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Search term: YKL104C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GFA1
SGD link S000001587
Alternative ID YKL104C
Description Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
Synonyms YKL104C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1268 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g24090 GI:15229578
Caenorhabditis elegans (Cel) CE03144
(WBGene00008546)		 GI:17532897 Q19130
Caenorhabditis elegans (Cel) CE03255
(WBGene00009035)		 GI:17539970 Q19699
Caenorhabditis elegans (Cel) CE27915 GI:17532899 Q19130
Drosophila melanogaster (Dme) 7289004 GI:17864236
Drosophila melanogaster (Dme) 7301670 GI:7301670
Homo sapiens (Hsa) Hs4503981 GI:4503981
Homo sapiens (Hsa) Hs4826742
(GFPT2)		 GI:4826742 O94808
Saccharomyces cerevisiae (Sce) YKL104c
(S000001587)		 GI:6322745 P14742
Saccharomyces cerevisiae (Sce) YMR084w GI:6323730 Q6B308
Saccharomyces cerevisiae (Sce) YMR085w GI:6323731
Saccharomyces cerevisiae (Sce) YNL191w
(S000005135)		 GI:6324138 P53871
Schizosaccharomyces pombe (Spo) SPBC12C2.11 GI:19112803 Q09740
Encephalitozoon cuniculi (Ecu) ECU07g1280 GI:19074551 Q8SRI2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001587
YMR085w
YMR084w
GO:0005737 cytoplasm C
IDA
SceS000005135
GO:0005829 cytosol C
IDA
SpoSPBC12C2.11
GO:0003674 molecular_function F
ND
SceYMR085w
YMR084w
GO:0004360 glutamine-fructose-6-phosphate transaminase
(isomerizing) activity		 F
IDA
SceS000001587
ISS
SpoSPBC12C2.11
GO:0008233 peptidase activity F
IGI
SceS000005135
GO:0008242 omega peptidase activity F
IGI
SceS000005135
GO:0008483 transaminase activity F
ISS
AthAt3g24090
GO:0016884 carbon-nitrogen ligase activity, with glutamine as
amido-N-donor		 F
ISS
SceS000005135
GO:0000003 reproduction P
IMP
CelWBGene00009035
WBGene00008546
GO:0000910 cytokinesis P
IMP
CelWBGene00009035
GO:0002119 nematode larval development P
IMP
CelWBGene00009035
GO:0006002 fructose 6-phosphate metabolic
process		 P
TAS
HsaGFPT2
GO:0006031 chitin biosynthetic process P
ISS
SpoSPBC12C2.11
GO:0006112 energy reserve metabolic process P
TAS
HsaGFPT2
GO:0006751 glutathione catabolic process P
IMP
SceS000005135
GO:0008150 biological_process P
ND
SceYMR085w
YMR084w
GO:0008152 metabolic process P
ISS
AthAt3g24090
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009035
WBGene00008546
GO:0034221 fungal-type cell wall chitin biosynthetic
process		 P
IGI
SceS000001587
GO:0040007 growth P
IMP
CelWBGene00009035
GO:0045229 external encapsulating structure
organization		 P
ISS
SpoSPBC12C2.11
GO:0046483 heterocycle metabolic process P
RCA
SceS000005135
GO:0051098 regulation of binding P
RCA
SceS000001587
GO:0051301 cell division P
IMP
CelWBGene00009035

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68439

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GFPT2 GI:4826742 O94808
Pan troglodytes (Ptr) GFPT2 GI:114603955
Canis familiaris (Cfa) GFPT2 GI:73970405
Mus musculus (Mmu) Gfpt2
(MGI:1338883)		 GI:7305087 Q3V0X4
Rattus norvegicus (Rno) Gfpt2
(RGD:1303097)		 GI:70778846
Gallus gallus (Gga) GFPT2 GI:118097497
Drosophila melanogaster (Dme) Gfat1 GI:161076234
Drosophila melanogaster (Dme) Gfat2
(FBgn0039580)		 GI:21357745
Anopheles gambiae (Aga) AgaP_AGAP011352 GI:58376929
Caenorhabditis elegans (Cel) F07A11.2
(CE03144;
WBGene00008546)		 GI:17532899 Q19130
Caenorhabditis elegans (Cel) F22B3.4
(CE03255;
WBGene00009035)		 GI:17539970 Q19699
Schizosaccharomyces pombe (Spo) SPBC12C2.11 GI:19112803 Q09740
Saccharomyces cerevisiae (Sce) GFA1
(S000001587)		 GI:6322745 P14742
Kluyveromyces lactis (Kla) KLLA0F13596g GI:50311335
Eremothecium gossypii (Ego) AGOS_ABL036C GI:45185194
Magnaporthe grisea (Mgr) MGG_11597 GI:145611510
Neurospora crassa (Ncr) NCU07366.1 GI:32414345
Arabidopsis thaliana (Ath) AT3G24090 GI:145338887
Oryza sativa (Osa) Os12g0131100 GI:115487174
Plasmodium falciparum (Pfa) PF10_0245 GI:124802604


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001587
GO:0005829 cytosol C
IDA
SpoSPBC12C2.11
GO:0020011 apicoplast C
RCA
PfaPF10_0245
GO:0004360 glutamine-fructose-6-phosphate transaminase
(isomerizing) activity		 F
IDA
SceS000001587
ISS
DmeFBgn0039580
Gfat1
PfaPF10_0245
SpoSPBC12C2.11
NAS
DmeGfat1
TAS
MmuMGI:1338883
GO:0008483 transaminase activity F
ISS
AthAt3g24090
GO:0000003 reproduction P
IMP
CelWBGene00009035
WBGene00008546
GO:0000910 cytokinesis P
IMP
CelWBGene00009035
GO:0002119 nematode larval development P
IMP
CelWBGene00009035
GO:0006002 fructose 6-phosphate metabolic
process		 P
TAS
HsaGFPT2
GO:0006031 chitin biosynthetic process P
ISS
SpoSPBC12C2.11
GO:0006041 glucosamine metabolic process P
ISS
PfaPF10_0245
GO:0006112 energy reserve metabolic process P
TAS
HsaGFPT2
GO:0006541 glutamine metabolic process P
TAS
MmuMGI:1338883
GO:0008152 metabolic process P
ISS
AthAt3g24090
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009035
WBGene00008546
GO:0034221 fungal-type cell wall chitin biosynthetic
process		 P
IGI
SceS000001587
GO:0040007 growth P
IMP
CelWBGene00009035
GO:0045229 external encapsulating structure
organization		 P
ISS
SpoSPBC12C2.11
GO:0051098 regulation of binding P
RCA
SceS000001587
GO:0051301 cell division P
IMP
CelWBGene00009035

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_306

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8418 ENSANGP00000018425
Ashbya gossypii (Ago) ago556 ABL036C
Arabidopsis thaliana (Ath) ath14732 At3g24090.1
Caenorhabditis elegans (Cel) cel5485 F07A11.2a
(CE03144;
WBGene00008546)
Caenorhabditis elegans (Cel) cel5486 F07A11.2b
(CE27915)
Caenorhabditis elegans (Cel) cel6981 F22B3.4
(CE03255;
WBGene00009035)
Candida glabrata (Cgl) cgl3890 CAGL0K08558g
Cryptococcus neoformans (Cne) cne593 163.m02726
Cryptococcus neoformans (Cne) cne594 163.m04728
Dictyostelium discoideum (Ddi) ddi7146 DDB0187034
Debaryomyces hansenii (Dha) dha5816 DEHA0G02706g
Drosophila melanogaster (Dme) dme15758 CG12449-PA
Drosophila melanogaster (Dme) dme15761 CG12449-PD
Drosophila melanogaster (Dme) dme14866 CG1345-PA
(FBgn0039580)
Danio rerio (Dre) dre25433 ENSDARP00000044463
Danio rerio (Dre) dre25434 ENSDARP00000047828
Escherichia coli (Eco) eco3608 16131597
Encephalitozoon cuniculi (Ecu) ecu1937 19074551
Takifugu rubripes (Fru) fru32560 SINFRUP00000157106
Takifugu rubripes (Fru) fru32561 SINFRUP00000167193
Takifugu rubripes (Fru) fru32562 SINFRUP00000170078
Gallus gallus (Gga) gga12665 ENSGALP00000000114
(RCJMB04_26h2)		 Q5ZIG5
Gallus gallus (Gga) gga12666 ENSGALP00000000115
(RCJMB04_26h2)
Gallus gallus (Gga) gga12667 ENSGALP00000000116
Gallus gallus (Gga) gga12664 ENSGALP00000000121
Gallus gallus (Gga) gga24818 ENSGALP00000001990
Homo sapiens (Hsa) hsa26315 ENSP00000253778
(GFPT2)		 O94808
Homo sapiens (Hsa) hsa17932 ENSP00000349860
(GFPT1)		 Q06210-1
Homo sapiens (Hsa) hsa17931 ENSP00000354347
(GFPT1)		 Q06210-2
Kluyveromyces lactis (Kla) kla4692 KLLA0F13596g
Mus musculus (Mmu) mmu3557 ENSMUSP00000020629
(MGI:1338883)		 Q9Z2Z9
Mus musculus (Mmu) mmu22270 ENSMUSP00000032057
(MGI:95698)		 P47856-1
Mus musculus (Mmu) mmu22269 ENSMUSP00000051106
(MGI:95698)		 P47856-2
Neurospora crassa (Ncr) ncr9924 NCU10234.2
Oryza sativa (Osa) osa1738 1893.m00187
Oryza sativa (Osa) osa60020 6553.m00186
Oryza sativa (Osa) osa64040 6635.m00179
Oryza sativa (Osa) osa72894 7099.m00188
Plasmodium falciparum (Pfa) pfa463 PF10_0245
Rattus norvegicus (Rno) rno4887 ENSRNOP00000003770
(RGD:1303097)		 Q4KMC4
Rattus norvegicus (Rno) rno21784 ENSRNOP00000025070
(RGD:1549703)		 P82808
Rattus norvegicus (Rno) rno21785 ENSRNOP00000025078
(RGD:1549703)
Saccharomyces cerevisiae (Sce) sce3773 YKL104C
(S000001587)
Schizosaccharomyces pombe (Spo) spo1187 SPBC12C2.11 Q09740
Yarrowia lipolytica (Yli) yli1636 YALI0B21428g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001587
GO:0005625 soluble fraction C
ISO
MmuMGI:95698
GO:0005829 cytosol C
IDA
SpoSPBC12C2.11
GO:0020011 apicoplast C
RCA
PfaPF10_0245
GO:0004360 glutamine-fructose-6-phosphate transaminase
(isomerizing) activity		 F
IDA
SceS000001587
ISO
MmuMGI:95698
ISS
DmeFBgn0039580
PfaPF10_0245
SpoSPBC12C2.11
TAS
MmuMGI:1338883
GO:0005529 sugar binding F
ISO
MmuMGI:95698
GO:0008483 transaminase activity F
ISS
AthAt3g24090
GO:0016597 amino acid binding F
ISO
MmuMGI:95698
GO:0000003 reproduction P
IMP
CelWBGene00009035
WBGene00008546
GO:0000910 cytokinesis P
IMP
CelWBGene00009035
GO:0002119 nematode larval development P
IMP
CelWBGene00009035
GO:0006002 fructose 6-phosphate metabolic
process		 P
ISO
MmuMGI:95698
GO:0006031 chitin biosynthetic process P
ISS
SpoSPBC12C2.11
GO:0006041 glucosamine metabolic process P
ISS
PfaPF10_0245
GO:0006042 glucosamine biosynthetic process P
ISO
MmuMGI:95698
GO:0006047 UDP-N-acetylglucosamine metabolic
process		 P
ISO
MmuMGI:95698
GO:0006541 glutamine metabolic process P
TAS
MmuMGI:1338883
GO:0008152 metabolic process P
ISS
AthAt3g24090
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00009035
WBGene00008546
GO:0034221 fungal-type cell wall chitin biosynthetic
process		 P
IGI
SceS000001587
GO:0040007 growth P
IMP
CelWBGene00009035
GO:0045229 external encapsulating structure
organization		 P
ISS
SpoSPBC12C2.11
GO:0045719 negative regulation of glycogen biosynthetic
process		 P
ISO
MmuMGI:95698
GO:0051098 regulation of binding P
RCA
SceS000001587
GO:0051289 protein homotetramerization P
ISO
MmuMGI:95698
GO:0051301 cell division P
IMP
CelWBGene00009035

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC12C2.11
(Q09740)		 YKL104C
(S000001587)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001587
GO:0005829 cytosol C
IDA
SpoSPBC12C2.11
GO:0004360 glutamine-fructose-6-phosphate transaminase
(isomerizing) activity		 F
IDA
SceS000001587
ISS
SpoSPBC12C2.11
GO:0006031 chitin biosynthetic process P
ISS
SpoSPBC12C2.11
GO:0034221 fungal-type cell wall chitin biosynthetic
process		 P
IGI
SceS000001587
GO:0045229 external encapsulating structure
organization		 P
ISS
SpoSPBC12C2.11
GO:0051098 regulation of binding P
RCA
SceS000001587

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