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Search term: YKR059W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name TIF1
SGD link S000001767
Alternative ID YKR059W
Description Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
Synonyms YKR059W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0327 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g12690 GI:15222047
Arabidopsis thaliana (Ath) At1g12770_1 GI:15220990
Arabidopsis thaliana (Ath) At1g54270 GI:15221761
Arabidopsis thaliana (Ath) At1g72730 GI:15218574
Arabidopsis thaliana (Ath) At3g13920 GI:18400210
Arabidopsis thaliana (Ath) At5g19210 GI:15239683
Caenorhabditis elegans (Cel) CE01338
(WBGene00018997)
GI:17553716 Q20935
Caenorhabditis elegans (Cel) CE01341
(WBGene00002083)
GI:17553942
Drosophila melanogaster (Dme) 7297048 GI:7297048
Homo sapiens (Hsa) Hs17459025 GI:17459025
Homo sapiens (Hsa) Hs17475661 GI:17475661
Homo sapiens (Hsa) Hs17476177 GI:17476177
Homo sapiens (Hsa) Hs20479405 GI:20479405
Homo sapiens (Hsa) Hs20482355 GI:20482355
Homo sapiens (Hsa) Hs20538426_2 GI:20538426
Homo sapiens (Hsa) Hs20548087 GI:20548087
Homo sapiens (Hsa) Hs22057430 GI:22057430
Homo sapiens (Hsa) Hs4503529
(EIF4A1)
GI:4503529 Q9NZR9
Homo sapiens (Hsa) Hs4503531 GI:4503531
Homo sapiens (Hsa) Hs4826688 GI:4826688
Saccharomyces cerevisiae (Sce) YJL138c
(S000003674)
GI:6322323 P10081
Saccharomyces cerevisiae (Sce) YKR059w
(S000001767)
GI:6322323 P10081
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Encephalitozoon cuniculi (Ecu) ECU09g1200 GI:19173239
Arabidopsis thaliana (Ath) At1g12690 GI:15222047
Arabidopsis thaliana (Ath) At1g12770_1 GI:15220990
Arabidopsis thaliana (Ath) At1g54270 GI:15221761
Arabidopsis thaliana (Ath) At1g72730 GI:15218574
Arabidopsis thaliana (Ath) At3g13920 GI:18400210
Arabidopsis thaliana (Ath) At5g19210 GI:15239683
Caenorhabditis elegans (Cel) CE01338
(WBGene00018997)
GI:17553716 Q20935
Caenorhabditis elegans (Cel) CE01341
(WBGene00002083)
GI:17553942
Drosophila melanogaster (Dme) 7297048 GI:7297048
Homo sapiens (Hsa) Hs17459025 GI:17459025
Homo sapiens (Hsa) Hs17475661 GI:17475661
Homo sapiens (Hsa) Hs17476177 GI:17476177
Homo sapiens (Hsa) Hs20479405 GI:20479405
Homo sapiens (Hsa) Hs20482355 GI:20482355
Homo sapiens (Hsa) Hs20538426_2 GI:20538426
Homo sapiens (Hsa) Hs20548087 GI:20548087
Homo sapiens (Hsa) Hs22057430 GI:22057430
Homo sapiens (Hsa) Hs4503529
(EIF4A1)
GI:4503529 Q9NZR9
Homo sapiens (Hsa) Hs4503531 GI:4503531
Homo sapiens (Hsa) Hs4826688 GI:4826688
Saccharomyces cerevisiae (Sce) YJL138c
(S000003674)
GI:6322323 P10081
Saccharomyces cerevisiae (Sce) YKR059w
(S000001767)
GI:6322323 P10081
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Encephalitozoon cuniculi (Ecu) ECU09g1200 GI:19173239
Arabidopsis thaliana (Ath) At1g12690 GI:15222047
Arabidopsis thaliana (Ath) At1g12770_1 GI:15220990
Arabidopsis thaliana (Ath) At1g54270 GI:15221761
Arabidopsis thaliana (Ath) At1g72730 GI:15218574
Arabidopsis thaliana (Ath) At3g13920 GI:18400210
Arabidopsis thaliana (Ath) At5g19210 GI:15239683
Caenorhabditis elegans (Cel) CE01338
(WBGene00018997)
GI:17553716 Q20935
Caenorhabditis elegans (Cel) CE01341
(WBGene00002083)
GI:17553942
Drosophila melanogaster (Dme) 7297048 GI:7297048
Homo sapiens (Hsa) Hs17459025 GI:17459025
Homo sapiens (Hsa) Hs17475661 GI:17475661
Homo sapiens (Hsa) Hs17476177 GI:17476177
Homo sapiens (Hsa) Hs20479405 GI:20479405
Homo sapiens (Hsa) Hs20482355 GI:20482355
Homo sapiens (Hsa) Hs20538426_2 GI:20538426
Homo sapiens (Hsa) Hs20548087 GI:20548087
Homo sapiens (Hsa) Hs22057430 GI:22057430
Homo sapiens (Hsa) Hs4503529
(EIF4A1)
GI:4503529 Q9NZR9
Homo sapiens (Hsa) Hs4503531 GI:4503531
Homo sapiens (Hsa) Hs4826688 GI:4826688
Saccharomyces cerevisiae (Sce) YJL138c
(S000003674)
GI:6322323 P10081
Saccharomyces cerevisiae (Sce) YKR059w
(S000001767)
GI:6322323 P10081
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Encephalitozoon cuniculi (Ecu) ECU09g1200 GI:19173239


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003674
GO:0005618 cell wall C
IDA
AthAt3g13920
GO:0005730 nucleolus C
IDA
AthAt3g13920
GO:0005737 cytoplasm C
IDA
SceS000003674
ISS
SceS000003674
GO:0005739 mitochondrion C
IDA
AthAt1g12770
GO:0005829 cytosol C
EXP
HsaEIF4A1
IDA
AthAt1g54270
At3g13920
At1g72730
SpoSPAC1006.07
GO:0005840 ribosome C
TAS
SceS000003674
S000001767
GO:0005886 plasma membrane C
IDA
AthAt1g54270
At1g72730
GO:0009505 plant-type cell wall C
IDA
AthAt1g72730
GO:0016020 membrane C
IDA
AthAt3g13920
GO:0016281 eukaryotic translation initiation factor 4F
complex
C
IGI
SceS000001767
S000003674
ISS
SceS000003674
S000001767
SpoSPAC1006.07
TAS
HsaEIF4A1
GO:0000339 RNA cap binding F
TAS
HsaEIF4A1
GO:0003724 RNA helicase activity F
ISS
AthAt1g12770
GO:0003729 mRNA binding F
TAS
HsaEIF4A1
GO:0003743 translation initiation factor activity F
IDA
SceS000003674
S000001767
IMP
SceS000001767
ISS
AthAt1g54270
At3g13920
SceS000003674
SpoSPAC1006.07
TAS
SceS000003674
GO:0004004 ATP-dependent RNA helicase activity F
IDA
SceS000001767
IMP
SceS000003674
S000001767
ISS
SpoSPAC1006.07
GO:0004386 helicase activity F
TAS
HsaEIF4A1
GO:0005515 protein binding F
IPI
AthAt3g13920
HsaEIF4A1
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0008026 ATP-dependent helicase activity F
ISS
AthAt1g54270
At5g19210
At1g72730
At3g13920
GO:0008135 translation factor activity, nucleic acid
binding
F
TAS
HsaEIF4A1
GO:0000003 reproduction P
IMP
CelWBGene00002083
WBGene00018997
GO:0002119 nematode larval development P
IMP
CelWBGene00018997
WBGene00002083
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006413 translational initiation P
IDA
SceS000001767
IMP
SceS000001767
ISS
AthAt3g13920
SpoSPAC1006.07
TAS
SceS000003674
GO:0006417 regulation of translation P
RCA
SceS000001767
S000003674
GO:0006446 regulation of translational initiation P
ISS
SceS000003674
GO:0008150 biological_process P
ND
AthAt1g72730
At5g19210
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002083
WBGene00018997
GO:0009663 plasmodesma organization P
IMP
AthAt1g12770
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00002083
WBGene00018997
GO:0009793 embryo development ending in seed
dormancy
P
NAS
AthAt1g12770
GO:0010497 plasmodesmata-mediated intercellular
transport
P
IMP
AthAt1g12770
GO:0019915 lipid storage P
IMP
CelWBGene00002083
WBGene00018997
GO:0040007 growth P
IMP
CelWBGene00018997
WBGene00002083
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002083
WBGene00018997
GO:0040011 locomotion P
IMP
CelWBGene00018997
WBGene00002083
GO:0045948 positive regulation of translational
initiation
P
ISS
SpoSPAC1006.07
GO:0046686 response to cadmium ion P
IEP
AthAt1g54270
At3g13920

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
103998

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EIF4A1 GI:4503529 Q9NZR9
Canis familiaris (Cfa) EIF4A1 GI:73966209
Mus musculus (Mmu) Eif4a1
(MGI:95303)
GI:21450625 A0N8T7
Rattus norvegicus (Rno) Eif4a1
(RGD:735141)
GI:40786436
Caenorhabditis elegans (Cel) inf-1
(CE01341;
WBGene00002083)
GI:71987143
Schizosaccharomyces pombe (Spo) SPAC1006.07 GI:19115766 P47943
Saccharomyces cerevisiae (Sce) TIF2
(S000003674)
GI:6322323 P10081
Saccharomyces cerevisiae (Sce) TIF1
(S000001767)
GI:6322912
Kluyveromyces lactis (Kla) KLLA0A05731g GI:50302639
Eremothecium gossypii (Ego) AGOS_ACR253C GI:45185939
Magnaporthe grisea (Mgr) MGG_04400 GI:145603147
Neurospora crassa (Ncr) NCU07420.1 GI:32414453
Arabidopsis thaliana (Ath) AT1G72730 GI:15218574
Plasmodium falciparum (Pfa) PF14_0655 GI:124810293


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003674
GO:0005737 cytoplasm C
IDA
SceS000003674
ISS
SceS000003674
GO:0005829 cytosol C
EXP
HsaEIF4A1
IDA
AthAt1g72730
SpoSPAC1006.07
GO:0005840 ribosome C
TAS
SceS000003674
S000001767
GO:0005886 plasma membrane C
IDA
AthAt1g72730
GO:0009505 plant-type cell wall C
IDA
AthAt1g72730
GO:0016281 eukaryotic translation initiation factor 4F
complex
C
IGI
SceS000001767
S000003674
ISS
PfaPF14_0655
SceS000003674
S000001767
SpoSPAC1006.07
TAS
HsaEIF4A1
GO:0000339 RNA cap binding F
ISS
PfaPF14_0655
TAS
HsaEIF4A1
GO:0003729 mRNA binding F
ISS
PfaPF14_0655
TAS
HsaEIF4A1
GO:0003743 translation initiation factor activity F
IDA
SceS000003674
S000001767
IMP
SceS000001767
ISS
PfaPF14_0655
SceS000003674
SpoSPAC1006.07
TAS
SceS000003674
GO:0004004 ATP-dependent RNA helicase activity F
IDA
SceS000001767
IMP
SceS000003674
S000001767
ISS
SpoSPAC1006.07
GO:0004386 helicase activity F
TAS
HsaEIF4A1
GO:0005515 protein binding F
IPI
HsaEIF4A1
GO:0005524 ATP binding F
IC
SpoSPAC1006.07
GO:0008026 ATP-dependent helicase activity F
ISS
AthAt1g72730
GO:0008135 translation factor activity, nucleic acid
binding
F
TAS
HsaEIF4A1
GO:0000003 reproduction P
IMP
CelWBGene00002083
GO:0002119 nematode larval development P
IMP
CelWBGene00002083
GO:0006200 ATP catabolic process P
ISS
SpoSPAC1006.07
GO:0006413 translational initiation P
IDA
SceS000001767
IMP
SceS000001767
ISS
SpoSPAC1006.07
TAS
SceS000003674
GO:0006417 regulation of translation P
RCA
SceS000001767
S000003674
GO:0006446 regulation of translational initiation P
ISS
PfaPF14_0655
SceS000003674
GO:0008150 biological_process P
ND
AthAt1g72730
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00002083
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00002083
GO:0019915 lipid storage P
IMP
CelWBGene00002083
GO:0040007 growth P
IMP
CelWBGene00002083
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00002083
GO:0040011 locomotion P
IMP
CelWBGene00002083
GO:0045948 positive regulation of translational
initiation
P
ISS
SpoSPAC1006.07

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_455

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga12143 ENSANGP00000014802
Anopheles gambiae (Aga) aga12144 ENSANGP00000023201
Ashbya gossypii (Ago) ago1300 ACR253C
Arabidopsis thaliana (Ath) ath4407 At1g51380.1
Arabidopsis thaliana (Ath) ath4739 At1g54270.1
Arabidopsis thaliana (Ath) ath6564 At1g72730.1
Arabidopsis thaliana (Ath)