Bahler Lab

Search term: YLR113W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name HOG1

SGD link S000004103

Alternative ID YLR113W

Description Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p

Synonyms YLR113W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0660 ACDHYP-

KOGs classification KOGs description

CELLULAR PROCESSES AND SIGNALING Mitogen-activated protein kinase

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005575 cellular_component C
ND
Ath At4g11330

GO:0005634 nucleus C
IDA
Ath At3g18040
At2g46070
At4g01370
Cel WBGene00004057
Sce S000000112
S000001072
S000003272
S000004103
Spo SPAC24B11.06c
SPAC31G5.09c
SPBC119.08
IGI
Sce S000001072
NAS
Dme FBgn0015765
FBgn0024846

GO:0005654 nucleoplasm C
EXP
Hsa MAPK11

GO:0005737 cytoplasm C
IDA
Ath At1g53510
At4g01370
Cel WBGene00004057
Sce S000000112
S000001072
S000004103
Spo SPAC24B11.06c
SPBC119.08

GO:0005739 mitochondrion C
IDA
Ath At3g18040
Sce S000000112
S000006258

GO:0005773 vacuole C
IDA
Ath At5g19010

GO:0005802 trans-Golgi network C
IDA
Ath At2g43790

GO:0005816 spindle pole body C
IDA
Spo SPAC31G5.09c
SPBC119.08

GO:0005829 cytosol C
EXP
Hsa MAPK11
IDA
Ath At3g18040
Spo SPAC31G5.09c
SPBC119.08
SPAC24B11.06c

GO:0005886 plasma membrane C
IDA
Ath At1g18150
At5g19010

GO:0005934 cellular bud tip C
IDA
Sce S000001072

GO:0009524 phragmoplast C
IDA
Ath At2g43790

GO:0009574 preprophase band C
IDA
Ath At2g43790

GO:0032153 cell division site C
IDA
Spo SPBC119.08

GO:0043332 mating projection tip C
IDA
Sce S000000112

GO:0004672 protein kinase activity F
IDA
Ath At1g59580
Cel WBGene00004055
TAS
Ath At3g45640

GO:0004674 protein serine/threonine kinase
activity F
EXP
Hsa MAPK11
IDA
Dme FBgn0024846
Hsa MAPK13
NAS
Dme FBgn0024846
FBgn0015765

GO:0004707 MAP kinase activity F
IDA
Ath At1g10210
At2g43790
At4g01370
Dme FBgn0015765
Sce S000000112
S000003272
S000006258
S000004103
IGI
Dme FBgn0015765
Spo SPAC31G5.09c
IMP
Sce S000006258
ISS
Ath At1g18150
At2g42880
At2g43790
At1g07880
At3g59790
At1g10210
At2g46070
At1g53510
At2g01450
At2g18170
At1g59580
At1g73670
At3g14720
At3g18040
At3g45640
At4g01370
At4g11330
At4g36450
At5g19010
Dme FBgn0024846
FBgn0015765
Sce S000001072
S000003272
S000006258
S000004103
Spo SPBC119.08
NAS
Dme FBgn0024846
FBgn0015765
TAS
Spo SPAC24B11.06c

GO:0005515 protein binding F
IPI
Ath At2g18170
At3g45640
Hsa MAPK11
MAPK13
Spo SPAC24B11.06c
SPBC119.08

GO:0005524 ATP binding F
ISS
Spo SPAC24B11.06c
SPAC31G5.09c
SPBC119.08

GO:0008134 transcription factor binding F
IPI
Cel WBGene00004055
Sce S000003272

GO:0008339 MP kinase activity F
IDA
Hsa MAPK11
MAPK13

GO:0016301 kinase activity F
IDA
Ath At2g46070
ISS
Ath At2g43790
At3g59790
At2g18170
At2g46070
At1g10210
At1g07880
At1g59580
At1g73670
At3g45640
At4g01370
At4g11330
At4g36450

GO:0016909 SAP kinase activity F
NAS
Dme FBgn0024846
TAS
Dme FBgn0015765

GO:0000003 reproduction P
IMP
Cel WBGene00003401
WBGene00004055

GO:0000165 MAPKKK cascade P
IC
Spo SPAC31G5.09c
IDA
Dme FBgn0024846
FBgn0015765
Spo SPBC119.08
IGI
Cel WBGene00004057
ISS
Dme FBgn0015765
NAS
Dme FBgn0015765
FBgn0024846

GO:0000169 activation of MAPK activity involved in
osmosensory signaling pathway P
IDA
Ath At3g45640

GO:0000302 response to reactive oxygen species P
IEP
Ath At2g43790

GO:0000746 conjugation P
RCA
Sce S000000112

GO:0000750 pheromone-dependent signal transduction involved
in conjugation with cellular fusion P
IDA
Sce S000000112
IEP
Sce S000003272
IMP
Sce S000003272

GO:0000751 cell cycle arrest in response to
pheromone P
TAS
Spo SPAC31G5.09c

GO:0000917 barrier septum formation P
IGI
Sce S000001072

GO:0001101 response to acid P
IMP
Sce S000001072

GO:0001402 signal transduction involved in filamentous
growth P
IGI
Sce S000003272
IMP
Sce S000003272

GO:0001403 invasive growth in response to glucose
limitation P
IMP
Sce S000000112
S000003272

GO:0002119 nematode larval development P
IMP
Cel WBGene00003401
WBGene00015478

GO:0002385 mucosal immune response P
IMP
Dme FBgn0015765

GO:0006468 protein amino acid phosphorylation P
IC
Spo SPAC31G5.09c
IDA
Ath At1g59580
Cel WBGene00004055
Sce S000000112
S000003272
S000006258
S000004103
IGI
Spo SPAC24B11.06c
IMP
Sce S000006258
ISS
Sce S000006258
S000001072
Spo SPBC119.08
NAS
Dme FBgn0015765
FBgn0024846

GO:0006793 phosphorus metabolic process P
RCA
Sce S000001072
S000004103

GO:0006883 cellular sodium ion homeostasis P
IGI
Spo SPAC24B11.06c
ISS
Spo SPBC119.08

GO:0006915 apoptosis P
IMP
Cel WBGene00004057

GO:0006950 response to stress P
IDA
Dme FBgn0024846
FBgn0015765
Hsa MAPK11
MAPK13
IMP
Dme FBgn0015765
TAS
Ath At2g43790
At3g45640
At4g01370

GO:0006952 defense response P
IMP
Cel WBGene00004055
WBGene00003401
NAS
Dme FBgn0015765
FBgn0024846

GO:0006955 immune response P
IDA
Dme FBgn0015765
IMP
Dme FBgn0024846

GO:0006970 response to osmotic stress P
IDA
Ath At2g43790
At3g45640
Dme FBgn0015765
RCA
Sce S000004103
TAS
Spo SPAC24B11.06c

GO:0006972 hyperosmotic response P
IGI
Cel WBGene00004055
IMP
Ath At4g01370
Sce S000004103

GO:0006979 response to oxidative stress P
IEP
Ath At2g43790
At3g45640
TAS
Ath At3g45640

GO:0006984 ER-nucleus signaling pathway P
RCA
Sce S000006258

GO:0006995 cellular response to nitrogen starvation P
IMP
Spo SPAC24B11.06c

GO:0007047 cellular cell wall organization P
IMP
Spo SPBC119.08
RCA
Sce S000001072

GO:0007050 cell cycle arrest P
IMP
Sce S000000112

GO:0007124 pseudohyphal growth P
RCA
Sce S000000112
S000003272

GO:0007165 signal transduction P
IC
Ath At3g45640
At3g59790
At4g11330
At1g10210
At1g07880
At2g43790
At1g18150
At2g18170
At1g53510
At1g59580
At2g42880
At2g01450
At1g73670
At2g46070
At3g14720
At4g01370
At3g18040
At4g36450
At5g19010
IMP
Sce S000001072
NAS
Dme FBgn0015765
TAS
Hsa MAPK11
MAPK6

GO:0007179 transforming growth factor beta receptor signaling
pathway P
IGI
Dme FBgn0024846

GO:0007231 osmosensory signaling pathway P
IMP
Sce S000004103

GO:0007243 intracellular protein kinase cascade P
IC
Ath At2g46070
IDA
Hsa MAPK11
MAPK13

GO:0007265 Ras protein signal transduction P
EXP
Hsa MAPK13
MAPK11
IGI
Cel WBGene00003401

GO:0007476 imaginal disc-derived wing morphogenesis P
IDA
Dme FBgn0024846

GO:0007623 circadian rhythm P
TAS
Ath At2g18170

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00003401
WBGene00004055

GO:0008348 negative regulation of antimicrobial humoral
response P
IMP
Dme FBgn0015765

GO:0008360 regulation of cell shape P
IMP
Spo SPBC119.08

GO:0008361 regulation of cell size P
IMP
Sce S000001072
RCA
Sce S000000112
S000003272

GO:0009267 cellular response to starvation P
TAS
Spo SPAC24B11.06c

GO:0009409 response to cold P
IDA
Ath At2g43790
At4g01370
IEP
Ath At3g45640

GO:0009607 response to biotic stimulus P
TAS
Ath At4g01370

GO:0009611 response to wounding P
IEP
Ath At3g45640

GO:0009617 response to bacterium P
IEP
Ath At3g45640

GO:0009620 response to fungus P
IMP
Ath At4g01370

GO:0009651 response to salt stress P
IDA
Ath At4g01370
IGI
Ath At2g43790
Dme FBgn0024846

GO:0009723 response to ethylene stimulus P
IDA
Ath At2g43790

GO:0009733 response to auxin stimulus P
IMP
Ath At2g46070

GO:0009734 auxin mediated signaling pathway P
TAS
Ath At1g10210

GO:0009737 response to abscisic acid stimulus P
IEP
Ath At2g43790
At4g01370

GO:0009738 abscisic acid mediated signaling
pathway P
IMP
Ath At3g18040
TAS
Ath At3g45640

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00003401
WBGene00015478

GO:0009861 jasmonic acid and ethylene-dependent systemic
resistance P
IMP
Ath At4g01370

GO:0009862 systemic acquired resistance, salicylic acid
mediated signaling pathway P
IMP
Ath At4g01370
TAS
Ath At4g01370

GO:0009864 induced systemic resistance, jasmonic acid
mediated signaling pathway P
IMP
Ath At2g43790

GO:0009868 jasmonic acid and ethylene-dependent systemic
resistance, jasmonic acid mediated signaling
pathway P
TAS
Ath At4g01370

GO:0009966 regulation of signal transduction P
RCA
Sce S000000112

GO:0010120 camalexin biosynthetic process P
IMP
Ath At3g45640
At2g43790

GO:0010200 response to chitin P
IEP
Ath At3g45640

GO:0010520 regulation of reciprocal meiotic
recombination P
IMP
Spo SPAC24B11.06c

GO:0010526 negative regulation of transposition,
RNA-mediated P
IMP
Sce S000000112

GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter P
IMP
Cel WBGene00004055

GO:0010847 regulation of chromatin assembly P
IMP
Spo SPAC24B11.06c

GO:0010848 regulation of chromatin disassembly P
IMP
Spo SPAC24B11.06c

GO:0012501 programmed cell death P
IMP
Cel WBGene00004055

GO:0016049 cell growth P
RCA
Sce S000000112
S000003272

GO:0016310 phosphorylation P
IDA
Ath At4g01370

GO:0019236 response to pheromone P
RCA
Sce S000000112

GO:0019953 sexual reproduction P
RCA
Sce S000001072
S000000112

GO:0030003 cellular cation homeostasis P
IGI
Spo SPAC24B11.06c

GO:0030242 peroxisome degradation P
IMP
Sce S000001072

GO:0030421 defecation P
IMP
Cel WBGene00003401

GO:0030435 sporulation resulting in formation of a cellular
spore P
RCA
Sce S000006258

GO:0030447 filamentous growth P
RCA
Sce S000000112
S000003272

GO:0030476 ascospore wall assembly P
IGI
Sce S000006258
IMP
Sce S000006258

GO:0030510 regulation of BMP signaling pathway P
IDA
Dme FBgn0024846

GO:0030968 endoplasmic reticulum unfolded protein
response P
IDA
Sce S000001072
IMP
Sce S000001072

GO:0030969 UFP-specific transcription factor mRNA processing
involved in endoplasmic reticulum unfolded protein
response P
IMP
Sce S000001072

GO:0031505 fungal-type cell wall organization P
TAS
Sce S000001072

GO:0031990 mRNA export from nucleus in response to heat
stress P
IMP
Spo SPAC24B11.06c

GO:0032005 regulation of conjugation with cellular fusion by
signal transduction P
IMP
Spo SPAC31G5.09c

GO:0033205 cell cycle cytokinesis P
IMP
Spo SPBC119.08

GO:0033554 cellular response to stress P
IGI
Spo SPBC119.08
IMP
Cel WBGene00004055

GO:0034599 cellular response to oxidative
stress P
TAS
Spo SPAC24B11.06c

GO:0034605 cellular response to heat P
TAS
Spo SPAC24B11.06c

GO:0034613 cellular protein localization P
IGI
Spo SPAC24B11.06c

GO:0034644 cellular response to UV P
TAS
Spo SPAC24B11.06c

GO:0035065 regulation of histone acetylation P
IMP
Spo SPAC24B11.06c

GO:0040007 growth P
IMP
Cel WBGene00003401
WBGene00015478

GO:0040010 positive regulation of growth rate P
IMP
Cel WBGene00003401

GO:0040025 vulval development P
IGI
Cel WBGene00003401

GO:0040027 negative regulation of vulval development P
IMP
Cel WBGene00003401

GO:0040035 hermaphrodite genitalia development P
IMP
Cel WBGene00003401

GO:0042174 negative regulation of sporulation resulting in
formation of a cellular spore P
IGI
Sce S000006258

GO:0042539 hypotonic salinity response P
IDA
Ath At4g01370

GO:0042542 response to hydrogen peroxide P
IDA
Ath At2g18170
At2g43790

GO:0042742 defense response to bacterium P
IEP
Ath At2g43790

GO:0043157 response to cation stress P
IGI
Spo SPAC24B11.06c

GO:0043409 negative regulation of MAPKKK cascade P
IPI
Sce S000000112

GO:0043433 negative regulation of transcription factor
activity P
IMP
Sce S000003272

GO:0043556 regulation of translation in response to oxidative
stress P
IDA
Spo SPAC24B11.06c
IMP
Spo SPAC24B11.06c

GO:0043557 regulation of translation in response to osmotic
stress P
IDA
Spo SPAC24B11.06c
IMP
Spo SPAC24B11.06c

GO:0043622 cortical microtubule organization P
IMP
Ath At1g53510
At4g01370

GO:0043949 regulation of cAMP-mediated signaling P
IMP
Spo SPAC24B11.06c

GO:0044262 cellular carbohydrate metabolic
process P
RCA
Sce S000001072

GO:0045087 innate immune response P
IMP
Cel WBGene00004055

GO:0045088 regulation of innate immune response P
IDA
Dme FBgn0024846

GO:0045931 positive regulation of mitotic cell
cycle P
IGI
Spo SPAC24B11.06c

GO:0045944 positive regulation of transcription from RNA
polymerase II promoter P
IDA
Sce S000004103

GO:0046020 negative regulation of transcription from RNA
polymerase II promoter by pheromones P
IEP
Sce S000004103

GO:0046685 response to arsenic P
IGI
Sce S000004103
IMP
Sce S000004103

GO:0048364 root development P
IMP
Ath At2g43790

GO:0048481 ovule development P
IGI
Ath At3g45640
At2g43790

GO:0050790 regulation of catalytic activity P
RCA
Sce S000000112

GO:0050807 regulation of synapse organization P
IGI
Cel WBGene00004057

GO:0050829 defense response to Gram-negative
bacterium P
IMP
Cel WBGene00004055

GO:0050850 positive regulation of calcium-mediated
signaling P
IMP
Spo SPBC119.08

GO:0051049 regulation of transport P
RCA
Sce S000003272

GO:0051101 regulation of DNA binding P
IDA
Spo SPAC24B11.06c

GO:0051301 cell division P
IMP
Ath At2g43790

GO:0051403 stress-activated MAPK cascade P
TAS
Spo SPAC24B11.06c

GO:0051445 regulation of meiotic cell cycle P
IMP
Spo SPAC24B11.06c

GO:0051595 response to methylglyoxal P
IDA
Spo SPAC24B11.06c
IMP
Spo SPAC24B11.06c

GO:0051729 germline cell cycle switching, mitotic to meiotic
cell cycle P
IMP
Cel WBGene00003401

GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape P
IMP
Spo SPBC119.08
SPAC24B11.06c

GO:0070301 cellular response to hydrogen peroxide P
IMP
Spo SPAC24B11.06c

GO:0070314 G1 to G0 transition P
IMP
Spo SPAC24B11.06c

GO:0070321 regulation of translation in response to nitrogen
starvation P
IDA
Spo SPAC24B11.06c

GO:0071243 cellular response to arsenic P
IMP
Spo SPAC24B11.06c

GO:0080026 response to indolebutyric acid
stimulus P
IMP
Ath At2g46070

GO:0080136 priming of cellular response to
stress P
IMP
Ath At3g45640
At2g43790

GO:2000037 regulation of stomatal complex
patterning P
IGI
Ath At2g43790
At3g45640

GO:2000038 regulation of stomatal complex
development P
IGI
Ath At2g43790
At3g45640

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

31777

Species Gene ID NCBI link UniProt link

Homo sapiens (Hsa) MAPK14 GI:4503069 Q15454

Pan troglodytes (Ptr) MAPK14 GI:57114001

Canis familiaris (Cfa) MAPK14 GI:50978968

Mus musculus (Mmu) Mapk14
(MGI:1346865) GI:10092590 P47811

Rattus norvegicus (Rno) Mapk14
(RGD:70496) GI:62461582

Gallus gallus (Gga) MAPK14 GI:118102268

Drosophila melanogaster (Dme) p38b
(FBgn0024846) GI:17137550

Drosophila melanogaster (Dme) Mpk2
(FBgn0015765) GI:17137202

Anopheles gambiae (Aga) AgaP_AGAP012148 GI:158300471

Caenorhabditis elegans (Cel) pmk-1
(CE06686;
WBGene00004055) GI:17541722 Q17446

Schizosaccharomyces pombe (Spo) phh1 GI:19113755

Saccharomyces cerevisiae (Sce) HOG1
(S000004103) GI:6323142 P32485

Kluyveromyces lactis (Kla) KLLA0F20053g GI:50311899

Eremothecium gossypii (Ego) AGOS_AGR048C GI:45201143

Magnaporthe grisea (Mgr) MGG_01822 GI:39952359

Neurospora crassa (Ncr) NCU07024.1 GI:32413661

Arabidopsis thaliana (Ath) ATMPK3 GI:15231196

Oryza sativa (Osa) Os03g0285800 GI:115452339

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000922 spindle pole C
IDA
Mmu MGI:1346865

GO:0005623 cell C
IDA
Mmu MGI:1346865

GO:0005625 soluble fraction C
ISO
Mmu MGI:1346865

GO:0005634 nucleus C
IDA
Mmu MGI:1346865
Sce S000004103
ISO
Mmu MGI:1346865
NAS
Dme FBgn0015765
FBgn0024846

GO:0005737 cytoplasm C
IDA
Mmu MGI:1346865
Sce S000004103

GO:0005829 cytosol C
EXP
Mmu MGI:1346865
ISO
Mmu MGI:1346865

GO:0044445 cytosolic part C
ISO
Mmu MGI:1346865

GO:0004672 protein kinase activity F
IDA
Cel WBGene00004055
Mmu MGI:1346865
TAS
Ath ATMPK3

GO:0004674 protein serine/threonine kinase
activity F
IDA
Dme FBgn0024846
NAS
Dme FBgn0024846
FBgn0015765

GO:0004707 MAP kinase activity F
IDA
Dme FBgn0015765
Mmu MGI:1346865
Sce S000004103
IGI
Dme FBgn0015765
ISO
Mmu MGI:1346865
ISS
Ath ATMPK3
Dme FBgn0024846
FBgn0015765
Sce S000004103
NAS
Dme FBgn0024846
FBgn0015765

GO:0005515 protein binding F
IPI
Ath ATMPK3
Mmu MGI:1346865

GO:0005524 ATP binding F
ISO
Mmu MGI:1346865

GO:0008022 protein C-terminus binding F
ISO
Mmu MGI:1346865

GO:0008134 transcription factor binding F
IPI
Cel WBGene00004055

GO:0008339 MP kinase activity F
IDA
Mmu MGI:1346865

GO:0016301 kinase activity F
IDA
Mmu MGI:1346865
ISS
Ath ATMPK3

GO:0016909 SAP kinase activity F
NAS
Dme FBgn0024846
TAS
Dme FBgn0015765

GO:0000003 reproduction P
IMP
Cel WBGene00004055

GO:0000077 DNA damage checkpoint P
IMP
Mmu MGI:1346865

GO:0000165 MAPKKK cascade P
IDA
Dme FBgn0024846
FBgn0015765
ISS
Dme FBgn0015765
NAS
Dme FBgn0015765
FBgn0024846

GO:0000169 activation of MAPK activity involved in
osmosensory signaling pathway P
IDA
Ath ATMPK3

GO:0000902 cell morphogenesis P
IGI
Mmu MGI:1346865

GO:0001525 angiogenesis P
IMP
Mmu MGI:1346865

GO:0002062 chondrocyte differentiation P
IDA
Mmu MGI:1346865

GO:0002385 mucosal immune response P
IMP
Dme FBgn0015765

GO:0006006 glucose metabolic process P
IMP
Mmu MGI:1346865

GO:0006468 protein amino acid phosphorylation P
IDA
Cel WBGene00004055
Mmu MGI:1346865
Sce S000004103
IMP
Mmu MGI:1346865
ISO
Mmu MGI:1346865
NAS
Dme FBgn0015765
FBgn0024846

GO:0006793 phosphorus metabolic process P
RCA
Sce S000004103

GO:0006950 response to stress P
IDA
Dme FBgn0024846
FBgn0015765
Mmu MGI:1346865
IMP
Dme FBgn0015765
TAS
Ath ATMPK3

GO:0006952 defense response P
IMP
Cel WBGene00004055
NAS
Dme FBgn0015765
FBgn0024846

GO:0006955 immune response P
IDA
Dme FBgn0015765
IMP
Dme FBgn0024846

GO:0006970 response to osmotic stress P
IDA
Ath ATMPK3
Dme FBgn0015765
RCA
Sce S000004103

GO:0006972 hyperosmotic response P
IGI
Cel WBGene00004055
IMP
Sce S000004103

GO:0006979 response to oxidative stress P
IEP
Ath ATMPK3
TAS
Ath ATMPK3

GO:0007165 signal transduction P
IC
Ath ATMPK3
NAS
Dme FBgn0015765

GO:0007179 transforming growth factor beta receptor signaling
pathway P
IGI
Dme FBgn0024846

GO:0007231 osmosensory signaling pathway P
IMP
Sce S000004103

GO:0007243 intracellular protein kinase cascade P
IDA
Mmu MGI:1346865

GO:0007476 imaginal disc-derived wing morphogenesis P
IDA
Dme FBgn0024846

GO:0007519 skeletal muscle tissue development P
IMP
Mmu MGI:1346865

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00004055

GO:0008348 negative regulation of antimicrobial humoral
response P
IMP
Dme FBgn0015765

GO:0009409 response to cold P
IEP
Ath ATMPK3

GO:0009611 response to wounding P
IEP
Ath ATMPK3

GO:0009617 response to bacterium P
IEP
Ath ATMPK3

GO:0009651 response to salt stress P
IGI
Dme FBgn0024846

GO:0009738 abscisic acid mediated signaling
pathway P
TAS
Ath ATMPK3

GO:0010120 camalexin biosynthetic process P
IMP
Ath ATMPK3

GO:0010200 response to chitin P
IEP
Ath ATMPK3

GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter P
IMP
Cel WBGene00004055

GO:0012501 programmed cell death P
IMP
Cel WBGene00004055

GO:0019395 fatty acid oxidation P
IMP
Mmu MGI:1346865

GO:0030510 regulation of BMP signaling pathway P
IDA
Dme FBgn0024846

GO:0031663 lipopolysaccharide-mediated signaling
pathway P
IDA
Mmu MGI:1346865

GO:0032495 response to muramyl dipeptide P
IDA
Mmu MGI:1346865

GO:0032496 response to lipopolysaccharide P
IDA
Mmu MGI:1346865

GO:0033554 cellular response to stress P
IMP
Cel WBGene00004055

GO:0045087 innate immune response P
IMP
Cel WBGene00004055

GO:0045088 regulation of innate immune response P
IDA
Dme FBgn0024846

GO:0045648 positive regulation of erythrocyte
differentiation P
IMP
Mmu MGI:1346865

GO:0045944 positive regulation of transcription from RNA
polymerase II promoter P
IDA
Sce S000004103
IMP
Mmu MGI:1346865

GO:0046020 negative regulation of transcription from RNA
polymerase II promoter by pheromones P
IEP
Sce S000004103

GO:0046685 response to arsenic P
IGI
Sce S000004103
IMP
Sce S000004103

GO:0046777 protein amino acid autophosphorylation P
ISO
Mmu MGI:1346865

GO:0048481 ovule development P
IGI
Ath ATMPK3

GO:0050829 defense response to Gram-negative
bacterium P
IMP
Cel WBGene00004055

GO:0051403 stress-activated MAPK cascade P
ISO
Mmu MGI:1346865

GO:0080136 priming of cellular response to
stress P
IMP
Ath ATMPK3

GO:2000037 regulation of stomatal complex
patterning P
IGI
Ath ATMPK3

GO:2000038 regulation of stomatal complex
development P
IGI
Ath ATMPK3

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_1084

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga9341 ENSANGP00000014018

Ashbya gossypii (Ago) ago4358 AGR048C

Arabidopsis thaliana (Ath) ath11577 At2g43790.1

Caenorhabditis elegans (Cel) cel180 B0218.3
(CE06686;
WBGene00004055)

Candida glabrata (Cgl) cgl5166 CAGL0M11748g

Cryptococcus neoformans (Cne) cne5763 179.m00638

Debaryomyces hansenii (Dha) dha4215 DEHA0E22110g

Drosophila melanogaster (Dme) dme2312 CG7393-PA
(FBgn0024846)

Danio rerio (Dre) dre17986 ENSDARP00000011298
(sapk3) O42376

Danio rerio (Dre) dre17988 ENSDARP00000013014

Danio rerio (Dre) dre17987 ENSDARP00000020408
(si:dkey-14d8.5) Q5RHW0

Danio rerio (Dre) dre8840 ENSDARP00000022610

Danio rerio (Dre) dre22666 ENSDARP00000040361
(mapk14a) Q9DGE2

Danio rerio (Dre) dre22471 ENSDARP00000043214

Takifugu rubripes (Fru) fru23332 SINFRUP00000135144

Takifugu rubripes (Fru) fru32284 SINFRUP00000154315

Takifugu rubripes (Fru) fru32283 SINFRUP00000154316

Takifugu rubripes (Fru) fru5901 SINFRUP00000169920

Takifugu rubripes (Fru) fru5900 SINFRUP00000174131

Gallus gallus (Gga) gga16398 ENSGALP00000001200
(MAPK14)

Gallus gallus (Gga) gga16399 ENSGALP00000001201
(MAPK14)

Gallus gallus (Gga) gga218 ENSGALP00000014008

Gallus gallus (Gga) gga219 ENSGALP00000014010

Gallus gallus (Gga) gga216 ENSGALP00000014011
(MAPK12)

Gallus gallus (Gga) gga217 ENSGALP00000014013
(MAPK11) Q5ZIK8

Gallus gallus (Gga) gga215 ENSGALP00000014016
(MAPK11)

Homo sapiens (Hsa) hsa21919 ENSP00000215659
(MAPK12) P53778

Homo sapiens (Hsa) hsa27025 ENSP00000229794
(MAPK14) Q16539-1

Homo sapiens (Hsa) hsa27024 ENSP00000229795
(MAPK14) Q16539-2

Homo sapiens (Hsa) hsa21920 ENSP00000333685
(MAPK11) Q15759

Homo sapiens (Hsa) hsa21921 ENSP00000346307

Kluyveromyces lactis (Kla) kla4981 KLLA0F20053g

Mus musculus (Mmu) mmu11292 ENSMUSP00000004990
(MGI:1346865) P47811-3

Mus musculus (Mmu) mmu9482 ENSMUSP00000015516

Mus musculus (Mmu) mmu9483 ENSMUSP00000015524

Mus musculus (Mmu) mmu11293 ENSMUSP00000061958
(MGI:1346865) P47811-1

Neurospora crassa (Ncr) ncr6836 NCU07024.2

Oryza sativa (Osa) osa36737 4845.m00237

Oryza sativa (Osa) osa76648 7303.m00125

Rattus norvegicus (Rno) rno17603 ENSRNOP00000000617
(RGD:70496) Q56A33

Rattus norvegicus (Rno) rno17602 ENSRNOP00000000618
(RGD:70496) P70618-1

Rattus norvegicus (Rno) rno27585 ENSRNOP00000009325
(RGD:1309340)

Rattus norvegicus (Rno) rno27583 ENSRNOP00000046455
(RGD:70975) Q63538

Saccharomyces cerevisiae (Sce) sce4195 YLR113W
(S000004103)

Schizosaccharomyces pombe (Spo) spo620 SPAC24B11.06c Q09892

Yarrowia lipolytica (Yli) yli4905 YALI0E25135g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000922 spindle pole C
IDA
Mmu MGI:1346865

GO:0005623 cell C
IDA
Mmu MGI:1346865

GO:0005625 soluble fraction C
ISO
Mmu MGI:1346865

GO:0005634 nucleus C
IDA
Mmu MGI:1346865
Sce S000004103
Spo SPAC24B11.06c
ISO
Mmu MGI:1346865
NAS
Dme FBgn0024846

GO:0005737 cytoplasm C
IDA
Mmu MGI:1346865
Sce S000004103
Spo SPAC24B11.06c

GO:0005802 trans-Golgi network C
IDA
Ath At2g43790

GO:0005829 cytosol C
EXP
Mmu MGI:1346865
IDA
Spo SPAC24B11.06c
ISO
Mmu MGI:1346865

GO:0009524 phragmoplast C
IDA
Ath At2g43790

GO:0009574 preprophase band C
IDA
Ath At2g43790

GO:0044445 cytosolic part C
ISO
Mmu MGI:1346865

GO:0004672 protein kinase activity F
IDA
Cel WBGene00004055
Mmu MGI:1346865

GO:0004674 protein serine/threonine kinase
activity F
IDA
Dme FBgn0024846
NAS
Dme FBgn0024846

GO:0004707 MAP kinase activity F
IDA
Ath At2g43790
Mmu MGI:1346865
Sce S000004103
ISO
Mmu MGI:1346865
ISS
Ath At2g43790
Dme FBgn0024846
Sce S000004103
NAS
Dme FBgn0024846
TAS
Spo SPAC24B11.06c

GO:0005515 protein binding F
IPI
Mmu MGI:1346865
Spo SPAC24B11.06c

GO:0005524 ATP binding F
ISO
Mmu MGI:1346865
ISS
Spo SPAC24B11.06c

GO:0008022 protein C-terminus binding F
ISO
Mmu MGI:1346865

GO:0008134 transcription factor binding F
IPI
Cel WBGene00004055

GO:0008339 MP kinase activity F
IDA
Mmu MGI:1346865

GO:0016301 kinase activity F
IDA
Mmu MGI:1346865
ISS
Ath At2g43790

GO:0016909 SAP kinase activity F
NAS
Dme FBgn0024846

GO:0000003 reproduction P
IMP
Cel WBGene00004055

GO:0000077 DNA damage checkpoint P
IMP
Mmu MGI:1346865

GO:0000165 MAPKKK cascade P
IDA
Dme FBgn0024846
NAS
Dme FBgn0024846

GO:0000302 response to reactive oxygen species P
IEP
Ath At2g43790

GO:0000902 cell morphogenesis P
IGI
Mmu MGI:1346865

GO:0001525 angiogenesis P
IMP
Mmu MGI:1346865

GO:0002062 chondrocyte differentiation P
IDA
Mmu MGI:1346865

GO:0006006 glucose metabolic process P
IMP
Mmu MGI:1346865

GO:0006468 protein amino acid phosphorylation P
IDA
Cel WBGene00004055
Mmu MGI:1346865
Sce S000004103
IGI
Spo SPAC24B11.06c
IMP
Mmu MGI:1346865
ISO
Mmu MGI:1346865
NAS
Dme FBgn0024846

GO:0006793 phosphorus metabolic process P
RCA
Sce S000004103

GO:0006883 cellular sodium ion homeostasis P
IGI
Spo SPAC24B11.06c

GO:0006950 response to stress P
IDA
Dme FBgn0024846
Mmu MGI:1346865
TAS
Ath At2g43790

GO:0006952 defense response P
IMP
Cel WBGene00004055
NAS
Dme FBgn0024846

GO:0006955 immune response P
IMP
Dme FBgn0024846

GO:0006970 response to osmotic stress P
IDA
Ath At2g43790
RCA
Sce S000004103
TAS
Spo SPAC24B11.06c

GO:0006972 hyperosmotic response P
IGI
Cel WBGene00004055
IMP
Sce S000004103

GO:0006979 response to oxidative stress P
IEP
Ath At2g43790

GO:0006995 cellular response to nitrogen starvation P
IMP
Spo SPAC24B11.06c

GO:0007165 signal transduction P
IC
Ath At2g43790

GO:0007179 transforming growth factor beta receptor signaling
pathway P
IGI
Dme FBgn0024846

GO:0007231 osmosensory signaling pathway P
IMP
Sce S000004103

GO:0007243 intracellular protein kinase cascade P
IDA
Mmu MGI:1346865

GO:0007476 imaginal disc-derived wing morphogenesis P
IDA
Dme FBgn0024846

GO:0007519 skeletal muscle tissue development P
IMP
Mmu MGI:1346865

GO:0008340 determination of adult lifespan P
IMP
Cel WBGene00004055

GO:0009267 cellular response to starvation P
TAS
Spo SPAC24B11.06c

GO:0009409 response to cold P
IDA
Ath At2g43790

GO:0009651 response to salt stress P
IGI
Ath At2g43790
Dme FBgn0024846

GO:0009723 response to ethylene stimulus P
IDA
Ath At2g43790

GO:0009737 response to abscisic acid stimulus P
IEP
Ath At2g43790

GO:0009864 induced systemic resistance, jasmonic acid
mediated signaling pathway P
IMP
Ath At2g43790

GO:0010120 camalexin biosynthetic process P
IMP
Ath At2g43790

GO:0010520 regulation of reciprocal meiotic
recombination P
IMP
Spo SPAC24B11.06c

GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter P
IMP
Cel WBGene00004055

GO:0010847 regulation of chromatin assembly P
IMP
Spo SPAC24B11.06c

GO:0010848 regulation of chromatin disassembly P
IMP
Spo SPAC24B11.06c

GO:0012501 programmed cell death P
IMP
Cel WBGene00004055

GO:0019395 fatty acid oxidation P
IMP
Mmu MGI:1346865

GO:0030003 cellular cation homeostasis P
IGI
Spo SPAC24B11.06c

GO:0030510 regulation of BMP signaling pathway P
IDA
Dme FBgn0024846

GO:0031663 lipopolysaccharide-mediated signaling
pathway P
IDA
Mmu MGI:1346865

GO:0031990 mRNA export from nucleus in response to heat
stress P
IMP
Spo SPAC24B11.06c

GO:0032495 response to muramyl dipeptide P
IDA
Mmu MGI:1346865

GO:0032496 response to lipopolysaccharide P
IDA
Mmu MGI:1346865

GO:0033554 cellular response to stress P
IMP
Cel WBGene00004055

GO:0034599 cellular response to oxidative
stress P
TAS
Spo SPAC24B11.06c

GO:0034605 cellular response to heat P
TAS
Spo SPAC24B11.06c

GO:0034613 cellular protein localization P
IGI
Spo SPAC24B11.06c

GO:0034644 cellular response to UV P
TAS
Spo SPAC24B11.06c

GO:0035065 regulation of histone acetylation P
IMP
Spo SPAC24B11.06c

GO:0042542 response to hydrogen peroxide P
IDA
Ath At2g43790

GO:0042742 defense response to bacterium P
IEP
Ath At2g43790

GO:0043157 response to cation stress P
IGI
Spo SPAC24B11.06c

GO:0043556 regulation of translation in response to oxidative
stress P
IDA
Spo SPAC24B11.06c
IMP
Spo SPAC24B11.06c

GO:0043557 regulation of translation in response to osmotic
stress P
IDA
Spo SPAC24B11.06c
IMP
Spo SPAC24B11.06c

GO:0043949 regulation of cAMP-mediated signaling P
IMP
Spo SPAC24B11.06c

GO:0045087 innate immune response P
IMP
Cel WBGene00004055

GO:0045088 regulation of innate immune response P
IDA
Dme FBgn0024846

GO:0045648 positive regulation of erythrocyte
differentiation P
IMP
Mmu MGI:1346865

GO:0045931 positive regulation of mitotic cell
cycle P
IGI
Spo SPAC24B11.06c

GO:0045944 positive regulation of transcription from RNA
polymerase II promoter P
IDA
Sce S000004103
IMP
Mmu MGI:1346865

GO:0046020 negative regulation of transcription from RNA
polymerase II promoter by pheromones P
IEP
Sce S000004103

GO:0046685 response to arsenic P
IGI
Sce S000004103
IMP
Sce S000004103

GO:0046777 protein amino acid autophosphorylation P
ISO
Mmu MGI:1346865

GO:0048364 root development P
IMP
Ath At2g43790

GO:0048481 ovule development P
IGI
Ath At2g43790

GO:0050829 defense response to Gram-negative
bacterium P
IMP
Cel WBGene00004055

GO:0051101 regulation of DNA binding P
IDA
Spo SPAC24B11.06c

GO:0051301 cell division P
IMP
Ath At2g43790

GO:0051403 stress-activated MAPK cascade P
ISO
Mmu MGI:1346865
TAS
Spo SPAC24B11.06c

GO:0051445 regulation of meiotic cell cycle P
IMP
Spo SPAC24B11.06c

GO:0051595 response to methylglyoxal P
IDA
Spo SPAC24B11.06c
IMP
Spo SPAC24B11.06c

GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape P
IMP
Spo SPAC24B11.06c

GO:0070301 cellular response to hydrogen peroxide P
IMP
Spo SPAC24B11.06c

GO:0070314 G1 to G0 transition P
IMP
Spo SPAC24B11.06c

GO:0070321 regulation of translation in response to nitrogen
starvation P
IDA
Spo SPAC24B11.06c

GO:0071243 cellular response to arsenic P
IMP
Spo SPAC24B11.06c

GO:0080136 priming of cellular response to
stress P
IMP
Ath At2g43790

GO:2000037 regulation of stomatal complex
patterning P
IGI
Ath At2g43790

GO:2000038 regulation of stomatal complex
development P
IGI
Ath At2g43790

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC24B11.06c
(Q09892) YLR113W
(S000004103)

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0660	ACDHYP-

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALING	Mitogen-activated protein kinase

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g07880	GI:15223026
Arabidopsis thaliana (Ath)	At1g10210	GI:15218451
Arabidopsis thaliana (Ath)	At1g18150	GI:15220976
Arabidopsis thaliana (Ath)	At1g53510	GI:15220806
Arabidopsis thaliana (Ath)	At1g59580	GI:18406388
Arabidopsis thaliana (Ath)	At1g73670	GI:12324206
Arabidopsis thaliana (Ath)	At2g01450	GI:15226278
Arabidopsis thaliana (Ath)	At2g18170	GI:15224120
Arabidopsis thaliana (Ath)	At2g42880	GI:15228019
Arabidopsis thaliana (Ath)	At2g43790	GI:15224359
Arabidopsis thaliana (Ath)	At2g46070	GI:15225924
Arabidopsis thaliana (Ath)	At3g14720	GI:15231915
Arabidopsis thaliana (Ath)	At3g18040	GI:15229573
Arabidopsis thaliana (Ath)	At3g45640	GI:15231196
Arabidopsis thaliana (Ath)	At3g59790	GI:15231753
Arabidopsis thaliana (Ath)	At4g01370	GI:15234152
Arabidopsis thaliana (Ath)	At4g11330	GI:7434325
Arabidopsis thaliana (Ath)	At4g36450	GI:15234397
Arabidopsis thaliana (Ath)	At5g19010	GI:15239634
Caenorhabditis elegans (Cel)	CE01583 (WBGene00003401)	GI:17554328
Caenorhabditis elegans (Cel)	CE02602_1	GI:17533003
Caenorhabditis elegans (Cel)	CE06686 (WBGene00004055)	GI:17541722	Q17446
Caenorhabditis elegans (Cel)	CE06762	GI:17531481
Caenorhabditis elegans (Cel)	CE17062	GI:17541724
Caenorhabditis elegans (Cel)	CE24971	GI:17554330
Caenorhabditis elegans (Cel)	CE27220	GI:17570271
Caenorhabditis elegans (Cel)	CE29020 (WBGene00015478)	GI:17552008
Caenorhabditis elegans (Cel)	CE29318 (WBGene00004057)	GI:17541726	O44514
Drosophila melanogaster (Dme)	7291043	GI:7291043
Drosophila melanogaster (Dme)	7298087 (FBgn0024846)	GI:17137550
Drosophila melanogaster (Dme)	7301110 (FBgn0015765)	GI:17137202
Homo sapiens (Hsa)	Hs18569585	GI:18569585
Homo sapiens (Hsa)	Hs18581346	GI:18581346
Homo sapiens (Hsa)	Hs20128774 (MAPK11)	GI:20128774	Q15759
Homo sapiens (Hsa)	Hs20502986	GI:20502986
Homo sapiens (Hsa)	Hs20543694	GI:20543694
Homo sapiens (Hsa)	Hs20562757	GI:20562757
Homo sapiens (Hsa)	Hs20986497	GI:14775572
Homo sapiens (Hsa)	Hs20986499	GI:20986499	Q13164
Homo sapiens (Hsa)	Hs20986501	GI:20986501
Homo sapiens (Hsa)	Hs20986512	GI:20986512	Q15454
Homo sapiens (Hsa)	Hs20986514	GI:20986514	Q15454
Homo sapiens (Hsa)	Hs20986516	GI:20986516	Q15454
Homo sapiens (Hsa)	Hs20986529	GI:20986529
Homo sapiens (Hsa)	Hs20986531	GI:14777622
Homo sapiens (Hsa)	Hs22066952	GI:22066952
Homo sapiens (Hsa)	Hs22066955	GI:22066955
Homo sapiens (Hsa)	Hs4503069 (MAPK14)	GI:4503069	Q15454
Homo sapiens (Hsa)	Hs4506085 (MAPK13)	GI:4506085	O15264
Homo sapiens (Hsa)	Hs4506089	GI:4506089
Homo sapiens (Hsa)	Hs4506091 (MAPK6)	GI:4506091	Q16659
Homo sapiens (Hsa)	Hs4506785	GI:4506785
Saccharomyces cerevisiae (Sce)	YBL016w (S000000112)	GI:6319455	P16892
Saccharomyces cerevisiae (Sce)	YGR040w (S000003272)	GI:6321477	P14681
Saccharomyces cerevisiae (Sce)	YHR030c (S000001072)	GI:6321819	Q00772
Saccharomyces cerevisiae (Sce)	YKL161c	GI:6322688	P36005
Saccharomyces cerevisiae (Sce)	YLR113w (S000004103)	GI:6323142	P32485
Saccharomyces cerevisiae (Sce)	YPR054w (S000006258)	GI:6325311	P41808
Schizosaccharomyces pombe (Spo)	SPAC24B11.06c	GI:19113755	Q09892
Schizosaccharomyces pombe (Spo)	SPAC31G5.09c	GI:19114921	P27638
Schizosaccharomyces pombe (Spo)	SPBC119.08	GI:19112081	Q92398
Arabidopsis thaliana (Ath)	At1g07880	GI:15223026
Arabidopsis thaliana (Ath)	At1g10210	GI:15218451
Arabidopsis thaliana (Ath)	At1g18150	GI:15220976
Arabidopsis thaliana (Ath)	At1g53510	GI:15220806
Arabidopsis thaliana (Ath)	At1g59580	GI:18406388
Arabidopsis thaliana (Ath)	At1g73670	GI:12324206
Arabidopsis thaliana (Ath)	At2g01450	GI:15226278
Arabidopsis thaliana (Ath)	At2g18170	GI:15224120
Arabidopsis thaliana (Ath)	At2g42880	GI:15228019
Arabidopsis thaliana (Ath)	At2g43790	GI:15224359
Arabidopsis thaliana (Ath)	At2g46070	GI:15225924
Arabidopsis thaliana (Ath)	At3g14720	GI:15231915
Arabidopsis thaliana (Ath)	At3g18040	GI:15229573
Arabidopsis thaliana (Ath)	At3g45640	GI:15231196
Arabidopsis thaliana (Ath)	At3g59790	GI:15231753
Arabidopsis thaliana (Ath)	At4g01370	GI:15234152
Arabidopsis thaliana (Ath)	At4g11330	GI:7434325
Arabidopsis thaliana (Ath)	At4g36450	GI:15234397
Arabidopsis thaliana (Ath)	At5g19010	GI:15239634
Caenorhabditis elegans (Cel)	CE01583 (WBGene00003401)	GI:17554328
Caenorhabditis elegans (Cel)	CE02602_1	GI:17533003
Caenorhabditis elegans (Cel)	CE06686 (WBGene00004055)	GI:17541722	Q17446
Caenorhabditis elegans (Cel)	CE06762	GI:17531481
Caenorhabditis elegans (Cel)	CE17062	GI:17541724
Caenorhabditis elegans (Cel)	CE24971	GI:17554330
Caenorhabditis elegans (Cel)	CE27220	GI:17570271
Caenorhabditis elegans (Cel)	CE29020 (WBGene00015478)	GI:17552008
Caenorhabditis elegans (Cel)	CE29318 (WBGene00004057)	GI:17541726	O44514
Drosophila melanogaster (Dme)	7291043	GI:7291043
Drosophila melanogaster (Dme)	7298087 (FBgn0024846)	GI:17137550
Drosophila melanogaster (Dme)	7301110 (FBgn0015765)	GI:17137202
Homo sapiens (Hsa)	Hs18569585	GI:18569585
Homo sapiens (Hsa)	Hs18581346	GI:18581346
Homo sapiens (Hsa)	Hs20128774 (MAPK11)	GI:20128774	Q15759
Homo sapiens (Hsa)	Hs20502986	GI:20502986
Homo sapiens (Hsa)	Hs20543694	GI:20543694
Homo sapiens (Hsa)	Hs20562757	GI:20562757
Homo sapiens (Hsa)	Hs20986497	GI:14775572
Homo sapiens (Hsa)	Hs20986499	GI:20986499	Q13164
Homo sapiens (Hsa)	Hs20986501	GI:20986501
Homo sapiens (Hsa)	Hs20986512	GI:20986512	Q15454
Homo sapiens (Hsa)	Hs20986514	GI:20986514	Q15454
Homo sapiens (Hsa)	Hs20986516	GI:20986516	Q15454
Homo sapiens (Hsa)	Hs20986529	GI:20986529
Homo sapiens (Hsa)	Hs20986531	GI:14777622
Homo sapiens (Hsa)	Hs22066952	GI:22066952
Homo sapiens (Hsa)	Hs22066955	GI:22066955
Homo sapiens (Hsa)	Hs4503069 (MAPK14)	GI:4503069	Q15454
Homo sapiens (Hsa)	Hs4506085 (MAPK13)	GI:4506085	O15264
Homo sapiens (Hsa)	Hs4506089	GI:4506089
Homo sapiens (Hsa)	Hs4506091 (MAPK6)	GI:4506091	Q16659
Homo sapiens (Hsa)	Hs4506785	GI:4506785
Saccharomyces cerevisiae (Sce)	YBL016w (S000000112)	GI:6319455	P16892
Saccharomyces cerevisiae (Sce)	YGR040w (S000003272)	GI:6321477	P14681
Saccharomyces cerevisiae (Sce)	YHR030c (S000001072)	GI:6321819	Q00772
Saccharomyces cerevisiae (Sce)	YKL161c	GI:6322688	P36005
Saccharomyces cerevisiae (Sce)	YLR113w (S000004103)	GI:6323142	P32485
Saccharomyces cerevisiae (Sce)	YPR054w (S000006258)	GI:6325311	P41808
Schizosaccharomyces pombe (Spo)	SPAC24B11.06c	GI:19113755	Q09892
Schizosaccharomyces pombe (Spo)	SPAC31G5.09c	GI:19114921	P27638
Schizosaccharomyces pombe (Spo)	SPBC119.08	GI:19112081	Q92398

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	MAPK14	GI:4503069	Q15454
Pan troglodytes (Ptr)	MAPK14	GI:57114001
Canis familiaris (Cfa)	MAPK14	GI:50978968
Mus musculus (Mmu)	Mapk14 (MGI:1346865)	GI:10092590	P47811
Rattus norvegicus (Rno)	Mapk14 (RGD:70496)	GI:62461582
Gallus gallus (Gga)	MAPK14	GI:118102268
Drosophila melanogaster (Dme)	p38b (FBgn0024846)	GI:17137550
Drosophila melanogaster (Dme)	Mpk2 (FBgn0015765)	GI:17137202
Anopheles gambiae (Aga)	AgaP_AGAP012148	GI:158300471
Caenorhabditis elegans (Cel)	pmk-1 (CE06686; WBGene00004055)	GI:17541722	Q17446
Schizosaccharomyces pombe (Spo)	phh1	GI:19113755
Saccharomyces cerevisiae (Sce)	HOG1 (S000004103)	GI:6323142	P32485
Kluyveromyces lactis (Kla)	KLLA0F20053g	GI:50311899
Eremothecium gossypii (Ego)	AGOS_AGR048C	GI:45201143
Magnaporthe grisea (Mgr)	MGG_01822	GI:39952359
Neurospora crassa (Ncr)	NCU07024.1	GI:32413661
Arabidopsis thaliana (Ath)	ATMPK3	GI:15231196
Oryza sativa (Osa)	Os03g0285800	GI:115452339

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga9341	ENSANGP00000014018
Ashbya gossypii (Ago)	ago4358	AGR048C
Arabidopsis thaliana (Ath)	ath11577	At2g43790.1
Caenorhabditis elegans (Cel)	cel180	B0218.3 (CE06686; WBGene00004055)
Candida glabrata (Cgl)	cgl5166	CAGL0M11748g
Cryptococcus neoformans (Cne)	cne5763	179.m00638
Debaryomyces hansenii (Dha)	dha4215	DEHA0E22110g
Drosophila melanogaster (Dme)	dme2312	CG7393-PA (FBgn0024846)
Danio rerio (Dre)	dre17986	ENSDARP00000011298 (sapk3)	O42376
Danio rerio (Dre)	dre17988	ENSDARP00000013014
Danio rerio (Dre)	dre17987	ENSDARP00000020408 (si:dkey-14d8.5)	Q5RHW0
Danio rerio (Dre)	dre8840	ENSDARP00000022610
Danio rerio (Dre)	dre22666	ENSDARP00000040361 (mapk14a)	Q9DGE2
Danio rerio (Dre)	dre22471	ENSDARP00000043214
Takifugu rubripes (Fru)	fru23332	SINFRUP00000135144
Takifugu rubripes (Fru)	fru32284	SINFRUP00000154315
Takifugu rubripes (Fru)	fru32283	SINFRUP00000154316
Takifugu rubripes (Fru)	fru5901	SINFRUP00000169920
Takifugu rubripes (Fru)	fru5900	SINFRUP00000174131
Gallus gallus (Gga)	gga16398	ENSGALP00000001200 (MAPK14)
Gallus gallus (Gga)	gga16399	ENSGALP00000001201 (MAPK14)
Gallus gallus (Gga)	gga218	ENSGALP00000014008
Gallus gallus (Gga)	gga219	ENSGALP00000014010
Gallus gallus (Gga)	gga216	ENSGALP00000014011 (MAPK12)
Gallus gallus (Gga)	gga217	ENSGALP00000014013 (MAPK11)	Q5ZIK8
Gallus gallus (Gga)	gga215	ENSGALP00000014016 (MAPK11)
Homo sapiens (Hsa)	hsa21919	ENSP00000215659 (MAPK12)	P53778
Homo sapiens (Hsa)	hsa27025	ENSP00000229794 (MAPK14)	Q16539-1
Homo sapiens (Hsa)	hsa27024	ENSP00000229795 (MAPK14)	Q16539-2
Homo sapiens (Hsa)	hsa21920	ENSP00000333685 (MAPK11)	Q15759
Homo sapiens (Hsa)	hsa21921	ENSP00000346307
Kluyveromyces lactis (Kla)	kla4981	KLLA0F20053g
Mus musculus (Mmu)	mmu11292	ENSMUSP00000004990 (MGI:1346865)	P47811-3
Mus musculus (Mmu)	mmu9482	ENSMUSP00000015516
Mus musculus (Mmu)	mmu9483	ENSMUSP00000015524
Mus musculus (Mmu)	mmu11293	ENSMUSP00000061958 (MGI:1346865)	P47811-1
Neurospora crassa (Ncr)	ncr6836	NCU07024.2
Oryza sativa (Osa)	osa36737	4845.m00237
Oryza sativa (Osa)	osa76648	7303.m00125
Rattus norvegicus (Rno)	rno17603	ENSRNOP00000000617 (RGD:70496)	Q56A33
Rattus norvegicus (Rno)	rno17602	ENSRNOP00000000618 (RGD:70496)	P70618-1
Rattus norvegicus (Rno)	rno27585	ENSRNOP00000009325 (RGD:1309340)
Rattus norvegicus (Rno)	rno27583	ENSRNOP00000046455 (RGD:70975)	Q63538
Saccharomyces cerevisiae (Sce)	sce4195	YLR113W (S000004103)
Schizosaccharomyces pombe (Spo)	spo620	SPAC24B11.06c	Q09892
Yarrowia lipolytica (Yli)	yli4905	YALI0E25135g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC24B11.06c (Q09892)	YLR113W (S000004103)