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Search term: YKR014C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YPT52
SGD link S000001722
Alternative ID YKR014C
Description GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
Synonyms YKR014C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0092 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING GTPase Rab5/YPT51 and related small G protein superfamily GTPases

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g54840 GI:15233104
Arabidopsis thaliana (Ath) At4g19640 GI:15235113
Arabidopsis thaliana (Ath) At5g45130 GI:15242309
Caenorhabditis elegans (Cel) CE04261
(WBGene00016874)		 GI:17551122 Q18773
Caenorhabditis elegans (Cel) CE09711
(WBGene00004268)		 GI:17506899 P91857
Drosophila melanogaster (Dme) 7291595
(FBgn0015372)		 GI:17864296
Drosophila melanogaster (Dme) 7295967 GI:17736973
Homo sapiens (Hsa) Hs10190714
(RAB22A)		 GI:10190714 Q9UL26
Homo sapiens (Hsa) Hs11967981
(RAB17)		 GI:11967981 Q9H0T7
Homo sapiens (Hsa) Hs13652324 GI:13652324
Homo sapiens (Hsa) Hs17436635 GI:17436635
Homo sapiens (Hsa) Hs18640748 GI:18640748
Homo sapiens (Hsa) Hs19923262
(RAB5A)		 GI:19923262 P20339
Homo sapiens (Hsa) Hs20473423_1 GI:20473423
Homo sapiens (Hsa) Hs22058538 GI:22058538
Homo sapiens (Hsa) Hs4506371
(RAB5B)		 GI:4506371 Q9H2I5
Homo sapiens (Hsa) Hs4759020 GI:4759020
Homo sapiens (Hsa) Hs5803131 GI:5803131
Homo sapiens (Hsa) Hs8923401
(RAB20)		 GI:8923401 Q9NX57
Saccharomyces cerevisiae (Sce) YBR264c
(S000000468)		 GI:6319741
Saccharomyces cerevisiae (Sce) YKR014c
(S000001722)		 GI:6322866 P36018
Saccharomyces cerevisiae (Sce) YNL093w
(S000005037)		 GI:6324236 P36019
Saccharomyces cerevisiae (Sce) YOR089c
(S000005615)		 GI:6324663 P36017
Schizosaccharomyces pombe (Spo) SPAC6F6.15 GI:19114819 P36586
Encephalitozoon cuniculi (Ecu) ECU08g0730 GI:19173399 Q8SRC8
Arabidopsis thaliana (Ath) At3g54840 GI:15233104
Arabidopsis thaliana (Ath) At4g19640 GI:15235113
Arabidopsis thaliana (Ath) At5g45130 GI:15242309
Caenorhabditis elegans (Cel) CE04261
(WBGene00016874)		 GI:17551122 Q18773
Caenorhabditis elegans (Cel) CE09711
(WBGene00004268)		 GI:17506899 P91857
Drosophila melanogaster (Dme) 7291595
(FBgn0015372)		 GI:17864296
Drosophila melanogaster (Dme) 7295967 GI:17736973
Homo sapiens (Hsa) Hs10190714
(RAB22A)		 GI:10190714 Q9UL26
Homo sapiens (Hsa) Hs11967981
(RAB17)		 GI:11967981 Q9H0T7
Homo sapiens (Hsa) Hs13652324 GI:13652324
Homo sapiens (Hsa) Hs17436635 GI:17436635
Homo sapiens (Hsa) Hs18640748 GI:18640748
Homo sapiens (Hsa) Hs19923262
(RAB5A)		 GI:19923262 P20339
Homo sapiens (Hsa) Hs20473423_1 GI:20473423
Homo sapiens (Hsa) Hs22058538 GI:22058538
Homo sapiens (Hsa) Hs4506371
(RAB5B)		 GI:4506371 Q9H2I5
Homo sapiens (Hsa) Hs4759020 GI:4759020
Homo sapiens (Hsa) Hs5803131 GI:5803131
Homo sapiens (Hsa) Hs8923401
(RAB20)		 GI:8923401 Q9NX57
Saccharomyces cerevisiae (Sce) YBR264c
(S000000468)		 GI:6319741
Saccharomyces cerevisiae (Sce) YKR014c
(S000001722)		 GI:6322866 P36018
Saccharomyces cerevisiae (Sce) YNL093w
(S000005037)		 GI:6324236 P36019
Saccharomyces cerevisiae (Sce) YOR089c
(S000005615)		 GI:6324663 P36017
Schizosaccharomyces pombe (Spo) SPAC6F6.15 GI:19114819 P36586
Encephalitozoon cuniculi (Ecu) ECU08g0730 GI:19173399 Q8SRC8
Arabidopsis thaliana (Ath) At3g54840 GI:15233104
Arabidopsis thaliana (Ath) At4g19640 GI:15235113
Arabidopsis thaliana (Ath) At5g45130 GI:15242309
Caenorhabditis elegans (Cel) CE04261
(WBGene00016874)		 GI:17551122 Q18773
Caenorhabditis elegans (Cel) CE09711
(WBGene00004268)		 GI:17506899 P91857
Drosophila melanogaster (Dme) 7291595
(FBgn0015372)		 GI:17864296
Drosophila melanogaster (Dme) 7295967 GI:17736973
Homo sapiens (Hsa) Hs10190714
(RAB22A)		 GI:10190714 Q9UL26
Homo sapiens (Hsa) Hs11967981
(RAB17)		 GI:11967981 Q9H0T7
Homo sapiens (Hsa) Hs13652324 GI:13652324
Homo sapiens (Hsa) Hs17436635 GI:17436635
Homo sapiens (Hsa) Hs18640748 GI:18640748
Homo sapiens (Hsa) Hs19923262
(RAB5A)		 GI:19923262 P20339
Homo sapiens (Hsa) Hs20473423_1 GI:20473423
Homo sapiens (Hsa) Hs22058538 GI:22058538
Homo sapiens (Hsa) Hs4506371
(RAB5B)		 GI:4506371 Q9H2I5
Homo sapiens (Hsa) Hs4759020 GI:4759020
Homo sapiens (Hsa) Hs5803131 GI:5803131
Homo sapiens (Hsa) Hs8923401
(RAB20)		 GI:8923401 Q9NX57
Saccharomyces cerevisiae (Sce) YBR264c
(S000000468)		 GI:6319741
Saccharomyces cerevisiae (Sce) YKR014c
(S000001722)		 GI:6322866 P36018
Saccharomyces cerevisiae (Sce) YNL093w
(S000005037)		 GI:6324236 P36019
Saccharomyces cerevisiae (Sce) YOR089c
(S000005615)		 GI:6324663 P36017
Schizosaccharomyces pombe (Spo) SPAC6F6.15 GI:19114819 P36586
Encephalitozoon cuniculi (Ecu) ECU08g0730 GI:19173399 Q8SRC8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IDA
HsaRAB17
RAB5B
GO:0005624 membrane fraction C
TAS
HsaRAB5B
GO:0005634 nucleus C
IDA
SpoSPAC6F6.15
GO:0005737 cytoplasm C
IDA
SceS000000468
GO:0005739 mitochondrion C
IDA
SceS000005615
GO:0005741 mitochondrial outer membrane C
IDA
SceS000005615
GO:0005768 endosome C
IDA
AthAt4g19640
At3g54840
CelWBGene00004268
HsaRAB5B
GO:0005769 early endosome C
IDA
AthAt3g54840
HsaRAB22A
RAB5A
GO:0005770 late endosome C
IMP
SceS000001722
S000005037
S000005615
ISS
SpoSPAC6F6.15
GO:0005829 cytosol C
IDA
SpoSPAC6F6.15
GO:0005886 plasma membrane C
IDA
AthAt4g19640
HsaRAB22A
ISS
DmeFBgn0015372
GO:0005938 cell cortex C
IDA
CelWBGene00004268
GO:0010009 external side of endosome membrane C
IDA
AthAt3g54840
GO:0003924 GTPase activity F
IDA
AthAt3g54840
CelWBGene00004268
HsaRAB5A
SceS000005037
S000001722
S000005615
IMP
SceS000001722
S000005615
S000005037
ISS
CelWBGene00004268
DmeFBgn0015372
SceS000000468
S000001722
S000005037
S000005615
SpoSPAC6F6.15
TAS
DmeFBgn0015372
HsaRAB22A
RAB5B
GO:0005515 protein binding F
IPI
HsaRAB17
RAB5A
RAB22A
RAB5B
GO:0005525 GTP binding F
IDA
HsaRAB5A
SceS000005615
SpoSPAC6F6.15
ISS
AthAt5g45130
At4g19640
At3g54840
DmeFBgn0015372
GO:0019001 guanyl nucleotide binding F
IDA
SceS000000468
GO:0019003 GDP binding F
IDA
HsaRAB5A
GO:0030742 GTP-dependent protein binding F
IDA
HsaRAB5B
GO:0000011 vacuole inheritance P
IMP
SceS000005615
GO:0000910 cytokinesis P
IMP
CelWBGene00004268
GO:0002119 nematode larval development P
IMP
CelWBGene00004268
GO:0006184 GTP catabolic process P
IDA
CelWBGene00004268
ISS
SpoSPAC6F6.15
GO:0006508 proteolysis P
RCA
SceS000001722
GO:0006623 protein targeting to vacuole P
IMP
SceS000001722
S000005037
S000005615
GO:0006897 endocytosis P
IDA
HsaRAB22A
RAB5A
IMP
SceS000001722
S000005037
S000005615
ISS
SpoSPAC6F6.15
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004268
GO:0007028 cytoplasm organization P
IMP
CelWBGene00004268
GO:0007030 Golgi organization P
IGI
SceS000000468
GO:0007032 endosome organization P
IEP
HsaRAB22A
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC6F6.15
GO:0007422 peripheral nervous system development P
IMP
DmeFBgn0015372
GO:0008105 asymmetric protein localization P
IMP
CelWBGene00004268
GO:0008219 cell death P
IMP
CelWBGene00004268
GO:0009306 protein secretion P
IMP
CelWBGene00004268
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004268
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004268
GO:0031338 regulation of vesicle fusion P
IMP
SpoSPAC6F6.15
GO:0031623 receptor internalization P
IDA
HsaRAB5A
GO:0033157 regulation of intracellular protein
transport		 P
IC
SpoSPAC6F6.15
GO:0040007 growth P
IMP
CelWBGene00004268
GO:0045022 early endosome to late endosome
transport		 P
IMP
AthAt3g54840
GO:0051301 cell division P
IMP
CelWBGene00004268
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC6F6.15

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
104027

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RAB5B GI:4506371 Q9H2I5
Pan troglodytes (Ptr) RAB5B GI:114644159
Canis familiaris (Cfa) RAB5B GI:73968313
Mus musculus (Mmu) Rab5b
(MGI:105938)		 GI:6755262 B2RPS1
Rattus norvegicus (Rno) Rab5b GI:109480137
Schizosaccharomyces pombe (Spo) ypt5
(SPAC6F6.15)		 GI:19114819 P36586
Saccharomyces cerevisiae (Sce) YPT52
(S000001722)		 GI:6322866 P36018
Kluyveromyces lactis (Kla) KLLA0D02376g GI:50306401
Eremothecium gossypii (Ego) AGOS_AAL176C GI:45184648
Magnaporthe grisea (Mgr) MGG_01185 GI:145614042
Neurospora crassa (Ncr) NCU00895.1 GI:32409189


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IDA
HsaRAB5B
GO:0005624 membrane fraction C
TAS
HsaRAB5B
GO:0005634 nucleus C
IDA
SpoSPAC6F6.15
GO:0005768 endosome C
IDA
HsaRAB5B
GO:0005770 late endosome C
IMP
SceS000001722
ISS
SpoSPAC6F6.15
GO:0005829 cytosol C
IDA
SpoSPAC6F6.15
GO:0030139 endocytic vesicle C
IDA
MmuMGI:105938
GO:0003924 GTPase activity F
IDA
SceS000001722
IMP
SceS000001722
ISS
SceS000001722
SpoSPAC6F6.15
TAS
HsaRAB5B
MmuMGI:105938
GO:0005515 protein binding F
IPI
HsaRAB5B
GO:0005525 GTP binding F
IDA
SpoSPAC6F6.15
GO:0030742 GTP-dependent protein binding F
IDA
HsaRAB5B
GO:0006184 GTP catabolic process P
ISS
SpoSPAC6F6.15
TAS
MmuMGI:105938
GO:0006508 proteolysis P
RCA
SceS000001722
GO:0006623 protein targeting to vacuole P
IMP
SceS000001722
GO:0006897 endocytosis P
IMP
SceS000001722
ISS
SpoSPAC6F6.15
GO:0007032 endosome organization P
IDA
MmuMGI:105938
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC6F6.15
GO:0030100 regulation of endocytosis P
IDA
MmuMGI:105938
GO:0031338 regulation of vesicle fusion P
IMP
SpoSPAC6F6.15
GO:0033157 regulation of intracellular protein
transport		 P
IC
SpoSPAC6F6.15
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC6F6.15

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_10436

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago11 AAL176C
Candida glabrata (Cgl) cgl1957 CAGL0G07689g
Debaryomyces hansenii (Dha) dha114 DEHA0A02585g
Kluyveromyces lactis (Kla) kla2173 KLLA0D02376g
Plasmodium falciparum (Pfa) pfa54 PFB0500c
Saccharomyces cerevisiae (Sce) sce3912 YKR014C
(S000001722)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005770 late endosome C
IMP
SceS000001722
GO:0003924 GTPase activity F
IDA
SceS000001722
IMP
SceS000001722
ISS
PfaPFB0500c
SceS000001722
GO:0006508 proteolysis P
RCA
SceS000001722
GO:0006623 protein targeting to vacuole P
IMP
SceS000001722
GO:0006897 endocytosis P
IMP
SceS000001722

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC6F6.15
(P36586)		 YKR014C
(S000001722)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC6F6.15
GO:0005770 late endosome C
IMP
SceS000001722
ISS
SpoSPAC6F6.15
GO:0005829 cytosol C
IDA
SpoSPAC6F6.15
GO:0003924 GTPase activity F
IDA
SceS000001722
IMP
SceS000001722
ISS
SceS000001722
SpoSPAC6F6.15
GO:0005525 GTP binding F
IDA
SpoSPAC6F6.15
GO:0006184 GTP catabolic process P
ISS
SpoSPAC6F6.15
GO:0006508 proteolysis P
RCA
SceS000001722
GO:0006623 protein targeting to vacuole P
IMP
SceS000001722
GO:0006897 endocytosis P
IMP
SceS000001722
ISS
SpoSPAC6F6.15
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC6F6.15
GO:0031338 regulation of vesicle fusion P
IMP
SpoSPAC6F6.15
GO:0033157 regulation of intracellular protein
transport		 P
IC
SpoSPAC6F6.15
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC6F6.15

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