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Search term: YKL188C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PXA2
SGD link S000001671
Alternative ID YKL188C
Description Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
Synonyms YKL188C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0064 -CDHY--

KOGs classification KOGs description
METABOLISM Peroxisomal long-chain acyl-CoA transporter, ABC superfamily

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE16325
(WBGene00004061)		 GI:17542146 O45730
Drosophila melanogaster (Dme) 7304333 GI:7304333 Q7JUN3
Homo sapiens (Hsa) Hs18574231 GI:18574231
Homo sapiens (Hsa) Hs18586625 GI:18586625
Homo sapiens (Hsa) Hs18600750 GI:18600750
Homo sapiens (Hsa) Hs7262393
(ABCD1)		 GI:7262393 P33897
Homo sapiens (Hsa) Hs9945308
(ABCD2)		 GI:9945308 Q9UBJ2
Saccharomyces cerevisiae (Sce) YKL188c
(S000001671)		 GI:6322660 P34230
Saccharomyces cerevisiae (Sce) YPL147w
(S000006068)		 GI:6325110 P41909
Caenorhabditis elegans (Cel) CE16325
(WBGene00004061)		 GI:17542146 O45730
Drosophila melanogaster (Dme) 7304333 GI:7304333 Q7JUN3
Homo sapiens (Hsa) Hs18574231 GI:18574231
Homo sapiens (Hsa) Hs18586625 GI:18586625
Homo sapiens (Hsa) Hs18600750 GI:18600750
Homo sapiens (Hsa) Hs7262393
(ABCD1)		 GI:7262393 P33897
Homo sapiens (Hsa) Hs9945308
(ABCD2)		 GI:9945308 Q9UBJ2
Saccharomyces cerevisiae (Sce) YKL188c
(S000001671)		 GI:6322660 P34230
Saccharomyces cerevisiae (Sce) YPL147w
(S000006068)		 GI:6325110 P41909
Caenorhabditis elegans (Cel) CE16325
(WBGene00004061)		 GI:17542146 O45730
Drosophila melanogaster (Dme) 7304333 GI:7304333 Q7JUN3
Homo sapiens (Hsa) Hs18574231 GI:18574231
Homo sapiens (Hsa) Hs18586625 GI:18586625
Homo sapiens (Hsa) Hs18600750 GI:18600750
Homo sapiens (Hsa) Hs7262393
(ABCD1)		 GI:7262393 P33897
Homo sapiens (Hsa) Hs9945308
(ABCD2)		 GI:9945308 Q9UBJ2
Saccharomyces cerevisiae (Sce) YKL188c
(S000001671)		 GI:6322660 P34230
Saccharomyces cerevisiae (Sce) YPL147w
(S000006068)		 GI:6325110 P41909


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005778 peroxisomal membrane C
EXP
HsaABCD1
GO:0005779 integral to peroxisomal membrane C
IDA
SceS000001671
S000006068
NAS
HsaABCD1
GO:0005887 integral to plasma membrane C
TAS
HsaABCD2
GO:0043190 ATP-binding cassette (ABC) transporter
complex		 C
TAS
HsaABCD2
GO:0005215 transporter activity F
NAS
HsaABCD1
GO:0005325 peroxisomal fatty acyl CoA transporter
activity		 F
EXP
HsaABCD1
GO:0005515 protein binding F
IPI
HsaABCD2
ABCD1
GO:0042626 ATPase activity, coupled to transmembrane movement
of substances		 F
IDA
SceS000001671
IMP
SceS000006068
ISS
SceS000006068
NAS
HsaABCD1
GO:0042802 identical protein binding F
IPI
HsaABCD1
GO:0006631 fatty acid metabolic process P
TAS
HsaABCD2
GO:0007031 peroxisome organization P
NAS
HsaABCD1
GO:0015908 fatty acid transport P
IDA
SceS000001671
IMP
SceS000006068
GO:0015919 peroxisomal membrane transport P
NAS
HsaABCD1
GO:0033540 fatty acid beta-oxidation using acyl-CoA
oxidase		 P
EXP
HsaABCD1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68799

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PXA2
(S000001671)		 GI:6322660 P34230
Kluyveromyces lactis (Kla) KLLA0B02563g GI:50303409
Eremothecium gossypii (Ego) AGOS_AER091W GI:45190697


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005779 integral to peroxisomal membrane C
IDA
SceS000001671
GO:0042626 ATPase activity, coupled to transmembrane movement
of substances		 F
IDA
SceS000001671
GO:0015908 fatty acid transport P
IDA
SceS000001671

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_182

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4181 ENSANGP00000019853
Anopheles gambiae (Aga) aga15057 ENSANGP00000020053
Ashbya gossypii (Ago) ago1175 ACR128C
Ashbya gossypii (Ago) ago2596 AER091W
Arabidopsis thaliana (Ath) ath4748 At1g54350.1
Arabidopsis thaliana (Ath) ath20810 At4g27910.1
Arabidopsis thaliana (Ath) ath22201 At4g39850.1
Arabidopsis thaliana (Ath) ath27309 At5g53430.1
Caenorhabditis elegans (Cel) cel3984 C44B7.8
(CE02546;
WBGene00004058)
Caenorhabditis elegans (Cel) cel3985 C44B7.9
(CE02547;
WBGene00004059)
Caenorhabditis elegans (Cel) cel4760 C54G10.3
(CE05518;
WBGene00004060)
Caenorhabditis elegans (Cel) cel14311 T02D1.5
(CE16325;
WBGene00004061)
Candida glabrata (Cgl) cgl673 CAGL0D00352g
Candida glabrata (Cgl) cgl4760 CAGL0M02387g
Cryptococcus neoformans (Cne) cne5486 179.m00339
Cryptococcus neoformans (Cne) cne2349 181.m08382
Dictyostelium discoideum (Ddi) ddi13378 DDB0214891
Dictyostelium discoideum (Ddi) ddi12219 DDB0215371
Dictyostelium discoideum (Ddi) ddi12220 DDB0215374
Debaryomyces hansenii (Dha) dha1065 DEHA0B08657g
Debaryomyces hansenii (Dha) dha1991 DEHA0C12727g
Drosophila melanogaster (Dme) dme18707 CG12703-PA
(FBgn0031069)
Drosophila melanogaster (Dme) dme15500 CG2316-PA
(FBgn0039890)
Drosophila melanogaster (Dme) dme15498 CG2316-PB
(FBgn0039890)
Drosophila melanogaster (Dme) dme15497 CG2316-PC
(FBgn0039890)
Drosophila melanogaster (Dme) dme15496 CG2316-PD
(FBgn0039890)
Drosophila melanogaster (Dme) dme15501 CG2316-PE
(FBgn0039890)
Drosophila melanogaster (Dme) dme15502 CG2316-PF
(FBgn0039890)
Drosophila melanogaster (Dme) dme15499 CG2316-PG
(FBgn0039890)
Danio rerio (Dre) dre10914 ENSDARP00000005424
Danio rerio (Dre) dre22283 ENSDARP00000007052
Danio rerio (Dre) dre10912 ENSDARP00000007440
(LOC555636)
Danio rerio (Dre) dre22282 ENSDARP00000007526
Danio rerio (Dre) dre16163 ENSDARP00000013511
(abcd3a)		 Q803I6
Danio rerio (Dre) dre30416 ENSDARP00000021864
Danio rerio (Dre) dre32026 ENSDARP00000040435
Danio rerio (Dre) dre32027 ENSDARP00000042087
Danio rerio (Dre) dre22284 ENSDARP00000047764
Escherichia coli (Eco) eco1456 16129455
Takifugu rubripes (Fru) fru24427 SINFRUP00000149951
Takifugu rubripes (Fru) fru32653 SINFRUP00000165459
Takifugu rubripes (Fru) fru32654 SINFRUP00000165461
Takifugu rubripes (Fru) fru24426 SINFRUP00000173316
Gallus gallus (Gga) gga22465 ENSGALP00000009044
Gallus gallus (Gga) gga22466 ENSGALP00000009045
(ABCD3)		 Q5F4B9
Gallus gallus (Gga) gga90 ENSGALP00000011553
(ABCD2)
Gallus gallus (Gga) gga19535 ENSGALP00000016609
Gallus gallus (Gga) gga19534 ENSGALP00000016610
(ABCD4)
Homo sapiens (Hsa) hsa33604 ENSP00000218104
(ABCD1)		 P33897
Homo sapiens (Hsa) hsa1524 ENSP00000263889
Homo sapiens (Hsa) hsa7332 ENSP00000310688
(ABCD2)		 Q9UBJ2
Homo sapiens (Hsa) hsa9807 ENSP00000349396
(ABCD4)		 O14678
Homo sapiens (Hsa) hsa9806 ENSP00000352473
(ABCD4)		 Q86U29
Kluyveromyces lactis (Kla) kla644 KLLA0B02563g
Kluyveromyces lactis (Kla) kla4603 KLLA0F11484g
Mus musculus (Mmu) mmu29132 ENSMUSP00000002084
(MGI:1349215)		 P48410
Mus musculus (Mmu) mmu5987 ENSMUSP00000021666
(MGI:1349217)		 O89016
Mus musculus (Mmu) mmu17483 ENSMUSP00000029770
(MGI:1349216)		 Q3U645
Mus musculus (Mmu) mmu9515 ENSMUSP00000068940
(MGI:1349467)		 Q61285
Neurospora crassa (Ncr) ncr1703 NCU01751.2
Neurospora crassa (Ncr) ncr8169 NCU08382.2
Oryza sativa (Osa) osa9155 2696.m00120
Oryza sativa (Osa) osa39538 4993.m00055
Oryza sativa (Osa) osa46437 5523.m00189
Oryza sativa (Osa) osa48910 5723.m00197
Rattus norvegicus (Rno) rno25423 ENSRNOP00000016040
(RGD:1307273)		 Q5FWT4
Rattus norvegicus (Rno) rno16940 ENSRNOP00000016739
(RGD:2007)		 P16970
Rattus norvegicus (Rno) rno27619 ENSRNOP00000021064
(RGD:69244)		 Q9QY44
Rattus norvegicus (Rno) rno32541 ENSRNOP00000025863
(RGD:1562128)
Saccharomyces cerevisiae (Sce) sce3863 YKL188C
(S000001671)
Saccharomyces cerevisiae (Sce) sce6306 YPL147W
(S000006068)
Yarrowia lipolytica (Yli) yli218 YALI0A06655g
Yarrowia lipolytica (Yli) yli2880 YALI0D04246g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1349216
MGI:1349467
MGI:1349215
ISO
MmuMGI:1349216
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:1349216
GO:0005777 peroxisome C
IDA
AthAt4g39850
ISO
MmuMGI:1349216
GO:0005778 peroxisomal membrane C
IDA
MmuMGI:1349215
MGI:1349216
ISO
MmuMGI:1349467
MGI:1349215
MGI:1349216
GO:0005779 integral to peroxisomal membrane C
IDA
SceS000001671
S000006068
ISS
DmeFBgn0031069
GO:0009507 chloroplast C
IDA
AthAt1g54350
GO:0043190 ATP-binding cassette (ABC) transporter
complex		 C
ISS
DmeFBgn0031069
FBgn0039890
GO:0046861 glyoxysomal membrane C
IDA
AthAt4g39850
GO:0003677 DNA binding F
ISS
AthAt5g53430
GO:0005215 transporter activity F
ISS
DmeFBgn0031069
FBgn0039890
GO:0005515 protein binding F
IPI
MmuMGI:1349467
MGI:1349216
MGI:1349215
GO:0005524 ATP binding F
ISO
MmuMGI:1349215
MGI:1349216
GO:0042626 ATPase activity, coupled to transmembrane movement
of substances		 F
IDA
SceS000001671
IMP
SceS000006068
ISS
AthAt1g54350
At4g39850
DmeFBgn0031069
FBgn0039890
SceS000006068
GO:0043621 protein self-association F
ISO
MmuMGI:1349216
GO:0006355 regulation of transcription, DNA-dependent P
ISS
AthAt5g53430
GO:0006635 fatty acid beta-oxidation P
IMP
AthAt4g39850
GO:0007031 peroxisome organization P
ISS
DmeFBgn0031069
GO:0009294 DNA mediated transformation P
IMP
AthAt5g53430
GO:0010030 positive regulation of seed germination P
IMP
AthAt4g39850
GO:0015908 fatty acid transport P
IDA
SceS000001671
IMP
SceS000006068
GO:0015916 fatty acyl CoA transport P
IMP
AthAt4g39850

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