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Search term: YKR038C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name KAE1
SGD link S000001746
Alternative ID YKR038C
Description Highly conserved putative glycoprotease proposed to be involved in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
Synonyms YKR038C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2708 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g22720 GI:15235778
Caenorhabditis elegans (Cel) CE27316 GI:17556412
Drosophila melanogaster (Dme) 7294127 GI:7294127
Homo sapiens (Hsa) Hs8923380
(OSGEP)		 GI:8923380 Q9NPF4
Saccharomyces cerevisiae (Sce) YKR038c
(S000001746)		 GI:6322891
Schizosaccharomyces pombe (Spo) SPBC16D10.03 GI:19113290 O94637
Encephalitozoon cuniculi (Ecu) ECU09g0140 GI:19173134


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000408 EKC/KEOPS protein complex C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000790 nuclear chromatin C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005575 cellular_component C
ND
AthAt4g22720
GO:0005634 nucleus C
IDA
SceS000001746
SpoSPBC16D10.03
ISS
SpoSPBC16D10.03
GO:0005737 cytoplasm C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005829 cytosol C
IDA
SpoSPBC16D10.03
GO:0004222 metalloendopeptidase activity F
ISS
SpoSPBC16D10.03
GO:0005515 protein binding F
IPI
HsaOSGEP
GO:0008270 zinc ion binding F
ISS
SpoSPBC16D10.03
GO:0031490 chromatin DNA binding F
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000723 telomere maintenance P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0006508 proteolysis P
ISS
AthAt4g22720
SpoSPBC16D10.03
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0051276 chromosome organization P
IMP
SceS000001746

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6395

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) OSGEP GI:8923380 Q9NPF4
Pan troglodytes (Ptr) OSGEP GI:114651752
Mus musculus (Mmu) Osgep
(MGI:1913496)		 GI:84662768 Q3UQ67
Rattus norvegicus (Rno) Osgep
(RGD:1308578)		 GI:62661313
Drosophila melanogaster (Dme) CG4933
(FBgn0036615)		 GI:21357207
Anopheles gambiae (Aga) AgaP_AGAP006952 GI:58376710
Caenorhabditis elegans (Cel) Y71H2AM.1
(CE37451;
WBGene00022166)		 GI:71995670
Schizosaccharomyces pombe (Spo) pgp2
(SPBC16D10.03)		 GI:19113290 O94637
Saccharomyces cerevisiae (Sce) KAE1
(S000001746)		 GI:37362674
Kluyveromyces lactis (Kla) KLLA0F21450g GI:50312019
Eremothecium gossypii (Ego) AGOS_AEL316W GI:45190290
Magnaporthe grisea (Mgr) MGG_06931 GI:39978093
Neurospora crassa (Ncr) NCU03836.1 GI:32405048
Arabidopsis thaliana (Ath) AT4G22720 GI:15235778
Oryza sativa (Osa) Os05g0194600 GI:115462517
Plasmodium falciparum (Pfa) PF10_0299 GI:124802749


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000408 EKC/KEOPS protein complex C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000790 nuclear chromatin C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005575 cellular_component C
ND
AthAt4g22720
DmeFBgn0036615
MmuMGI:1913496
PfaPF10_0299
GO:0005634 nucleus C
IDA
SceS000001746
SpoSPBC16D10.03
ISS
SpoSPBC16D10.03
GO:0005737 cytoplasm C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005829 cytosol C
IDA
SpoSPBC16D10.03
GO:0003674 molecular_function F
ND
MmuMGI:1913496
GO:0004222 metalloendopeptidase activity F
ISS
DmeFBgn0036615
SpoSPBC16D10.03
GO:0005515 protein binding F
IPI
HsaOSGEP
GO:0008270 zinc ion binding F
ISS
SpoSPBC16D10.03
GO:0031490 chromatin DNA binding F
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000723 telomere maintenance P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0006508 proteolysis P
ISS
AthAt4g22720
SpoSPBC16D10.03
GO:0008150 biological_process P
ND
MmuMGI:1913496
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00022166
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0051276 chromosome organization P
IMP
SceS000001746

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_236

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga605 ENSANGP00000010411
Anopheles gambiae (Aga) aga2409 ENSANGP00000021729
Ashbya gossypii (Ago) ago2189 AEL316W
Ashbya gossypii (Ago) ago2998 AFL197C
Arabidopsis thaliana (Ath) ath11749 At2g45270.1
Arabidopsis thaliana (Ath) ath20200 At4g22720.1
Arabidopsis thaliana (Ath) ath20201 At4g22720.2
Caenorhabditis elegans (Cel) cel721 C01G10.10
(CE20480;
WBGene00007237)
Caenorhabditis elegans (Cel) cel20628 Y71H2AM.1
(CE37451;
WBGene00022166)
Candida glabrata (Cgl) cgl4217 CAGL0L03245g
Candida glabrata (Cgl) cgl4403 CAGL0L07392g
Cryptococcus neoformans (Cne) cne1531 180.m02963
Cryptococcus neoformans (Cne) cne2105 181.m08094
Dictyostelium discoideum (Ddi) ddi10565 DDB0183804
Dictyostelium discoideum (Ddi) ddi660 DDB0189338
Debaryomyces hansenii (Dha) dha4308 DEHA0E24288g
Debaryomyces hansenii (Dha) dha6742 DEHA0G23364g
Drosophila melanogaster (Dme) dme18691 CG14231-PA
(FBgn0031060)
Drosophila melanogaster (Dme) dme9790 CG4933-PA
(FBgn0036615)
Danio rerio (Dre) dre29535 ENSDARP00000001156
(osgepl1)		 Q32LQ3
Danio rerio (Dre) dre18011 ENSDARP00000026284
Escherichia coli (Eco) eco2962 16130960
Encephalitozoon cuniculi (Ecu) ecu1285 19173134
Takifugu rubripes (Fru) fru6318 SINFRUP00000150388
Takifugu rubripes (Fru) fru27647 SINFRUP00000163227
Gallus gallus (Gga) gga21058 ENSGALP00000003745
(OSGEPL1)
Homo sapiens (Hsa) hsa9146 ENSP00000206542
(OSGEP)		 Q9NPF4
Homo sapiens (Hsa) hsa19003 ENSP00000264151
(OSGEPL1)		 Q9H4B0-1
Kluyveromyces lactis (Kla) kla2501 KLLA0D09911g
Kluyveromyces lactis (Kla) kla5041 KLLA0F21450g
Mus musculus (Mmu) mmu8073 ENSMUSP00000006452
(MGI:1913496)		 Q8BWU5
Mus musculus (Mmu) mmu332 ENSMUSP00000027265
(MGI:1919335)		 Q6PEB4-1
Mus musculus (Mmu) mmu333 ENSMUSP00000065648
Neurospora crassa (Ncr) ncr3726 NCU03836.2
Neurospora crassa (Ncr) ncr9068 NCU09308.2
Oryza sativa (Osa) osa48407 5815.m00184
Oryza sativa (Osa) osa63608 6626.m00117
Oryza sativa (Osa) osa72711 7062.m00096
Oryza sativa (Osa) osa69500 7079.m00141
Oryza sativa (Osa) osa69521 7079.m00187
Plasmodium falciparum (Pfa) pfa517 PF10_0299
Rattus norvegicus (Rno) rno29987 ENSRNOP00000005408
(RGD:1305575)		 Q4V7F3
Rattus norvegicus (Rno) rno11231 ENSRNOP00000012789
(RGD:1308578)		 B0BMW7
Rattus norvegicus (Rno) rno29988 ENSRNOP00000049478
(RGD:1305575)		 Q6AYN7
Saccharomyces cerevisiae (Sce) sce876 YDL104C
(S000002262)
Saccharomyces cerevisiae (Sce) sce3937 YKR038C
(S000001746)
Schizosaccharomyces pombe (Spo) spo3389 SPBC16D10.03 O94637
Schizosaccharomyces pombe (Spo) spo2501 SPCC1259.10 O94710
Yarrowia lipolytica (Yli) yli1928 YALI0C05280g
Yarrowia lipolytica (Yli) yli3038 YALI0D07920g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000408 EKC/KEOPS protein complex C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000790 nuclear chromatin C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005575 cellular_component C
ND
AthAt4g22720
DmeFBgn0036615
FBgn0031060
MmuMGI:1913496
PfaPF10_0299
GO:0005634 nucleus C
IDA
SceS000001746
SpoSPBC16D10.03
ISS
SpoSPBC16D10.03
GO:0005737 cytoplasm C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005739 mitochondrion C
IDA
MmuMGI:1919335
SceS000002262
SpoSPCC1259.10
GO:0005743 mitochondrial inner membrane C
IDA
AthAt2g45270
GO:0005829 cytosol C
IDA
SpoSPBC16D10.03
GO:0003674 molecular_function F
ND
MmuMGI:1913496
MGI:1919335
SceS000002262
GO:0004222 metalloendopeptidase activity F
ISS
DmeFBgn0036615
SpoSPBC16D10.03
GO:0004252 serine-type endopeptidase activity F
IGI
SpoSPCC1259.10
GO:0008270 zinc ion binding F
ISS
SpoSPBC16D10.03
SPCC1259.10
GO:0031490 chromatin DNA binding F
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000002 mitochondrial genome maintenance P
IMP
SceS000002262
NAS
SpoSPCC1259.10
GO:0000723 telomere maintenance P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0006508 proteolysis P
ISS
AthAt4g22720
At2g45270
SpoSPBC16D10.03
GO:0008150 biological_process P
ND
MmuMGI:1913496
MGI:1919335
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00022166
GO:0009790 embryo development P
IMP
AthAt2g45270
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0051276 chromosome organization P
IMP
SceS000001746

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC16D10.03
(O94637)		 YKR038C
(S000001746)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000408 EKC/KEOPS protein complex C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000790 nuclear chromatin C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005634 nucleus C
IDA
SceS000001746
SpoSPBC16D10.03
ISS
SpoSPBC16D10.03
GO:0005737 cytoplasm C
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0005829 cytosol C
IDA
SpoSPBC16D10.03
GO:0004222 metalloendopeptidase activity F
ISS
SpoSPBC16D10.03
GO:0008270 zinc ion binding F
ISS
SpoSPBC16D10.03
GO:0031490 chromatin DNA binding F
IDA
SceS000001746
ISS
SpoSPBC16D10.03
GO:0000723 telomere maintenance P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0006508 proteolysis P
ISS
SpoSPBC16D10.03
GO:0045944 positive regulation of transcription from RNA
polymerase II promoter		 P
IPI
SceS000001746
ISS
SpoSPBC16D10.03
GO:0051276 chromosome organization P
IMP
SceS000001746

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GO info in one table:

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