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Search term: YLR172C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DPH5
SGD link S000004162
Alternative ID YLR172C
Description Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
Synonyms YLR172C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3123 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Diphthine synthase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g31790 GI:15236075
Caenorhabditis elegans (Cel) CE02109
(WBGene00007194)		 GI:17531369 Q17514
Drosophila melanogaster (Dme) 7300882 GI:17738127
Homo sapiens (Hsa) Hs7706272 GI:7706272
Saccharomyces cerevisiae (Sce) YLR172c
(S000004162)		 GI:6323201 P32469
Schizosaccharomyces pombe (Spo) SPCC576.14 GI:19075941 O74898
Encephalitozoon cuniculi (Ecu) ECU11g1430 GI:19074943 Q8SQT9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g31790
GO:0005634 nucleus C
IDA
SpoSPCC576.14
GO:0005737 cytoplasm C
IDA
SceS000004162
ISS
SpoSPCC576.14
GO:0005829 cytosol C
IDA
SpoSPCC576.14
GO:0004164 diphthine synthase activity F
IDA
SceS000004162
IMP
SceS000004162
ISS
AthAt4g31790
SpoSPCC576.14
GO:0008168 methyltransferase activity F
ISS
AthAt4g31790
GO:0006417 regulation of translation P
IC
SpoSPCC576.14
GO:0008152 metabolic process P
ISS
AthAt4g31790
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IDA
SceS000004162
IMP
SceS000004162
ISS
AthAt4g31790
SpoSPCC576.14
GO:0032259 methylation P
ISS
SpoSPCC576.14

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6471

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) DPH5 GI:117190324
Pan troglodytes (Ptr) DPH5 GI:114557984
Canis familiaris (Cfa) DPH5 GI:73959983
Mus musculus (Mmu) Dph5
(MGI:1916990)		 GI:40254183 Q6PAC5
Rattus norvegicus (Rno) Dph5
(RGD:1307867)		 GI:62945254
Gallus gallus (Gga) DPH5 GI:50751240
Drosophila melanogaster (Dme) Dph5
(FBgn0024558)		 GI:28572120
Anopheles gambiae (Aga) AgaP_AGAP004412 GI:158292140
Caenorhabditis elegans (Cel) B0491.7
(CE02109;
WBGene00007194)		 GI:17531369 Q17514
Schizosaccharomyces pombe (Spo) SPCC576.14 GI:19075941 O74898
Saccharomyces cerevisiae (Sce) DPH5
(S000004162)		 GI:6323201 P32469
Kluyveromyces lactis (Kla) KLLA0F22836g GI:50312133
Eremothecium gossypii (Ego) AGOS_AFR123W GI:45198641
Magnaporthe grisea (Mgr) MGG_10496 GI:39969773
Neurospora crassa (Ncr) NCU07266.1 GI:32414145
Arabidopsis thaliana (Ath) AT4G31790 GI:15236075
Oryza sativa (Osa) Os03g0355800 GI:115453073
Plasmodium falciparum (Pfa) PF10_0087 GI:124802121


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g31790
HsaDPH5
MmuMGI:1916990
PfaPF10_0087
GO:0005634 nucleus C
IDA
SpoSPCC576.14
GO:0005737 cytoplasm C
IDA
SceS000004162
ISS
SpoSPCC576.14
GO:0005829 cytosol C
IDA
SpoSPCC576.14
GO:0003674 molecular_function F
ND
MmuMGI:1916990
GO:0004164 diphthine synthase activity F
IDA
SceS000004162
IMP
SceS000004162
ISS
AthAt4g31790
DmeFBgn0024558
SpoSPCC576.14
NAS
HsaDPH5
GO:0008168 methyltransferase activity F
ISS
AthAt4g31790
GO:0006417 regulation of translation P
IC
SpoSPCC576.14
GO:0008150 biological_process P
ND
MmuMGI:1916990
GO:0008152 metabolic process P
ISS
AthAt4g31790
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IDA
SceS000004162
IMP
SceS000004162
ISS
AthAt4g31790
DmeFBgn0024558
SpoSPCC576.14
NAS
HsaDPH5
GO:0032259 methylation P
ISS
SpoSPCC576.14

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1274

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6954 ENSANGP00000003767
Ashbya gossypii (Ago) ago3315 AFR123W
Arabidopsis thaliana (Ath) ath21261 At4g31790.1
Arabidopsis thaliana (Ath) ath21262 At4g31790.2
Caenorhabditis elegans (Cel) cel533 B0491.7
(CE02109;
WBGene00007194)
Candida glabrata (Cgl) cgl420 CAGL0B04961g
Cryptococcus neoformans (Cne) cne1233 180.m00171
Dictyostelium discoideum (Ddi) ddi2398 DDB0169516
Debaryomyces hansenii (Dha) dha4354 DEHA0E25344g
Drosophila melanogaster (Dme) dme13880 CG31289-PA
(FBgn0024558)
Danio rerio (Dre) dre14310 ENSDARP00000022829
(dph5)		 Q5U3P6
Danio rerio (Dre) dre14312 ENSDARP00000048417
Danio rerio (Dre) dre14313 ENSDARP00000049941
Encephalitozoon cuniculi (Ecu) ecu1031 19074943
Takifugu rubripes (Fru) fru5390 SINFRUP00000163854
Takifugu rubripes (Fru) fru5388 SINFRUP00000166840
Takifugu rubripes (Fru) fru5387 SINFRUP00000171891
Gallus gallus (Gga) gga22413 ENSGALP00000008387
(DPH5)
Gallus gallus (Gga) gga22414 ENSGALP00000008388
Homo sapiens (Hsa) hsa1576 ENSP00000251159
Kluyveromyces lactis (Kla) kla5098 KLLA0F22836g
Mus musculus (Mmu) mmu17446 ENSMUSP00000043730
(MGI:1916990)		 Q6PAC5
Neurospora crassa (Ncr) ncr7072 NCU07266.2
Oryza sativa (Osa) osa58809 6471.m00173
Oryza sativa (Osa) osa58841 6471.m00399
Plasmodium falciparum (Pfa) pfa309 PF10_0087
Rattus norvegicus (Rno) rno16906 ENSRNOP00000018367
(RGD:1307867)		 Q569A7
Saccharomyces cerevisiae (Sce) sce4272 YLR172C
(S000004162)
Schizosaccharomyces pombe (Spo) spo2029 SPCC576.14 O74898
Yarrowia lipolytica (Yli) yli6060 YALI0F17138g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g31790
MmuMGI:1916990
PfaPF10_0087
GO:0005634 nucleus C
IDA
SpoSPCC576.14
GO:0005737 cytoplasm C
IDA
SceS000004162
ISS
SpoSPCC576.14
GO:0005829 cytosol C
IDA
SpoSPCC576.14
GO:0003674 molecular_function F
ND
MmuMGI:1916990
GO:0004164 diphthine synthase activity F
IDA
SceS000004162
IMP
SceS000004162
ISS
AthAt4g31790
DmeFBgn0024558
SpoSPCC576.14
GO:0008168 methyltransferase activity F
ISS
AthAt4g31790
GO:0006417 regulation of translation P
IC
SpoSPCC576.14
GO:0008150 biological_process P
ND
MmuMGI:1916990
GO:0008152 metabolic process P
ISS
AthAt4g31790
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IDA
SceS000004162
IMP
SceS000004162
ISS
AthAt4g31790
DmeFBgn0024558
SpoSPCC576.14
GO:0032259 methylation P
ISS
SpoSPCC576.14

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC576.14
(O74898)		 YLR172C
(S000004162)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPCC576.14
GO:0005737 cytoplasm C
IDA
SceS000004162
ISS
SpoSPCC576.14
GO:0005829 cytosol C
IDA
SpoSPCC576.14
GO:0004164 diphthine synthase activity F
IDA
SceS000004162
IMP
SceS000004162
ISS
SpoSPCC576.14
GO:0006417 regulation of translation P
IC
SpoSPCC576.14
GO:0017183 peptidyl-diphthamide biosynthetic process from
peptidyl-histidine		 P
IDA
SceS000004162
IMP
SceS000004162
ISS
SpoSPCC576.14
GO:0032259 methylation P
ISS
SpoSPCC576.14

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GO info in one table:

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