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Search term: YLR100W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ERG27
SGD link S000004090
Alternative ID YLR100W
Description 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
Synonyms YLR100W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1478 ---HYP-

KOGs classification KOGs description
METABOLISM 3-keto sterol reductase

Species KOG link NCBI link UniProt link
Homo sapiens (Hsa) Hs7705421
(HSD17B7)		 GI:7705421 P56937
Homo sapiens (Hsa) Hs22052524 GI:22052524
Saccharomyces cerevisiae (Sce) YLR100w
(S000004090)		 GI:6323129 Q12452
Schizosaccharomyces pombe (Spo) SPBC1709.07 GI:19112232 O74732


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005741 mitochondrial outer membrane C
IDA
SceS000004090
GO:0005783 endoplasmic reticulum C
IDA
SceS000004090
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaHSD17B7
IDA
SceS000004090
ISS
SpoSPBC1709.07
GO:0000253 3-keto sterol reductase activity F
EXP
HsaHSD17B7
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0006066 alcohol metabolic process P
RCA
SceS000004090
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004090

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40728

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) HSD17B7 GI:7705421 P56937
Pan troglodytes (Ptr) HSD17B7 GI:114561037
Canis familiaris (Cfa) HSD17B7 GI:74006237
Mus musculus (Mmu) Hsd17b7
(MGI:1330808)		 GI:87162470 O88736
Rattus norvegicus (Rno) Hsd17b7
(RGD:2837)		 GI:8393576
Gallus gallus (Gga) HSD17B7 GI:118094026
Schizosaccharomyces pombe (Spo) erg27
(SPBC1709.07)		 GI:19112232 O74732
Saccharomyces cerevisiae (Sce) ERG27
(S000004090)		 GI:6323129 Q12452
Kluyveromyces lactis (Kla) KLLA0F19756g GI:50311871
Eremothecium gossypii (Ego) AGOS_AGR068W GI:45201163


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005741 mitochondrial outer membrane C
IDA
SceS000004090
GO:0005783 endoplasmic reticulum C
IDA
MmuMGI:1330808
SceS000004090
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaHSD17B7
IDA
SceS000004090
ISS
SpoSPBC1709.07
GO:0000253 3-keto sterol reductase activity F
EXP
HsaHSD17B7
IDA
MmuMGI:1330808
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0005148 prolactin receptor binding F
ISO
MmuMGI:1330808
GO:0005515 protein binding F
IPI
MmuMGI:1330808
GO:0006066 alcohol metabolic process P
RCA
SceS000004090
GO:0006695 cholesterol biosynthetic process P
IDA
MmuMGI:1330808
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0007165 signal transduction P
ISO
MmuMGI:1330808
GO:0007565 female pregnancy P
ISO
MmuMGI:1330808
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004090

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4751

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago4378 AGR068W
Candida glabrata (Cgl) cgl5155 CAGL0M11506g
Cryptococcus neoformans (Cne) cne890 163.m06278
Debaryomyces hansenii (Dha) dha4182 DEHA0E21263g
Danio rerio (Dre) dre30071 ENSDARP00000025263
Takifugu rubripes (Fru) fru1271 SINFRUP00000135503
Takifugu rubripes (Fru) fru9682 SINFRUP00000138492
Takifugu rubripes (Fru) fru1270 SINFRUP00000168409
Gallus gallus (Gga) gga22170 ENSGALP00000004214
(HSD17B7)
Homo sapiens (Hsa) hsa2504 ENSP00000254521
(HSD17B7)		 P56937-1
Homo sapiens (Hsa) hsa3749 ENSP00000314303
(HSD17B7P2)		 Q9NRW6
Homo sapiens (Hsa) hsa2505 ENSP00000348664
(HSD17B7P2)
Kluyveromyces lactis (Kla) kla4967 KLLA0F19756g
Mus musculus (Mmu) mmu1439 ENSMUSP00000027989
(MGI:1330808)		 O88736
Neurospora crassa (Ncr) ncr5823 NCU05991.2
Rattus norvegicus (Rno) rno9473 ENSRNOP00000003812
(RGD:2837)		 Q62904
Saccharomyces cerevisiae (Sce) sce4182 YLR100W
(S000004090)
Schizosaccharomyces pombe (Spo) spo4520 SPBC1709.07 O74732
Yarrowia lipolytica (Yli) yli1479 YALI0B17644g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005741 mitochondrial outer membrane C
IDA
SceS000004090
GO:0005783 endoplasmic reticulum C
IDA
MmuMGI:1330808
SceS000004090
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000004090
ISS
SpoSPBC1709.07
GO:0000253 3-keto sterol reductase activity F
IDA
MmuMGI:1330808
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0005148 prolactin receptor binding F
ISO
MmuMGI:1330808
GO:0005515 protein binding F
IPI
MmuMGI:1330808
GO:0006066 alcohol metabolic process P
RCA
SceS000004090
GO:0006695 cholesterol biosynthetic process P
IDA
MmuMGI:1330808
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0007165 signal transduction P
ISO
MmuMGI:1330808
GO:0007565 female pregnancy P
ISO
MmuMGI:1330808
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004090

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC1709.07
(O74732)		 YLR100W
(S000004090)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005741 mitochondrial outer membrane C
IDA
SceS000004090
GO:0005783 endoplasmic reticulum C
IDA
SceS000004090
GO:0005789 endoplasmic reticulum membrane C
IDA
SceS000004090
ISS
SpoSPBC1709.07
GO:0000253 3-keto sterol reductase activity F
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0006066 alcohol metabolic process P
RCA
SceS000004090
GO:0006696 ergosterol biosynthetic process P
IMP
SceS000004090
ISS
SpoSPBC1709.07
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000004090

Back to the top
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s.khadayate@ucl.ac.uk