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Search term: YKL181W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PRS1
SGD link S000001664
Alternative ID YKL181W
Description 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
Synonyms YKL181W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1448 ACDHYP-

KOGs classification KOGs description
METABOLISMMETABOLISM Ribose-phosphate pyrophosphokinase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g10700 GI:15220191
Arabidopsis thaliana (Ath) At1g32380 GI:15223189
Arabidopsis thaliana (Ath) At2g35390 GI:15226977
Arabidopsis thaliana (Ath) At2g42910 GI:15228027
Arabidopsis thaliana (Ath) At2g44530 GI:15224894
Caenorhabditis elegans (Cel) CE00745
(WBGene00020107)		 GI:17554702 Q21994
Caenorhabditis elegans (Cel) CE27199 GI:17554700
Caenorhabditis elegans (Cel) CE29454 GI:17554704 Q21994
Drosophila melanogaster (Dme) 7294893 GI:7294893
Drosophila melanogaster (Dme) 7294894 GI:7294894
Homo sapiens (Hsa) Hs20539448 GI:20539448
Homo sapiens (Hsa) Hs20542182 GI:20542182
Homo sapiens (Hsa) Hs4506127
(PRPS1)		 GI:4506127 Q15244
Homo sapiens (Hsa) Hs4506129 GI:4506129 P11908
Saccharomyces cerevisiae (Sce) YBL068w
(S000000164)		 GI:6319403
Saccharomyces cerevisiae (Sce) YER099c
(S000000901)		 GI:6320946 P38620
Saccharomyces cerevisiae (Sce) YHL011c
(S000001003)		 GI:6321776 P38689
Saccharomyces cerevisiae (Sce) YKL181w
(S000001664)		 GI:6322667 P32895
Saccharomyces cerevisiae (Sce) YOL061w
(S000005422)		 GI:6324511 Q12265
Schizosaccharomyces pombe (Spo) SPAC4A8.14 GI:19114738 P41831
Schizosaccharomyces pombe (Spo) SPBC3D6.06c GI:19112310 P87171
Schizosaccharomyces pombe (Spo) SPCC1620.06c GI:19075964 O94413


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC4A8.14
GO:0005737 cytoplasm C
IDA
AthAt2g42910
SceS000000901
S000005422
S000000164
S000001003
S000001664
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0005829 cytosol C
EXP
HsaPRPS1
IDA
SpoSPCC1620.06c
SPAC4A8.14
GO:0005886 plasma membrane C
IDA
AthAt2g42910
GO:0004749 ribose phosphate diphosphokinase
activity		 F
EXP
HsaPRPS1
IDA
HsaPRPS1
IGI
SceS000000901
S000000164
S000001003
S000001664
S000005422
IMP
HsaPRPS1
ISS
AthAt1g32380
At2g35390
At2g44530
At2g42910
At1g10700
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0005524 ATP binding F
IDA
HsaPRPS1
GO:0042803 protein homodimerization activity F
IPI
HsaPRPS1
GO:0000105 histidine biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000001664
S000000901
S000000164
S000001003
S000005422
IMP
SceS000000164
S000000901
S000005422
S000001003
S000001664
GO:0006144 purine base metabolic process P
IMP
HsaPRPS1
GO:0006164 purine nucleotide biosynthetic
process		 P
IMP
HsaPRPS1
GO:0006166 purine ribonucleoside salvage P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPBC3D6.06c
SPAC4A8.14
SPCC1620.06c
GO:0006221 pyrimidine nucleotide biosynthetic
process		 P
NAS
HsaPRPS1
GO:0007399 nervous system development P
IMP
HsaPRPS1
GO:0008361 regulation of cell size P
IMP
SceS000001003
GO:0009116 nucleoside metabolic process P
RCA
SceS000000164
S000000901
S000001003
S000005422
GO:0009117 nucleotide metabolic process P
RCA
SceS000000901
S000001003
S000000164
S000001664
S000005422
GO:0009165 nucleotide biosynthetic process P
ISS
AthAt2g44530
At1g10700
At2g35390
At2g42910
At1g32380
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00020107
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000000164
GO:0031505 fungal-type cell wall organization P
IPI
SceS000000164
S000000901
S000001003
S000001664
S000005422
GO:0034418 urate biosynthetic process P
IMP
HsaPRPS1
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001003
S000005422
S000001664
GO:0046101 hypoxanthine biosynthetic process P
IMP
HsaPRPS1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74728

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) prs1
(SPBC19C7.06)		 GI:19114738 O60155
Saccharomyces cerevisiae (Sce) PRS1
(S000001664)		 GI:6322667 P32895
Kluyveromyces lactis (Kla) KLLA0B02783g GI:50303429
Eremothecium gossypii (Ego) AGOS_AER083C GI:45190689
Magnaporthe grisea (Mgr) MGG_01828 GI:145613171
Neurospora crassa (Ncr) NCU05254.1 GI:32408259


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000001664
GO:0005829 cytosol C
IDA
SpoSPBC19C7.06
GO:0004749 ribose phosphate diphosphokinase
activity		 F
IGI
SceS000001664
GO:0004827 proline-tRNA ligase activity F
ISS
SpoSPBC19C7.06
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000001664
IMP
SceS000001664
GO:0006433 prolyl-tRNA aminoacylation P
IC
SpoSPBC19C7.06
GO:0009117 nucleotide metabolic process P
RCA
SceS000001664
GO:0031505 fungal-type cell wall organization P
IPI
SceS000001664
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001664

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_15233

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago2588 AER083C
Candida glabrata (Cgl) cgl682 CAGL0D00550g
Debaryomyces hansenii (Dha) dha1041 DEHA0B08107g
Kluyveromyces lactis (Kla) kla654 KLLA0B02783g
Neurospora crassa (Ncr) ncr5099 NCU05254.2
Saccharomyces cerevisiae (Sce) sce3855 YKL181W
(S000001664)
Schizosaccharomyces pombe (Spo) spo797 SPAC4A8.14 P41831
Yarrowia lipolytica (Yli) yli1298 YALI0B13552g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC4A8.14
GO:0005737 cytoplasm C
IDA
SceS000001664
ISS
SpoSPAC4A8.14
GO:0005829 cytosol C
IDA
SpoSPAC4A8.14
GO:0004749 ribose phosphate diphosphokinase
activity		 F
IGI
SceS000001664
ISS
SpoSPAC4A8.14
GO:0000105 histidine biosynthetic process P
ISS
SpoSPAC4A8.14
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPAC4A8.14
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000001664
IMP
SceS000001664
GO:0006166 purine ribonucleoside salvage P
ISS
SpoSPAC4A8.14
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPAC4A8.14
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPAC4A8.14
GO:0009117 nucleotide metabolic process P
RCA
SceS000001664
GO:0031505 fungal-type cell wall organization P
IPI
SceS000001664
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001664

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1620.06c
(O94413)		 YKL181W
(S000001664)
SPBC3D6.06c
(P87171)		 YKL181W
(S000001664)
SPAC4A8.14
(P41831)		 YKL181W
(S000001664)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC4A8.14
GO:0005737 cytoplasm C
IDA
SceS000001664
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0005829 cytosol C
IDA
SpoSPCC1620.06c
SPAC4A8.14
GO:0004749 ribose phosphate diphosphokinase
activity		 F
IGI
SceS000001664
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0000105 histidine biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0000162 tryptophan biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic
process		 P
IGI
SceS000001664
IMP
SceS000001664
GO:0006166 purine ribonucleoside salvage P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006189 'de novo' IMP biosynthetic process P
ISS
SpoSPAC4A8.14
SPBC3D6.06c
SPCC1620.06c
GO:0006207 'de novo' pyrimidine base biosynthetic
process		 P
ISS
SpoSPBC3D6.06c
SPAC4A8.14
SPCC1620.06c
GO:0009117 nucleotide metabolic process P
RCA
SceS000001664
GO:0031505 fungal-type cell wall organization P
IPI
SceS000001664
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000001664

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GO info in one table:

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