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Search term: YKL157W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name APE2
SGD link S000001640
Alternative ID YKL157W
Description Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W
Synonyms YKL157W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1046 ACDHYPE

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALING Puromycin-sensitive aminopeptidase and related aminopeptidases

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g63770 GI:15222531
Arabidopsis thaliana (Ath) At4g33090 GI:15234067
Caenorhabditis elegans (Cel) CE00646
(WBGene00007139)		 GI:17551792 P46557
Caenorhabditis elegans (Cel) CE05135 GI:17557172
Caenorhabditis elegans (Cel) CE10790
(WBGene00003914)		 GI:17540512
Caenorhabditis elegans (Cel) CE13593 GI:17542358
Caenorhabditis elegans (Cel) CE16077_2 GI:17507467
Caenorhabditis elegans (Cel) CE18904
(WBGene00010999)		 GI:17569221 Q21673
Caenorhabditis elegans (Cel) CE18905
(WBGene00011000)		 GI:17569225 Q9XVV9
Caenorhabditis elegans (Cel) CE20255
(WBGene00012776)		 GI:17565628 Q9U2H2
Caenorhabditis elegans (Cel) CE21162
(WBGene00011587)		 GI:17564056
Caenorhabditis elegans (Cel) CE24087 GI:17510737
Caenorhabditis elegans (Cel) CE25399 GI:17537469
Caenorhabditis elegans (Cel) CE26001 GI:17555066
Caenorhabditis elegans (Cel) CE27507 GI:17543972
Drosophila melanogaster (Dme) 7291178 GI:7291178 Q9W2S8
Drosophila melanogaster (Dme) 7291179 GI:7291179 Q9W2S7
Drosophila melanogaster (Dme) 7291558 GI:7291558
Drosophila melanogaster (Dme) 7292091 GI:7292091 Q8IRH1
Drosophila melanogaster (Dme) 7294697 GI:7294697
Drosophila melanogaster (Dme) 7298258 GI:19921406
Drosophila melanogaster (Dme) 7299744 GI:7299744
Drosophila melanogaster (Dme) 7299745 GI:7299745
Drosophila melanogaster (Dme) 7299746 GI:7299746
Drosophila melanogaster (Dme) 7299747 GI:7299747
Drosophila melanogaster (Dme) 7300767 GI:7300767
Drosophila melanogaster (Dme) 7300768 GI:7300768
Drosophila melanogaster (Dme) 7300769 GI:7300769
Drosophila melanogaster (Dme) 7300975 GI:7300975
Drosophila melanogaster (Dme) 7301517 GI:7301517
Drosophila melanogaster (Dme) 7301751 GI:7301751
Drosophila melanogaster (Dme) 7301770 GI:7301770 Q9VAM2
Drosophila melanogaster (Dme) 7301771 GI:7301771
Drosophila melanogaster (Dme) 7301772 GI:7301772 Q0KI00
Homo sapiens (Hsa) Hs11641261 GI:11641261 Q6P179
Homo sapiens (Hsa) Hs15451907 GI:15451907
Homo sapiens (Hsa) Hs17465355 GI:17465355
Homo sapiens (Hsa) Hs17472410 GI:17472410
Homo sapiens (Hsa) Hs20149637 GI:20149637
Homo sapiens (Hsa) Hs20534524 GI:20534524
Homo sapiens (Hsa) Hs22064092 GI:22064092
Homo sapiens (Hsa) Hs4502095 GI:4502095
Homo sapiens (Hsa) Hs4503575 GI:4503575
Homo sapiens (Hsa) Hs5031881 GI:5031881
Homo sapiens (Hsa) Hs7019561
(TRHDE)		 GI:7019561 Q9UKU6
Saccharomyces cerevisiae (Sce) YHR047c
(S000001089)		 GI:6321837 P37898
Saccharomyces cerevisiae (Sce) YIL137c
(S000001399)		 GI:6322054 P40462
Saccharomyces cerevisiae (Sce) YKL157w
(S000001640)		 GI:9755335 P32454
Schizosaccharomyces pombe (Spo) SPBC1921.05 GI:19112790 Q9USX1
Encephalitozoon cuniculi (Ecu) ECU01g0140 GI:19075026
Encephalitozoon cuniculi (Ecu) ECU01g1470 GI:19075158
Encephalitozoon cuniculi (Ecu) ECU08g0070 GI:19173333 Q8SRG3
Arabidopsis thaliana (Ath) At1g63770 GI:15222531
Arabidopsis thaliana (Ath) At4g33090 GI:15234067
Caenorhabditis elegans (Cel) CE00646
(WBGene00007139)		 GI:17551792 P46557
Caenorhabditis elegans (Cel) CE05135 GI:17557172
Caenorhabditis elegans (Cel) CE10790
(WBGene00003914)		 GI:17540512
Caenorhabditis elegans (Cel) CE13593 GI:17542358
Caenorhabditis elegans (Cel) CE16077_2 GI:17507467
Caenorhabditis elegans (Cel) CE18904
(WBGene00010999)		 GI:17569221 Q21673
Caenorhabditis elegans (Cel) CE18905
(WBGene00011000)		 GI:17569225 Q9XVV9
Caenorhabditis elegans (Cel) CE20255
(WBGene00012776)		 GI:17565628 Q9U2H2
Caenorhabditis elegans (Cel) CE21162
(WBGene00011587)		 GI:17564056
Caenorhabditis elegans (Cel) CE24087 GI:17510737
Caenorhabditis elegans (Cel) CE25399 GI:17537469
Caenorhabditis elegans (Cel) CE26001 GI:17555066
Caenorhabditis elegans (Cel) CE27507 GI:17543972
Drosophila melanogaster (Dme) 7291178 GI:7291178 Q9W2S8
Drosophila melanogaster (Dme) 7291179 GI:7291179 Q9W2S7
Drosophila melanogaster (Dme) 7291558 GI:7291558
Drosophila melanogaster (Dme) 7292091 GI:7292091 Q8IRH1
Drosophila melanogaster (Dme) 7294697 GI:7294697
Drosophila melanogaster (Dme) 7298258 GI:19921406
Drosophila melanogaster (Dme) 7299744 GI:7299744
Drosophila melanogaster (Dme) 7299745 GI:7299745
Drosophila melanogaster (Dme) 7299746 GI:7299746
Drosophila melanogaster (Dme) 7299747 GI:7299747
Drosophila melanogaster (Dme) 7300767 GI:7300767
Drosophila melanogaster (Dme) 7300768 GI:7300768
Drosophila melanogaster (Dme) 7300769 GI:7300769
Drosophila melanogaster (Dme) 7300975 GI:7300975
Drosophila melanogaster (Dme) 7301517 GI:7301517
Drosophila melanogaster (Dme) 7301751 GI:7301751
Drosophila melanogaster (Dme) 7301770 GI:7301770 Q9VAM2
Drosophila melanogaster (Dme) 7301771 GI:7301771
Drosophila melanogaster (Dme) 7301772 GI:7301772 Q0KI00
Homo sapiens (Hsa) Hs11641261 GI:11641261 Q6P179
Homo sapiens (Hsa) Hs15451907 GI:15451907
Homo sapiens (Hsa) Hs17465355 GI:17465355
Homo sapiens (Hsa) Hs17472410 GI:17472410
Homo sapiens (Hsa) Hs20149637 GI:20149637
Homo sapiens (Hsa) Hs20534524 GI:20534524
Homo sapiens (Hsa) Hs22064092 GI:22064092
Homo sapiens (Hsa) Hs4502095 GI:4502095
Homo sapiens (Hsa) Hs4503575 GI:4503575
Homo sapiens (Hsa) Hs5031881 GI:5031881
Homo sapiens (Hsa) Hs7019561
(TRHDE)		 GI:7019561 Q9UKU6
Saccharomyces cerevisiae (Sce) YHR047c
(S000001089)		 GI:6321837 P37898
Saccharomyces cerevisiae (Sce) YIL137c
(S000001399)		 GI:6322054 P40462
Saccharomyces cerevisiae (Sce) YKL157w
(S000001640)		 GI:9755335 P32454
Schizosaccharomyces pombe (Spo) SPBC1921.05 GI:19112790 Q9USX1
Encephalitozoon cuniculi (Ecu) ECU01g0140 GI:19075026
Encephalitozoon cuniculi (Ecu) ECU01g1470 GI:19075158
Encephalitozoon cuniculi (Ecu) ECU08g0070 GI:19173333 Q8SRG3


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005576 extracellular region C
IDA
SceS000001640
GO:0005634 nucleus C
IDA
SceS000001089
GO:0005737 cytoplasm C
IDA
CelWBGene00003914
SceS000001089
S000001399
GO:0005739 mitochondrion C
IDA
SceS000001640
GO:0005773 vacuole C
IDA
AthAt1g63770
GO:0005829 cytosol C
IDA
SpoSPBC1921.05
GO:0005840 ribosome C
IDA
SceS000001399
GO:0005886 plasma membrane C
IDA
AthAt1g63770
At4g33090
GO:0005887 integral to plasma membrane C
TAS
HsaTRHDE
GO:0009507 chloroplast C
IDA
AthAt1g63770
GO:0009570 chloroplast stroma C
IDA
AthAt1g63770
GO:0009941 chloroplast envelope C
IDA
AthAt1g63770
GO:0030287 cell wall-bounded periplasmic space C
IDA
SceS000001640
GO:0048046 apoplast C
IDA
AthAt1g63770
GO:0003674 molecular_function F
ND
SceS000001399
GO:0004177 aminopeptidase activity F
IDA
AthAt4g33090
ISS
SceS000001089
SpoSPBC1921.05
GO:0008233 peptidase activity F
RCA
SceS000001399
GO:0070006 metalloaminopeptidase activity F
IDA
SceS000001640
GO:0070011 peptidase activity, acting on L-amino acid
peptides		 F
RCA
SceS000001399
GO:0000003 reproduction P
IMP
CelWBGene00007139
GO:0002119 nematode larval development P
IMP
CelWBGene00007139
GO:0005977 glycogen metabolic process P
IMP
SceS000001089
GO:0006414 translational elongation P
RCA
SceS000001089
GO:0006508 proteolysis P
IMP
SceS000001089
ISS
AthAt1g63770
SpoSPBC1921.05
GO:0007165 signal transduction P
TAS
HsaTRHDE
GO:0007267 cell-cell signaling P
TAS
HsaTRHDE
GO:0008150 biological_process P
ND
SceS000001399
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003914
WBGene00007139
GO:0009926 auxin polar transport P
TAS
AthAt4g33090
GO:0040007 growth P
IMP
CelWBGene00007139
GO:0040011 locomotion P
IMP
CelWBGene00007139
GO:0043171 peptide catabolic process P
IDA
SceS000001640
IMP
SceS000001640
GO:0044248 cellular catabolic process P
NAS
SpoSPBC1921.05
GO:0046686 response to cadmium ion P
IEP
AthAt1g63770

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
36199

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NPEPPS GI:158937236
Pan troglodytes (Ptr) NPEPPS GI:114666415
Canis familiaris (Cfa) NPEPPS GI:73966164
Mus musculus (Mmu) Npepps
(MGI:1101358)		 GI:68226731 Q11011
Rattus norvegicus (Rno) Npepps
(RGD:619962)		 GI:34873499
Gallus gallus (Gga) NPEPPS GI:118102937
Drosophila melanogaster (Dme) Psa
(FBgn0035226)		 GI:24655257
Anopheles gambiae (Aga) AgaP_AGAP005728 GI:158294663
Caenorhabditis elegans (Cel) pam-1
(CE10790;
WBGene00003914)		 GI:71989076
Schizosaccharomyces pombe (Spo) ape1
(SPBC1921.05)		 GI:19112790 Q9USX1
Saccharomyces cerevisiae (Sce) APE2
(S000001640)		 GI:9755335 P32454
Kluyveromyces lactis (Kla) KLLA0C11033g GI:50305465
Eremothecium gossypii (Ego) AGOS_AAL127W GI:45184697
Magnaporthe grisea (Mgr) MGG_10606 GI:39969995
Neurospora crassa (Ncr) NCU09228.1 GI:32422353
Arabidopsis thaliana (Ath) APM1 GI:22329112
Oryza sativa (Osa) Os02g0218200 GI:115445047


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005576 extracellular region C
IDA
SceS000001640
GO:0005737 cytoplasm C
IDA
CelWBGene00003914
GO:0005739 mitochondrion C
IDA
SceS000001640
GO:0005829 cytosol C
IDA
SpoSPBC1921.05
GO:0005886 plasma membrane C
IDA
AthAPM1
GO:0030287 cell wall-bounded periplasmic space C
IDA
SceS000001640
GO:0004177 aminopeptidase activity F
IDA
AthAPM1
ISO
MmuMGI:1101358
ISS
SpoSPBC1921.05
GO:0005515 protein binding F
IPI
HsaNPEPPS
GO:0070006 metalloaminopeptidase activity F
IDA
SceS000001640
GO:0006508 proteolysis P
ISS
SpoSPBC1921.05
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003914
GO:0009926 auxin polar transport P
TAS
AthAPM1
GO:0043171 peptide catabolic process P
IDA
SceS000001640
IMP
SceS000001640
GO:0044248 cellular catabolic process P
NAS
SpoSPBC1921.05

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_818

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1149 ENSANGP00000004374
Anopheles gambiae (Aga) aga1150 ENSANGP00000026472
Ashbya gossypii (Ago) ago60 AAL127W
Ashbya gossypii (Ago) ago4671 AGR360C
Arabidopsis thaliana (Ath) ath21422 At4g33090.1
Caenorhabditis elegans (Cel) cel9755 F49E8.3
Candida glabrata (Cgl) cgl1213 CAGL0E06226g
Candida glabrata (Cgl) cgl3007 CAGL0J00341g
Cryptococcus neoformans (Cne) cne5011 186.m03930
Dictyostelium discoideum (Ddi) ddi3519 DDB0168194
Dictyostelium discoideum (Ddi) ddi1419 DDB0217184
Dictyostelium discoideum (Ddi) ddi11750 DDB0231238
Dictyostelium discoideum (Ddi) ddi11999 DDB0231240
Debaryomyces hansenii (Dha) dha1108 DEHA0B09966g
Debaryomyces hansenii (Dha) dha2957 DEHA0D14718g
Drosophila melanogaster (Dme) dme7409 CG1009-PA
(FBgn0035226)
Drosophila melanogaster (Dme) dme7408 CG1009-PB
(FBgn0035226)
Drosophila melanogaster (Dme) dme7410 CG1009-PC
(FBgn0035226)
Drosophila melanogaster (Dme) dme7407 CG1009-PD
(FBgn0035226)
Drosophila melanogaster (Dme) dme7411 CG1009-PE
(FBgn0035226)
Drosophila melanogaster (Dme) dme7412 CG1009-PF
(FBgn0035226)
Danio rerio (Dre) dre2465 ENSDARP00000003594
Encephalitozoon cuniculi (Ecu) ecu1663 19075026
Encephalitozoon cuniculi (Ecu) ecu1795 19075158
Encephalitozoon cuniculi (Ecu) ecu164 19173333
Takifugu rubripes (Fru) fru25846 SINFRUP00000159528
Takifugu rubripes (Fru) fru25847 SINFRUP00000174769
Takifugu rubripes (Fru) fru25848 SINFRUP00000175493
Gallus gallus (Gga) gga26754 ENSGALP00000022242
(NPEPPS)
Gallus gallus (Gga) gga26755 ENSGALP00000022243
(NPEPPS)		 Q5F3J3
Homo sapiens (Hsa) hsa13902 ENSP00000320324
(NPEPPS)		 P55786
Kluyveromyces lactis (Kla) kla1691 KLLA0C11033g
Kluyveromyces lactis (Kla) kla2644 KLLA0D13068g
Mus musculus (Mmu) mmu4679 ENSMUSP00000001480
(MGI:1101358)		 Q3UZE0
Neurospora crassa (Ncr) ncr2254 NCU02319.2
Neurospora crassa (Ncr) ncr8995 NCU09228.2
Oryza sativa (Osa) osa29412 4325.m00150
Oryza sativa (Osa) osa45375 5679.m00145
Oryza sativa (Osa) osa45377 5679.m00146
Oryza sativa (Osa) osa72102 7214.m00086
Rattus norvegicus (Rno) rno5980 ENSRNOP00000033290
(RGD:619962)		 Q3B8Q9
Saccharomyces cerevisiae (Sce) sce2799 YHR047C
(S000001089)
Saccharomyces cerevisiae (Sce) sce3830 YKL157W
(S000001640)
Schizosaccharomyces pombe (Spo) spo4083 SPBC1921.05 Q9USX1
Yarrowia lipolytica (Yli) yli1216 YALI0B11594g
Yarrowia lipolytica (Yli) yli1346 YALI0B14641g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005576 extracellular region C
IDA
SceS000001640
GO:0005634 nucleus C
IDA
SceS000001089
GO:0005737 cytoplasm C
IDA
SceS000001089
GO:0005739 mitochondrion C
IDA
SceS000001640
GO:0005829 cytosol C
IDA
SpoSPBC1921.05
GO:0005886 plasma membrane C
IDA
AthAt4g33090
GO:0030287 cell wall-bounded periplasmic space C
IDA
SceS000001640
GO:0004177 aminopeptidase activity F
IDA
AthAt4g33090
ISO
MmuMGI:1101358
ISS
SceS000001089
SpoSPBC1921.05
GO:0070006 metalloaminopeptidase activity F
IDA
SceS000001640
GO:0005977 glycogen metabolic process P
IMP
SceS000001089
GO:0006414 translational elongation P
RCA
SceS000001089
GO:0006508 proteolysis P
IMP
SceS000001089
ISS
SpoSPBC1921.05
GO:0009926 auxin polar transport P
TAS
AthAt4g33090
GO:0043171 peptide catabolic process P
IDA
SceS000001640
IMP
SceS000001640
GO:0044248 cellular catabolic process P
NAS
SpoSPBC1921.05

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1921.05
(Q9USX1)		 YKL157W
(S000001640)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005576 extracellular region C
IDA
SceS000001640
GO:0005739 mitochondrion C
IDA
SceS000001640
GO:0005829 cytosol C
IDA
SpoSPBC1921.05
GO:0030287 cell wall-bounded periplasmic space C
IDA
SceS000001640
GO:0004177 aminopeptidase activity F
ISS
SpoSPBC1921.05
GO:0070006 metalloaminopeptidase activity F
IDA
SceS000001640
GO:0006508 proteolysis P
ISS
SpoSPBC1921.05
GO:0043171 peptide catabolic process P
IDA
SceS000001640
IMP
SceS000001640
GO:0044248 cellular catabolic process P
NAS
SpoSPBC1921.05

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GO info in one table:

s.khadayate@ucl.ac.uk