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Search term: YKL017C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HCS1
SGD link S000001500
Alternative ID YKL017C
Description Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
Synonyms YKL017C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1803 AC-HYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA helicase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g03270 GI:7446669
Arabidopsis thaliana (Ath) At5g35970 GI:15239247
Caenorhabditis elegans (Cel) CE08664 GI:17505965
Caenorhabditis elegans (Cel) CE18803 GI:17568451
Caenorhabditis elegans (Cel) CE19303 GI:17510845
Caenorhabditis elegans (Cel) CE25118 GI:17510867
Homo sapiens (Hsa) Hs4504623 GI:4504623
Saccharomyces cerevisiae (Sce) YKL017c
(S000001500)		 GI:6322835 P34243
Schizosaccharomyces pombe (Spo) SPCC737.07c GI:19075869 O94247
Encephalitozoon cuniculi (Ecu) ECU05g1110 GI:19173651 Q8SVI3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
ISS
SpoSPCC737.07c
GO:0005575 cellular_component C
ND
AthAt2g03270
GO:0005634 nucleus C
IDA
SpoSPCC737.07c
GO:0005658 alpha DNA polymerase:primase complex C
IDA
SceS000001500
ISS
SpoSPCC737.07c
GO:0005829 cytosol C
IDA
SpoSPCC737.07c
GO:0009507 chloroplast C
IDA
AthAt5g35970
GO:0009941 chloroplast envelope C
IDA
AthAt5g35970
GO:0033203 DNA helicase A complex C
IDA
SceS000001500
GO:0043596 nuclear replication fork C
IC
SpoSPCC737.07c
GO:0003677 DNA binding F
ISS
AthAt5g35970
At2g03270
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC737.07c
GO:0043141 ATP-dependent 5'-3' DNA helicase
activity		 F
IDA
SceS000001500
GO:0006200 ATP catabolic process P
ISS
SpoSPCC737.07c
GO:0006273 lagging strand elongation P
IC
SceS000001500
ISS
SpoSPCC737.07c
GO:0008150 biological_process P
ND
AthAt5g35970

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1642

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) IGHMBP2 GI:119392094
Pan troglodytes (Ptr) IGHMBP2 GI:114638980
Canis familiaris (Cfa) IGHMBP2 GI:73983575
Mus musculus (Mmu) Ighmbp2
(MGI:99954)		 GI:6678029 P40694
Rattus norvegicus (Rno) Ighmbp2
(RGD:68325)		 GI:13928794
Schizosaccharomyces pombe (Spo) SPCC737.07c GI:19075869 O94247
Saccharomyces cerevisiae (Sce) HCS1
(S000001500)		 GI:6322835 P34243
Kluyveromyces lactis (Kla) KLLA0E18150g GI:50309513
Eremothecium gossypii (Ego) AGOS_ACL098C GI:45185590
Magnaporthe grisea (Mgr) MGG_11568 GI:145611308
Neurospora crassa (Ncr) NCU07395.1 GI:32414403
Arabidopsis thaliana (Ath) AT2G03270 GI:18395518
Oryza sativa (Osa) Os03g0586900 GI:115453945


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
ISS
SpoSPCC737.07c
GO:0005575 cellular_component C
ND
AthAt2g03270
GO:0005634 nucleus C
IDA
HsaIGHMBP2
MmuMGI:99954
SpoSPCC737.07c
GO:0005658 alpha DNA polymerase:primase complex C
IDA
SceS000001500
ISS
SpoSPCC737.07c
GO:0005737 cytoplasm C
IDA
HsaIGHMBP2
MmuMGI:99954
GO:0005829 cytosol C
IDA
SpoSPCC737.07c
GO:0030424 axon C
IDA
MmuMGI:99954
ISS
HsaIGHMBP2
GO:0030426 growth cone C
IDA
MmuMGI:99954
ISS
HsaIGHMBP2
GO:0030529 ribonucleoprotein complex C
IDA
MmuMGI:99954
ISS
HsaIGHMBP2
GO:0032797 SMN complex C
IDA
HsaIGHMBP2
GO:0033203 DNA helicase A complex C
IDA
SceS000001500
GO:0043025 neuronal cell body C
IDA
MmuMGI:99954
GO:0043596 nuclear replication fork C
IC
SpoSPCC737.07c
GO:0048471 perinuclear region of cytoplasm C
IDA
MmuMGI:99954
GO:0000049 tRNA binding F
IDA
HsaIGHMBP2
ISO
MmuMGI:99954
GO:0003677 DNA binding F
IDA
HsaIGHMBP2
ISO
MmuMGI:99954
ISS
AthAt2g03270
GO:0003678 DNA helicase activity F
TAS
HsaIGHMBP2
GO:0003697 single-stranded DNA binding F
TAS
HsaIGHMBP2
GO:0003702 RNA polymerase II transcription factor
activity		 F
ISO
MmuMGI:99954
GO:0003723 RNA binding F
IDA
HsaIGHMBP2
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC737.07c
GO:0005515 protein binding F
IPI
HsaIGHMBP2
GO:0005524 ATP binding F
IDA
HsaIGHMBP2
GO:0008094 DNA-dependent ATPase activity F
IDA
HsaIGHMBP2
GO:0008134 transcription factor binding F
IPI
HsaIGHMBP2
GO:0008186 RNA-dependent ATPase activity F
IDA
HsaIGHMBP2
GO:0032575 ATP-dependent 5'-3' RNA helicase
activity		 F
IDA
HsaIGHMBP2
GO:0043022 ribosome binding F
IDA
HsaIGHMBP2
MmuMGI:99954
GO:0043141 ATP-dependent 5'-3' DNA helicase
activity		 F
IDA
HsaIGHMBP2
SceS000001500
GO:0000122 negative regulation of transcription from RNA
polymerase II promoter		 P
ISO
MmuMGI:99954
GO:0006200 ATP catabolic process P
ISS
SpoSPCC737.07c
GO:0006260 DNA replication P
TAS
HsaIGHMBP2
GO:0006273 lagging strand elongation P
IC
SceS000001500
ISS
SpoSPCC737.07c
GO:0006281 DNA repair P
TAS
HsaIGHMBP2
GO:0006310 DNA recombination P
TAS
HsaIGHMBP2
GO:0006412 translation P
NAS
HsaIGHMBP2
MmuMGI:99954
GO:0021522 spinal cord motor neuron differentiation P
IMP
MmuMGI:99954
GO:0051260 protein homooligomerization P
IPI
HsaIGHMBP2
ISO
MmuMGI:99954

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1576

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1369 ENSANGP00000013515
Ashbya gossypii (Ago) ago951 ACL098C
Arabidopsis thaliana (Ath) ath7735 At2g03270.1
Candida glabrata (Cgl) cgl4499 CAGL0L09735g
Cryptococcus neoformans (Cne) cne133 162.m02656
Dictyostelium discoideum (Ddi) ddi1216 DDB0168508
Debaryomyces hansenii (Dha) dha5588 DEHA0F26906g
Danio rerio (Dre) dre9208 ENSDARP00000023522
Danio rerio (Dre) dre9207 ENSDARP00000041549
Danio rerio (Dre) dre9254 ENSDARP00000045914
Danio rerio (Dre) dre9206 ENSDARP00000046060
Danio rerio (Dre) dre9253 ENSDARP00000047254
Danio rerio (Dre) dre9255 ENSDARP00000049936
Encephalitozoon cuniculi (Ecu) ecu1213 19173651
Takifugu rubripes (Fru) fru26993 SINFRUP00000130490
Gallus gallus (Gga) gga18643 ENSGALP00000006889
Gallus gallus (Gga) gga18642 ENSGALP00000006890
(IGHMBP2)		 Q5ZHN2
Homo sapiens (Hsa) hsa6118 ENSP00000255078
(IGHMBP2)		 P38935
Kluyveromyces lactis (Kla) kla3765 KLLA0E18150g
Mus musculus (Mmu) mmu13019 ENSMUSP00000025751
(MGI:99954)		 P40694
Neurospora crassa (Ncr) ncr7198 NCU07395.2
Oryza sativa (Osa) osa41654 5262.m00211
Oryza sativa (Osa) osa85555 8378.m00194
Plasmodium falciparum (Pfa) pfa1028 PF11_0078
Rattus norvegicus (Rno) rno3390 ENSRNOP00000018487
(RGD:68325)		 Q9EQN5
Saccharomyces cerevisiae (Sce) sce3679 YKL017C
(S000001500)
Schizosaccharomyces pombe (Spo) spo4350 SPCC737.07c O94247
Yarrowia lipolytica (Yli) yli1019 YALI0B06897g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
ISS
SpoSPCC737.07c
GO:0005575 cellular_component C
ND
AthAt2g03270
GO:0005634 nucleus C
IDA
MmuMGI:99954
SpoSPCC737.07c
GO:0005658 alpha DNA polymerase:primase complex C
IDA
SceS000001500
ISS
SpoSPCC737.07c
GO:0005737 cytoplasm C
IDA
MmuMGI:99954
GO:0005829 cytosol C
IDA
SpoSPCC737.07c
GO:0030424 axon C
IDA
MmuMGI:99954
GO:0030426 growth cone C
IDA
MmuMGI:99954
GO:0030529 ribonucleoprotein complex C
IDA
MmuMGI:99954
GO:0033203 DNA helicase A complex C
IDA
SceS000001500
GO:0043025 neuronal cell body C
IDA
MmuMGI:99954
GO:0043596 nuclear replication fork C
IC
SpoSPCC737.07c
GO:0048471 perinuclear region of cytoplasm C
IDA
MmuMGI:99954
GO:0000049 tRNA binding F
ISO
MmuMGI:99954
GO:0003677 DNA binding F
ISO
MmuMGI:99954
ISS
AthAt2g03270
GO:0003702 RNA polymerase II transcription factor
activity		 F
ISO
MmuMGI:99954
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPCC737.07c
GO:0043022 ribosome binding F
IDA
MmuMGI:99954
GO:0043141 ATP-dependent 5'-3' DNA helicase
activity		 F
IDA
SceS000001500
GO:0000122 negative regulation of transcription from RNA
polymerase II promoter		 P
ISO
MmuMGI:99954
GO:0006200 ATP catabolic process P
ISS
SpoSPCC737.07c
GO:0006273 lagging strand elongation P
IC
SceS000001500
ISS
SpoSPCC737.07c
GO:0006412 translation P
NAS
MmuMGI:99954
GO:0021522 spinal cord motor neuron differentiation P
IMP
MmuMGI:99954
GO:0051260 protein homooligomerization P
ISO
MmuMGI:99954

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC737.07c
(O94247)		 YKL017C
(S000001500)