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Search term: YKL124W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SSH4
SGD link S000001607
Alternative ID YKL124W
Description Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
Synonyms YKL124W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1477 AC-HYP-

KOGs classification KOGs description
POORLY CHARACTERIZED SPRY domain-containing proteins

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g35470 GI:15219607
Arabidopsis thaliana (Ath) At4g09200 GI:15233790
Arabidopsis thaliana (Ath) At4g09250 GI:15233807
Arabidopsis thaliana (Ath) At4g09310 GI:15233834
Arabidopsis thaliana (Ath) At4g09330 GI:15233836
Arabidopsis thaliana (Ath) At4g09340 GI:15233837
Caenorhabditis elegans (Cel) CE20318
(WBGene00013202)
GI:17510281 Q9XWK4
Homo sapiens (Hsa) Hs4885571 GI:4885571
Homo sapiens (Hsa) Hs14776143 GI:14776143
Homo sapiens (Hsa) Hs14249554
(SPRYD3)
GI:14249554 Q8N2P1
Saccharomyces cerevisiae (Sce) YGL227w
(S000003196)
GI:6321210 P53076
Saccharomyces cerevisiae (Sce) YKL124w
(S000001607)
GI:6322725 P32343
Saccharomyces cerevisiae (Sce) YMR171c
(S000004781)
GI:6323823 Q03212
Schizosaccharomyces pombe (Spo) SPCC1259.12c GI:19075568 O94712
Schizosaccharomyces pombe (Spo) SPCC285.10c GI:19075838 O74497


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000001607
GO:0005575 cellular_component C
ND
AthAt4g09250
At4g09340
At1g35470
At4g09310
At4g09200
GO:0005634 nucleus C
IDA
SceS000003196
ISS
SpoSPCC1259.12c
GO:0005737 cytoplasm C
IDA
SceS000003196
SpoSPCC285.10c
ISS
SpoSPCC1259.12c
GO:0005768 endosome C
IDA
SceS000004781
GO:0034657 GID complex C
IDA
SceS000003196
ISS
SpoSPCC1259.12c
GO:0003674 molecular_function F
ND
AthAt4g09310
At4g09250
At4g09200
At1g35470
SceS000004781
S000001607
S000003196
SpoSPCC285.10c
GO:0008536 Ran GTPase binding F
ISS
SpoSPCC1259.12c
GO:0006508 proteolysis P
RCA
SceS000003196
GO:0006808 regulation of nitrogen utilization P
IMP
SceS000003196
GO:0006914 autophagy P
RCA
SceS000003196
GO:0007039 vacuolar protein catabolic process P
IMP
SceS000003196
ISS
SpoSPCC1259.12c
RCA
SceS000003196
GO:0007165 signal transduction P
NAS
SpoSPCC1259.12c
GO:0008150 biological_process P
ND
AthAt4g09310
At4g09250
At4g09200
At1g35470
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00013202
GO:0016192 vesicle-mediated transport P
IGI
SceS000001607
GO:0033554 cellular response to stress P
IEP
SpoSPCC285.10c
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process
P
IMP
SceS000003196
ISS
SpoSPCC1259.12c
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000004781
S000001607
GO:0045721 negative regulation of gluconeogenesis P
IC
SpoSPCC1259.12c
IMP
SceS000003196

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39532

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) SSH4
(S000001607)
GI:6322725 P32343
Kluyveromyces lactis (Kla) KLLA0B12760g GI:50304299


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000001607
GO:0003674 molecular_function F
ND
SceS000001607
GO:0016192 vesicle-mediated transport P
IGI
SceS000001607
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000001607

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_24590

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Ashbya gossypii (Ago) ago566 ABL026W
Candida glabrata (Cgl) cgl4942 CAGL0M06545g
Debaryomyces hansenii (Dha) dha2602 DEHA0D06886g
Kluyveromyces lactis (Kla) kla1097 KLLA0B12760g
Saccharomyces cerevisiae (Sce) sce3794 YKL124W
(S000001607)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000001607
GO:0003674 molecular_function F
ND
SceS000001607
GO:0016192 vesicle-mediated transport P
IGI
SceS000001607
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000001607

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPCC285.10c
(O74497)
YKL124W
(S000001607)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000001607
GO:0005737 cytoplasm C
IDA
SpoSPCC285.10c
GO:0003674 molecular_function F
ND
SceS000001607
SpoSPCC285.10c
GO:0016192 vesicle-mediated transport P
IGI
SceS000001607
GO:0033554 cellular response to stress P
IEP
SpoSPCC285.10c
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000001607

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s.khadayate@ucl.ac.uk