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Search term: YKL085W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MDH1
SGD link S000001568
Alternative ID YKL085W
Description Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
Synonyms YKL085W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1494 ACDHYP-

KOGs classification KOGs description
METABOLISM NAD-dependent malate dehydrogenase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g53240 GI:7769871
Arabidopsis thaliana (Ath) At2g22780 GI:15227752
Arabidopsis thaliana (Ath) At3g15020 GI:15232468
Arabidopsis thaliana (Ath) At3g47520 GI:15232820
Arabidopsis thaliana (Ath) At3g53910 GI:15232361
Arabidopsis thaliana (Ath) At5g09660 GI:15242466
Caenorhabditis elegans (Cel) CE09512
(WBGene00003162)		 GI:17554310 O02640
Drosophila melanogaster (Dme) 7294520 GI:7294520
Drosophila melanogaster (Dme) 7294521 GI:7294521 Q9VU28
Drosophila melanogaster (Dme) 7300357 GI:7300357
Homo sapiens (Hsa) Hs21735621
(MDH2)		 GI:21735621 P40926
Homo sapiens (Hsa) HsM5174541 GI:5174541
Saccharomyces cerevisiae (Sce) YDL078c
(S000002236)		 GI:6320125 P32419
Saccharomyces cerevisiae (Sce) YKL085w
(S000001568)		 GI:6322765 P17505
Saccharomyces cerevisiae (Sce) YOL126c
(S000005486)		 GI:6324446
Schizosaccharomyces pombe (Spo) SPCC306.08c GI:19075316 Q9Y7R8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt1g53240
GO:0005737 cytoplasm C
IDA
SceS000005486
GO:0005739 mitochondrion C
IDA
AthAt3g47520
At3g15020
At1g53240
HsaMDH2
SceS000001568
SpoSPCC306.08c
IMP
SceS000001568
IPI
SceS000001568
ISS
CelWBGene00003162
GO:0005759 mitochondrial matrix C
EXP
HsaMDH2
IDA
SceS000001568
ISS
SpoSPCC306.08c
GO:0005773 vacuole C
IDA
AthAt5g09660
GO:0005777 peroxisome C
IDA
AthAt5g09660
At2g22780
SceS000002236
GO:0005782 peroxisomal matrix C
TAS
SceS000002236
GO:0005829 cytosol C
IDA
SceS000005486
GO:0005886 plasma membrane C
IDA
AthAt3g47520
GO:0009507 chloroplast C
IDA
AthAt5g09660
At2g22780
At3g47520
At1g53240
GO:0009570 chloroplast stroma C
IDA
AthAt3g47520
GO:0009941 chloroplast envelope C
IDA
AthAt3g47520
At5g09660
GO:0010319 stromule C
IDA
AthAt3g47520
GO:0016020 membrane C
IDA
AthAt3g47520
At3g15020
GO:0042579 microbody C
ISS
AthAt5g09660
GO:0048046 apoplast C
IDA
AthAt3g47520
At5g09660
At3g15020
GO:0005507 copper ion binding F
IDA
AthAt3g15020
At1g53240
GO:0016615 malate dehydrogenase activity F
IDA
AthAt1g53240
ISS
AthAt5g09660
At2g22780
At3g47520
At3g15020
GO:0030060 L-malate dehydrogenase activity F
EXP
HsaMDH2
IDA
HsaMDH2
SceS000005486
S000001568
IMP
HsaMDH2
SceS000002236
S000001568
S000005486
ISS
CelWBGene00003162
SpoSPCC306.08c
TAS
SceS000002236
GO:0001300 chronological cell aging P
IMP
SceS000001568
GO:0001302 replicative cell aging P
IMP
SceS000001568
GO:0006094 gluconeogenesis P
IEP
SceS000005486
IMP
SceS000005486
GO:0006097 glyoxylate cycle P
TAS
SceS000002236
GO:0006099 tricarboxylic acid cycle P
IMP
SceS000001568
ISS
SpoSPCC306.08c
GO:0006108 malate metabolic process P
IDA
HsaMDH2
IMP
HsaMDH2
ISS
CelWBGene00003162
SpoSPCC306.08c
TAS
SceS000002236
S000005486
GO:0006635 fatty acid beta-oxidation P
TAS
SceS000002236
GO:0006735 NADH regeneration P
TAS
SceS000002236
GO:0006793 phosphorus metabolic process P
RCA
SceS000001568
GO:0006811 ion transport P
RCA
SceS000001568
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003162
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003162
GO:0009060 aerobic respiration P
IMP
SceS000001568
GO:0009117 nucleotide metabolic process P
RCA
SceS000001568
GO:0009409 response to cold P
IEP
AthAt1g53240
At3g47520
GO:0009651 response to salt stress P
IEP
AthAt1g53240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003162
GO:0016558 protein import into peroxisome
matrix		 P
IMP
SceS000005486
GO:0031998 regulation of fatty acid beta-oxidation P
IGI
AthAt2g22780
At5g09660
IMP
AthAt5g09660
At2g22780
GO:0033554 cellular response to stress P
IEP
SpoSPCC306.08c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003162
GO:0042742 defense response to bacterium P
IEP
AthAt1g53240
At3g15020
GO:0046686 response to cadmium ion P
IEP
AthAt1g53240
GO:0051186 cofactor metabolic process P
RCA
SceS000001568
GO:0055114 oxidation reduction P
RCA
SceS000001568
GO:0080093 regulation of photorespiration P
IMP
AthAt2g22780
At5g09660

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55938

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MDH2 GI:21735621 P40926
Pan troglodytes (Ptr) MDH2 GI:114614114
Canis familiaris (Cfa) MDH2 GI:73957776
Mus musculus (Mmu) Mdh2
(MGI:97050)		 GI:31982186 P08249
Rattus norvegicus (Rno) Mdh2 GI:42476181
Gallus gallus (Gga) MDH2 GI:50758110
Drosophila melanogaster (Dme) CG7998
(FBgn0038587)		 GI:24647881
Anopheles gambiae (Aga) AgaP_AGAP001903 GI:158301478
Caenorhabditis elegans (Cel) mdh-1
(CE09512;
WBGene00003162)		 GI:17554310 O02640
Schizosaccharomyces pombe (Spo) SPCC306.08c GI:19075316 Q9Y7R8
Saccharomyces cerevisiae (Sce) MDH1
(S000001568)		 GI:6322765 P17505
Kluyveromyces lactis (Kla) KLLA0F25960g GI:50312405
Magnaporthe grisea (Mgr) MGG_09367 GI:39960255
Neurospora crassa (Ncr) NCU04899.1 GI:32407475
Arabidopsis thaliana (Ath) AT1G53240 GI:18404382
Arabidopsis thaliana (Ath) AT3G15020 GI:15232468
Oryza sativa (Osa) Os01g0649100 GI:115438875
Oryza sativa (Osa) Os05g0574400 GI:115465579


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt1g53240
GO:0005739 mitochondrion C
IDA
AthAt3g15020
At1g53240
HsaMDH2
MmuMGI:97050
SceS000001568
SpoSPCC306.08c
IMP
SceS000001568
IPI
SceS000001568
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
CelWBGene00003162
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:97050
GO:0005759 mitochondrial matrix C
EXP
HsaMDH2
IDA
SceS000001568
ISO
MmuMGI:97050
ISS
DmeFBgn0038587
SpoSPCC306.08c
GO:0005811 lipid particle C
IDA
DmeFBgn0038587
GO:0009507 chloroplast C
IDA
AthAt1g53240
GO:0016020 membrane C
IDA
AthAt3g15020
GO:0048046 apoplast C
IDA
AthAt3g15020
GO:0005507 copper ion binding F
IDA
AthAt3g15020
At1g53240
GO:0016615 malate dehydrogenase activity F
IDA
AthAt1g53240
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
AthAt3g15020
GO:0030060 L-malate dehydrogenase activity F
EXP
HsaMDH2
IDA
HsaMDH2
MmuMGI:97050
SceS000001568
IMP
HsaMDH2
SceS000001568
ISO
MmuMGI:97050
ISS
CelWBGene00003162
DmeFBgn0038587
SpoSPCC306.08c
GO:0043621 protein self-association F
ISO
MmuMGI:97050
GO:0046554 malate dehydrogenase (NADP+) activity F
ISO
MmuMGI:97050
GO:0001300 chronological cell aging P
IMP
SceS000001568
GO:0001302 replicative cell aging P
IMP
SceS000001568
GO:0006099 tricarboxylic acid cycle P
IMP
SceS000001568
ISO
MmuMGI:97050
ISS
DmeFBgn0038587
SpoSPCC306.08c
GO:0006107 oxaloacetate metabolic process P
ISO
MmuMGI:97050
GO:0006108 malate metabolic process P
IDA
HsaMDH2
IMP
HsaMDH2
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
CelWBGene00003162
SpoSPCC306.08c
GO:0006734 NADH metabolic process P
ISO
MmuMGI:97050
GO:0006793 phosphorus metabolic process P
RCA
SceS000001568
GO:0006811 ion transport P
RCA
SceS000001568
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003162
GO:0008152 metabolic process P
IDA
MmuMGI:97050
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003162
GO:0009060 aerobic respiration P
IMP
SceS000001568
GO:0009117 nucleotide metabolic process P
RCA
SceS000001568
GO:0009409 response to cold P
IEP
AthAt1g53240
GO:0009651 response to salt stress P
IEP
AthAt1g53240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003162
GO:0033554 cellular response to stress P
IEP
SpoSPCC306.08c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003162
GO:0042742 defense response to bacterium P
IEP
AthAt1g53240
At3g15020
GO:0046686 response to cadmium ion P
IEP
AthAt1g53240
GO:0051186 cofactor metabolic process P
RCA
SceS000001568
GO:0055114 oxidation reduction P
RCA
SceS000001568

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