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Search term: YKR003W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name OSH6
SGD link S000001711
Alternative ID YKR003W
Description Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
Synonyms YKR003W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2210 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Oxysterol-binding protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g25850 GI:7485480
Arabidopsis thaliana (Ath) At4g25860 GI:15236023
Arabidopsis thaliana (Ath) At5g57240 GI:15242072
Caenorhabditis elegans (Cel) CE06680 GI:17570767
Caenorhabditis elegans (Cel) CE08539
(WBGene00016331)		 GI:17505815 O01686
Drosophila melanogaster (Dme) 7292023 GI:19923032 Q9W0K9
Drosophila melanogaster (Dme) 7303831 GI:7303831
Homo sapiens (Hsa) Hs14149740
(OSBPL5)		 GI:14149740 Q8WVV2
Homo sapiens (Hsa) Hs17473098 GI:17473098
Homo sapiens (Hsa) Hs18079218
(OSBPL8)		 GI:18079218 Q9BZF1
Homo sapiens (Hsa) Hs19923592
(OSBPL11)		 GI:19923592 Q9GZM0
Homo sapiens (Hsa) Hs19923812
(OSBPL10)		 GI:19923812 Q9NX98
Homo sapiens (Hsa) Hs20070331
(OSBPL9)		 GI:20070331 Q96SU4
Homo sapiens (Hsa) Hs22035609 GI:22035609 Q8WVV2
Homo sapiens (Hsa) Hs22043228 GI:22043228
Homo sapiens (Hsa) Hs22066714 GI:22066714
Saccharomyces cerevisiae (Sce) YHR001w
(S000001043)		 GI:6321787 P38755
Saccharomyces cerevisiae (Sce) YKR003w
(S000001711)		 GI:6322855 Q02201
Saccharomyces cerevisiae (Sce) YOR237w
(S000005763)		 GI:6324811 P35843
Saccharomyces cerevisiae (Sce) YPL145c
(S000006066)		 GI:6325112 P35844
Schizosaccharomyces pombe (Spo) SPBC1271.12 GI:19111930 O74178
Schizosaccharomyces pombe (Spo) SPBC354.07c GI:19112023 O43021
Schizosaccharomyces pombe (Spo) SPBC646.08c GI:19112158 O94512
Schizosaccharomyces pombe (Spo) SPCC23B6.01c GI:19075624 Q9UUA1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000139 Golgi membrane C
IDA
SceS000006066
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
SceS000001711
GO:0005575 cellular_component C
ND
AthAt5g57240
At4g25860
At4g25850
SceS000005763
GO:0005625 soluble fraction C
IDA
SceS000001043
S000001711
GO:0005634 nucleus C
IDA
SpoSPCC23B6.01c
GO:0005737 cytoplasm C
IDA
SceS000001711
S000001043
S000006066
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.07c
SPBC646.08c
GO:0005829 cytosol C
IDA
SpoSPCC23B6.01c
NAS
HsaOSBPL5
GO:0019898 extrinsic to membrane C
IDA
SceS000006066
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000001711
GO:0032153 cell division site C
IDA
SpoSPBC1271.12
GO:0005515 protein binding F
IPI
HsaOSBPL5
GO:0005516 calmodulin binding F
IPI
CelWBGene00016331
GO:0005543 phospholipid binding F
RCA
SceS000001043
S000005763
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
IMP
SceS000006066
IPI
SceS000006066
GO:0008142 oxysterol binding F
IDA
SceS000005763
IMP
SceS000006066
IPI
SceS000006066
ISS
AthAt5g57240
At4g25850
At4g25860
SceS000001043
S000001711
S000005763
S000006066
SpoSPBC1271.12
SPBC354.07c
SPBC646.08c
SPCC23B6.01c
NAS
HsaOSBPL5
GO:0010314 phosphatidylinositol-5-phosphate
binding		 F
IDA
SceS000001711
GO:0015485 cholesterol binding F
IPI
SceS000006066
GO:0035091 phosphoinositide binding F
RCA
SceS000001043
S000005763
GO:0043325 phosphatidylinositol-3,4-bisphosphate
binding		 F
IDA
SceS000001711
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001711
GO:0070300 phosphatidic acid binding F
IDA
SceS000001711
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001711
GO:0006694 steroid biosynthetic process P
ISS
SpoSPBC646.08c
SPBC354.07c
SPBC1271.12
SPCC23B6.01c
GO:0006869 lipid transport P
RCA
SceS000006066
GO:0006887 exocytosis P
IGI
SceS000001043
S000001711
S000005763
S000006066
GO:0006892 post-Golgi vesicle-mediated transport P
IGI
SceS000006066
GO:0006893 Golgi to plasma membrane transport P
NAS
HsaOSBPL5
GO:0006897 endocytosis P
IGI
SceS000001043
S000001711
S000006066
S000005763
GO:0008202 steroid metabolic process P
ISS
AthAt5g57240
At4g25850
At4g25860
GO:0008203 cholesterol metabolic process P
NAS
HsaOSBPL5
GO:0015918 sterol transport P
IDA
SceS000006066
IGI
SceS000001711
S000001043
S000005763
S000006066
IMP
SceS000005763
GO:0016125 sterol metabolic process P
IGI
SceS000001043
S000001711
GO:0030011 maintenance of cell polarity P
IGI
SceS000001043
S000001711
S000006066
S000005763
GO:0030100 regulation of endocytosis P
ISS
SpoSPBC646.08c
GO:0030301 cholesterol transport P
NAS
HsaOSBPL5
GO:0033554 cellular response to stress P
IEP
SpoSPCC23B6.01c
GO:0045324 late endosome to vacuole transport P
IMP
SceS000001043
GO:0055092 sterol homeostasis P
IMP
SceS000001711

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68813

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) OSBPL8 GI:18079218 Q9BZF1
Pan troglodytes (Ptr) OSBPL8 GI:114645962
Canis familiaris (Cfa) OSBPL8 GI:73977434
Mus musculus (Mmu) Osbpl8
(MGI:2443807)		 GI:51243034 B9EJ86
Rattus norvegicus (Rno) RGD1561474 GI:109480510
Gallus gallus (Gga) OSBPL8 GI:118082441
Drosophila melanogaster (Dme) CG5077
(FBgn0038786)		 GI:62484308
Anopheles gambiae (Aga) AgaP_AGAP003484 GI:158287709
Caenorhabditis elegans (Cel) obr-3
(CE31672;
WBGene00014215)		 GI:25152502
Schizosaccharomyces pombe (Spo) SPCC23B6.01c GI:19075624 Q9UUA1
Saccharomyces cerevisiae (Sce) OSH6
(S000001711)		 GI:6322855 Q02201
Magnaporthe grisea (Mgr) MGG_09949 GI:145605325
Neurospora crassa (Ncr) NCU03258.1 GI:32420501


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
SceS000001711
GO:0005575 cellular_component C
ND
MmuMGI:2443807
GO:0005625 soluble fraction C
IDA
SceS000001711
GO:0005634 nucleus C
IDA
SpoSPCC23B6.01c
GO:0005737 cytoplasm C
IDA
SceS000001711
GO:0005829 cytosol C
IDA
SpoSPCC23B6.01c
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000001711
GO:0003674 molecular_function F
ND
MmuMGI:2443807
GO:0005515 protein binding F
IDA
CelWBGene00014215
GO:0008142 oxysterol binding F
ISS
SceS000001711
SpoSPCC23B6.01c
GO:0010314 phosphatidylinositol-5-phosphate
binding		 F
IDA
SceS000001711
GO:0043325 phosphatidylinositol-3,4-bisphosphate
binding		 F
IDA
SceS000001711
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001711
GO:0070300 phosphatidic acid binding F
IDA
SceS000001711
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001711
GO:0006694 steroid biosynthetic process P
ISS
SpoSPCC23B6.01c
GO:0006887 exocytosis P
IGI
SceS000001711
GO:0006897 endocytosis P
IGI
SceS000001711
GO:0007179 transforming growth factor beta receptor signaling
pathway		 P
IMP
CelWBGene00014215
GO:0008150 biological_process P
ND
MmuMGI:2443807
GO:0015918 sterol transport P
IGI
SceS000001711
GO:0016125 sterol metabolic process P
IGI
SceS000001711
GO:0030011 maintenance of cell polarity P
IGI
SceS000001711
GO:0033554 cellular response to stress P
IEP
SpoSPCC23B6.01c
GO:0040014 regulation of multicellular organism
growth		 P
IMP
CelWBGene00014215
GO:0055092 sterol homeostasis P
IMP
SceS000001711

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_889

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5898 ENSANGP00000013607
Anopheles gambiae (Aga) aga5907 ENSANGP00000019711
Ashbya gossypii (Ago) ago2218 AEL287C
Arabidopsis thaliana (Ath) ath20572 At4g25850.1
Arabidopsis thaliana (Ath) ath20573 At4g25860.1
Arabidopsis thaliana (Ath) ath27745 At5g57240.1
Caenorhabditis elegans (Cel) cel21540 ZK1086.1a
(CE31672;
WBGene00014215)
Caenorhabditis elegans (Cel) cel21541 ZK1086.1b
(CE31673)
Candida glabrata (Cgl) cgl3644 CAGL0K02849g
Cryptococcus neoformans (Cne) cne3363 167.m05853
Dictyostelium discoideum (Ddi) ddi2857 DDB0168846
Dictyostelium discoideum (Ddi) ddi9180 DDB0186367
Debaryomyces hansenii (Dha) dha3766 DEHA0E11858g
Drosophila melanogaster (Dme) dme13482 CG5077-PA
(FBgn0038786)
Drosophila melanogaster (Dme) dme13483 CG5077-PB
(FBgn0038786)
Drosophila melanogaster (Dme) dme13484 CG5077-PC
(FBgn0038786)
Drosophila melanogaster (Dme) dme13485 CG5077-PD
(FBgn0038786)
Danio rerio (Dre) dre24753 ENSDARP00000015840
Danio rerio (Dre) dre6990 ENSDARP00000044721
Takifugu rubripes (Fru) fru11492 SINFRUP00000130177
Takifugu rubripes (Fru) fru31420 SINFRUP00000148541
Takifugu rubripes (Fru) fru31421 SINFRUP00000148543
Takifugu rubripes (Fru) fru11493 SINFRUP00000172236
Gallus gallus (Gga) gga18867 ENSGALP00000010318
Gallus gallus (Gga) gga18868 ENSGALP00000010319
(OSBPL5)
Gallus gallus (Gga) gga526 ENSGALP00000016641
(OSBPL8)
Gallus gallus (Gga) gga527 ENSGALP00000016642
Gallus gallus (Gga) gga528 ENSGALP00000016643
Gallus gallus (Gga) gga529 ENSGALP00000016644
Homo sapiens (Hsa) hsa7908 ENSP00000261183
(OSBPL8)		 Q5HYM3
Homo sapiens (Hsa) hsa4990 ENSP00000263650
(OSBPL5)		 Q9H0X9
Homo sapiens (Hsa) hsa4989 ENSP00000302872
(OSBPL5)		 A8KAD5
Homo sapiens (Hsa) hsa7907 ENSP00000326167
Kluyveromyces lactis (Kla) kla120 KLLA0A02827g
Mus musculus (Mmu) mmu2832 ENSMUSP00000020415
Mus musculus (Mmu) mmu25487 ENSMUSP00000046609
(MGI:1930265)		 Q6ZPN6
Mus musculus (Mmu) mmu2830 ENSMUSP00000047268
(MGI:2443807)		 Q69ZJ4
Neurospora crassa (Ncr) ncr3156 NCU03258.2
Oryza sativa (Osa) osa16727 3094.m00118
Oryza sativa (Osa) osa67331 6953.m00084
Rattus norvegicus (Rno) rno3360 ENSRNOP00000028119
(RGD:1308402)
Rattus norvegicus (Rno) rno26742 ENSRNOP00000030955
(RGD:1561474)
Saccharomyces cerevisiae (Sce) sce2744 YHR001W
(S000001043)
Saccharomyces cerevisiae (Sce) sce3901 YKR003W
(S000001711)
Schizosaccharomyces pombe (Spo) spo4249 SPCC23B6.01c Q9UUA1
Yarrowia lipolytica (Yli) yli88 YALI0A02354g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
SceS000001711
GO:0005575 cellular_component C
ND
AthAt5g57240
At4g25860
At4g25850
MmuMGI:2443807
GO:0005625 soluble fraction C
IDA
SceS000001043
S000001711
GO:0005634 nucleus C
IDA
SpoSPCC23B6.01c
GO:0005737 cytoplasm C
IDA
SceS000001711
S000001043
GO:0005829 cytosol C
IDA
SpoSPCC23B6.01c
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000001711
GO:0003674 molecular_function F
ND
MmuMGI:2443807
GO:0005515 protein binding F
IDA
CelWBGene00014215
GO:0005543 phospholipid binding F
RCA
SceS000001043
GO:0008142 oxysterol binding F
ISS
AthAt5g57240
At4g25850
At4g25860
SceS000001043
S000001711
SpoSPCC23B6.01c
GO:0010314 phosphatidylinositol-5-phosphate
binding		 F
IDA
SceS000001711
GO:0035091 phosphoinositide binding F
RCA
SceS000001043
GO:0043325 phosphatidylinositol-3,4-bisphosphate
binding		 F
IDA
SceS000001711
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001711
GO:0070300 phosphatidic acid binding F
IDA
SceS000001711
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001711
GO:0006694 steroid biosynthetic process P
ISS
SpoSPCC23B6.01c
GO:0006887 exocytosis P
IGI
SceS000001043
S000001711
GO:0006897 endocytosis P
IGI
SceS000001043
S000001711
GO:0007179 transforming growth factor beta receptor signaling
pathway		 P
IMP
CelWBGene00014215
GO:0008150 biological_process P
ND
MmuMGI:2443807
GO:0008202 steroid metabolic process P
ISS
AthAt5g57240
At4g25850
At4g25860
GO:0015918 sterol transport P
IGI
SceS000001711
S000001043
GO:0016125 sterol metabolic process P
IGI
SceS000001043
S000001711
GO:0030011 maintenance of cell polarity P
IGI
SceS000001043
S000001711
GO:0033554 cellular response to stress P
IEP
SpoSPCC23B6.01c
GO:0040014 regulation of multicellular organism
growth		 P
IMP
CelWBGene00014215
GO:0045324 late endosome to vacuole transport P
IMP
SceS000001043
GO:0055092 sterol homeostasis P
IMP
SceS000001711

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC23B6.01c
(Q9UUA1)		 YKR003W
(S000001711)
SPBC646.08c
(O94512)		 YKR003W
(S000001711)
SPBC354.07c
(O43021)		 YKR003W
(S000001711)
SPBC1271.12
(O74178)		 YKR003W
(S000001711)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
SceS000001711
GO:0005625 soluble fraction C
IDA
SceS000001711
GO:0005634 nucleus C
IDA
SpoSPCC23B6.01c
GO:0005737 cytoplasm C
IDA
SceS000001711
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.07c
SPBC646.08c
GO:0005829 cytosol C
IDA
SpoSPCC23B6.01c
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000001711
GO:0032153 cell division site C
IDA
SpoSPBC1271.12
GO:0008142 oxysterol binding F
ISS
SceS000001711
SpoSPBC1271.12
SPBC354.07c
SPBC646.08c
SPCC23B6.01c
GO:0010314 phosphatidylinositol-5-phosphate
binding		 F
IDA
SceS000001711
GO:0043325 phosphatidylinositol-3,4-bisphosphate
binding		 F
IDA
SceS000001711
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001711
GO:0070300 phosphatidic acid binding F
IDA
SceS000001711
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001711
GO:0006694 steroid biosynthetic process P
ISS
SpoSPBC646.08c
SPBC354.07c
SPBC1271.12
SPCC23B6.01c
GO:0006887 exocytosis P
IGI
SceS000001711
GO:0006897 endocytosis P
IGI
SceS000001711
GO:0015918 sterol transport P
IGI
SceS000001711
GO:0016125 sterol metabolic process P
IGI
SceS000001711
GO:0030011 maintenance of cell polarity P
IGI
SceS000001711
GO:0030100 regulation of endocytosis P
ISS
SpoSPBC646.08c
GO:0033554 cellular response to stress P
IEP
SpoSPCC23B6.01c
GO:0055092 sterol homeostasis P
IMP
SceS000001711

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