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Search term: YLR148W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PEP3
SGD link S000004138
Alternative ID YLR148W
Description Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
Synonyms YLR148W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2034 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Vacuolar sorting protein PEP3/VPS18

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g12470 GI:15221363
Caenorhabditis elegans (Cel) CE25141 GI:17536747
Caenorhabditis elegans (Cel) CE29420 GI:
Drosophila melanogaster (Dme) 7290189 GI:7290189
Homo sapiens (Hsa) HsM17978485
(VPS18)		 GI:17978485 Q9P253
Homo sapiens (Hsa) Hs17978487 GI:17978487
Saccharomyces cerevisiae (Sce) YLR148w
(S000004138)		 GI:6323177 P27801
Schizosaccharomyces pombe (Spo) SPCC790.02 GI:19075998 O74925


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004138
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004138
GO:0005737 cytoplasm C
IDA
SpoSPCC790.02
GO:0005829 cytosol C
IDA
SpoSPCC790.02
GO:0030897 HOPS complex C
IDA
HsaVPS18
IPI
SceS000004138
ISS
SpoSPCC790.02
GO:0032153 cell division site C
IDA
SpoSPCC790.02
GO:0033263 CORVET complex C
IDA
SceS000004138
GO:0034515 proteasome storage granule C
IC
SceS000004138
GO:0004842 ubiquitin-protein ligase activity F
ISS
SpoSPCC790.02
GO:0005515 protein binding F
IMP
SceS000004138
IPI
HsaVPS18
SceS000004138
GO:0008270 zinc ion binding F
ISS
SpoSPCC790.02
GO:0035091 phosphoinositide binding F
IDA
SceS000004138
GO:0006623 protein targeting to vacuole P
ISS
SpoSPCC790.02
GO:0006895 Golgi to endosome transport P
IGI
SceS000004138
ISS
SpoSPCC790.02
GO:0006904 vesicle docking involved in exocytosis P
IMP
SceS000004138
GO:0006914 autophagy P
RCA
SceS000004138
GO:0007032 endosome organization P
IDA
HsaVPS18
GO:0007033 vacuole organization P
ISS
SpoSPCC790.02
RCA
SceS000004138
GO:0007034 vacuolar transport P
RCA
SceS000004138
GO:0007040 lysosome organization P
IDA
HsaVPS18
GO:0016567 protein ubiquitination P
ISS
SpoSPCC790.02
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004138
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000004138
GO:0042144 vacuole fusion, non-autophagic P
IDA
SceS000004138
IMP
SceS000004138
ISS
SpoSPCC790.02
GO:0045184 establishment of protein localization P
RCA
SceS000004138
GO:0045324 late endosome to vacuole transport P
IGI
SceS000004138
ISS
SpoSPCC790.02
GO:0048278 vesicle docking P
ISS
SpoSPCC790.02

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68838

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PEP3
(S000004138)		 GI:6323177 P27801
Kluyveromyces lactis (Kla) KLLA0D17182g GI:50307681
Eremothecium gossypii (Ego) AGOS_AGL156W GI:45200941


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004138
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004138
GO:0030897 HOPS complex C
IPI
SceS000004138
GO:0033263 CORVET complex C
IDA
SceS000004138
GO:0034515 proteasome storage granule C
IC
SceS000004138
GO:0005515 protein binding F
IMP
SceS000004138
IPI
SceS000004138
GO:0035091 phosphoinositide binding F
IDA
SceS000004138
GO:0006895 Golgi to endosome transport P
IGI
SceS000004138
GO:0006904 vesicle docking involved in exocytosis P
IMP
SceS000004138
GO:0006914 autophagy P
RCA
SceS000004138
GO:0007033 vacuole organization P
RCA
SceS000004138
GO:0007034 vacuolar transport P
RCA
SceS000004138
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004138
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000004138
GO:0042144 vacuole fusion, non-autophagic P
IDA
SceS000004138
IMP
SceS000004138
GO:0045184 establishment of protein localization P
RCA
SceS000004138
GO:0045324 late endosome to vacuole transport P
IGI
SceS000004138

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2419

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15693 ENSANGP00000005373
Anopheles gambiae (Aga) aga15694 ENSANGP00000025982
Ashbya gossypii (Ago) ago4156 AGL156W
Arabidopsis thaliana (Ath) ath1314 At1g12470.1
Caenorhabditis elegans (Cel) cel17121 W06B4.3
(CE32071;
WBGene00021058)
Candida glabrata (Cgl) cgl4860 CAGL0M04653g
Cryptococcus neoformans (Cne) cne5265 179.m00114
Dictyostelium discoideum (Ddi) ddi4095 DDB0190675
Debaryomyces hansenii (Dha) dha4163 DEHA0E20823g
Drosophila melanogaster (Dme) dme16090 CG3093-PA
(FBgn0000482)
Danio rerio (Dre) dre12435 ENSDARP00000004613
Takifugu rubripes (Fru) fru26875 SINFRUP00000135915
Gallus gallus (Gga) gga19200 ENSGALP00000013826
(VPS18)
Gallus gallus (Gga) gga19201 ENSGALP00000013827
Gallus gallus (Gga) gga19202 ENSGALP00000013828
Homo sapiens (Hsa) hsa10463 ENSP00000220509
(VPS18)		 Q9P253-1
Kluyveromyces lactis (Kla) kla2819 KLLA0D17182g
Mus musculus (Mmu) mmu15283 ENSMUSP00000036915
(MGI:2443626)		 Q3UG80
Neurospora crassa (Ncr) ncr6008 NCU06183.2
Oryza sativa (Osa) osa15581 3040.m00138
Plasmodium falciparum (Pfa) pfa4156 PF13_0053
Rattus norvegicus (Rno) rno19477 ENSRNOP00000018717
(RGD:1311556)		 B5DFJ4
Saccharomyces cerevisiae (Sce) sce4231 YLR148W
(S000004138)
Schizosaccharomyces pombe (Spo) spo4278 SPCC790.02 O74925
Yarrowia lipolytica (Yli) yli637 YALI0A19008g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000306 extrinsic to vacuolar membrane C
IDA
SceS000004138
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000004138
GO:0005737 cytoplasm C
IDA
SpoSPCC790.02
GO:0005764 lysosome C
IDA
DmeFBgn0000482
GO:0005769 early endosome C
IDA
MmuMGI:2443626
GO:0005829 cytosol C
IDA
SpoSPCC790.02
GO:0005884 actin filament C
IDA
MmuMGI:2443626
GO:0030897 HOPS complex C
IPI
SceS000004138
ISS
SpoSPCC790.02
GO:0032153 cell division site C
IDA
SpoSPCC790.02
GO:0033263 CORVET complex C
IDA
SceS000004138
GO:0034515 proteasome storage granule C
IC
SceS000004138
GO:0045202 synapse C
IMP
DmeFBgn0000482
GO:0003779 actin binding F
IDA
MmuMGI:2443626
GO:0004842 ubiquitin-protein ligase activity F
ISS
SpoSPCC790.02
GO:0005515 protein binding F
IMP
SceS000004138
IPI
DmeFBgn0000482
MmuMGI:2443626
SceS000004138
GO:0008270 zinc ion binding F
ISS
SpoSPCC790.02
GO:0035091 phosphoinositide binding F
IDA
SceS000004138
GO:0006622 protein targeting to lysosome P
IMP
DmeFBgn0000482
GO:0006623 protein targeting to vacuole P
ISS
SpoSPCC790.02
GO:0006726 eye pigment biosynthetic process P
TAS
DmeFBgn0000482
GO:0006727 ommochrome biosynthetic process P
IMP
DmeFBgn0000482
GO:0006728 pteridine biosynthetic process P
IMP
DmeFBgn0000482
GO:0006895 Golgi to endosome transport P
IGI
SceS000004138
ISS
SpoSPCC790.02
GO:0006904 vesicle docking involved in exocytosis P
IMP
SceS000004138
GO:0006914 autophagy P
RCA
SceS000004138
GO:0007032 endosome organization P
IDA
MmuMGI:2443626
IMP
DmeFBgn0000482
GO:0007033 vacuole organization P
ISS
SpoSPCC790.02
RCA
SceS000004138
GO:0007034 vacuolar transport P
RCA
SceS000004138
GO:0007298 border follicle cell migration P
IMP
DmeFBgn0000482
GO:0008057 eye pigment granule organization P
IMP
DmeFBgn0000482
GO:0008219 cell death P
IMP
CelWBGene00021058
GO:0008333 endosome to lysosome transport P
NAS
DmeFBgn0000482
TAS
DmeFBgn0000482
GO:0008340 determination of adult lifespan P
IMP
DmeFBgn0000482
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00021058
GO:0010171 body morphogenesis P
IMP
CelWBGene00021058
GO:0016567 protein ubiquitination P
ISS
SpoSPCC790.02
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000004138