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Search term: YLR116W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MSL5
SGD link S000004106
Alternative ID YLR116W
Description Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
Synonyms YLR116W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0119 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Splicing factor 1/branch point binding protein (RRM superfamily)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g32940 GI:15232812
Arabidopsis thaliana (Ath) At5g51300 GI:15241418
Caenorhabditis elegans (Cel) CE28108
(WBGene00013808)		 GI:17544462 Q9U2U1
Drosophila melanogaster (Dme) 7300268 GI:7300268
Homo sapiens (Hsa) Hs4759340 GI:4759340
Saccharomyces cerevisiae (Sce) YLR116w
(S000004106)		 GI:6323145 Q12186
Schizosaccharomyces pombe (Spo) SPCC962.06c GI:19075371 O74555
Encephalitozoon cuniculi (Ecu) ECU02g1160 GI:19074035 Q8SWB0
Arabidopsis thaliana (Ath) At3g32940 GI:15232812
Arabidopsis thaliana (Ath) At5g51300 GI:15241418
Caenorhabditis elegans (Cel) CE28108
(WBGene00013808)		 GI:17544462 Q9U2U1
Drosophila melanogaster (Dme) 7300268 GI:7300268
Homo sapiens (Hsa) Hs4759340 GI:4759340
Saccharomyces cerevisiae (Sce) YLR116w
(S000004106)		 GI:6323145 Q12186
Schizosaccharomyces pombe (Spo) SPCC962.06c GI:19075371 O74555
Encephalitozoon cuniculi (Ecu) ECU02g1160 GI:19074035 Q8SWB0
Arabidopsis thaliana (Ath) At3g32940 GI:15232812
Arabidopsis thaliana (Ath) At5g51300 GI:15241418
Caenorhabditis elegans (Cel) CE28108
(WBGene00013808)		 GI:17544462 Q9U2U1
Drosophila melanogaster (Dme) 7300268 GI:7300268
Homo sapiens (Hsa) Hs4759340 GI:4759340
Saccharomyces cerevisiae (Sce) YLR116w
(S000004106)		 GI:6323145 Q12186
Schizosaccharomyces pombe (Spo) SPCC962.06c GI:19075371 O74555
Encephalitozoon cuniculi (Ecu) ECU02g1160 GI:19074035 Q8SWB0


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000243 commitment complex C
IDA
SceS000004106
SpoSPCC962.06c
GO:0005634 nucleus C
IDA
SpoSPCC962.06c
GO:0005829 cytosol C
IDA
SpoSPCC962.06c
GO:0003723 RNA binding F
ISS
SpoSPCC962.06c
GO:0045131 pre-mRNA branch point binding F
IDA
SceS000004106
GO:0000003 reproduction P
IMP
CelWBGene00013808
GO:0000349 generation of catalytic spliceosome for first
transesterification step		 P
IDA
SpoSPCC962.06c
GO:0000398 nuclear mRNA splicing, via spliceosome P
IPI
SceS000004106
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00013808
GO:0002119 nematode larval development P
IMP
CelWBGene00013808
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00013808
GO:0008380 RNA splicing P
NAS
AthAt5g51300
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013808
GO:0010171 body morphogenesis P
IMP
CelWBGene00013808
GO:0040007 growth P
IMP
CelWBGene00013808
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013808
GO:0040011 locomotion P
IMP
CelWBGene00013808
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00013808

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6461

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SF1 GI:42544130
Pan troglodytes (Ptr) SF1 GI:114638387
Canis familiaris (Cfa) SF1 GI:73983197
Mus musculus (Mmu) Sf1
(MGI:1095403)		 GI:7106451 Q3TZI3
Rattus norvegicus (Rno) Sf1
(RGD:620645)		 GI:61097924
Drosophila melanogaster (Dme) SF1
(FBgn0025571)		 GI:24647704
Caenorhabditis elegans (Cel) sfa-1
(CE28108;
WBGene00013808)		 GI:17544462 Q9U2U1
Schizosaccharomyces pombe (Spo) bpb1
(SPCC962.06c)		 GI:19075371 O74555
Saccharomyces cerevisiae (Sce) MSL5
(S000004106)		 GI:6323145 Q12186
Kluyveromyces lactis (Kla) KLLA0F18018g GI:50311721
Eremothecium gossypii (Ego) AGOS_AGL183C GI:45200914
Magnaporthe grisea (Mgr) MGG_06748 GI:39977727
Neurospora crassa (Ncr) NCU04110.1 GI:32405674
Arabidopsis thaliana (Ath) AT5G51300 GI:79330558
Oryza sativa (Osa) Os04g0385700 GI:115458038


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000243 commitment complex C
IDA
SceS000004106
SpoSPCC962.06c
GO:0005634 nucleus C
IDA
DmeFBgn0025571
HsaSF1
SpoSPCC962.06c
ISS
MmuMGI:1095403
NAS
HsaSF1
GO:0005681 spliceosomal complex C
IDA
HsaSF1
ISS
DmeFBgn0025571
NAS
DmeFBgn0025571
GO:0005737 cytoplasm C
ISS
MmuMGI:1095403
GO:0005829 cytosol C
IDA
SpoSPCC962.06c
GO:0005840 ribosome C
NAS
HsaSF1
GO:0071011 precatalytic spliceosome C
IDA
DmeFBgn0025571
GO:0003676 nucleic acid binding F
NAS
HsaSF1
GO:0003702 RNA polymerase II transcription factor
activity		 F
TAS
HsaSF1
GO:0003714 transcription corepressor activity F
TAS
HsaSF1
GO:0003723 RNA binding F
ISS
SpoSPCC962.06c
TAS
HsaSF1
GO:0005515 protein binding F
IPI
HsaSF1
GO:0045131 pre-mRNA branch point binding F
IDA
SceS000004106
GO:0000003 reproduction P
IMP
CelWBGene00013808
GO:0000245 spliceosome assembly P
NAS
HsaSF1
GO:0000349 generation of catalytic spliceosome for first
transesterification step		 P
IDA
SpoSPCC962.06c
GO:0000389 nuclear mRNA 3'-splice site recognition P
TAS
HsaSF1
GO:0000398 nuclear mRNA splicing, via spliceosome P
IC
DmeFBgn0025571
HsaSF1
IPI
SceS000004106
ISS
DmeFBgn0025571
NAS
DmeFBgn0025571
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00013808
GO:0002119 nematode larval development P
IMP
CelWBGene00013808
GO:0002121 inter-male aggressive behavior P
IMP
DmeFBgn0025571
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00013808
GO:0008380 RNA splicing P
NAS
AthAt5g51300
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013808
GO:0010171 body morphogenesis P
IMP
CelWBGene00013808
GO:0022402 cell cycle process P
IGI
MmuMGI:1095403
GO:0030238 male sex determination P
IGI
MmuMGI:1095403
GO:0033327 Leydig cell differentiation P
IGI
MmuMGI:1095403
GO:0040007 growth P
IMP
CelWBGene00013808
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013808
GO:0040011 locomotion P
IMP
CelWBGene00013808
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00013808
GO:0050810 regulation of steroid biosynthetic
process		 P
IGI
MmuMGI:1095403

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1304

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14604 ENSANGP00000017356
Ashbya gossypii (Ago) ago4129 AGL183C
Arabidopsis thaliana (Ath) ath27068 At5g51300.1
Arabidopsis thaliana (Ath) ath27069 At5g51300.2
Caenorhabditis elegans (Cel) cel17737 Y116A8C.32
(CE28108;
WBGene00013808)
Candida glabrata (Cgl) cgl762 CAGL0D02354g
Cryptococcus neoformans (Cne) cne595 163.m02728
Dictyostelium discoideum (Ddi) ddi11120 DDB0192004
Debaryomyces hansenii (Dha) dha2649 DEHA0D07975g
Drosophila melanogaster (Dme) dme13084 CG5836-PA
(FBgn0025571)
Danio rerio (Dre) dre25593 ENSDARP00000026464
(LOC572785)
Danio rerio (Dre) dre21240 ENSDARP00000032938
Encephalitozoon cuniculi (Ecu) ecu114 19074035
Takifugu rubripes (Fru) fru23050 SINFRUP00000161127
Takifugu rubripes (Fru) fru17874 SINFRUP00000173153
Gallus gallus (Gga) gga15119 ENSGALP00000018821
(QKI)		 Q9YH18-1
Homo sapiens (Hsa) hsa5902 ENSP00000227503
(SF1)		 Q15637-4
Homo sapiens (Hsa) hsa5903 ENSP00000334414
(SF1)		 Q15637-2
Homo sapiens (Hsa) hsa5904 ENSP00000351110
Kluyveromyces lactis (Kla) kla4888 KLLA0F18018g
Mus musculus (Mmu) mmu13208 ENSMUSP00000071954
Mus musculus (Mmu) mmu13207 ENSMUSP00000075689
(MGI:1095403)		 Q64213-1
Mus musculus (Mmu) mmu13206 ENSMUSP00000079284
Neurospora crassa (Ncr) ncr3986 NCU04110.2
Oryza sativa (Osa) osa81877 8172.m00181
Plasmodium falciparum (Pfa) pfa2966 PFF1135w
Rattus norvegicus (Rno) rno3561 ENSRNOP00000028628
(RGD:620645)
Rattus norvegicus (Rno) rno3563 ENSRNOP00000040094
Rattus norvegicus (Rno) rno3562 ENSRNOP00000041676
(RGD:620645)		 O88629
Saccharomyces cerevisiae (Sce) sce4198 YLR116W
(S000004106)
Schizosaccharomyces pombe (Spo) spo631 SPCC962.06c O74555
Yarrowia lipolytica (Yli) yli6113 YALI0F18370g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000243 commitment complex C
IDA
SceS000004106
SpoSPCC962.06c
GO:0005634 nucleus C
IDA
DmeFBgn0025571
SpoSPCC962.06c
ISS
MmuMGI:1095403
GO:0005681 spliceosomal complex C
ISS
DmeFBgn0025571
NAS
DmeFBgn0025571
GO:0005737 cytoplasm C
ISS
MmuMGI:1095403
GO:0005829 cytosol C
IDA
SpoSPCC962.06c
GO:0071011 precatalytic spliceosome C
IDA
DmeFBgn0025571
GO:0003723 RNA binding F
ISS
PfaPFF1135w
SpoSPCC962.06c
GO:0045131 pre-mRNA branch point binding F
IDA
SceS000004106
GO:0000003 reproduction P
IMP
CelWBGene00013808
GO:0000349 generation of catalytic spliceosome for first
transesterification step		 P
IDA
SpoSPCC962.06c
GO:0000398 nuclear mRNA splicing, via spliceosome P
IC
DmeFBgn0025571
IPI
SceS000004106
ISS
DmeFBgn0025571
NAS
DmeFBgn0025571
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00013808
GO:0002119 nematode larval development P
IMP
CelWBGene00013808
GO:0002121 inter-male aggressive behavior P
IMP
DmeFBgn0025571
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00013808
GO:0008380 RNA splicing P
ISS
PfaPFF1135w
NAS
AthAt5g51300
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013808
GO:0010171 body morphogenesis P
IMP
CelWBGene00013808
GO:0022402 cell cycle process P
IGI
MmuMGI:1095403
GO:0030238 male sex determination P
IGI
MmuMGI:1095403
GO:0033327 Leydig cell differentiation P
IGI
MmuMGI:1095403
GO:0040007 growth P
IMP
CelWBGene00013808
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013808
GO:0040011 locomotion P
IMP
CelWBGene00013808
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00013808
GO:0050810 regulation of steroid biosynthetic
process		 P
IGI
MmuMGI:1095403

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC962.06c
(O74555)		 YLR116W
(S000004106)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000243 commitment complex C
IDA
SceS000004106
SpoSPCC962.06c
GO:0005634 nucleus C
IDA
SpoSPCC962.06c
GO:0005829 cytosol C
IDA
SpoSPCC962.06c
GO:0003723 RNA binding F
ISS
SpoSPCC962.06c
GO:0045131 pre-mRNA branch point binding F
IDA
SceS000004106
GO:0000349 generation of catalytic spliceosome for first
transesterification step		 P
IDA
SpoSPCC962.06c
GO:0000398 nuclear mRNA splicing, via spliceosome P
IPI
SceS000004106

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s.khadayate@ucl.ac.uk