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Search term: YKL191W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DPH2
SGD link S000001674
Alternative ID YKL191W
Description Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
Synonyms YKL191W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2648 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Diphthamide biosynthesis protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g59630 GI:15231723
Arabidopsis thaliana (Ath) At5g62030 GI:15240408
Caenorhabditis elegans (Cel) CE15608
(WBGene00007488)		 GI:17531715 Q09454
Caenorhabditis elegans (Cel) CE17401
(WBGene00007576)		 GI:17552166 P49958
Drosophila melanogaster (Dme) 7294688 GI:7294688 Q9VTM2
Drosophila melanogaster (Dme) 7299937 GI:7299937
Homo sapiens (Hsa) Hs21536476 GI:14742688
Homo sapiens (Hsa) Hs4503361 GI:4503361
Homo sapiens (Hsa) HsM4557533 GI:4557533
Saccharomyces cerevisiae (Sce) YIL103w
(S000001365)		 GI:6322088 P40487
Saccharomyces cerevisiae (Sce) YKL191w
(S000001674)		 GI:6322657 P32461
Schizosaccharomyces pombe (Spo) SPBC17D1.02 GI:19113176 Q10206
Schizosaccharomyces pombe (Spo) SPBC3B8.05 GI:19113201 O59713
Encephalitozoon cuniculi (Ecu) ECU07g0980 GI:19074520 Q8SUZ5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g59630
At5g62030
GO:0005634 nucleus C
IDA
SpoSPBC3B8.05
GO:0005737 cytoplasm C
IDA
SceS000001674
S000001365
ISS
SpoSPBC3B8.05
SPBC17D1.02
GO:0005829 cytosol C
IDA
SpoSPBC3B8.05
SPBC17D1.02
GO:0003674 molecular_function F
ND
AthAt5g62030
At3g59630
SceS000001365
S000001674
SpoSPBC17D1.02
SPBC3B8.05
GO:0000003 reproduction P
IMP
CelWBGene00007576
GO:0002119 nematode larval development P
IMP
CelWBGene00007576
GO:0006417 regulation of translation P
IC
SpoSPBC17D1.02
SPBC3B8.05
GO:0008150 biological_process P
ND
AthAt5g62030
At3g59630
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IMP
SceS000001365
S000001674
ISS
SpoSPBC3B8.05
SPBC17D1.02
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000001365
S000001674
GO:0040002 collagen and cuticulin-based cuticle
development		 P
IMP
CelWBGene00007488
GO:0040007 growth P
IMP
CelWBGene00007576
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00007576

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1060

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) DPH2 GI:21536476
Canis familiaris (Cfa) DPH2 GI:73978015
Mus musculus (Mmu) Dph2
(MGI:1914978)		 GI:33468993 Q9CR25
Rattus norvegicus (Rno) Dph2
(RGD:1304634)		 GI:62543509
Gallus gallus (Gga) DPH2 GI:57529649
Drosophila melanogaster (Dme) CG7265
(FBgn0038272)		 GI:21357831
Anopheles gambiae (Aga) AgaP_AGAP000934 GI:158287071
Schizosaccharomyces pombe (Spo) SPBC17D1.02 GI:19113176 Q10206
Saccharomyces cerevisiae (Sce) DPH2
(S000001674)		 GI:6322657 P32461
Kluyveromyces lactis (Kla) KLLA0D02948g GI:50306451
Eremothecium gossypii (Ego) AGOS_AER097C GI:45190703
Magnaporthe grisea (Mgr) MGG_12288 GI:145612157
Neurospora crassa (Ncr) NCU06168.1 GI:32411085
Arabidopsis thaliana (Ath) AT3G59630 GI:15231723
Oryza sativa (Osa) Os11g0265600 GI:115485035


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g59630
MmuMGI:1914978
GO:0005737 cytoplasm C
IDA
SceS000001674
ISS
SpoSPBC17D1.02
GO:0005829 cytosol C
IDA
SpoSPBC17D1.02
GO:0003674 molecular_function F
ND
AthAt3g59630
SceS000001674
SpoSPBC17D1.02
GO:0005515 protein binding F
IPI
MmuMGI:1914978
GO:0006417 regulation of translation P
IC
SpoSPBC17D1.02
GO:0008150 biological_process P
ND
AthAt3g59630
MmuMGI:1914978
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IMP
SceS000001674
ISS
DmeFBgn0038272
SpoSPBC17D1.02
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000001674

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3118

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15630 ENSANGP00000005327
Ashbya gossypii (Ago) ago2602 AER097C
Arabidopsis thaliana (Ath) ath17382 At3g59630.1
Caenorhabditis elegans (Cel) cel1673 C09G5.2
(CE15608;
WBGene00007488)
Candida glabrata (Cgl) cgl3188 CAGL0J04576g
Cryptococcus neoformans (Cne) cne1581 164.m02172
Debaryomyces hansenii (Dha) dha4669 DEHA0F06336g
Drosophila melanogaster (Dme) dme12649 CG7265-PA
(FBgn0038272)
Danio rerio (Dre) dre21811 ENSDARP00000010196
Takifugu rubripes (Fru) fru4803 SINFRUP00000154563
Gallus gallus (Gga) gga22660 ENSGALP00000016389
(DPH2)		 Q5ZKI2
Homo sapiens (Hsa) hsa1024 ENSP00000255108
(DPH2)		 Q9BQC3
Kluyveromyces lactis (Kla) kla2198 KLLA0D02948g
Mus musculus (Mmu) mmu18735 ENSMUSP00000030265
(MGI:1914978)		 Q9CR25
Neurospora crassa (Ncr) ncr5993 NCU06168.2
Oryza sativa (Osa) osa65197 6753.m00158
Oryza sativa (Osa) osa65272 6755.m00110
Plasmodium falciparum (Pfa) pfa1725 PF14_0274
Rattus norvegicus (Rno) rno23763 ENSRNOP00000026739
(RGD:1304634)		 Q568Y2
Saccharomyces cerevisiae (Sce) sce3866 YKL191W
(S000001674)
Schizosaccharomyces pombe (Spo) spo45 SPBC17D1.02 Q10206
Yarrowia lipolytica (Yli) yli681 YALI0A19954g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt3g59630
MmuMGI:1914978
PfaPF14_0274
GO:0005737 cytoplasm C
IDA
SceS000001674
ISS
SpoSPBC17D1.02
GO:0005829 cytosol C
IDA
SpoSPBC17D1.02
GO:0003674 molecular_function F
ND
AthAt3g59630
PfaPF14_0274
SceS000001674
SpoSPBC17D1.02
GO:0005515 protein binding F
IPI
MmuMGI:1914978
GO:0006417 regulation of translation P
IC
SpoSPBC17D1.02
GO:0008150 biological_process P
ND
AthAt3g59630
MmuMGI:1914978
PfaPF14_0274
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IMP
SceS000001674
ISS
DmeFBgn0038272
SpoSPBC17D1.02
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000001674
GO:0040002 collagen and cuticulin-based cuticle
development		 P
IMP
CelWBGene00007488

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC17D1.02
(Q10206)		 YKL191W
(S000001674)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000001674
ISS
SpoSPBC17D1.02
GO:0005829 cytosol C
IDA
SpoSPBC17D1.02
GO:0003674 molecular_function F
ND
SceS000001674
SpoSPBC17D1.02
GO:0006417 regulation of translation P
IC
SpoSPBC17D1.02
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IMP
SceS000001674
ISS
SpoSPBC17D1.02
GO:0018193 peptidyl-amino acid modification P
RCA
SceS000001674

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