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Search term: YLL050C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name COF1
SGD link S000003973
Alternative ID YLL050C
Description Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
Synonyms YLL050C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1735 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Actin depolymerizing factor

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g01750 GI:15223471
Arabidopsis thaliana (Ath) At2g16700 GI:15227286
Arabidopsis thaliana (Ath) At2g31200 GI:13926245
Arabidopsis thaliana (Ath) At3g45990 GI:15231305
Arabidopsis thaliana (Ath) At3g46000 GI:11276987
Arabidopsis thaliana (Ath) At3g46010 GI:15231309
Arabidopsis thaliana (Ath) At4g00680 GI:7441448
Arabidopsis thaliana (Ath) At4g25590 GI:15235159
Arabidopsis thaliana (Ath) At4g34970 GI:15236233
Arabidopsis thaliana (Ath) At5g52360 GI:10177402
Arabidopsis thaliana (Ath) At5g59880 GI:15238550
Arabidopsis thaliana (Ath) At5g59890 GI:15215859
Caenorhabditis elegans (Cel) CE20547
(WBGene00006794)		 GI:17564912
Caenorhabditis elegans (Cel) CE20548 GI:17564916
Caenorhabditis elegans (Cel) CE20549 GI:17564914
Drosophila melanogaster (Dme) 7291724
(FBgn0011726)		 GI:17136986
Drosophila melanogaster (Dme) 7293502 GI:7293502
Homo sapiens (Hsa) Hs14719392
(CFL2)		 GI:14719392 Q9Y281
Homo sapiens (Hsa) Hs17433952 GI:17433952
Homo sapiens (Hsa) Hs17435363 GI:17435363
Homo sapiens (Hsa) Hs17439599 GI:17439599
Homo sapiens (Hsa) Hs18546358 GI:18546358
Homo sapiens (Hsa) Hs18571222 GI:18571222
Homo sapiens (Hsa) Hs22042272 GI:22042272
Homo sapiens (Hsa) Hs22044643 GI:22044643
Homo sapiens (Hsa) Hs22057765 GI:22057765
Homo sapiens (Hsa) Hs22057868 GI:22057868
Homo sapiens (Hsa) Hs5031635
(CFL1)		 GI:5031635 P23528
Homo sapiens (Hsa) Hs5802966
(DSTN)		 GI:5802966 P60981
Saccharomyces cerevisiae (Sce) YLL050c
(S000003973)		 GI:6322978 Q03048
Schizosaccharomyces pombe (Spo) SPAC20G4.06c GI:19115653 P78929


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003973
GO:0005622 intracellular C
ISS
AthAt3g45990
At2g16700
At2g31200
At1g01750
At5g59890
At3g46010
At4g25590
At3g46000
At4g00680
At4g34970
At5g59880
At5g52360
GO:0005634 nucleus C
IDA
AthAt3g46000
TAS
HsaCFL1
GO:0005737 cytoplasm C
IDA
AthAt3g46000
CelWBGene00006794
TAS
HsaCFL1
GO:0005739 mitochondrion C
IDA
AthAt5g59880
GO:0005865 striated muscle thin filament C
IDA
CelWBGene00006794
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0011726
GO:0005886 plasma membrane C
IDA
AthAt3g46000
At5g59880
GO:0009507 chloroplast C
IDA
AthAt5g59880
GO:0015629 actin cytoskeleton C
TAS
HsaDSTN
GO:0030479 actin cortical patch C
IDA
SceS000003973
TAS
SpoSPAC20G4.06c
GO:0032153 cell division site C
IDA
SpoSPAC20G4.06c
GO:0051286 cell tip C
IDA
SpoSPAC20G4.06c
GO:0003779 actin binding F
IMP
DmeFBgn0011726
ISS
DmeFBgn0011726
SpoSPAC20G4.06c
NAS
DmeFBgn0011726
TAS
AthAt3g46010
GO:0005515 protein binding F
IPI
HsaCFL1
CFL2
GO:0051015 actin filament binding F
IDA
CelWBGene00006794
SceS000003973
GO:0000003 reproduction P
IMP
CelWBGene00006794
GO:0000910 cytokinesis P
IMP
DmeFBgn0011726
GO:0000915 cytokinesis, actomyosin contractile ring
assembly		 P
TAS
DmeFBgn0011726
SpoSPAC20G4.06c
GO:0001736 establishment of planar polarity P
IMP
DmeFBgn0011726
GO:0001737 establishment of imaginal disc-derived wing hair
orientation		 P
IMP
DmeFBgn0011726
GO:0002119 nematode larval development P
IMP
CelWBGene00006794
GO:0006916 anti-apoptosis P
TAS
HsaCFL1
GO:0006979 response to oxidative stress P
IDA
AthAt5g59880
GO:0007015 actin filament organization P
IMP
AthAt3g46010
DmeFBgn0011726
GO:0007266 Rho protein signal transduction P
TAS
HsaCFL1
GO:0007298 border follicle cell migration P
IMP
DmeFBgn0011726
GO:0007409 axonogenesis P
IMP
DmeFBgn0011726
GO:0008150 biological_process P
ND
AthAt1g01750
At3g46000
At2g31200
At4g34970
At5g52360
At3g45990
At4g00680
At4g25590
At2g16700
GO:0008154 actin polymerization or depolymerization P
TAS
HsaDSTN
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006794
GO:0008585 female gonad development P
IMP
DmeFBgn0011726
GO:0009615 response to virus P
IEP
HsaCFL1
GO:0009790 embryo development P
IMP
CelWBGene00006794
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006794
GO:0009870 defense response signaling pathway, resistance
gene-dependent		 P
IMP
AthAt5g59890
GO:0010591 regulation of lamellipodium assembly P
IMP
DmeFBgn0011726
GO:0016319 mushroom body development P
IMP
DmeFBgn0011726
GO:0030036 actin cytoskeleton organization P
TAS
HsaCFL1
GO:0030041 actin filament polymerization P
IMP
DmeFBgn0011726
GO:0030042 actin filament depolymerization P
IDA
CelWBGene00006794
SceS000003973
IMP
CelWBGene00006794
NAS
DmeFBgn0011726
TAS
SpoSPAC20G4.06c
GO:0030240 skeletal muscle thin filament assembly P
IMP
CelWBGene00006794
GO:0030838 positive regulation of actin filament
polymerization		 P
IDA
CelWBGene00006794
GO:0035286 leg segmentation P
IMP
DmeFBgn0011726
GO:0040007 growth P
IMP
CelWBGene00006794
GO:0040011 locomotion P
IMP
CelWBGene00006794
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00006794
GO:0042067 establishment of ommatidial planar
polarity		 P
IMP
DmeFBgn0011726
GO:0042742 defense response to bacterium P
IMP
AthAt5g59890
GO:0046686 response to cadmium ion P
IEP
AthAt5g59880
GO:0048749 compound eye development P
IGI
DmeFBgn0011726
GO:0051014 actin filament severing P
IDA
SceS000003973
TAS
HsaDSTN
GO:0071519 actin filament bundle assembly involved in
actomyosin contractile ring formation		 P
NAS
SpoSPAC20G4.06c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39624

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) CFL2 GI:14719392 Q9Y281
Pan troglodytes (Ptr) CFL2 GI:55640589
Canis familiaris (Cfa) CFL2 GI:73963026
Mus musculus (Mmu) Cfl2
(MGI:101763)		 GI:6671746 P45591
Rattus norvegicus (Rno) Cfl2 GI:109478222
Gallus gallus (Gga) CFL2 GI:52138701
Schizosaccharomyces pombe (Spo) adf1
(SPAC20G4.06c)		 GI:19115653 P78929
Saccharomyces cerevisiae (Sce) COF1
(S000003973)		 GI:6322978 Q03048
Kluyveromyces lactis (Kla) KLLA0E00396g GI:50307937
Eremothecium gossypii (Ego) AGOS_ADR235W GI:45188108
Magnaporthe grisea (Mgr) MGG_03164 GI:39942168
Neurospora crassa (Ncr) NCU01587.1 GI:32415093
Arabidopsis thaliana (Ath) ADF11 GI:15223471
Arabidopsis thaliana (Ath) ADF8 GI:18411410
Oryza sativa (Osa) Os07g0484200 GI:115472099


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003973
GO:0005575 cellular_component C
ND
MmuMGI:101763
GO:0005622 intracellular C
ISS
AthADF8
ADF11
GO:0030479 actin cortical patch C
IDA
SceS000003973
TAS
SpoSPAC20G4.06c
GO:0032153 cell division site C
IDA
SpoSPAC20G4.06c
GO:0051286 cell tip C
IDA
SpoSPAC20G4.06c
GO:0003674 molecular_function F
ND
MmuMGI:101763
GO:0003779 actin binding F
ISS
SpoSPAC20G4.06c
GO:0005515 protein binding F
IPI
HsaCFL2
GO:0051015 actin filament binding F
IDA
SceS000003973
GO:0000915 cytokinesis, actomyosin contractile ring
assembly		 P
TAS
SpoSPAC20G4.06c
GO:0008150 biological_process P
ND
AthADF8
ADF11
MmuMGI:101763
GO:0030042 actin filament depolymerization P
IDA
SceS000003973
TAS
SpoSPAC20G4.06c
GO:0051014 actin filament severing P
IDA
SceS000003973
GO:0071519 actin filament bundle assembly involved in
actomyosin contractile ring formation		 P
NAS
SpoSPAC20G4.06c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_373

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14231 ENSANGP00000012938
Anopheles gambiae (Aga) aga14232 ENSANGP00000023741
Anopheles gambiae (Aga) aga9240 ENSANGP00000023756
Anopheles gambiae (Aga) aga9241 ENSANGP00000026391
Ashbya gossypii (Ago) ago1976 ADR235W
Arabidopsis thaliana (Ath) ath85 At1g01750.1
Arabidopsis thaliana (Ath) ath10114 At2g31200.1
Arabidopsis thaliana (Ath) ath15879 At3g46000.1
Arabidopsis thaliana (Ath) ath15880 At3g46010.1
Arabidopsis thaliana (Ath) ath17912 At4g00680.1
Arabidopsis thaliana (Ath) ath20543 At4g25590.1
Arabidopsis thaliana (Ath) ath27188 At5g52360.1
Arabidopsis thaliana (Ath) ath28061 At5g59880.1
Arabidopsis thaliana (Ath) ath28062 At5g59880.2
Arabidopsis thaliana (Ath) ath28063 At5g59890.1
Arabidopsis thaliana (Ath) ath28064 At5g59890.2
Caenorhabditis elegans (Cel) cel3684 C38C3.5a
(CE20547;
WBGene00006794)
Caenorhabditis elegans (Cel) cel3685 C38C3.5b
(CE31893)
Caenorhabditis elegans (Cel) cel3686 C38C3.5c
(CE20549)
Candida glabrata (Cgl) cgl1116 CAGL0E04048g
Cryptococcus neoformans (Cne) cne5857 179.m00733
Dictyostelium discoideum (Ddi) ddi5642 DDB0185473
Dictyostelium discoideum (Ddi) ddi13388 DDB0201631
Dictyostelium discoideum (Ddi) ddi12284 DDB0214987
Debaryomyces hansenii (Dha) dha1025 DEHA0B07755g
Drosophila melanogaster (Dme) dme6927 CG4254-PA
(FBgn0011726)
Danio rerio (Dre) dre4436 ENSDARP00000006420
(cfl1)		 Q7ZWD8
Danio rerio (Dre) dre28464 ENSDARP00000006783
(cfl2)		 Q6NZW3
Danio rerio (Dre) dre5411 ENSDARP00000023177
(cfl2l)		 Q6TH32
Takifugu rubripes (Fru) fru31504 SINFRUP00000134387
Takifugu rubripes (Fru) fru14889 SINFRUP00000139969
Takifugu rubripes (Fru) fru20030 SINFRUP00000148510
Gallus gallus (Gga) gga6915 ENSGALP00000014097
(DSTN)		 P18359
Gallus gallus (Gga) gga19469 ENSGALP00000016266
(CFL2)		 P21566
Homo sapiens (Hsa) hsa19867 ENSP00000246069
(DSTN)		 P60981
Homo sapiens (Hsa) hsa9402 ENSP00000298159
(CFL2)		 Q9Y281
Homo sapiens (Hsa) hsa5990 ENSP00000309629
(CFL1)		 P23528
Homo sapiens (Hsa) hsa9403 ENSP00000340635
(CFL2)		 Q9Y281
Homo sapiens (Hsa) hsa19866 ENSP00000344921
Kluyveromyces lactis (Kla) kla2966 KLLA0E00396g
Mus musculus (Mmu) mmu15616 ENSMUSP00000016076
Mus musculus (Mmu) mmu13146 ENSMUSP00000064557
(MGI:101757)		 Q9CX22
Mus musculus (Mmu) mmu25910 ENSMUSP00000070605
Mus musculus (Mmu) mmu5709 ENSMUSP00000077262
(MGI:101763)		 P45591
Neurospora crassa (Ncr) ncr1541 NCU01587.2
Oryza sativa (Osa) osa6549 2454.m00142
Oryza sativa (Osa) osa51955 5991.m00114
Oryza sativa (Osa) osa63134 6700.m00199
Oryza sativa (Osa) osa65883 6881.m00191
Oryza sativa (Osa) osa69575 7081.m00146
Oryza sativa (Osa) osa79713 7450.m00126
Oryza sativa (Osa) osa173 748.m00197
Plasmodium falciparum (Pfa) pfa3839 PF13_0326
Rattus norvegicus (Rno) rno17268 ENSRNOP00000000975
Rattus norvegicus (Rno) rno19845 ENSRNOP00000007794
(RGD:1588366)		 Q7M0E3
Rattus norvegicus (Rno) rno25110 ENSRNOP00000008229
Rattus norvegicus (Rno) rno3510 ENSRNOP00000028041
(RGD:69285)
Rattus norvegicus (Rno) rno3135 ENSRNOP00000041881
Saccharomyces cerevisiae (Sce) sce4060 YLL050C
(S000003973)
Schizosaccharomyces pombe (Spo) spo4811 SPAC20G4.06c P78929
Yarrowia lipolytica (Yli) yli6220 YALI0F20856g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003973
GO:0005575 cellular_component C
ND
MmuMGI:101763
GO:0005576 extracellular region C
EXP
MmuMGI:101757
GO:0005622 intracellular C
ISS
AthAt2g31200
At1g01750
At5g59890
At3g46010
At4g25590
At3g46000
At4g00680
At5g59880
At5g52360
GO:0005634 nucleus C
IDA
AthAt3g46000
GO:0005737 cytoplasm C
IDA
AthAt3g46000
CelWBGene00006794
MmuMGI:101757
ISO
MmuMGI:101757
GO:0005739 mitochondrion C
IDA
AthAt5g59880
GO:0005829 cytosol C
EXP
MmuMGI:101757
GO:0005856 cytoskeleton C
ISS
PfaPF13_0326
GO:0005865 striated muscle thin filament C
IDA
CelWBGene00006794
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0011726
GO:0005886 plasma membrane C
IDA
AthAt3g46000
At5g59880
GO:0009507 chloroplast C
IDA
AthAt5g59880
GO:0030027 lamellipodium C
ISO
MmuMGI:101757
GO:0030479 actin cortical patch C
IDA
SceS000003973
TAS
SpoSPAC20G4.06c
GO:0030864 cortical actin cytoskeleton C
IDA
MmuMGI:101757
GO:0031252 cell leading edge C
ISO
MmuMGI:101757
GO:0032153 cell division site C
IDA
SpoSPAC20G4.06c
GO:0051286 cell tip C
IDA
SpoSPAC20G4.06c
GO:0003674 molecular_function F
ND
MmuMGI:101763
GO:0003779 actin binding F
IMP
DmeFBgn0011726
ISO
MmuMGI:101757
ISS
DmeFBgn0011726
SpoSPAC20G4.06c
NAS
DmeFBgn0011726
TAS
AthAt3g46010
GO:0051015 actin filament binding F
IDA
CelWBGene00006794
SceS000003973
GO:0000003 reproduction P
IMP
CelWBGene00006794
GO:0000910 cytokinesis P
IMP
DmeFBgn0011726
MmuMGI:101757
GO:0000915 cytokinesis, actomyosin contractile ring
assembly		 P
TAS
DmeFBgn0011726
SpoSPAC20G4.06c
GO:0001736 establishment of planar polarity P
IMP
DmeFBgn0011726
GO:0001737 establishment of imaginal disc-derived wing hair
orientation		 P
IMP
DmeFBgn0011726
GO:0001755 neural crest cell migration P
IMP
MmuMGI:101757
GO:0001842 neural fold formation P
IMP
MmuMGI:101757
GO:0002119 nematode larval development P
IMP
CelWBGene00006794
GO:0006468 protein amino acid phosphorylation P
IDA
MmuMGI:101757
GO:0006606 protein import into nucleus P
ISO
MmuMGI:101757
GO:0006928 cellular component movement P
IMP
MmuMGI:101757
GO:0006979 response to oxidative stress P
IDA
AthAt5g59880
GO:0007015 actin filament organization P
IMP
AthAt3g46010
DmeFBgn0011726
MmuMGI:101757
GO:0007298 border follicle cell migration P
IMP
DmeFBgn0011726
GO:0007409 axonogenesis P
IMP
DmeFBgn0011726
GO:0008150 biological_process P
ND
AthAt1g01750
At3g46000
At2g31200
At5g52360
At4g00680
At4g25590
MmuMGI:101763
GO:0008154 actin polymerization or depolymerization P
ISS
PfaPF13_0326
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006794
GO:0008585 female gonad development P
IMP
DmeFBgn0011726
GO:0009790 embryo development P
IMP
CelWBGene00006794
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006794
GO:0009870 defense response signaling pathway, resistance
gene-dependent		 P
IMP
AthAt5g59890
GO:0010591 regulation of lamellipodium assembly P
IMP
DmeFBgn0011726
GO:0016319 mushroom body development P
IMP
DmeFBgn0011726
GO:0030010 establishment of cell polarity P
IMP
MmuMGI:101757
GO:0030030 cell projection organization P
ISO
MmuMGI:101757
GO:0030041 actin filament polymerization P
IMP
DmeFBgn0011726
GO:0030042 actin filament depolymerization P
IDA
CelWBGene00006794
SceS000003973
IMP
CelWBGene00006794
ISS
PfaPF13_0326
NAS
DmeFBgn0011726
TAS
SpoSPAC20G4.06c
GO:0030240 skeletal muscle thin filament assembly P
IMP
CelWBGene00006794
GO:0030836 positive regulation of actin filament
depolymerization		 P
IMP
MmuMGI:101757
GO:0030838 positive regulation of actin filament
polymerization		 P
IDA
CelWBGene00006794
GO:0035286 leg segmentation P
IMP
DmeFBgn0011726
GO:0040007 growth P
IMP
CelWBGene00006794
GO:0040011 locomotion P
IMP
CelWBGene00006794
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00006794
GO:0042067 establishment of ommatidial planar
polarity		 P
IMP
DmeFBgn0011726
GO:0042742 defense response to bacterium P
IMP
AthAt5g59890
GO:0043200 response to amino acid stimulus P
IDA
MmuMGI:101757
GO:0045792 negative regulation of cell size P
ISO
MmuMGI:101757
GO:0046686 response to cadmium ion P
IEP
AthAt5g59880
GO:0048749 compound eye development P
IGI
DmeFBgn0011726
GO:0051014 actin filament severing P
IDA
SceS000003973
GO:0071519 actin filament bundle assembly involved in
actomyosin contractile ring formation		 P
NAS
SpoSPAC20G4.06c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC20G4.06c
(P78929)		 YLL050C
(S000003973)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001950 plasma membrane enriched fraction C
IDA
SceS000003973
GO:0030479 actin cortical patch C
IDA
SceS000003973
TAS
SpoSPAC20G4.06c
GO:0032153 cell division site C
IDA
SpoSPAC20G4.06c
GO:0051286 cell tip C
IDA
SpoSPAC20G4.06c
GO:0003779 actin binding F
ISS
SpoSPAC20G4.06c
GO:0051015 actin filament binding F
IDA
SceS000003973
GO:0000915 cytokinesis, actomyosin contractile ring
assembly		 P
TAS
SpoSPAC20G4.06c
GO:0030042 actin filament depolymerization P
IDA
SceS000003973
TAS
SpoSPAC20G4.06c
GO:0051014 actin filament severing P
IDA
SceS000003973
GO:0071519 actin filament bundle assembly involved in
actomyosin contractile ring formation		 P
NAS
SpoSPAC20G4.06c

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GO info in one table:

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