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Search term: YKR072C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SIS2
SGD link S000001780
Alternative ID YKR072C
Description Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
Synonyms YKR072C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0672 AC-HYP-

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALING Halotolerance protein HAL3 (contains flavoprotein domain)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g48610 GI:15221911
Arabidopsis thaliana (Ath) At3g18030 GI:15229569
Caenorhabditis elegans (Cel) CE09663
(WBGene00009138)		 GI:17560194 P91988
Homo sapiens (Hsa) Hs21361900 GI:14042206 Q96CD2
Homo sapiens (Hsa) HsM11141897 GI:11141897
Saccharomyces cerevisiae (Sce) YKL088w
(S000001571)		 GI:6322762 P36076
Saccharomyces cerevisiae (Sce) YKR072c
(S000001780)		 GI:6322925 P36024
Saccharomyces cerevisiae (Sce) YOR054c
(S000005580)		 GI:6324629 Q08438
Schizosaccharomyces pombe (Spo) SPAC15E1.04_1 GI:19115217 Q9UTI7
Arabidopsis thaliana (Ath) At1g48610 GI:15221911
Arabidopsis thaliana (Ath) At3g18030 GI:15229569
Caenorhabditis elegans (Cel) CE09663
(WBGene00009138)		 GI:17560194 P91988
Homo sapiens (Hsa) Hs21361900 GI:14042206 Q96CD2
Homo sapiens (Hsa) HsM11141897 GI:11141897
Saccharomyces cerevisiae (Sce) YKL088w
(S000001571)		 GI:6322762 P36076
Saccharomyces cerevisiae (Sce) YKR072c
(S000001780)		 GI:6322925 P36024
Saccharomyces cerevisiae (Sce) YOR054c
(S000005580)		 GI:6324629 Q08438
Schizosaccharomyces pombe (Spo) SPAC15E1.04_1 GI:19115217 Q9UTI7


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g48610
At3g18030
GO:0005634 nucleus C
IDA
SceS000001780
IPI
SceS000001780
GO:0005737 cytoplasm C
IC
SceS000001780
IDA
SceS000001571
IPI
SceS000001780
GO:0005829 cytosol C
IDA
SpoSPAC15E1.04
GO:0071513 phosphopantothenoylcysteine decarboxylase
complex		 C
IDA
SceS000005580
S000001571
S000001780
GO:0003677 DNA binding F
ISS
AthAt1g48610
GO:0004633 phosphopantothenoylcysteine decarboxylase
activity		 F
IDA
AthAt3g18030
SceS000001780
S000001571
S000005580
IMP
SceS000001780
S000001571
S000005580
ISS
SceS000001780
S000001571
S000005580
TAS
AthAt3g18030
GO:0004799 thymidylate synthase activity F
ISS
SpoSPAC15E1.04
GO:0004864 phosphoprotein phosphatase inhibitor
activity		 F
IDA
SceS000001780
S000005580
RCA
SceS000001571
GO:0010181 FMN binding F
ISS
AthAt3g18030
GO:0017076 purine nucleotide binding F
ISS
SceS000001571
GO:0019212 phosphatase inhibitor activity F
RCA
SceS000001571
GO:0050660 FAD binding F
ISS
SpoSPAC15E1.04
GO:0000003 reproduction P
IMP
CelWBGene00009138
GO:0002119 nematode larval development P
IMP
CelWBGene00009138
GO:0006231 dTMP biosynthetic process P
ISS
SpoSPAC15E1.04
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00009138
GO:0007346 regulation of mitotic cell cycle P
IGI
SceS000001780
GO:0008150 biological_process P
ND
AthAt1g48610
GO:0009651 response to salt stress P
IGI
SceS000001780
S000001571
IMP
SceS000001780
GO:0015937 coenzyme A biosynthetic process P
IGI
SceS000001571
ISS
SceS000001780
S000001571
S000005580
TAS
AthAt3g18030
GO:0030004 cellular monovalent inorganic cation
homeostasis		 P
IGI
SceS000005580
IPI
SceS000005580
GO:0032259 methylation P
ISS
SpoSPAC15E1.04
GO:0040007 growth P
IMP
CelWBGene00009138
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00009138
GO:0042538 hyperosmotic salinity response P
IEP
AthAt3g18030
IMP
AthAt3g18030

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_864

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9153 ENSANGP00000016461
Anopheles gambiae (Aga) aga14316 ENSANGP00000028590
Ashbya gossypii (Ago) ago1898 ADR156C
Arabidopsis thaliana (Ath) ath4131 At1g48605.1
Arabidopsis thaliana (Ath) ath14060 At3g18030.1
Caenorhabditis elegans (Cel) cel7304 F25H9.6
(CE09663;
WBGene00009138)
Candida glabrata (Cgl) cgl4309 CAGL0L05302g
Cryptococcus neoformans (Cne) cne754 163.m03819
Cryptococcus neoformans (Cne) cne2059 181.m08743
Dictyostelium discoideum (Ddi) ddi12683 DDB0231515
Debaryomyces hansenii (Dha) dha4041 DEHA0E18040g
Drosophila melanogaster (Dme) dme6407 CG30290-PA
(FBgn0050290)
Danio rerio (Dre) dre9079 ENSDARP00000042267
Danio rerio (Dre) dre9030 ENSDARP00000050061
(ppcdc)		 Q1LWK2
Escherichia coli (Eco) eco3519 49176381
Takifugu rubripes (Fru) fru8700 SINFRUP00000137213
Gallus gallus (Gga) gga3586 ENSGALP00000002623
(PPCDC)
Homo sapiens (Hsa) hsa10942 ENSP00000343190
(PPCDC)		 Q96CD2-1
Kluyveromyces lactis (Kla) kla3777 KLLA0E18414g
Mus musculus (Mmu) mmu27700 ENSMUSP00000073288
Neurospora crassa (Ncr) ncr4113 NCU04237.2
Oryza sativa (Osa) osa2905 1993.m00174
Oryza sativa (Osa) osa62176 6498.m00147
Oryza sativa (Osa) osa62208 6498.m00456
Plasmodium falciparum (Pfa) pfa2076 MAL8P1.81
Rattus norvegicus (Rno) rno28683 ENSRNOP00000025289
(RGD:1306267)
Saccharomyces cerevisiae (Sce) sce3754 YKL088W
(S000001571)
Saccharomyces cerevisiae (Sce) sce3971 YKR072C
(S000001780)
Yarrowia lipolytica (Yli) yli4129 YALI0E06413g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g48605
At3g18030
GO:0005634 nucleus C
IDA
SceS000001780
IPI
SceS000001780
GO:0005737 cytoplasm C
IC
SceS000001780
IDA
SceS000001571
IPI
SceS000001780
GO:0071513 phosphopantothenoylcysteine decarboxylase
complex		 C
IDA
SceS000001571
S000001780
GO:0004633 phosphopantothenoylcysteine decarboxylase
activity		 F
IDA
AthAt3g18030
SceS000001780
S000001571
IGI
AthAt1g48605
IMP
SceS000001780
S000001571
ISA
DmeFBgn0050290
ISS
SceS000001780
S000001571
TAS
AthAt3g18030
GO:0004864 phosphoprotein phosphatase inhibitor
activity		 F
IDA
SceS000001780
RCA
SceS000001571
GO:0009055 electron carrier activity F
ISS
AthAt1g48605
GO:0010181 FMN binding F
ISS
AthAt1g48605
At3g18030
GO:0017076 purine nucleotide binding F
ISS
SceS000001571
GO:0019212 phosphatase inhibitor activity F
RCA
SceS000001571
GO:0000003 reproduction P
IMP
CelWBGene00009138
GO:0002119 nematode larval development P
IMP
CelWBGene00009138
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00009138
GO:0007346 regulation of mitotic cell cycle P
IGI
SceS000001780
GO:0009651 response to salt stress P
IGI
SceS000001780
S000001571
IMP
SceS000001780
GO:0015937 coenzyme A biosynthetic process P
IGI
SceS000001571
IMP
AthAt1g48605
ISA
DmeFBgn0050290
ISS
SceS000001780
S000001571
TAS
AthAt3g18030
GO:0040007 growth P
IMP
CelWBGene00009138
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00009138
GO:0042538 hyperosmotic salinity response P
IEP
AthAt1g48605
At3g18030
IMP
AthAt3g18030

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GO info in one table:

s.khadayate@ucl.ac.uk