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Search term: YKL218C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SRY1
SGD link S000001701
Alternative ID YKL218C
Description 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
Synonyms YKL218C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1251 AC-HYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGMETABOLISM Serine racemase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g11640 GI:15234252
Caenorhabditis elegans (Cel) CE13016
(WBGene00011353)		 GI:17508781 Q93968
Homo sapiens (Hsa) Hs11345492
(SRR)		 GI:11345492 Q9GZT4
Saccharomyces cerevisiae (Sce) YKL218c
(S000001701)		 GI:6322631 P36007
Schizosaccharomyces pombe (Spo) SPCC320.14 GI:19075215 O59791
Arabidopsis thaliana (Ath) At4g11640 GI:15234252
Caenorhabditis elegans (Cel) CE13016
(WBGene00011353)		 GI:17508781 Q93968
Homo sapiens (Hsa) Hs11345492
(SRR)		 GI:11345492 Q9GZT4
Saccharomyces cerevisiae (Sce) YKL218c
(S000001701)		 GI:6322631 P36007
Schizosaccharomyces pombe (Spo) SPCC320.14 GI:19075215 O59791


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001701
SpoSPCC320.14
GO:0005625 soluble fraction C
IDA
HsaSRR
GO:0005737 cytoplasm C
IDA
HsaSRR
GO:0043025 neuronal cell body C
IDA
HsaSRR
GO:0003941 L-serine ammonia-lyase activity F
IDA
HsaSRR
GO:0005509 calcium ion binding F
ISS
HsaSRR
GO:0005524 ATP binding F
ISS
HsaSRR
GO:0016594 glycine binding F
ISS
HsaSRR
GO:0018114 threonine racemase activity F
ISS
HsaSRR
GO:0030165 PDZ domain binding F
IPI
HsaSRR
GO:0030170 pyridoxal phosphate binding F
ISS
HsaSRR
GO:0030378 serine racemase activity F
IDA
AthAt4g11640
HsaSRR
ISS
AthAt4g11640
GO:0030848 threo-3-hydroxyaspartate ammonia-lyase
activity		 F
IDA
SceS000001701
IMP
SceS000001701
ISS
SpoSPCC320.14
GO:0042803 protein homodimerization activity F
IDA
HsaSRR
GO:0006082 organic acid metabolic process P
RCA
SceS000001701
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000001701
GO:0006563 L-serine metabolic process P
IDA
HsaSRR
GO:0006567 threonine catabolic process P
ISS
SpoSPCC320.14
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000001701
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000001701
GO:0009069 serine family amino acid metabolic
process		 P
IDA
AthAt4g11640
ISS
AthAt4g11640
HsaSRR
GO:0032496 response to lipopolysaccharide P
IEP
HsaSRR
GO:0042219 cellular amino acid derivative catabolic
process		 P
IDA
SceS000001701
IMP
SceS000001701
GO:0042866 pyruvate biosynthetic process P
IDA
HsaSRR
GO:0051289 protein homotetramerization P
ISS
HsaSRR
GO:0070179 D-serine biosynthetic process P
IDA
HsaSRR

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
101611

Species Gene ID NCBI link UniProt link
Drosophila melanogaster (Dme) CG8129
(FBgn0037684)		 GI:21355833
Anopheles gambiae (Aga) AgaP_AGAP003571 GI:158291787
Caenorhabditis elegans (Cel) K01C8.1
(CE36943;
WBGene00010456)		 GI:71991565
Schizosaccharomyces pombe (Spo) SPCC320.14 GI:19075215 O59791
Saccharomyces cerevisiae (Sce) SRY1
(S000001701)		 GI:6322631 P36007


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001701
SpoSPCC320.14
GO:0004794 L-threonine ammonia-lyase activity F
ISS
DmeFBgn0037684
GO:0030848 threo-3-hydroxyaspartate ammonia-lyase
activity		 F
IDA
SceS000001701
IMP
SceS000001701
ISS
SpoSPCC320.14
GO:0006082 organic acid metabolic process P
RCA
SceS000001701
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000001701
GO:0006567 threonine catabolic process P
ISS
SpoSPCC320.14
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000001701
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000001701
GO:0042219 cellular amino acid derivative catabolic
process		 P
IDA
SceS000001701
IMP
SceS000001701

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_425

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6012 ENSANGP00000010432
Ashbya gossypii (Ago) ago1279 ACR232C
Arabidopsis thaliana (Ath) ath13091 At3g10050.1
Arabidopsis thaliana (Ath) ath18903 At4g11640.1
Caenorhabditis elegans (Cel) cel11559 K01C8.1
(CE36943;
WBGene00010456)
Caenorhabditis elegans (Cel) cel14282 T01H8.2
(CE13016;
WBGene00011353)
Candida glabrata (Cgl) cgl2744 CAGL0I05126g
Cryptococcus neoformans (Cne) cne3549 176.m02282
Dictyostelium discoideum (Ddi) ddi12878 DDB0230209
Dictyostelium discoideum (Ddi) ddi12769 DDB0230210
Debaryomyces hansenii (Dha) dha4499 DEHA0F02530g
Drosophila melanogaster (Dme) dme11679 CG8129-PA
(FBgn0037684)
Drosophila melanogaster (Dme) dme11678 CG8129-PB
(FBgn0037684)
Danio rerio (Dre) dre27984 ENSDARP00000044617
Escherichia coli (Eco) eco3012 16131010
Escherichia coli (Eco) eco3642 16131630
Takifugu rubripes (Fru) fru4579 SINFRUP00000137987
Takifugu rubripes (Fru) fru11995 SINFRUP00000162860
Gallus gallus (Gga) gga20197 ENSGALP00000004145
(LOC423635)
Gallus gallus (Gga) gga8870 ENSGALP00000004984
(SRR)
Homo sapiens (Hsa) hsa12788 ENSP00000339435
(SRR)		 Q9GZT4
Kluyveromyces lactis (Kla) kla3845 KLLA0E19877g
Mus musculus (Mmu) mmu4225 ENSMUSP00000067552
(MGI:1351636)		 Q9QZX7-1
Neurospora crassa (Ncr) ncr3498 NCU03607.2
Neurospora crassa (Ncr) ncr9885 NCU10180.2
Oryza sativa (Osa) osa5382 2187.m00134
Oryza sativa (Osa) osa523 761.m00075
Oryza sativa (Osa) osa83159 8287.m00114
Rattus norvegicus (Rno) rno5555 ENSRNOP00000042536
(RGD:735094)
Rattus norvegicus (Rno) rno5554 ENSRNOP00000050774
(RGD:735094)		 Q76EQ0
Saccharomyces cerevisiae (Sce) sce1816 YER086W
(S000000888)
Saccharomyces cerevisiae (Sce) sce3891 YKL218C
(S000001701)
Schizosaccharomyces pombe (Spo) spo141 SPBC1677.03c O94634
Schizosaccharomyces pombe (Spo) spo2179 SPCC320.14 O59791
Yarrowia lipolytica (Yli) yli1550 YALI0B19360g
Yarrowia lipolytica (Yli) yli2812 YALI0D02497g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001701
SpoSPCC320.14
GO:0005737 cytoplasm C
IDA
SpoSPBC1677.03c
ISO
MmuMGI:1351636
GO:0005739 mitochondrion C
IDA
SceS000000888
ISS
SpoSPBC1677.03c
GO:0005886 plasma membrane C
ISO
MmuMGI:1351636
GO:0045177 apical part of cell C
ISO
MmuMGI:1351636
GO:0004794 L-threonine ammonia-lyase activity F
IMP
AthAt3g10050
SceS000000888
ISS
AthAt3g10050
DmeFBgn0037684
SpoSPBC1677.03c
GO:0005509 calcium ion binding F
IDA
MmuMGI:1351636
GO:0005515 protein binding F
IPI
MmuMGI:1351636
GO:0005524 ATP binding F
IDA
MmuMGI:1351636
GO:0016594 glycine binding F
IDA
MmuMGI:1351636
GO:0018114 threonine racemase activity F
IDA
MmuMGI:1351636
GO:0030170 pyridoxal phosphate binding F
IMP
MmuMGI:1351636
ISO
MmuMGI:1351636
GO:0030378 serine racemase activity F
IDA
AthAt4g11640
MmuMGI:1351636
ISO
MmuMGI:1351636
ISS
AthAt4g11640
GO:0030848 threo-3-hydroxyaspartate ammonia-lyase
activity		 F
IDA
SceS000001701
IMP
SceS000001701
ISS
SpoSPCC320.14
GO:0042803 protein homodimerization activity F
IDA
MmuMGI:1351636
GO:0006082 organic acid metabolic process P
RCA
SceS000001701
S000000888
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000001701
S000000888
GO:0006563 L-serine metabolic process P
IDA
MmuMGI:1351636
ISO
MmuMGI:1351636
GO:0006566 threonine metabolic process P
ISS
AthAt3g10050
GO:0006567 threonine catabolic process P
IGI
SceS000000888
ISS
SpoSPCC320.14
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000000888
S000001701
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000001701
S000000888
GO:0009069 serine family amino acid metabolic
process		 P
IDA
AthAt4g11640
MmuMGI:1351636
ISS
AthAt4g11640
GO:0009097 isoleucine biosynthetic process P
IMP
SceS000000888
ISS
SpoSPBC1677.03c
TAS
AthAt3g10050
GO:0042219 cellular amino acid derivative catabolic
process		 P
IDA
SceS000001701
IMP
SceS000001701
GO:0051289 protein homotetramerization P
IDA
MmuMGI:1351636
GO:0070179 D-serine biosynthetic process P
IDA
MmuMGI:1351636

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC320.14
(O59791)		 YKL218C
(S000001701)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000001701
SpoSPCC320.14
GO:0030848 threo-3-hydroxyaspartate ammonia-lyase
activity		 F
IDA
SceS000001701
IMP
SceS000001701
ISS
SpoSPCC320.14
GO:0006082 organic acid metabolic process P
RCA
SceS000001701
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000001701
GO:0006567 threonine catabolic process P
ISS
SpoSPCC320.14
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000001701
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000001701
GO:0042219 cellular amino acid derivative catabolic
process		 P
IDA
SceS000001701
IMP
SceS000001701

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GO info in one table:

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