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Search term: YLR032W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RAD5
SGD link S000004022
Alternative ID YLR032W
Description DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p
Synonyms YLR032W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1001 AC-HYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g11100 GI:15220286
Arabidopsis thaliana (Ath) At1g50410 GI:15222964
Arabidopsis thaliana (Ath) At1g61140 GI:15219872
Arabidopsis thaliana (Ath) At3g16600 GI:15228256
Arabidopsis thaliana (Ath) At3g20010 GI:15231009
Arabidopsis thaliana (Ath) At5g05130 GI:15238450
Arabidopsis thaliana (Ath) At5g22750 GI:15242960
Arabidopsis thaliana (Ath) At5g43530 GI:15239896
Caenorhabditis elegans (Cel) CE01705_1 GI:17538147
Caenorhabditis elegans (Cel) CE17468 GI:17558240
Caenorhabditis elegans (Cel) CE17469
(WBGene00007725)		 GI:17558242
Caenorhabditis elegans (Cel) CE17473
(WBGene00007728)		 GI:17558250
Caenorhabditis elegans (Cel) CE18078 GI:17562670 O62080
Caenorhabditis elegans (Cel) CE18079 GI:17562672
Caenorhabditis elegans (Cel) CE20697
(WBGene00008944)		 GI:17559866 Q9XXT0
Caenorhabditis elegans (Cel) CE21896
(WBGene00012822)		 GI:17565668
Caenorhabditis elegans (Cel) CE21897
(WBGene00012823)		 GI:17565670 Q9XWY2
Caenorhabditis elegans (Cel) CE21898
(WBGene00012824)		 GI:17565672 Q9XWW9
Homo sapiens (Hsa) Hs21071052
(HLTF)		 GI:21071052 Q14527
Saccharomyces cerevisiae (Sce) YLR032w
(S000004022)		 GI:6323060 P32849
Saccharomyces cerevisiae (Sce) YOR191w
(S000005717)		 GI:6324765 Q08562
Schizosaccharomyces pombe (Spo) SPAC13G6.01c GI:19113739 P36607
Schizosaccharomyces pombe (Spo) SPAC17A2.12 GI:19115158 O13762
Schizosaccharomyces pombe (Spo) SPBC23E6.02 GI:19113394 O60177
Schizosaccharomyces pombe (Spo) SPBC582.10c GI:19111970 Q10332
Arabidopsis thaliana (Ath) At1g11100 GI:15220286
Arabidopsis thaliana (Ath) At1g50410 GI:15222964
Arabidopsis thaliana (Ath) At1g61140 GI:15219872
Arabidopsis thaliana (Ath) At3g16600 GI:15228256
Arabidopsis thaliana (Ath) At3g20010 GI:15231009
Arabidopsis thaliana (Ath) At5g05130 GI:15238450
Arabidopsis thaliana (Ath) At5g22750 GI:15242960
Arabidopsis thaliana (Ath) At5g43530 GI:15239896
Caenorhabditis elegans (Cel) CE01705_1 GI:17538147
Caenorhabditis elegans (Cel) CE17468 GI:17558240
Caenorhabditis elegans (Cel) CE17469
(WBGene00007725)		 GI:17558242
Caenorhabditis elegans (Cel) CE17473
(WBGene00007728)		 GI:17558250
Caenorhabditis elegans (Cel) CE18078 GI:17562670 O62080
Caenorhabditis elegans (Cel) CE18079 GI:17562672
Caenorhabditis elegans (Cel) CE20697
(WBGene00008944)		 GI:17559866 Q9XXT0
Caenorhabditis elegans (Cel) CE21896
(WBGene00012822)		 GI:17565668
Caenorhabditis elegans (Cel) CE21897
(WBGene00012823)		 GI:17565670 Q9XWY2
Caenorhabditis elegans (Cel) CE21898
(WBGene00012824)		 GI:17565672 Q9XWW9
Homo sapiens (Hsa) Hs21071052
(HLTF)		 GI:21071052 Q14527
Saccharomyces cerevisiae (Sce) YLR032w
(S000004022)		 GI:6323060 P32849
Saccharomyces cerevisiae (Sce) YOR191w
(S000005717)		 GI:6324765 Q08562
Schizosaccharomyces pombe (Spo) SPAC13G6.01c GI:19113739 P36607
Schizosaccharomyces pombe (Spo) SPAC17A2.12 GI:19115158 O13762
Schizosaccharomyces pombe (Spo) SPBC23E6.02 GI:19113394 O60177
Schizosaccharomyces pombe (Spo) SPBC582.10c GI:19111970 Q10332


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000113 nucleotide-excision repair factor 4
complex		 C
ISS
SpoSPBC582.10c
GO:0000790 nuclear chromatin C
IDA
SceS000004022
ISS
SpoSPAC17A2.12
SPBC23E6.02
GO:0005634 nucleus C
IDA
HsaHLTF
SceS000005717
SpoSPAC13G6.01c
SPAC17A2.12
SPBC23E6.02
IPI
SceS000005717
TAS
SpoSPAC13G6.01c
GO:0005730 nucleolus C
IDA
SceS000005717
GO:0005737 cytoplasm C
IDA
SpoSPBC582.10c
GO:0005739 mitochondrion C
IDA
SceS000005717
GO:0005829 cytosol C
IDA
SpoSPAC17A2.12
SPBC582.10c
GO:0009941 chloroplast envelope C
IDA
AthAt5g43530
GO:0016585 chromatin remodeling complex C
ISS
SpoSPAC17A2.12
SPBC23E6.02
GO:0000400 four-way junction DNA binding F
IDA
SceS000004022
GO:0000403 Y-form DNA binding F
IDA
SceS000004022
GO:0003677 DNA binding F
ISS
AthAt1g61140
At5g43530
At5g22750
At1g50410
At3g16600
At1g11100
At3g20010
At5g05130
GO:0004003 ATP-dependent DNA helicase activity F
ISS
SpoSPAC17A2.12
SPBC23E6.02
GO:0004386 helicase activity F
ISS
AthAt1g11100
At3g16600
At1g50410
At5g43530
At1g61140
At5g22750
At3g20010
At5g05130
GO:0004842 ubiquitin-protein ligase activity F
ISS
SpoSPAC13G6.01c
SPAC17A2.12
SPBC23E6.02
RCA
SceS000004022
GO:0005515 protein binding F
ISS
AthAt1g50410
At5g22750
At5g43530
At3g20010
At3g16600
At1g61140
At5g05130
GO:0005524 ATP binding F
IC
SpoSPAC13G6.01c
ISS
AthAt1g50410
At1g61140
At1g11100
At5g43530
At5g22750
At5g05130
At3g16600
At3g20010
GO:0008094 DNA-dependent ATPase activity F
IDA
SceS000004022
ISS
SceS000005717
SpoSPBC582.10c
GO:0008270 zinc ion binding F
ISS
AthAt1g61140
At5g05130
At1g50410
At3g16600
At5g22750
At5g43530
At3g20010
SpoSPAC17A2.12
SPBC23E6.02
GO:0009378 four-way junction helicase activity F
IDA
SceS000004022
GO:0016874 ligase activity F
RCA
SceS000004022
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000004022
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000004022
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000004022
GO:0032183 SUMO binding F
IPI
SceS000005717
GO:0000209 protein polyubiquitination P
IDA
SceS000004022
GO:0006200 ATP catabolic process P
ISS
SpoSPBC23E6.02
SPAC17A2.12
SPBC582.10c
GO:0006281 DNA repair P
IGI
SpoSPAC13G6.01c
IMP
SpoSPAC13G6.01c
ISS
SpoSPAC17A2.12
SPBC23E6.02
GO:0006289 nucleotide-excision repair P
IMP
SpoSPAC13G6.01c
ISS
SpoSPBC582.10c
GO:0006301 postreplication repair P
IDA
SceS000004022
ISS
SpoSPAC13G6.01c
GO:0006302 double-strand break repair P
IGI
SceS000004022
IMP
SceS000004022
GO:0006333 chromatin assembly or disassembly P
IGI
SceS000005717
IMP
SceS000005717
IPI
SceS000005717
GO:0006338 chromatin remodeling P
ISS
SpoSPAC17A2.12
SPBC23E6.02
GO:0006355 regulation of transcription, DNA-dependent P
TAS
HsaHLTF
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC13G6.01c
GO:0007533 mating type switching P
IMP
SceS000005717
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00012822
GO:0009294 DNA mediated transformation P
IMP
AthAt5g22750
GO:0009553 embryo sac development P
IMP
AthAt1g61140
GO:0009650 UV protection P
IMP
SpoSPAC13G6.01c
GO:0010994 free ubiquitin chain polymerization P
IDA
SceS000004022
GO:0016567 protein ubiquitination P
ISS
SpoSPAC17A2.12
SPBC23E6.02
NAS
SpoSPAC13G6.01c
GO:0032446 protein modification by small protein
conjugation		 P
RCA
SceS000004022

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6441

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) rad8
(SPAC13G6.01c)		 GI:67989453 P36607
Saccharomyces cerevisiae (Sce) RAD5
(S000004022)		 GI:6323060 P32849
Kluyveromyces lactis (Kla) KLLA0F17479g GI:50311677
Eremothecium gossypii (Ego) AGOS_AFR220W GI:45198738
Magnaporthe grisea (Mgr) MGG_05032 GI:39940416
Neurospora crassa (Ncr) NCU09516.1 GI:32418794
Arabidopsis thaliana (Ath) RAD5 GI:15242960
Oryza sativa (Osa) Os02g0527100 GI:115446443


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IDA
SceS000004022
GO:0005575 cellular_component C
ND
AthRAD5
GO:0005634 nucleus C
IDA
AthRAD5
SpoSPAC13G6.01c
TAS
SpoSPAC13G6.01c
GO:0005737 cytoplasm C
IDA
AthRAD5
GO:0030870 Mre11 complex C
TAS
AthRAD5
GO:0000150 recombinase activity F
ISS
AthRAD5
GO:0000400 four-way junction DNA binding F
IDA
SceS000004022
GO:0000403 Y-form DNA binding F
IDA
SceS000004022
GO:0003677 DNA binding F
ISS
AthRAD5
GO:0003684 damaged DNA binding F
ISS
AthRAD5
GO:0003697 single-stranded DNA binding F
ISS
AthRAD5
GO:0004386 helicase activity F
ISS
AthRAD5
GO:0004842 ubiquitin-protein ligase activity F
ISS
SpoSPAC13G6.01c
RCA
SceS000004022
GO:0005515 protein binding F
IPI
AthRAD5
ISS
AthRAD5
GO:0005524 ATP binding F
IC
SpoSPAC13G6.01c
ISS
AthRAD5
GO:0008094 DNA-dependent ATPase activity F
IDA
SceS000004022
GO:0008270 zinc ion binding F
ISS
AthRAD5
GO:0009378 four-way junction helicase activity F
IDA
SceS000004022
GO:0016874 ligase activity F
RCA
SceS000004022
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000004022
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000004022
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000004022
GO:0000209 protein polyubiquitination P
IDA
SceS000004022
GO:0000723 telomere maintenance P
IMP
AthRAD5
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
AthRAD5
GO:0002831 regulation of response to biotic
stimulus		 P
IMP
AthRAD5
GO:0006259 DNA metabolic process P
IDA
AthRAD5
TAS
AthRAD5
GO:0006281 DNA repair P
IGI
SpoSPAC13G6.01c
IMP
AthRAD5
SpoSPAC13G6.01c
ISS
AthRAD5
GO:0006289 nucleotide-excision repair P
IMP
SpoSPAC13G6.01c
GO:0006301 postreplication repair P
IDA
SceS000004022
ISS
SpoSPAC13G6.01c
GO:0006302 double-strand break repair P
IGI
SceS000004022
IMP
AthRAD5
SceS000004022
GO:0006312 mitotic recombination P
IMP
AthRAD5
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC13G6.01c
GO:0007126 meiosis P
IMP
AthRAD5
GO:0007131 reciprocal meiotic recombination P
IMP
AthRAD5
GO:0007140 male meiosis P
IMP
AthRAD5
GO:0007143 female meiosis P
IMP
AthRAD5
GO:0009294 DNA mediated transformation P
IMP
AthRAD5
GO:0009314 response to radiation P
NAS
AthRAD5
GO:0009650 UV protection P
IMP
SpoSPAC13G6.01c
GO:0010332 response to gamma radiation P
IEP
AthRAD5
GO:0010994 free ubiquitin chain polymerization P
IDA
SceS000004022
GO:0016233 telomere capping P
IMP
AthRAD5
GO:0016444 somatic cell DNA recombination P
IMP
AthRAD5
GO:0016567 protein ubiquitination P
NAS
SpoSPAC13G6.01c
GO:0032446 protein modification by small protein
conjugation		 P
RCA
SceS000004022

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2099

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago3412 AFR220W
Arabidopsis thaliana (Ath) ath22686 At5g05130.1
Arabidopsis thaliana (Ath) ath24511 At5g22750.1
Arabidopsis thaliana (Ath) ath26167 At5g43530.1
Candida glabrata (Cgl) cgl144 CAGL0A03432g
Cryptococcus neoformans (Cne) cne2060 181.m08045
Dictyostelium discoideum (Ddi) ddi6028 DDB0205141
Dictyostelium discoideum (Ddi) ddi12227 DDB0215339
Debaryomyces hansenii (Dha) dha6123 DEHA0G09526g
Debaryomyces hansenii (Dha) dha6126 DEHA0G09570g
Danio rerio (Dre) dre11190 ENSDARP00000029649
(LOC564651)
Danio rerio (Dre) dre11188 ENSDARP00000032185
(LOC564651)
Danio rerio (Dre) dre11187 ENSDARP00000033001
Danio rerio (Dre) dre11189 ENSDARP00000033504
Takifugu rubripes (Fru) fru23685 SINFRUP00000137679
Takifugu rubripes (Fru) fru23684 SINFRUP00000137682
Takifugu rubripes (Fru) fru23686 SINFRUP00000167437
Homo sapiens (Hsa) hsa23289 ENSP00000308944
(HLTF)		 Q14527-1
Homo sapiens (Hsa) hsa23288 ENSP00000330929
Kluyveromyces lactis (Kla) kla4865 KLLA0F17479g
Mus musculus (Mmu) mmu16411 ENSMUSP00000002502
(MGI:1196437)		 Q6PCN7
Neurospora crassa (Ncr) ncr7767 NCU07975.2
Neurospora crassa (Ncr) ncr9264 NCU09516.2
Oryza sativa (Osa) osa25537 3849.m00136
Oryza sativa (Osa) osa29756 4282.m00161
Oryza sativa (Osa) osa46618 5714.m00137
Oryza sativa (Osa) osa56626 6197.m00141
Plasmodium falciparum (Pfa) pfa3958 MAL13P1.216
Rattus norvegicus (Rno) rno15837 ENSRNOP00000000095
(RGD:1309031)
Saccharomyces cerevisiae (Sce) sce4112 YLR032W
(S000004022)
Schizosaccharomyces pombe (Spo) spo2434 SPAC13G6.01c P36607
Yarrowia lipolytica (Yli) yli5580 YALI0F05698g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IDA
SceS000004022
GO:0005575 cellular_component C
ND
MmuMGI:1196437
GO:0005634 nucleus C
IDA
SpoSPAC13G6.01c
TAS
SpoSPAC13G6.01c
GO:0009941 chloroplast envelope C
IDA
AthAt5g43530
GO:0000400 four-way junction DNA binding F
IDA
SceS000004022
GO:0000403 Y-form DNA binding F
IDA
SceS000004022
GO:0003677 DNA binding F
ISS
AthAt5g43530
At5g22750
At5g05130
GO:0003678 DNA helicase activity F
ISS
PfaMAL13P1.216
GO:0003702 RNA polymerase II transcription factor
activity		 F
IDA
MmuMGI:1196437
GO:0004386 helicase activity F
ISS
AthAt5g43530
At5g22750
At5g05130
GO:0004842 ubiquitin-protein ligase activity F
ISS
SpoSPAC13G6.01c
RCA
SceS000004022
GO:0005515 protein binding F
ISS
AthAt5g22750
At5g43530
At5g05130
GO:0005524 ATP binding F
IC
SpoSPAC13G6.01c
ISS
AthAt5g43530
At5g22750
At5g05130
GO:0008094 DNA-dependent ATPase activity F
IDA
SceS000004022
GO:0008270 zinc ion binding F
ISS
AthAt5g05130
At5g22750
At5g43530
GO:0009378 four-way junction helicase activity F
IDA
SceS000004022
GO:0016563 transcription activator activity F
IDA
MmuMGI:1196437
GO:0016874 ligase activity F
RCA
SceS000004022
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000004022
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000004022
GO:0016887 ATPase activity F
IDA
MmuMGI:1196437
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000004022
GO:0000209 protein polyubiquitination P
IDA
SceS000004022
GO:0006200 ATP catabolic process P
IDA
MmuMGI:1196437
GO:0006281 DNA repair P
IGI
SpoSPAC13G6.01c
IMP
SpoSPAC13G6.01c
GO:0006289 nucleotide-excision repair P
IMP
SpoSPAC13G6.01c
GO:0006301 postreplication repair P
IDA
SceS000004022
ISS
SpoSPAC13G6.01c
GO:0006302 double-strand break repair P
IGI
SceS000004022
IMP
SceS000004022
GO:0006357 regulation of transcription from RNA polymerase II
promoter		 P
IDA
MmuMGI:1196437
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC13G6.01c
GO:0009294 DNA mediated transformation P
IMP
AthAt5g22750
GO:0009650 UV protection P
IMP
SpoSPAC13G6.01c
GO:0010994 free ubiquitin chain polymerization P
IDA
SceS000004022
GO:0016567 protein ubiquitination P
NAS
SpoSPAC13G6.01c
GO:0032446 protein modification by small protein
conjugation		 P
RCA
SceS000004022
GO:0045941 positive regulation of transcription P
IDA
MmuMGI:1196437

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC13G6.01c
(P36607)		 YLR032W
(S000004022)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IDA
SceS000004022
GO:0005634 nucleus C
IDA
SpoSPAC13G6.01c
TAS
SpoSPAC13G6.01c
GO:0000400 four-way junction DNA binding F
IDA
SceS000004022
GO:0000403 Y-form DNA binding F
IDA
SceS000004022
GO:0004842 ubiquitin-protein ligase activity F
ISS
SpoSPAC13G6.01c
RCA
SceS000004022
GO:0005524 ATP binding F
IC
SpoSPAC13G6.01c
GO:0008094 DNA-dependent ATPase activity F
IDA
SceS000004022
GO:0009378 four-way junction helicase activity F
IDA
SceS000004022
GO:0016874 ligase activity F
RCA
SceS000004022
GO:0016879 ligase activity, forming carbon-nitrogen
bonds		 F
RCA
SceS000004022
GO:0016881 acid-amino acid ligase activity F
RCA
SceS000004022
GO:0019787 small conjugating protein ligase
activity		 F
RCA
SceS000004022
GO:0000209 protein polyubiquitination P
IDA
SceS000004022
GO:0006281 DNA repair P
IGI
SpoSPAC13G6.01c
IMP
SpoSPAC13G6.01c
GO:0006289 nucleotide-excision repair P
IMP
SpoSPAC13G6.01c
GO:0006301 postreplication repair P
IDA
SceS000004022
ISS
SpoSPAC13G6.01c
GO:0006302 double-strand break repair P
IGI
SceS000004022
IMP
SceS000004022
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC13G6.01c
GO:0009650 UV protection P
IMP
SpoSPAC13G6.01c
GO:0010994 free ubiquitin chain polymerization P
IDA
SceS000004022
GO:0016567 protein ubiquitination P
NAS
SpoSPAC13G6.01c
GO:0032446 protein modification by small protein
conjugation		 P
RCA
SceS000004022

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