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Search term: YKL085W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MDH1
SGD link S000001568
Alternative ID YKL085W
Description Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
Synonyms YKL085W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1494 ACDHYP-

KOGs classification KOGs description
METABOLISM NAD-dependent malate dehydrogenase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g53240 GI:7769871
Arabidopsis thaliana (Ath) At2g22780 GI:15227752
Arabidopsis thaliana (Ath) At3g15020 GI:15232468
Arabidopsis thaliana (Ath) At3g47520 GI:15232820
Arabidopsis thaliana (Ath) At3g53910 GI:15232361
Arabidopsis thaliana (Ath) At5g09660 GI:15242466
Caenorhabditis elegans (Cel) CE09512
(WBGene00003162)		 GI:17554310 O02640
Drosophila melanogaster (Dme) 7294520 GI:7294520
Drosophila melanogaster (Dme) 7294521 GI:7294521 Q9VU28
Drosophila melanogaster (Dme) 7300357 GI:7300357
Homo sapiens (Hsa) Hs21735621
(MDH2)		 GI:21735621 P40926
Homo sapiens (Hsa) HsM5174541 GI:5174541
Saccharomyces cerevisiae (Sce) YDL078c
(S000002236)		 GI:6320125 P32419
Saccharomyces cerevisiae (Sce) YKL085w
(S000001568)		 GI:6322765 P17505
Saccharomyces cerevisiae (Sce) YOL126c
(S000005486)		 GI:6324446
Schizosaccharomyces pombe (Spo) SPCC306.08c GI:19075316 Q9Y7R8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt1g53240
GO:0005737 cytoplasm C
IDA
SceS000005486
GO:0005739 mitochondrion C
IDA
AthAt3g47520
At3g15020
At1g53240
HsaMDH2
SceS000001568
SpoSPCC306.08c
IMP
SceS000001568
IPI
SceS000001568
ISS
CelWBGene00003162
GO:0005759 mitochondrial matrix C
EXP
HsaMDH2
IDA
SceS000001568
ISS
SpoSPCC306.08c
GO:0005773 vacuole C
IDA
AthAt5g09660
GO:0005777 peroxisome C
IDA
AthAt5g09660
At2g22780
SceS000002236
GO:0005782 peroxisomal matrix C
TAS
SceS000002236
GO:0005829 cytosol C
IDA
SceS000005486
GO:0005886 plasma membrane C
IDA
AthAt3g47520
GO:0009507 chloroplast C
IDA
AthAt5g09660
At2g22780
At3g47520
At1g53240
GO:0009570 chloroplast stroma C
IDA
AthAt3g47520
GO:0009941 chloroplast envelope C
IDA
AthAt3g47520
At5g09660
GO:0010319 stromule C
IDA
AthAt3g47520
GO:0016020 membrane C
IDA
AthAt3g47520
At3g15020
GO:0042579 microbody C
ISS
AthAt5g09660
GO:0048046 apoplast C
IDA
AthAt3g47520
At5g09660
At3g15020
GO:0005507 copper ion binding F
IDA
AthAt3g15020
At1g53240
GO:0016615 malate dehydrogenase activity F
IDA
AthAt1g53240
ISS
AthAt5g09660
At2g22780
At3g47520
At3g15020
GO:0030060 L-malate dehydrogenase activity F
EXP
HsaMDH2
IDA
HsaMDH2
SceS000005486
S000001568
IMP
HsaMDH2
SceS000002236
S000001568
S000005486
ISS
CelWBGene00003162
SpoSPCC306.08c
TAS
SceS000002236
GO:0001300 chronological cell aging P
IMP
SceS000001568
GO:0001302 replicative cell aging P
IMP
SceS000001568
GO:0006094 gluconeogenesis P
IEP
SceS000005486
IMP
SceS000005486
GO:0006097 glyoxylate cycle P
TAS
SceS000002236
GO:0006099 tricarboxylic acid cycle P
IMP
SceS000001568
ISS
SpoSPCC306.08c
GO:0006108 malate metabolic process P
IDA
HsaMDH2
IMP
HsaMDH2
ISS
CelWBGene00003162
SpoSPCC306.08c
TAS
SceS000002236
S000005486
GO:0006635 fatty acid beta-oxidation P
TAS
SceS000002236
GO:0006735 NADH regeneration P
TAS
SceS000002236
GO:0006793 phosphorus metabolic process P
RCA
SceS000001568
GO:0006811 ion transport P
RCA
SceS000001568
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003162
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003162
GO:0009060 aerobic respiration P
IMP
SceS000001568
GO:0009117 nucleotide metabolic process P
RCA
SceS000001568
GO:0009409 response to cold P
IEP
AthAt1g53240
At3g47520
GO:0009651 response to salt stress P
IEP
AthAt1g53240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003162
GO:0016558 protein import into peroxisome
matrix		 P
IMP
SceS000005486
GO:0031998 regulation of fatty acid beta-oxidation P
IGI
AthAt2g22780
At5g09660
IMP
AthAt5g09660
At2g22780
GO:0033554 cellular response to stress P
IEP
SpoSPCC306.08c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003162
GO:0042742 defense response to bacterium P
IEP
AthAt1g53240
At3g15020
GO:0046686 response to cadmium ion P
IEP
AthAt1g53240
GO:0051186 cofactor metabolic process P
RCA
SceS000001568
GO:0055114 oxidation reduction P
RCA
SceS000001568
GO:0080093 regulation of photorespiration P
IMP
AthAt2g22780
At5g09660

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55938

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MDH2 GI:21735621 P40926
Pan troglodytes (Ptr) MDH2 GI:114614114
Canis familiaris (Cfa) MDH2 GI:73957776
Mus musculus (Mmu) Mdh2
(MGI:97050)		 GI:31982186 P08249
Rattus norvegicus (Rno) Mdh2 GI:42476181
Gallus gallus (Gga) MDH2 GI:50758110
Drosophila melanogaster (Dme) CG7998
(FBgn0038587)		 GI:24647881
Anopheles gambiae (Aga) AgaP_AGAP001903 GI:158301478
Caenorhabditis elegans (Cel) mdh-1
(CE09512;
WBGene00003162)		 GI:17554310 O02640
Schizosaccharomyces pombe (Spo) SPCC306.08c GI:19075316 Q9Y7R8
Saccharomyces cerevisiae (Sce) MDH1
(S000001568)		 GI:6322765 P17505
Kluyveromyces lactis (Kla) KLLA0F25960g GI:50312405
Magnaporthe grisea (Mgr) MGG_09367 GI:39960255
Neurospora crassa (Ncr) NCU04899.1 GI:32407475
Arabidopsis thaliana (Ath) AT1G53240 GI:18404382
Arabidopsis thaliana (Ath) AT3G15020 GI:15232468
Oryza sativa (Osa) Os01g0649100 GI:115438875
Oryza sativa (Osa) Os05g0574400 GI:115465579


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt1g53240
GO:0005739 mitochondrion C
IDA
AthAt3g15020
At1g53240
HsaMDH2
MmuMGI:97050
SceS000001568
SpoSPCC306.08c
IMP
SceS000001568
IPI
SceS000001568
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
CelWBGene00003162
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:97050
GO:0005759 mitochondrial matrix C
EXP
HsaMDH2
IDA
SceS000001568
ISO
MmuMGI:97050
ISS
DmeFBgn0038587
SpoSPCC306.08c
GO:0005811 lipid particle C
IDA
DmeFBgn0038587
GO:0009507 chloroplast C
IDA
AthAt1g53240
GO:0016020 membrane C
IDA
AthAt3g15020
GO:0048046 apoplast C
IDA
AthAt3g15020
GO:0005507 copper ion binding F
IDA
AthAt3g15020
At1g53240
GO:0016615 malate dehydrogenase activity F
IDA
AthAt1g53240
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
AthAt3g15020
GO:0030060 L-malate dehydrogenase activity F
EXP
HsaMDH2
IDA
HsaMDH2
MmuMGI:97050
SceS000001568
IMP
HsaMDH2
SceS000001568
ISO
MmuMGI:97050
ISS
CelWBGene00003162
DmeFBgn0038587
SpoSPCC306.08c
GO:0043621 protein self-association F
ISO
MmuMGI:97050
GO:0046554 malate dehydrogenase (NADP+) activity F
ISO
MmuMGI:97050
GO:0001300 chronological cell aging P
IMP
SceS000001568
GO:0001302 replicative cell aging P
IMP
SceS000001568
GO:0006099 tricarboxylic acid cycle P
IMP
SceS000001568
ISO
MmuMGI:97050
ISS
DmeFBgn0038587
SpoSPCC306.08c
GO:0006107 oxaloacetate metabolic process P
ISO
MmuMGI:97050
GO:0006108 malate metabolic process P
IDA
HsaMDH2
IMP
HsaMDH2
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
CelWBGene00003162
SpoSPCC306.08c
GO:0006734 NADH metabolic process P
ISO
MmuMGI:97050
GO:0006793 phosphorus metabolic process P
RCA
SceS000001568
GO:0006811 ion transport P
RCA
SceS000001568
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003162
GO:0008152 metabolic process P
IDA
MmuMGI:97050
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003162
GO:0009060 aerobic respiration P
IMP
SceS000001568
GO:0009117 nucleotide metabolic process P
RCA
SceS000001568
GO:0009409 response to cold P
IEP
AthAt1g53240
GO:0009651 response to salt stress P
IEP
AthAt1g53240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003162
GO:0033554 cellular response to stress P
IEP
SpoSPCC306.08c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003162
GO:0042742 defense response to bacterium P
IEP
AthAt1g53240
At3g15020
GO:0046686 response to cadmium ion P
IEP
AthAt1g53240
GO:0051186 cofactor metabolic process P
RCA
SceS000001568
GO:0055114 oxidation reduction P
RCA
SceS000001568

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1632

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4003 ENSANGP00000020184
Ashbya gossypii (Ago) ago1893 ADR152C
Arabidopsis thaliana (Ath) ath4618 At1g53240.1
Arabidopsis thaliana (Ath) ath9176 At2g22780.1
Arabidopsis thaliana (Ath) ath13714 At3g15020.1
Arabidopsis thaliana (Ath) ath16040 At3g47520.1
Arabidopsis thaliana (Ath) ath23159 At5g09660.1
Caenorhabditis elegans (Cel) cel6862 F20H11.3
(CE09512;
WBGene00003162)
Candida glabrata (Cgl) cgl4306 CAGL0L05236g
Cryptococcus neoformans (Cne) cne4437 177.m03189
Debaryomyces hansenii (Dha) dha818 DEHA0B03047g
Drosophila melanogaster (Dme) dme13186 CG7998-PA
(FBgn0038587)
Danio rerio (Dre) dre2006 ENSDARP00000045721
Danio rerio (Dre) dre2008 ENSDARP00000048494
Escherichia coli (Eco) eco3127 16131126
Takifugu rubripes (Fru) fru4960 SINFRUP00000136061
Gallus gallus (Gga) gga8769 ENSGALP00000003012
(MDH2)
Homo sapiens (Hsa) hsa28839 ENSP00000327070
(MDH2)		 P40926
Kluyveromyces lactis (Kla) kla5236 KLLA0F25960g
Mus musculus (Mmu) mmu21075 ENSMUSP00000019323
(MGI:97050)		 P08249
Neurospora crassa (Ncr) ncr4759 NCU04899.2
Oryza sativa (Osa) osa10106 2720.m00059
Oryza sativa (Osa) osa12877 2849.m00174
Oryza sativa (Osa) osa15376 2990.m00151
Oryza sativa (Osa) osa17825 3321.m00193
Oryza sativa (Osa) osa17866 3321.m00263
Oryza sativa (Osa) osa28649 4205.m00149
Oryza sativa (Osa) osa31704 4437.m00146
Oryza sativa (Osa) osa39333 4989.m00098
Oryza sativa (Osa) osa53746 6035.m00152
Oryza sativa (Osa) osa62841 6682.m00131
Oryza sativa (Osa) osa67877 7006.m00083
Oryza sativa (Osa) osa67891 7006.m00118
Oryza sativa (Osa) osa67892 7006.m00119
Oryza sativa (Osa) osa72481 7224.m00138
Rattus norvegicus (Rno) rno8382 ENSRNOP00000001958
(RGD:619719)		 P04636
Saccharomyces cerevisiae (Sce) sce3751 YKL085W
(S000001568)
Schizosaccharomyces pombe (Spo) spo4753 SPCC306.08c Q9Y7R8
Yarrowia lipolytica (Yli) yli3396 YALI0D16753g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005618 cell wall C
IDA
AthAt1g53240
GO:0005739 mitochondrion C
IDA
AthAt3g47520
At3g15020
At1g53240
MmuMGI:97050
SceS000001568
SpoSPCC306.08c
IMP
SceS000001568
IPI
SceS000001568
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
CelWBGene00003162
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:97050
GO:0005759 mitochondrial matrix C
IDA
SceS000001568
ISO
MmuMGI:97050
ISS
DmeFBgn0038587
SpoSPCC306.08c
GO:0005773 vacuole C
IDA
AthAt5g09660
GO:0005777 peroxisome C
IDA
AthAt5g09660
At2g22780
GO:0005811 lipid particle C
IDA
DmeFBgn0038587
GO:0005886 plasma membrane C
IDA
AthAt3g47520
GO:0009507 chloroplast C
IDA
AthAt5g09660
At2g22780
At3g47520
At1g53240
GO:0009570 chloroplast stroma C
IDA
AthAt3g47520
GO:0009941 chloroplast envelope C
IDA
AthAt3g47520
At5g09660
GO:0010319 stromule C
IDA
AthAt3g47520
GO:0016020 membrane C
IDA
AthAt3g47520
At3g15020
GO:0042579 microbody C
ISS
AthAt5g09660
GO:0048046 apoplast C
IDA
AthAt3g47520
At5g09660
At3g15020
GO:0005507 copper ion binding F
IDA
AthAt3g15020
At1g53240
GO:0016615 malate dehydrogenase activity F
IDA
AthAt1g53240
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
AthAt5g09660
At2g22780
At3g47520
At3g15020
GO:0030060 L-malate dehydrogenase activity F
IDA
MmuMGI:97050
SceS000001568
IMP
SceS000001568
ISO
MmuMGI:97050
ISS
CelWBGene00003162
DmeFBgn0038587
SpoSPCC306.08c
GO:0043621 protein self-association F
ISO
MmuMGI:97050
GO:0046554 malate dehydrogenase (NADP+) activity F
ISO
MmuMGI:97050
GO:0001300 chronological cell aging P
IMP
SceS000001568
GO:0001302 replicative cell aging P
IMP
SceS000001568
GO:0006099 tricarboxylic acid cycle P
IMP
SceS000001568
ISO
MmuMGI:97050
ISS
DmeFBgn0038587
SpoSPCC306.08c
GO:0006107 oxaloacetate metabolic process P
ISO
MmuMGI:97050
GO:0006108 malate metabolic process P
ISA
MmuMGI:97050
ISO
MmuMGI:97050
ISS
CelWBGene00003162
SpoSPCC306.08c
GO:0006734 NADH metabolic process P
ISO
MmuMGI:97050
GO:0006793 phosphorus metabolic process P
RCA
SceS000001568
GO:0006811 ion transport P
RCA
SceS000001568
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00003162
GO:0008152 metabolic process P
IDA
MmuMGI:97050
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003162
GO:0009060 aerobic respiration P
IMP
SceS000001568
GO:0009117 nucleotide metabolic process P
RCA
SceS000001568
GO:0009409 response to cold P
IEP
AthAt1g53240
At3g47520
GO:0009651 response to salt stress P
IEP
AthAt1g53240
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003162
GO:0031998 regulation of fatty acid beta-oxidation P
IGI
AthAt2g22780
At5g09660
IMP
AthAt5g09660
At2g22780
GO:0033554 cellular response to stress P
IEP
SpoSPCC306.08c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003162
GO:0042742 defense response to bacterium P
IEP
AthAt1g53240
At3g15020
GO:0046686 response to cadmium ion P
IEP
AthAt1g53240
GO:0051186 cofactor metabolic process P
RCA
SceS000001568
GO:0055114 oxidation reduction P
RCA
SceS000001568
GO:0080093 regulation of photorespiration P
IMP
AthAt2g22780
At5g09660

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC306.08c
(Q9Y7R8)		 YKL085W
(S000001568)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000001568
SpoSPCC306.08c
IMP
SceS000001568
IPI
SceS000001568
GO:0005759 mitochondrial matrix C
IDA
SceS000001568
ISS
SpoSPCC306.08c
GO:0030060 L-malate dehydrogenase activity F
IDA
SceS000001568
IMP
SceS000001568
ISS
SpoSPCC306.08c
GO:0001300 chronological cell aging P
IMP
SceS000001568
GO:0001302 replicative cell aging P
IMP
SceS000001568
GO:0006099 tricarboxylic acid cycle P
IMP
SceS000001568
ISS
SpoSPCC306.08c
GO:0006108 malate metabolic process P
ISS
SpoSPCC306.08c
GO:0006793 phosphorus metabolic process P
RCA
SceS000001568
GO:0006811 ion transport P
RCA
SceS000001568
GO:0009060 aerobic respiration P
IMP
SceS000001568
GO:0009117 nucleotide metabolic process P
RCA
SceS000001568
GO:0033554 cellular response to stress P
IEP
SpoSPCC306.08c
GO:0051186 cofactor metabolic process P
RCA
SceS000001568
GO:0055114 oxidation reduction P
RCA
SceS000001568

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Query species:

Include wild-cards:   

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GO info in one table:

s.khadayate@ucl.ac.uk