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Search term: YKR026C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GCN3
SGD link S000001734
Alternative ID YKR026C
Description Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
Synonyms YKR026C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1466 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g53880_2 GI:18404685
Arabidopsis thaliana (Ath) At1g53900_2 GI:15220970
Arabidopsis thaliana (Ath) At1g72340 GI:12325267
Caenorhabditis elegans (Cel) CE00367
(WBGene00014221)		 GI:17557123 P34604
Drosophila melanogaster (Dme) 7301868 GI:7301868
Homo sapiens (Hsa) Hs4503503
(EIF2B1)		 GI:4503503 Q14232
Saccharomyces cerevisiae (Sce) YKR026c
(S000001734)		 GI:6322878 P14741
Schizosaccharomyces pombe (Spo) SPCC11E10.07c GI:19075703 Q9USP0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
HsaEIF2B1
GO:0005634 nucleus C
IDA
SpoSPCC11E10.07c
GO:0005737 cytoplasm C
IDA
HsaEIF2B1
GO:0005829 cytosol C
IDA
SpoSPCC11E10.07c
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
HsaEIF2B1
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
ISS
AthAt1g72340
At1g53900
At1g53880
SpoSPCC11E10.07c
GO:0005886 plasma membrane C
IDA
HsaEIF2B1
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000001734
GO:0003743 translation initiation factor activity F
IDA
HsaEIF2B1
SceS000001734
IMP
SceS000001734
ISS
AthAt1g72340
At1g53900
At1g53880
SpoSPCC11E10.07c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
HsaEIF2B1
SceS000001734
GO:0005515 protein binding F
IPI
HsaEIF2B1
GO:0005525 GTP binding F
ISS
AthAt1g53880
At1g72340
At1g53900
GO:0030234 enzyme regulator activity F
IGI
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
GO:0006413 translational initiation P
IDA
HsaEIF2B1
ISS
AthAt1g72340
At1g53900
At1g53880
SpoSPCC11E10.07c
GO:0006446 regulation of translational initiation P
IDA
SceS000001734
IGI
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
GO:0009408 response to heat P
ISS
HsaEIF2B1
TAS
HsaEIF2B1
GO:0009749 response to glucose stimulus P
ISS
HsaEIF2B1
GO:0014003 oligodendrocyte development P
IMP
HsaEIF2B1
GO:0043434 response to peptide hormone stimulus P
ISS
HsaEIF2B1
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPCC11E10.07c
GO:0051716 cellular response to stimulus P
IDA
HsaEIF2B1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1080

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EIF2B1 GI:4503503 Q14232
Pan troglodytes (Ptr) EIF2B1 GI:114647701
Canis familiaris (Cfa) EIF2B1 GI:57105538
Mus musculus (Mmu) Eif2b1
(MGI:2384802)		 GI:21703744 Q3UZR8
Rattus norvegicus (Rno) Eif2b1
(RGD:620819)		 GI:25282453
Drosophila melanogaster (Dme) eIF2B-alpha GI:21358605
Anopheles gambiae (Aga) AgaP_AGAP003650 GI:58384766
Anopheles gambiae (Aga) AgaP_AGAP012611 GI:58375348
Anopheles gambiae (Aga) AgaP_AGAP012799 GI:158284465
Caenorhabditis elegans (Cel) ZK1098.4
(CE00367;
WBGene00014221)		 GI:17557123 P34604
Schizosaccharomyces pombe (Spo) SPCC11E10.07c GI:19075703 Q9USP0
Saccharomyces cerevisiae (Sce) GCN3
(S000001734)		 GI:6322878 P14741
Kluyveromyces lactis (Kla) KLLA0F13970g GI:50311369
Eremothecium gossypii (Ego) AGOS_AFR084C GI:45198602
Arabidopsis thaliana (Ath) AT1G53880 GI:79365595
Arabidopsis thaliana (Ath) AT1G53900 GI:79365631
Arabidopsis thaliana (Ath) AT1G72340 GI:18410057
Oryza sativa (Osa) Os12g0497400 GI:115488640


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
HsaEIF2B1
ISO
MmuMGI:2384802
GO:0005625 soluble fraction C
ISO
MmuMGI:2384802
GO:0005634 nucleus C
IDA
SpoSPCC11E10.07c
GO:0005737 cytoplasm C
IDA
HsaEIF2B1
ISO
MmuMGI:2384802
GO:0005829 cytosol C
IDA
SpoSPCC11E10.07c
ISS
DmeeIF2B-alpha
GO:0005850 eukaryotic translation initiation factor 2
complex		 C
ISO
MmuMGI:2384802
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
HsaEIF2B1
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
ISO
MmuMGI:2384802
ISS
AthAt1g72340
At1g53900
At1g53880
DmeeIF2B-alpha
SpoSPCC11E10.07c
GO:0005886 plasma membrane C
IDA
HsaEIF2B1
ISO
MmuMGI:2384802
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000001734
GO:0003743 translation initiation factor activity F
IDA
HsaEIF2B1
SceS000001734
IMP
SceS000001734
ISO
MmuMGI:2384802
ISS
AthAt1g72340
At1g53900
At1g53880
DmeeIF2B-alpha
SpoSPCC11E10.07c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
HsaEIF2B1
SceS000001734
ISO
MmuMGI:2384802
MGI:2384802
GO:0005515 protein binding F
IPI
HsaEIF2B1
MmuMGI:2384802
GO:0005525 GTP binding F
ISO
MmuMGI:2384802
ISS
AthAt1g53880
At1g72340
At1g53900
GO:0019003 GDP binding F
ISO
MmuMGI:2384802
GO:0030234 enzyme regulator activity F
IGI
DmeeIF2B-alpha
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
ISO
MmuMGI:2384802
GO:0006412 translation P
ISO
MmuMGI:2384802
GO:0006413 translational initiation P
IDA
HsaEIF2B1
ISO
MmuMGI:2384802
ISS
AthAt1g72340
At1g53900
At1g53880
DmeeIF2B-alpha
SpoSPCC11E10.07c
GO:0006417 regulation of translation P
ISO
MmuMGI:2384802
GO:0006446 regulation of translational initiation P
IDA
SceS000001734
IGI
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
GO:0009408 response to heat P
ISO
MmuMGI:2384802
ISS
HsaEIF2B1
TAS
HsaEIF2B1
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:2384802
ISS
HsaEIF2B1
GO:0014003 oligodendrocyte development P
IMP
HsaEIF2B1
GO:0032057 negative regulation of translational initiation in
response to stress		 P
ISO
MmuMGI:2384802
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:2384802
ISS
HsaEIF2B1
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPCC11E10.07c
GO:0051716 cellular response to stimulus P
IDA
HsaEIF2B1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1946

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga13743 ENSANGP00000011855
Anopheles gambiae (Aga) aga14039 ENSANGP00000012082
Anopheles gambiae (Aga) aga6109 ENSANGP00000019638
Ashbya gossypii (Ago) ago3276 AFR084C
Arabidopsis thaliana (Ath) ath4691 At1g53880.1
Arabidopsis thaliana (Ath) ath4694 At1g53900.1
Arabidopsis thaliana (Ath) ath6522 At1g72340.1
Caenorhabditis elegans (Cel) cel21550 ZK1098.4
(CE00367;
WBGene00014221)
Candida glabrata (Cgl) cgl4206 CAGL0L03003g
Cryptococcus neoformans (Cne) cne5779 179.m00653
Dictyostelium discoideum (Ddi) ddi12862 DDB0231375
Debaryomyces hansenii (Dha) dha5426 DEHA0F23331g
Drosophila melanogaster (Dme) dme15121 CG7883-PA
(FBgn0039726)
Danio rerio (Dre) dre3292 ENSDARP00000003875
(eif2b1)		 Q6IQQ8
Takifugu rubripes (Fru) fru29316 SINFRUP00000136413
Gallus gallus (Gga) gga7158 ENSGALP00000005151
Homo sapiens (Hsa) hsa8418 ENSP00000228958
(EIF2B1)		 Q14232
Kluyveromyces lactis (Kla) kla4709 KLLA0F13970g
Mus musculus (Mmu) mmu20954 ENSMUSP00000031334
(MGI:2384802)		 Q99LC8
Neurospora crassa (Ncr) ncr4220 NCU04344.2
Oryza sativa (Osa) osa68683 7025.m00165
Oryza sativa (Osa) osa82000 8232.m00155
Plasmodium falciparum (Pfa) pfa2103 PF08_0009
Rattus norvegicus (Rno) rno8517 ENSRNOP00000001373
(RGD:620819)		 Q64270
Saccharomyces cerevisiae (Sce) sce3924 YKR026C
(S000001734)
Schizosaccharomyces pombe (Spo) spo154 SPCC11E10.07c Q9USP0
Yarrowia lipolytica (Yli) yli2444 YALI0C18161g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
ISO
MmuMGI:2384802
GO:0005625 soluble fraction C
ISO
MmuMGI:2384802
GO:0005634 nucleus C
IDA
SpoSPCC11E10.07c
GO:0005737 cytoplasm C
ISO
MmuMGI:2384802
GO:0005829 cytosol C
IDA
SpoSPCC11E10.07c
ISS
DmeFBgn0039726
GO:0005850 eukaryotic translation initiation factor 2
complex		 C
ISO
MmuMGI:2384802
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
ISO
MmuMGI:2384802
ISS
AthAt1g72340
At1g53900
At1g53880
DmeFBgn0039726
PfaPF08_0009
SpoSPCC11E10.07c
GO:0005886 plasma membrane C
ISO
MmuMGI:2384802
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000001734
GO:0003743 translation initiation factor activity F
IDA
SceS000001734
IMP
SceS000001734
ISO
MmuMGI:2384802
ISS
AthAt1g72340
At1g53900
At1g53880
DmeFBgn0039726
PfaPF08_0009
SpoSPCC11E10.07c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000001734
ISO
MmuMGI:2384802
MGI:2384802
GO:0005515 protein binding F
IPI
MmuMGI:2384802
GO:0005525 GTP binding F
ISO
MmuMGI:2384802
ISS
AthAt1g53880
At1g72340
At1g53900
GO:0019003 GDP binding F
ISO
MmuMGI:2384802
GO:0030234 enzyme regulator activity F
IGI
DmeFBgn0039726
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
ISO
MmuMGI:2384802
GO:0006412 translation P
ISO
MmuMGI:2384802
GO:0006413 translational initiation P
ISO
MmuMGI:2384802
ISS
AthAt1g72340
At1g53900
At1g53880
DmeFBgn0039726
PfaPF08_0009
SpoSPCC11E10.07c
GO:0006417 regulation of translation P
ISO
MmuMGI:2384802
GO:0006446 regulation of translational initiation P
IDA
SceS000001734
IGI
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
GO:0009408 response to heat P
ISO
MmuMGI:2384802
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:2384802
GO:0032057 negative regulation of translational initiation in
response to stress		 P
ISO
MmuMGI:2384802
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:2384802
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPCC11E10.07c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC11E10.07c
(Q9USP0)		 YKR026C
(S000001734)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC11E10.07c
GO:0005829 cytosol C
IDA
SpoSPCC11E10.07c
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
ISS
SpoSPCC11E10.07c
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000001734
GO:0003743 translation initiation factor activity F
IDA
SceS000001734
IMP
SceS000001734
ISS
SpoSPCC11E10.07c
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000001734
GO:0030234 enzyme regulator activity F
IGI
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
GO:0006413 translational initiation P
ISS
SpoSPCC11E10.07c
GO:0006446 regulation of translational initiation P
IDA
SceS000001734
IGI
SceS000001734
IMP
SceS000001734
IPI
SceS000001734
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPCC11E10.07c

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