GO:0004842 ubiquitin-protein ligase activity F
IC
AthAt3g62980
IDA
SceS000003813
ISS
AthAt1g77000
At2g25490
At2g17020
At1g80570
At2g36370
At3g62980
At3g26810
At4g05470
At3g50080
At1g47056
At2g39940
At1g12820
At3g07550
At4g03190
At4g05490
At4g07400
At4g08980
At4g30640
At4g05460
At4g24390
At4g33210
At5g01720
At5g49980
At5g67250
At5g27920
NAS
HsaFBXL7
FBXL3
TAS
HsaFBXL6
SceS000003850
GO:0005515 protein binding F
IPI
AthAt2g25490
At2g39940
At3g62980
At4g03190
At5g25350
At5g57900
HsaFBXL7
KDM2A
SceS000000362
SpoSPCC330.02
SPBC25B2.11
ISS
AthAt1g80630
At1g15740
TAS
SceS000003850
GO:0008094 DNA-dependent ATPase activity F
IDA
SceS000003813
GO:0010011 auxin binding F
IDA
AthAt3g62980
IGI
AthAt3g26810
At1g12820
At3g62980
At4g03190
GO:0030674 protein binding, bridging F
ISS
SpoSPBC25B2.11
GO:0000082 G1/S transition of mitotic cell
cycle		 P
TAS
SceS000003850
GO:0000715 nucleotide-excision repair, DNA damage
recognition		 P
IDA
SceS000003813
IMP
SceS000003813
GO:0000751 cell cycle arrest in response to
pheromone		 P
IMP
SceS000003850
GO:0001100 negative regulation of exit from
mitosis		 P
IGI
SceS000000362
IMP
SceS000000362
GO:0002237 response to molecule of bacterial
origin		 P
IEP
AthAt3g26810
At1g12820
At3g62980
At4g03190
GO:0006289 nucleotide-excision repair P
IGI
SpoSPCC330.02
GO:0006508 proteolysis P
TAS
HsaFBXL6
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IGI
AthAt4g03190
ISS
AthAt5g01720
NAS
DmeFBgn0020257
HsaFBXL7
TAS
AthAt2g17020
At1g77000
At2g36370
At2g39940
At1g80570
At2g25490
At3g50080
At3g62980
At3g07550
At4g03190
At4g07400
At4g05490
At4g05460
At4g05470
At4g08980
At4g24390
At4g30640
At4g33210
At5g01720
At5g25350
HsaFBXL4
GO:0006952 defense response P
TAS
AthAt2g39940
GO:0006974 response to DNA damage stimulus P
IMP
SceS000003850
GO:0007093 mitotic cell cycle checkpoint P
IMP
SceS000000362
GO:0008150 biological_process P
ND
AthAt1g80630
At3g48880
At3g58530
At1g55590
At4g03630
At5g07670
At5g40470
At5g23340
At5g51370
At5g27920
At5g51380
At5g52480
At5g57900
SpoSPBC25B2.11
GO:0009611 response to wounding P
IMP
AthAt2g39940
GO:0009625 response to insect P
IMP
AthAt2g39940
GO:0009641 shade avoidance P
IMP
AthAt2g39940
GO:0009723 response to ethylene stimulus P
IMP
AthAt2g25490
At5g25350
GO:0009733 response to auxin stimulus P
IMP
AthAt3g62980
At4g03190
GO:0009753 response to jasmonic acid stimulus P
IMP
AthAt2g39940
GO:0009861 jasmonic acid and ethylene-dependent systemic
resistance		 P
TAS
AthAt2g39940
GO:0009867 jasmonic acid mediated signaling
pathway		 P
IGI
AthAt2g39940
TAS
AthAt2g39940
GO:0009909 regulation of flower development P
IMP
AthAt2g39940
GO:0010105 negative regulation of ethylene mediated signaling
pathway		 P
TAS
AthAt2g25490
At5g25350
GO:0010118 stomatal movement P
IMP
AthAt2g39940
GO:0010152 pollen maturation P
IGI
AthAt3g26810
At1g12820
At3g62980
At4g03190
GO:0010218 response to far red light P
IMP
AthAt2g39940
GO:0010252 auxin homeostasis P
IMP
AthAt4g33210
GO:0010286 heat acclimation P
IEP
AthAt1g77000
GO:0010311 lateral root formation P
IMP
AthAt3g62980
GO:0010608 posttranscriptional regulation of gene
expression		 P
IMP
AthAt4g08980
GO:0016036 cellular response to phosphate
starvation		 P
IEP
AthAt3g62980
GO:0016567 protein ubiquitination P
IGI
SceS000003850
IPI
SceS000003850
NAS
HsaFBXL3
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent
protein catabolic process		 P
IMP
AthAt2g39940
IPI
AthAt1g21410
SceS000003850
GO:0031348 negative regulation of defense
response		 P
IMP
AthAt2g39940
GO:0034644 cellular response to UV P
IGI
SpoSPCC330.02
GO:0042742 defense response to bacterium P
IMP
AthAt2g39940
GO:0042787 protein ubiquitination involved in
ubiquitin-dependent protein catabolic
process		 P
IMP
SceS000003813
GO:0045014 negative regulation of transcription by
glucose		 P
TAS
AthAt4g03190
GO:0048443 stamen development P
IGI
AthAt3g26810
At1g12820
At3g62980
At4g03190
GO:0048527 lateral root development P
IMP
AthAt1g12820
GO:0048589 developmental growth P
IGI
AthAt4g03190
GO:0048645 organ formation P
IMP
AthAt4g33210
GO:0050832 defense response to fungus P
IMP
AthAt2g39940
GO:0051603 proteolysis involved in cellular protein catabolic
process		 P
IMP
AthAt1g77000
GO:0051781 positive regulation of cell division P
IMP
AthAt1g21410
GO:0071249 cellular response to nitrate P
IEP
AthAt1g12820
GO:0080022 primary root development P
IMP
AthAt1g12820

Back to the top

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
32144

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) FBXL2 GI:16306582 Q9UKC9
Pan troglodytes (Ptr) FBXL2 GI:114586239
Canis familiaris (Cfa) FBXL2 GI:73990001
Mus musculus (Mmu) Fbxl2
(MGI:1919429)		 GI:30519963 Q3TQM5
Rattus norvegicus (Rno) Fbxl2 GI:109484033
Gallus gallus (Gga) FBXL2 GI:118086164
Caenorhabditis elegans (Cel) C02F5.7
(CE24780;
WBGene00015350)		 GI:25151696
Schizosaccharomyces pombe (Spo) pof2
(SPBC25B2.11)		 GI:19112871 O74783
Saccharomyces cerevisiae (Sce) GRR1
(S000003850)		 GI:6322549 P24814
Kluyveromyces lactis (Kla) KLLA0E06006g GI:50308435
Eremothecium gossypii (Ego) AGOS_AER398W GI:45190999
Magnaporthe grisea (Mgr) MGG_13065 GI:145615219
Neurospora crassa (Ncr) NCU01216.1 GI:32412458


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000142 cellular bud neck contractile ring C
IDA
SceS000003850
GO:0000151 ubiquitin ligase complex C
ISS
SpoSPBC25B2.11
GO:0005575 cellular_component C
ND
MmuMGI:1919429
GO:0005634 nucleus C
IDA
SceS000003850
GO:0005737 cytoplasm C
IDA
SceS000003850
TAS
HsaFBXL2
GO:0005739 mitochondrion C
IDA
SpoSPBC25B2.11
GO:0019005 SCF ubiquitin ligase complex C
IMP
SceS000003850
GO:0003674 molecular_function F
ND
MmuMGI:1919429
GO:0004842 ubiquitin-protein ligase activity F
TAS
HsaFBXL2
SceS000003850
GO:0005515 protein binding F
IPI
SpoSPBC25B2.11
TAS
SceS000003850
GO:0030674 protein binding, bridging F
ISS
SpoSPBC25B2.11
GO:0000082 G1/S transition of mitotic cell
cycle		 P
TAS
SceS000003850
GO:0000751 cell cycle arrest in response to
pheromone		 P
IMP
SceS000003850
GO:0006464 protein modification process P
TAS
HsaFBXL2
GO:0006508 proteolysis P
TAS
HsaFBXL2
GO:0006974 response to DNA damage stimulus P
IMP
SceS000003850
GO:0008150 biological_process P
ND
MmuMGI:1919429
SpoSPBC25B2.11
GO:0016567 protein ubiquitination P
IGI
SceS000003850
IPI
SceS000003850
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent
protein catabolic process		 P
IPI
SceS000003850

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2631

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9723 ENSANGP00000010053
Ashbya gossypii (Ago) ago2898 AER398W
Arabidopsis thaliana (Ath) ath19365 At4g15475.1
Arabidopsis thaliana (Ath) ath24579 At5g23340.1
Caenorhabditis elegans (Cel) cel868 C02F5.7a
(CE24780;
WBGene00015350)
Caenorhabditis elegans (Cel) cel869 C02F5.7b
(CE30418)
Candida glabrata (Cgl) cgl5052 CAGL0M09130g
Dictyostelium discoideum (Ddi) ddi9220 DDB0187476
Debaryomyces hansenii (Dha) dha6850 DEHA0G25905g
Drosophila melanogaster (Dme) dme4532 CG9003-PA
(FBgn0033639)
Danio rerio (Dre) dre10694 ENSDARP00000018003
(fbxl2)		 Q6PBJ7
Takifugu rubripes (Fru) fru30670 SINFRUP00000153597
Takifugu rubripes (Fru) fru16357 SINFRUP00000161829
Gallus gallus (Gga) gga10158 ENSGALP00000019508
(FBXL2)
Homo sapiens (Hsa) hsa13566 ENSP00000264658
(FBXL20)		 Q96IG2-1
Homo sapiens (Hsa) hsa22221 ENSP00000283627
Kluyveromyces lactis (Kla) kla3218 KLLA0E06006g
Mus musculus (Mmu) mmu28410 ENSMUSP00000035090
(MGI:1919429)		 Q8BH16
Mus musculus (Mmu) mmu28411 ENSMUSP00000035091
Mus musculus (Mmu) mmu4707 ENSMUSP00000074580
(MGI:1919444)		 Q9CZV8-4
Neurospora crassa (Ncr) ncr1179 NCU01216.2
Oryza sativa (Osa) osa25799 3854.m00246
Rattus norvegicus (Rno) rno6007 ENSRNOP00000007327
(RGD:621722)
Rattus norvegicus (Rno) rno29391 ENSRNOP00000033447
(RGD:1562243)
Saccharomyces cerevisiae (Sce) sce3584 YJR090C
(S000003850)
Schizosaccharomyces pombe (Spo) spo2933 SPBC25B2.11 O74783
Yarrowia lipolytica (Yli) yli2312 YALI0C14740g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000142 cellular bud neck contractile ring C
IDA
SceS000003850
GO:0000151 ubiquitin ligase complex C
ISS
SpoSPBC25B2.11
GO:0005575 cellular_component C
ND
AthAt5g23340
MmuMGI:1919429
MGI:1919444
GO:0005634 nucleus C
IDA
SceS000003850
GO:0005737 cytoplasm C
IDA
SceS000003850
GO:0005739 mitochondrion C
IDA
SpoSPBC25B2.11
GO:0019005 SCF ubiquitin ligase complex C
IMP
SceS000003850
GO:0003674 molecular_function F
ND
MmuMGI:1919429
GO:0004842 ubiquitin-protein ligase activity F
ISS
AthAt4g15475
TAS
SceS000003850
GO:0005515 protein binding F
IPI
MmuMGI:1919444
SpoSPBC25B2.11
TAS
SceS000003850
GO:0030674 protein binding, bridging F
ISS
SpoSPBC25B2.11
GO:0000082 G1/S transition of mitotic cell
cycle		 P
TAS
SceS000003850
GO:0000751 cell cycle arrest in response to
pheromone		 P
IMP
SceS000003850
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
AthAt4g15475
GO:0006974 response to DNA damage stimulus P
IMP
SceS000003850
GO:0008150 biological_process P
ND
AthAt5g23340
MmuMGI:1919429
MGI:1919444
SpoSPBC25B2.11
GO:0016567 protein ubiquitination P
IGI
SceS000003850
IPI
SceS000003850
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent
protein catabolic process		 P
IPI
SceS000003850

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC25B2.11
(O74783)		 YJR090C
(S000003850)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000142 cellular bud neck contractile ring C
IDA
SceS000003850
GO:0000151 ubiquitin ligase complex C
ISS
SpoSPBC25B2.11
GO:0005634 nucleus C
IDA
SceS000003850
GO:0005737 cytoplasm C
IDA
SceS000003850
GO:0005739 mitochondrion C
IDA
SpoSPBC25B2.11
GO:0019005 SCF ubiquitin ligase complex C
IMP
SceS000003850
GO:0004842 ubiquitin-protein ligase activity F
TAS
SceS000003850
GO:0005515 protein binding F
IPI
SpoSPBC25B2.11
TAS
SceS000003850
GO:0030674 protein binding, bridging F
ISS
SpoSPBC25B2.11
GO:0000082 G1/S transition of mitotic cell
cycle		 P
TAS
SceS000003850
GO:0000751 cell cycle arrest in response to
pheromone		 P
IMP
SceS000003850
GO:0006974 response to DNA damage stimulus P
IMP
SceS000003850
GO:0008150 biological_process P
ND
SpoSPBC25B2.11
GO:0016567 protein ubiquitination P
IGI
SceS000003850
IPI
SceS000003850
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent
protein catabolic process		 P
IPI
SceS000003850

Back to the top
YOGY Home YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk