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Search term: YKL019W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RAM2
SGD link S000001502
Alternative ID YKL019W
Description Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
Synonyms YKL019W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0530 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g59380 GI:12643807
Caenorhabditis elegans (Cel) CE18099
(WBGene00019823)		 GI:17541746 O44501
Drosophila melanogaster (Dme) 7295671 GI:7295671
Homo sapiens (Hsa) Hs4503771
(FNTA)		 GI:4503771 P49354
Saccharomyces cerevisiae (Sce) YKL019w
(S000001502)		 GI:6322833 P29703
Schizosaccharomyces pombe (Spo) SPAPB1A10.04c GI:19114430 O60052
Arabidopsis thaliana (Ath) At3g59380 GI:12643807
Caenorhabditis elegans (Cel) CE18099
(WBGene00019823)		 GI:17541746 O44501
Drosophila melanogaster (Dme) 7295671 GI:7295671
Homo sapiens (Hsa) Hs4503771
(FNTA)		 GI:4503771 P49354
Saccharomyces cerevisiae (Sce) YKL019w
(S000001502)		 GI:6322833 P29703
Schizosaccharomyces pombe (Spo) SPAPB1A10.04c GI:19114430 O60052
Arabidopsis thaliana (Ath) At3g59380 GI:12643807
Caenorhabditis elegans (Cel) CE18099
(WBGene00019823)		 GI:17541746 O44501
Drosophila melanogaster (Dme) 7295671 GI:7295671
Homo sapiens (Hsa) Hs4503771
(FNTA)		 GI:4503771 P49354
Saccharomyces cerevisiae (Sce) YKL019w
(S000001502)		 GI:6322833 P29703
Schizosaccharomyces pombe (Spo) SPAPB1A10.04c GI:19114430 O60052


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAPB1A10.04c
GO:0005829 cytosol C
EXP
HsaFNTA
GO:0005875 microtubule associated complex C
IDA
HsaFNTA
GO:0005953 CAAX-protein geranylgeranyltransferase
complex		 C
IDA
SceS000001502
IPI
AthAt3g59380
NAS
SpoSPAPB1A10.04c
GO:0005965 protein farnesyltransferase complex C
IDA
SceS000001502
IPI
AthAt3g59380
GO:0004311 farnesyltranstransferase activity F
TAS
AthAt3g59380
GO:0004660 protein farnesyltransferase activity F
IDA
HsaFNTA
SceS000001502
GO:0004661 protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
SpoSPAPB1A10.04c
TAS
HsaFNTA
GO:0004662 CAAX-protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
GO:0004663 Rab geranylgeranyltransferase activity F
ISS
SpoSPAPB1A10.04c
GO:0005515 protein binding F
IPI
HsaFNTA
SpoSPAPB1A10.04c
GO:0008017 microtubule binding F
IDA
HsaFNTA
GO:0008318 protein prenyltransferase activity F
IDA
AthAt3g59380
GO:0043014 alpha-tubulin binding F
IDA
HsaFNTA
GO:0046982 protein heterodimerization activity F
IPI
AthAt3g59380
GO:0000003 reproduction P
IMP
CelWBGene00019823
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019823
GO:0002119 nematode larval development P
IMP
CelWBGene00019823
GO:0006075 1,3-beta-glucan biosynthetic process P
IPI
SpoSPAPB1A10.04c
GO:0007179 transforming growth factor beta receptor signaling
pathway		 P
TAS
HsaFNTA
GO:0007323 peptide pheromone maturation P
IDA
SceS000001502
GO:0008360 regulation of cell shape P
IMP
AthAt3g59380
GO:0009414 response to water deprivation P
IMP
AthAt3g59380
GO:0009788 negative regulation of abscisic acid mediated
signaling pathway		 P
IMP
AthAt3g59380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019823
GO:0010171 body morphogenesis P
IMP
CelWBGene00019823
GO:0018346 protein amino acid prenylation P
IDA
AthAt3g59380
GO:0018347 protein amino acid farnesylation P
IDA
HsaFNTA
SceS000001502
TAS
AthAt3g59380
GO:0018348 protein amino acid geranylgeranylation P
IC
SpoSPAPB1A10.04c
IDA
AthAt3g59380
SceS000001502
TAS
HsaFNTA
GO:0018991 oviposition P
IMP
CelWBGene00019823
GO:0040007 growth P
IMP
CelWBGene00019823
GO:0040011 locomotion P
IMP
CelWBGene00019823
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00019823
GO:0048509 regulation of meristem development P
IMP
AthAt3g59380
GO:0090044 positive regulation of tubulin
deacetylation		 P
IDA
HsaFNTA
GO:0090045 positive regulation of deacetylase
activity		 P
IDA
HsaFNTA

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1534

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) FNTA GI:4503771 P49354
Pan troglodytes (Ptr) FNTA GI:114619982
Canis familiaris (Cfa) FNTA GI:73979092
Mus musculus (Mmu) Fnta
(MGI:104683)		 GI:6679821 Q541Z2
Rattus norvegicus (Rno) Fnta
(RGD:2625)		 GI:6978849 41202
Gallus gallus (Gga) FNTA GI:118104309
Drosophila melanogaster (Dme) CG2976
(FBgn0031633)		 GI:24581731
Anopheles gambiae (Aga) AgaP_AGAP011767 GI:158300946
Caenorhabditis elegans (Cel) R02D3.5
(CE18099;
WBGene00019823)		 GI:17541746 O44501
Schizosaccharomyces pombe (Spo) cwp1
(SPAPB1A10.04c)		 GI:19114430 O60052
Saccharomyces cerevisiae (Sce) RAM2
(S000001502)		 GI:6322833 P29703
Kluyveromyces lactis (Kla) KLLA0E18051g GI:50309503
Eremothecium gossypii (Ego) AGOS_ACR094C GI:45185780
Magnaporthe grisea (Mgr) MGG_06947 GI:39978125
Neurospora crassa (Ncr) NCU03632.1 GI:32404642
Arabidopsis thaliana (Ath) FTA GI:18411158
Oryza sativa (Osa) Os09g0514400 GI:115480131


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAPB1A10.04c
GO:0005737 cytoplasm C
ISO
MmuMGI:104683
GO:0005829 cytosol C
EXP
HsaFNTA
GO:0005875 microtubule associated complex C
IDA
HsaFNTA
GO:0005953 CAAX-protein geranylgeranyltransferase
complex		 C
IDA
SceS000001502
IPI
AthFTA
ISO
MmuMGI:104683
NAS
SpoSPAPB1A10.04c
GO:0005965 protein farnesyltransferase complex C
IDA
SceS000001502
IPI
AthFTA
ISS
DmeFBgn0031633
GO:0004311 farnesyltranstransferase activity F
TAS
AthFTA
GO:0004660 protein farnesyltransferase activity F
IDA
HsaFNTA
SceS000001502
ISO
MmuMGI:104683
ISS
DmeFBgn0031633
GO:0004661 protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
SpoSPAPB1A10.04c
TAS
HsaFNTA
GO:0004662 CAAX-protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
ISO
MmuMGI:104683
GO:0004663 Rab geranylgeranyltransferase activity F
ISS
SpoSPAPB1A10.04c
GO:0005515 protein binding F
IPI
HsaFNTA
SpoSPAPB1A10.04c
GO:0008017 microtubule binding F
IDA
HsaFNTA
GO:0008144 drug binding F
ISO
MmuMGI:104683
GO:0008270 zinc ion binding F
ISO
MmuMGI:104683
GO:0008318 protein prenyltransferase activity F
IDA
AthFTA
GO:0019840 isoprenoid binding F
ISO
MmuMGI:104683
GO:0030548 acetylcholine receptor regulator
activity		 F
IMP
MmuMGI:104683
GO:0042277 peptide binding F
ISO
MmuMGI:104683
GO:0043014 alpha-tubulin binding F
IDA
HsaFNTA
GO:0046982 protein heterodimerization activity F
IPI
AthFTA
GO:0000003 reproduction P
IMP
CelWBGene00019823
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019823
GO:0002119 nematode larval development P
IMP
CelWBGene00019823
GO:0006075 1,3-beta-glucan biosynthetic process P
IPI
SpoSPAPB1A10.04c
GO:0007179 transforming growth factor beta receptor signaling
pathway		 P
TAS
HsaFNTA
GO:0007323 peptide pheromone maturation P
IDA
SceS000001502
GO:0008284 positive regulation of cell proliferation P
ISO
MmuMGI:104683
GO:0008360 regulation of cell shape P
IMP
AthFTA
GO:0009414 response to water deprivation P
IMP
AthFTA
GO:0009788 negative regulation of abscisic acid mediated
signaling pathway		 P
IMP
AthFTA
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019823
GO:0010035 response to inorganic substance P
ISO
MmuMGI:104683
GO:0010171 body morphogenesis P
IMP
CelWBGene00019823
GO:0010469 regulation of receptor activity P
IMP
MmuMGI:104683
GO:0014070 response to organic cyclic substance P
ISO
MmuMGI:104683
GO:0018346 protein amino acid prenylation P
IDA
AthFTA
GO:0018347 protein amino acid farnesylation P
IDA
HsaFNTA
SceS000001502
TAS
AthFTA
GO:0018348 protein amino acid geranylgeranylation P
IC
SpoSPAPB1A10.04c
IDA
AthFTA
SceS000001502
TAS
HsaFNTA
GO:0018991 oviposition P
IMP
CelWBGene00019823
GO:0034097 response to cytokine stimulus P
ISO
MmuMGI:104683
GO:0040007 growth P
IMP
CelWBGene00019823
GO:0040011 locomotion P
IMP
CelWBGene00019823
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00019823
GO:0043066 negative regulation of apoptosis P
ISO
MmuMGI:104683
GO:0045213 neurotransmitter receptor metabolic
process		 P
IMP
MmuMGI:104683
GO:0045787 positive regulation of cell cycle P
ISO
MmuMGI:104683
GO:0048509 regulation of meristem development P
IMP
AthFTA
GO:0051773 positive regulation of nitric-oxide synthase 2
biosynthetic process		 P
ISO
MmuMGI:104683
GO:0051774 negative regulation of nitric-oxide synthase 2
biosynthetic process		 P
ISO
MmuMGI:104683
GO:0051789 response to protein stimulus P
ISO
MmuMGI:104683
GO:0090044 positive regulation of tubulin
deacetylation		 P
IDA
HsaFNTA
GO:0090045 positive regulation of deacetylase
activity		 P
IDA
HsaFNTA

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2004

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8911 ENSANGP00000020029
Ashbya gossypii (Ago) ago1141 ACR094C
Arabidopsis thaliana (Ath) ath17355 At3g59380.1
Caenorhabditis elegans (Cel) cel13184 R02D3.5
(CE18099;
WBGene00019823)
Candida glabrata (Cgl) cgl4502 CAGL0L09801g
Cryptococcus neoformans (Cne) cne3126 167.m05884
Dictyostelium discoideum (Ddi) ddi6146 DDB0218423
Debaryomyces hansenii (Dha) dha4918 DEHA0F12034g
Drosophila melanogaster (Dme) dme754 CG2976-PA
(FBgn0031633)
Danio rerio (Dre) dre27296 ENSDARP00000017608
Takifugu rubripes (Fru) fru22270 SINFRUP00000147062
Gallus gallus (Gga) gga27943 ENSGALP00000024792
(FNTA)
Homo sapiens (Hsa) hsa30254 ENSP00000303423
(FNTA)		 P49354-1
Homo sapiens (Hsa) hsa30255 ENSP00000343931
(FNTA)		 P49354-2
Kluyveromyces lactis (Kla) kla3760 KLLA0E18051g
Mus musculus (Mmu) mmu25794 ENSMUSP00000016138
(MGI:104683)		 Q61239
Neurospora crassa (Ncr) ncr3523 NCU03632.2
Oryza sativa (Osa) osa7344 2515.m00165
Oryza sativa (Osa) osa7394 2515.m00225
Oryza sativa (Osa) osa7395 2515.m00226
Oryza sativa (Osa) osa21464 3602.m00257
Oryza sativa (Osa) osa21660 3606.m00325
Plasmodium falciparum (Pfa) pfa5191 PFL2050w
Rattus norvegicus (Rno) rno12617 ENSRNOP00000019594
(RGD:2625)		 Q04631
Saccharomyces cerevisiae (Sce) sce3682 YKL019W
(S000001502)
Schizosaccharomyces pombe (Spo) spo5 SPAPB1A10.04c O60052
Yarrowia lipolytica (Yli) yli1415 YALI0B16126g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAPB1A10.04c
GO:0005737 cytoplasm C
ISO
MmuMGI:104683
GO:0005953 CAAX-protein geranylgeranyltransferase
complex		 C
IDA
SceS000001502
IPI
AthAt3g59380
ISO
MmuMGI:104683
NAS
SpoSPAPB1A10.04c
GO:0005965 protein farnesyltransferase complex C
IDA
SceS000001502
IPI
AthAt3g59380
ISS
DmeFBgn0031633
GO:0004311 farnesyltranstransferase activity F
TAS
AthAt3g59380
GO:0004660 protein farnesyltransferase activity F
IDA
SceS000001502
ISO
MmuMGI:104683
ISS
DmeFBgn0031633
GO:0004661 protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
SpoSPAPB1A10.04c
GO:0004662 CAAX-protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
ISO
MmuMGI:104683
GO:0004663 Rab geranylgeranyltransferase activity F
ISS
SpoSPAPB1A10.04c
GO:0005515 protein binding F
IPI
SpoSPAPB1A10.04c
GO:0008144 drug binding F
ISO
MmuMGI:104683
GO:0008270 zinc ion binding F
ISO
MmuMGI:104683
GO:0008318 protein prenyltransferase activity F
IDA
AthAt3g59380
GO:0019840 isoprenoid binding F
ISO
MmuMGI:104683
GO:0030548 acetylcholine receptor regulator
activity		 F
IMP
MmuMGI:104683
GO:0042277 peptide binding F
ISO
MmuMGI:104683
GO:0046982 protein heterodimerization activity F
IPI
AthAt3g59380
GO:0000003 reproduction P
IMP
CelWBGene00019823
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00019823
GO:0002119 nematode larval development P
IMP
CelWBGene00019823
GO:0006075 1,3-beta-glucan biosynthetic process P
IPI
SpoSPAPB1A10.04c
GO:0007323 peptide pheromone maturation P
IDA
SceS000001502
GO:0008284 positive regulation of cell proliferation P
ISO
MmuMGI:104683
GO:0008360 regulation of cell shape P
IMP
AthAt3g59380
GO:0009414 response to water deprivation P
IMP
AthAt3g59380
GO:0009788 negative regulation of abscisic acid mediated
signaling pathway		 P
IMP
AthAt3g59380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00019823
GO:0010035 response to inorganic substance P
ISO
MmuMGI:104683
GO:0010171 body morphogenesis P
IMP
CelWBGene00019823
GO:0010469 regulation of receptor activity P
IMP
MmuMGI:104683
GO:0014070 response to organic cyclic substance P
ISO
MmuMGI:104683
GO:0018346 protein amino acid prenylation P
IDA
AthAt3g59380
GO:0018347 protein amino acid farnesylation P
IDA
SceS000001502
TAS
AthAt3g59380
GO:0018348 protein amino acid geranylgeranylation P
IC
SpoSPAPB1A10.04c
IDA
AthAt3g59380
SceS000001502
GO:0018991 oviposition P
IMP
CelWBGene00019823
GO:0034097 response to cytokine stimulus P
ISO
MmuMGI:104683
GO:0040007 growth P
IMP
CelWBGene00019823
GO:0040011 locomotion P
IMP
CelWBGene00019823
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00019823
GO:0043066 negative regulation of apoptosis P
ISO
MmuMGI:104683
GO:0045213 neurotransmitter receptor metabolic
process		 P
IMP
MmuMGI:104683
GO:0045787 positive regulation of cell cycle P
ISO
MmuMGI:104683
GO:0048509 regulation of meristem development P
IMP
AthAt3g59380
GO:0051773 positive regulation of nitric-oxide synthase 2
biosynthetic process		 P
ISO
MmuMGI:104683
GO:0051774 negative regulation of nitric-oxide synthase 2
biosynthetic process		 P
ISO
MmuMGI:104683
GO:0051789 response to protein stimulus P
ISO
MmuMGI:104683

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAPB1A10.04c
(O60052)		 YKL019W
(S000001502)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAPB1A10.04c
GO:0005953 CAAX-protein geranylgeranyltransferase
complex		 C
IDA
SceS000001502
NAS
SpoSPAPB1A10.04c
GO:0005965 protein farnesyltransferase complex C
IDA
SceS000001502
GO:0004660 protein farnesyltransferase activity F
IDA
SceS000001502
GO:0004661 protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
SpoSPAPB1A10.04c
GO:0004662 CAAX-protein geranylgeranyltransferase
activity		 F
IDA
SceS000001502
GO:0004663 Rab geranylgeranyltransferase activity F
ISS
SpoSPAPB1A10.04c
GO:0005515 protein binding F
IPI
SpoSPAPB1A10.04c
GO:0006075 1,3-beta-glucan biosynthetic process P
IPI
SpoSPAPB1A10.04c
GO:0007323 peptide pheromone maturation P
IDA
SceS000001502
GO:0018347 protein amino acid farnesylation P
IDA
SceS000001502
GO:0018348 protein amino acid geranylgeranylation P
IC
SpoSPAPB1A10.04c
IDA
SceS000001502

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Query species:

Include wild-cards:   

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GO info in one table:

s.khadayate@ucl.ac.uk