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Search term: YKL054C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DEF1
SGD link S000001537
Alternative ID YKL054C
Description RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
Synonyms YKL054C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68809

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) DEF1
(S000001537)		 GI:6322796
Kluyveromyces lactis (Kla) KLLA0C12672g GI:50305607
Eremothecium gossypii (Ego) AGOS_ABR077C GI:45185306


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IMP
SceS000001537
GO:0003674 molecular_function F
ND
SceS000001537
GO:0000723 telomere maintenance P
IMP
SceS000001537
GO:0006283 transcription-coupled nucleotide-excision
repair		 P
IGI
SceS000001537
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000001537
IMP
SceS000001537
GO:0006974 response to DNA damage stimulus P
IMP
SceS000001537

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2402

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3061 ENSANGP00000020719
Ashbya gossypii (Ago) ago4249 AGL062C
Caenorhabditis elegans (Cel) cel14541 T05A10.1a
(CE36395;
WBGene00004862)
Caenorhabditis elegans (Cel) cel14542 T05A10.1b
(CE36396)
Caenorhabditis elegans (Cel) cel14543 T05A10.1c
(CE36397)
Caenorhabditis elegans (Cel) cel14544 T05A10.1d
(CE36398)
Caenorhabditis elegans (Cel) cel14545 T05A10.1e
(CE36399)
Caenorhabditis elegans (Cel) cel14546 T05A10.1f
(CE36400)
Caenorhabditis elegans (Cel) cel14547 T05A10.1g
(CE36401)
Caenorhabditis elegans (Cel) cel14549 T05A10.1i
(CE36403)
Caenorhabditis elegans (Cel) cel14550 T05A10.1j
(CE36404)
Cryptococcus neoformans (Cne) cne4605 186.m03446
Drosophila melanogaster (Dme) dme4424 CG7734-PA
(FBgn0003396)
Drosophila melanogaster (Dme) dme4425 CG7734-PB
(FBgn0003396)
Drosophila melanogaster (Dme) dme4426 CG7734-PC
(FBgn0003396)
Drosophila melanogaster (Dme) dme4423 CG7734-PD
(FBgn0003396)
Danio rerio (Dre) dre2319 ENSDARP00000004950
Danio rerio (Dre) dre27547 ENSDARP00000025141
Takifugu rubripes (Fru) fru11870 SINFRUP00000175194
Gallus gallus (Gga) gga12773 ENSGALP00000000901
Gallus gallus (Gga) gga7443 ENSGALP00000010366
Mus musculus (Mmu) mmu17085 ENSMUSP00000044998
(MGI:1099055)		 P97347
Mus musculus (Mmu) mmu30128 ENSMUSP00000054987
Neurospora crassa (Ncr) ncr7659 NCU07863.2
Oryza sativa (Osa) osa68166 6902.m00132
Oryza sativa (Osa) osa68951 7030.m00155
Rattus norvegicus (Rno) rno16541 ENSRNOP00000025249
(RGD:1311687)
Saccharomyces cerevisiae (Sce) sce3719 YKL054C
(S000001537)
Yarrowia lipolytica (Yli) yli5480 YALI0F03366g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001533 cornified envelope C
IDA
MmuMGI:1099055
GO:0005634 nucleus C
IDA
CelWBGene00004862
IMP
SceS000001537
NAS
DmeFBgn0003396
GO:0003674 molecular_function F
ND
SceS000001537
GO:0003700 transcription factor activity F
ISS
DmeFBgn0003396
NAS
DmeFBgn0003396
GO:0003702 RNA polymerase II transcription factor
activity		 F
IMP
DmeFBgn0003396
NAS
DmeFBgn0003396
GO:0016563 transcription activator activity F
IMP
CelWBGene00004862
GO:0016564 transcription repressor activity F
IMP
CelWBGene00004862
GO:0000122 negative regulation of transcription from RNA
polymerase II promoter		 P
NAS
DmeFBgn0003396
GO:0000723 telomere maintenance P
IMP
SceS000001537
GO:0001745 compound eye morphogenesis P
NAS
DmeFBgn0003396
GO:0006283 transcription-coupled nucleotide-excision
repair		 P
IGI
SceS000001537
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000001537
IMP
SceS000001537
GO:0006974 response to DNA damage stimulus P
IMP
SceS000001537
GO:0007179 transforming growth factor beta receptor signaling
pathway		 P
IGI
CelWBGene00004862
NAS
DmeFBgn0003396
TAS
DmeFBgn0003396
GO:0007391 dorsal closure P
TAS
DmeFBgn0003396
GO:0007398 ectoderm development P
IMP
DmeFBgn0003396
GO:0007422 peripheral nervous system development P
NAS
DmeFBgn0003396
GO:0007476 imaginal disc-derived wing morphogenesis P
IGI
DmeFBgn0003396
IMP
DmeFBgn0003396
GO:0007494 midgut development P
IMP
DmeFBgn0003396
GO:0007611 learning or memory P
IMP
DmeFBgn0003396
GO:0008283 cell proliferation P
IMP
DmeFBgn0003396
GO:0008285 negative regulation of cell proliferation P
NAS
DmeFBgn0003396
GO:0008355 olfactory learning P
IMP
DmeFBgn0003396
GO:0008586 imaginal disc-derived wing vein
morphogenesis		 P
IMP
DmeFBgn0003396
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00004862
GO:0045138 tail tip morphogenesis P
IMP
CelWBGene00004862
GO:0045705 negative regulation of salivary gland boundary
specification		 P
TAS
DmeFBgn0003396
GO:0048100 wing disc anterior/posterior pattern
formation		 P
IMP
DmeFBgn0003396
GO:0048190 wing disc dorsal/ventral pattern
formation		 P
IGI
DmeFBgn0003396

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC354.10
(O43024)		 YKL054C
(S000001537)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IMP
SceS000001537
ISS
SpoSPBC354.10
GO:0005829 cytosol C
IDA
SpoSPBC354.10
GO:0003674 molecular_function F
ND
SceS000001537
SpoSPBC354.10
GO:0000723 telomere maintenance P
IMP
SceS000001537
ISS
SpoSPBC354.10
GO:0006283 transcription-coupled nucleotide-excision
repair		 P
IGI
SceS000001537
ISS
SpoSPBC354.10
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000001537
IMP
SceS000001537
ISS
SpoSPBC354.10
GO:0006974 response to DNA damage stimulus P
IMP
SceS000001537
ISS
SpoSPBC354.10

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s.khadayate@ucl.ac.uk