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Search term: YKL080W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VMA5
SGD link S000001563
Alternative ID YKL080W
Description Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
Synonyms YKL080W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2909 ACDHYPE

KOGs classification KOGs description
METABOLISM Vacuolar H+-ATPase V1 sector, subunit C

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g12840 GI:15222083
Caenorhabditis elegans (Cel) CE27612 GI:17543172
Drosophila melanogaster (Dme) 7302940
(FBgn0020611)		 GI:17137392 B7YZI0
Drosophila melanogaster (Dme) 7302941 GI:7302941 B7YZI0
Drosophila melanogaster (Dme) 7302942 GI:7302942
Homo sapiens (Hsa) Hs21389365 GI:15082451 Q8NEY4
Homo sapiens (Hsa) Hs4502315
(ATP6V1C1)		 GI:4502315 P21283
Saccharomyces cerevisiae (Sce) YKL080w
(S000001563)		 GI:6322770 P31412
Schizosaccharomyces pombe (Spo) SPAPB2B4.05 GI:19114803 Q9HDW6
Encephalitozoon cuniculi (Ecu) ECU03g0500 GI:19173010 Q8SSB2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
AthAt1g12840
ISS
DmeFBgn0020611
SpoSPAPB2B4.05
NAS
DmeFBgn0020611
TAS
SceS000001563
GO:0000325 plant-type vacuole C
IDA
AthAt1g12840
GO:0000329 fungal-type vacuole membrane C
TAS
SceS000001563
GO:0005773 vacuole C
IDA
AthAt1g12840
GO:0005774 vacuolar membrane C
IDA
AthAt1g12840
GO:0005829 cytosol C
IDA
SpoSPAPB2B4.05
GO:0005886 plasma membrane C
IDA
AthAt1g12840
DmeFBgn0020611
ISS
HsaATP6V1C1
GO:0009507 chloroplast C
IDA
AthAt1g12840
GO:0016469 proton-transporting two-sector ATPase
complex		 C
TAS
HsaATP6V1C1
GO:0005215 transporter activity F
NAS
HsaATP6V1C1
GO:0005515 protein binding F
IPI
HsaATP6V1C1
GO:0005524 ATP binding F
IC
SpoSPAPB2B4.05
GO:0008553 hydrogen-exporting ATPase activity,
phosphorylative mechanism		 F
ISS
DmeFBgn0020611
NAS
DmeFBgn0020611
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IGI
AthAt1g12840
ISS
SpoSPAPB2B4.05
TAS
HsaATP6V1C1
SceS000001563
GO:0006811 ion transport P
RCA
SceS000001563
GO:0007035 vacuolar acidification P
ISS
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0007557 regulation of juvenile hormone biosynthetic
process		 P
TAS
DmeFBgn0020611
GO:0009117 nucleotide metabolic process P
RCA
SceS000001563
GO:0009809 lignin biosynthetic process P
IGI
AthAt1g12840
GO:0009826 unidimensional cell growth P
IMP
AthAt1g12840
GO:0015991 ATP hydrolysis coupled proton transport P
IC
SpoSPAPB2B4.05
GO:0015992 proton transport P
ISS
DmeFBgn0020611
GO:0043255 regulation of carbohydrate biosynthetic
process		 P
IGI
AthAt1g12840
GO:0050801 ion homeostasis P
RCA
SceS000001563

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1281

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ATP6V1C1 GI:4502315 P21283
Pan troglodytes (Ptr) ATP6V1C1 GI:114621193
Canis familiaris (Cfa) ATP6V1C1 GI:73974248
Mus musculus (Mmu) Atp6v1c1
(MGI:1913585)		 GI:13384916 Q3TG21
Rattus norvegicus (Rno) Atp6v1c1
(RGD:1311082)		 GI:58865560
Gallus gallus (Gga) ATP6V1C1 GI:50731811
Drosophila melanogaster (Dme) Vha44
(FBgn0020611)		 GI:17137392 B7YZI0
Anopheles gambiae (Aga) AgaP_AGAP005845 GI:158294869
Schizosaccharomyces pombe (Spo) vma5
(SPAPB2B4.05)		 GI:19114803 Q9HDW6
Saccharomyces cerevisiae (Sce) VMA5
(S000001563)		 GI:6322770 P31412
Kluyveromyces lactis (Kla) KLLA0F26114g GI:50312419
Magnaporthe grisea (Mgr) MGG_06349 GI:145608820
Neurospora crassa (Ncr) NCU09897.1 GI:32418334
Arabidopsis thaliana (Ath) DET3 GI:18391442
Oryza sativa (Osa) Os05g0593100 GI:115465801
Plasmodium falciparum (Pfa) MAL1P1.52 GI:124505757


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
AthDET3
ISS
DmeFBgn0020611
SpoSPAPB2B4.05
NAS
DmeFBgn0020611
TAS
SceS000001563
GO:0000325 plant-type vacuole C
IDA
AthDET3
GO:0000329 fungal-type vacuole membrane C
TAS
SceS000001563
GO:0005737 cytoplasm C
ISO
MmuMGI:1913585
GO:0005773 vacuole C
IDA
AthDET3
GO:0005774 vacuolar membrane C
IDA
AthDET3
GO:0005829 cytosol C
IDA
SpoSPAPB2B4.05
GO:0005886 plasma membrane C
IDA
AthDET3
DmeFBgn0020611
MmuMGI:1913585
ISS
HsaATP6V1C1
GO:0009507 chloroplast C
IDA
AthDET3
GO:0016469 proton-transporting two-sector ATPase
complex		 C
TAS
HsaATP6V1C1
GO:0031410 cytoplasmic vesicle C
ISO
MmuMGI:1913585
GO:0045177 apical part of cell C
ISO
MmuMGI:1913585
GO:0005215 transporter activity F
NAS
HsaATP6V1C1
GO:0005515 protein binding F
IPI
HsaATP6V1C1
MmuMGI:1913585
GO:0005524 ATP binding F
IC
SpoSPAPB2B4.05
GO:0008553 hydrogen-exporting ATPase activity,
phosphorylative mechanism		 F
IDA
MmuMGI:1913585
ISS
DmeFBgn0020611
NAS
DmeFBgn0020611
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IGI
AthDET3
ISS
SpoSPAPB2B4.05
TAS
HsaATP6V1C1
SceS000001563
GO:0006200 ATP catabolic process P
IDA
MmuMGI:1913585
GO:0006811 ion transport P
RCA
SceS000001563
GO:0007035 vacuolar acidification P
ISS
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0007557 regulation of juvenile hormone biosynthetic
process		 P
TAS
DmeFBgn0020611
GO:0009117 nucleotide metabolic process P
RCA
SceS000001563
GO:0009809 lignin biosynthetic process P
IGI
AthDET3
GO:0009826 unidimensional cell growth P
IMP
AthDET3
GO:0015991 ATP hydrolysis coupled proton transport P
IC
SpoSPAPB2B4.05
GO:0015992 proton transport P
IDA
MmuMGI:1913585
ISS
DmeFBgn0020611
GO:0034220 ion transmembrane transport P
IDA
MmuMGI:1913585
GO:0043255 regulation of carbohydrate biosynthetic
process		 P
IGI
AthDET3
GO:0050801 ion homeostasis P
RCA
SceS000001563

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1117

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1287 ENSANGP00000017401
Anopheles gambiae (Aga) aga1288 ENSANGP00000027104
Ashbya gossypii (Ago) ago1887 ADR146C
Arabidopsis thaliana (Ath) ath1350 At1g12840.1
Caenorhabditis elegans (Cel) cel18375 Y38F2AL.3a
(CE29997;
WBGene00006920)
Candida glabrata (Cgl) cgl4301 CAGL0L05126g
Cryptococcus neoformans (Cne) cne5762 179.m00637
Dictyostelium discoideum (Ddi) ddi12918 DDB0191419
Debaryomyces hansenii (Dha) dha1172 DEHA0B11418g
Drosophila melanogaster (Dme) dme5426 CG8048-PA
(FBgn0020611)
Drosophila melanogaster (Dme) dme5427 CG8048-PB
(FBgn0020611)
Drosophila melanogaster (Dme) dme5428 CG8048-PC
(FBgn0020611)
Drosophila melanogaster (Dme) dme5429 CG8048-PD
(FBgn0020611)
Danio rerio (Dre) dre10468 ENSDARP00000011661
Danio rerio (Dre) dre10460 ENSDARP00000036884
(atp6v1c1)		 Q7T385
Encephalitozoon cuniculi (Ecu) ecu417 19173010
Takifugu rubripes (Fru) fru9384 SINFRUP00000147913
Takifugu rubripes (Fru) fru30792 SINFRUP00000163269
Gallus gallus (Gga) gga11406 ENSGALP00000025836
(ATP6V1C1)
Gallus gallus (Gga) gga15976 ENSGALP00000026483
(ATP6V1C2)
Gallus gallus (Gga) gga15977 ENSGALP00000026484
Gallus gallus (Gga) gga15978 ENSGALP00000026485
Gallus gallus (Gga) gga15975 ENSGALP00000026486
Gallus gallus (Gga) gga25631 ENSGALP00000028247
(LOC425509)
Homo sapiens (Hsa) hsa17467 ENSP00000272238
(ATP6V1C2)		 Q8NEY4-1
Homo sapiens (Hsa) hsa30605 ENSP00000285415
(ATP6V1C1)		 A8MQ60
Kluyveromyces lactis (Kla) kla5243 KLLA0F26114g
Mus musculus (Mmu) mmu5506 ENSMUSP00000020884
(MGI:1916025)		 Q99L60-2
Mus musculus (Mmu) mmu8914 ENSMUSP00000022904
(MGI:1913585)		 Q9Z1G3
Neurospora crassa (Ncr) ncr9641 NCU09897.2
Oryza sativa (Osa) osa48287 5813.m00148
Plasmodium falciparum (Pfa) pfa2570 PFA0300c
Rattus norvegicus (Rno) rno26987 ENSRNOP00000006917
(RGD:1311082)		 Q5FVI6
Saccharomyces cerevisiae (Sce) sce3746 YKL080W
(S000001563)
Schizosaccharomyces pombe (Spo) spo724 SPAPB2B4.05 Q9HDW6
Yarrowia lipolytica (Yli) yli378 YALI0A11143g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
IDA
AthAt1g12840
ISS
DmeFBgn0020611
SpoSPAPB2B4.05
NAS
DmeFBgn0020611
TAS
SceS000001563
GO:0000325 plant-type vacuole C
IDA
AthAt1g12840
GO:0000329 fungal-type vacuole membrane C
TAS
SceS000001563
GO:0005575 cellular_component C
ND
MmuMGI:1916025
GO:0005737 cytoplasm C
ISO
MmuMGI:1913585
GO:0005753 mitochondrial proton-transporting ATP synthase
complex		 C
ISS
PfaPFA0300c
GO:0005773 vacuole C
IDA
AthAt1g12840
GO:0005774 vacuolar membrane C
IDA
AthAt1g12840
GO:0005829 cytosol C
IDA
SpoSPAPB2B4.05
GO:0005886 plasma membrane C
IDA
AthAt1g12840
DmeFBgn0020611
MmuMGI:1913585
GO:0009507 chloroplast C
IDA
AthAt1g12840
GO:0031410 cytoplasmic vesicle C
ISO
MmuMGI:1913585
GO:0043229 intracellular organelle C
IDA
CelWBGene00006920
GO:0045177 apical part of cell C
ISO
MmuMGI:1913585
GO:0005515 protein binding F
IPI
MmuMGI:1913585
MGI:1916025
GO:0005524 ATP binding F
IC
SpoSPAPB2B4.05
GO:0008553 hydrogen-exporting ATPase activity,
phosphorylative mechanism		 F
IDA
MmuMGI:1913585
MGI:1916025
ISS
DmeFBgn0020611
NAS
DmeFBgn0020611
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
IGI
AthAt1g12840
ISS
PfaPFA0300c
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0000003 reproduction P
IMP
CelWBGene00006920
GO:0002119 nematode larval development P
IMP
CelWBGene00006920
GO:0006200 ATP catabolic process P
IDA
MmuMGI:1913585
MGI:1916025
GO:0006811 ion transport P
RCA
SceS000001563
GO:0007035 vacuolar acidification P
ISS
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0007557 regulation of juvenile hormone biosynthetic
process		 P
TAS
DmeFBgn0020611
GO:0009117 nucleotide metabolic process P
RCA
SceS000001563
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006920
GO:0009809 lignin biosynthetic process P
IGI
AthAt1g12840
GO:0009826 unidimensional cell growth P
IMP
AthAt1g12840
GO:0015991 ATP hydrolysis coupled proton transport P
IC
SpoSPAPB2B4.05
GO:0015992 proton transport P
IDA
MmuMGI:1913585
MGI:1916025
ISS
DmeFBgn0020611
GO:0016246 RNA interference P
IMP
CelWBGene00006920
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00006920
GO:0034220 ion transmembrane transport P
IDA
MmuMGI:1913585
MGI:1916025
GO:0040007 growth P
IMP
CelWBGene00006920
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00006920
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00006920
GO:0043255 regulation of carbohydrate biosynthetic
process		 P
IGI
AthAt1g12840
GO:0050801 ion homeostasis P
RCA
SceS000001563

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAPB2B4.05
(Q9HDW6)		 YKL080W
(S000001563)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000221 vacuolar proton-transporting V-type ATPase, V1
domain		 C
ISS
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0000329 fungal-type vacuole membrane C
TAS
SceS000001563
GO:0005829 cytosol C
IDA
SpoSPAPB2B4.05
GO:0005524 ATP binding F
IC
SpoSPAPB2B4.05
GO:0046961 proton-transporting ATPase activity, rotational
mechanism		 F
ISS
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0006811 ion transport P
RCA
SceS000001563
GO:0007035 vacuolar acidification P
ISS
SpoSPAPB2B4.05
TAS
SceS000001563
GO:0009117 nucleotide metabolic process P
RCA
SceS000001563
GO:0015991 ATP hydrolysis coupled proton transport P
IC
SpoSPAPB2B4.05
GO:0050801 ion homeostasis P
RCA
SceS000001563

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s.khadayate@ucl.ac.uk