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Search term: YLR207W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HRD3
SGD link S000004197
Alternative ID YLR207W
Description Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
Synonyms YLR207W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1550 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Extracellular protein SEL-1 and related proteins

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g18260 GI:15221034
Arabidopsis thaliana (Ath) At1g70590 GI:12324759
Arabidopsis thaliana (Ath) At1g73570 GI:15219499
Arabidopsis thaliana (Ath) At2g25570 GI:18400868
Caenorhabditis elegans (Cel) CE16043
(WBGene00004759)		 GI:17563256 Q20423
Drosophila melanogaster (Dme) 7301042 GI:5901858
Homo sapiens (Hsa) Hs7661940 GI:7661940
Homo sapiens (Hsa) Hs19923669
(SEL1L)		 GI:19923669 Q12916
Homo sapiens (Hsa) Hs14733014 GI:14733014
Homo sapiens (Hsa) Hs20559528 GI:20559528
Homo sapiens (Hsa) Hs8922177 GI:8922177
Saccharomyces cerevisiae (Sce) YBL061c
(S000000157)		 GI:6319410 P34226
Saccharomyces cerevisiae (Sce) YDL203c
(S000002362)		 GI:6319998 Q07622
Saccharomyces cerevisiae (Sce) YER096w
(S000000898)		 GI:6320943 P39000
Saccharomyces cerevisiae (Sce) YLR207w
(S000004197)		 GI:6323236 Q05787
Schizosaccharomyces pombe (Spo) SPAC1B3.10c GI:19115706 O13875
Schizosaccharomyces pombe (Spo) SPAC24B11.10c GI:19113759 Q09897
Schizosaccharomyces pombe (Spo) SPBC1289.01c GI:19113617 O94614
Schizosaccharomyces pombe (Spo) SPBC28F2.08c GI:19112461 Q9USV0
Schizosaccharomyces pombe (Spo) SPBC3E7.12c GI:19112891 O59732
Schizosaccharomyces pombe (Spo) SPCC417.05c GI:19075782 O94486
Encephalitozoon cuniculi (Ecu) ECU02g1030 GI:19074022 Q8SWB7
Encephalitozoon cuniculi (Ecu) ECU06g0540 GI:19074304 Q8SVD0
Encephalitozoon cuniculi (Ecu) ECU07g0510 GI:19074473 Q8SV26
Encephalitozoon cuniculi (Ecu) ECU11g0430 GI:19074843 Q8SU70


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
IDA
SceS000000157
GO:0000144 cellular bud neck septin ring C
IDA
SceS000000157
GO:0000148 1,3-beta-glucan synthase complex C
IPI
SpoSPBC1289.01c
GO:0000151 ubiquitin ligase complex C
NAS
SpoSPBC28F2.08c
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex C
IDA
SceS000004197
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000004197
GO:0000935 barrier septum C
IDA
SpoSPBC1289.01c
GO:0005575 cellular_component C
ND
SpoSPAC1B3.10c
GO:0005628 prospore membrane C
IDA
SceS000000898
GO:0005634 nucleus C
IDA
SpoSPAC24B11.10c
SPCC417.05c
SPBC1289.01c
GO:0005739 mitochondrion C
IDA
SceS000002362
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g18260
SpoSPBC28F2.08c
GO:0005789 endoplasmic reticulum membrane C
IPI
SceS000004197
ISS
SpoSPBC28F2.08c
GO:0005816 spindle pole body C
IDA
SpoSPAC24B11.10c
GO:0005829 cytosol C
IDA
SpoSPAC24B11.10c
SPCC417.05c
SPBC3E7.12c
SPBC1289.01c
GO:0005935 cellular bud neck C
IDA
SceS000000157
GO:0016020 membrane C
IDA
AthAt1g18260
GO:0016021 integral to membrane C
NAS
HsaSEL1L
GO:0016023 cytoplasmic membrane-bounded vesicle C
IDA
CelWBGene00004759
GO:0032153 cell division site C
IDA
SpoSPAC24B11.10c
SPCC417.05c
SPBC1289.01c
GO:0034099 luminal surveillance complex C
IDA
SceS000004197
GO:0046658 anchored to plasma membrane C
RCA
SpoSPCC417.05c
SPBC1289.01c
GO:0051286 cell tip C
IDA
SpoSPAC24B11.10c
SPBC1289.01c
GO:0003674 molecular_function F
ND
SceS000002362
SpoSPAC1B3.10c
SPAC24B11.10c
SPBC28F2.08c
SPBC3E7.12c
SPCC417.05c
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004197
GO:0005515 protein binding F
IPI
HsaSEL1L
GO:0008047 enzyme activator activity F
IGI
SceS000000898
IMP
SceS000000157
GO:0043495 protein anchor F
RCA
SpoSPBC1289.01c
GO:0000003 reproduction P
RCA
SceS000000157
GO:0000910 cytokinesis P
TAS
SceS000000157
GO:0000917 barrier septum formation P
IMP
SpoSPBC1289.01c
GO:0006031 chitin biosynthetic process P
IGI
SceS000000898
GO:0006970 response to osmotic stress P
IMP
SpoSPBC1289.01c
TAS
SceS000000157
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000000157
GO:0007047 cellular cell wall organization P
RCA
SceS000000157
GO:0008150 biological_process P
ND
AthAt2g25570
At1g73570
At1g70590
At1g18260
SpoSPAC1B3.10c
GO:0009966 regulation of signal transduction P
RCA
SceS000000157
GO:0009967 positive regulation of signal transduction P
IMP
SceS000002362
GO:0010962 regulation of glucan biosynthetic
process		 P
IDA
SpoSPBC1289.01c
GO:0016567 protein ubiquitination P
NAS
SpoSPBC28F2.08c
GO:0019953 sexual reproduction P
RCA
SceS000000157
GO:0030433 ER-associated protein catabolic
process		 P
IDA
SceS000004197
ISS
SpoSPBC28F2.08c
GO:0030437 ascospore formation P
IDA
SceS000000898
GO:0031505 fungal-type cell wall organization P
IMP
SceS000002362
GO:0032951 regulation of beta-glucan biosynthetic
process		 P
IGI
SpoSPBC1289.01c
GO:0033554 cellular response to stress P
IEP
SpoSPCC417.05c
GO:0034221 fungal-type cell wall chitin biosynthetic
process		 P
IMP
SceS000000157
GO:0034223 regulation of ascospore wall chitin biosynthetic
process		 P
TAS
SpoSPAC24B11.10c
GO:0034613 cellular protein localization P
IMP
SpoSPBC1289.01c
GO:0045746 negative regulation of Notch signaling
pathway		 P
IGI
CelWBGene00004759
GO:0051278 fungal-type cell wall polysaccharide biosynthetic
process		 P
TAS
SpoSPBC3E7.12c
SPCC417.05c
GO:0090093 regulation of fungal-type cell wall beta-glucan
biosynthetic process		 P
IDA
SpoSPBC1289.01c
IMP
SpoSPBC1289.01c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
39731

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) HRD3
(S000004197)		 GI:6323236 Q05787
Kluyveromyces lactis (Kla) KLLA0C16665g GI:50305969


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex C
IDA
SceS000004197
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000004197
GO:0005789 endoplasmic reticulum membrane C
IPI
SceS000004197
GO:0034099 luminal surveillance complex C
IDA
SceS000004197
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004197
GO:0030433 ER-associated protein catabolic
process		 P
IDA
SceS000004197

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_511

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15258 ENSANGP00000019196
Ashbya gossypii (Ago) ago889 ACL160C
Arabidopsis thaliana (Ath) ath1956 At1g18260.1
Arabidopsis thaliana (Ath) ath6340 At1g70590.1
Arabidopsis thaliana (Ath) ath6655 At1g73570.1
Caenorhabditis elegans (Cel) cel9216 F45D3.5
(CE16043;
WBGene00004759)
Candida glabrata (Cgl) cgl3374 CAGL0J08756g
Cryptococcus neoformans (Cne) cne4055 185.m02680
Dictyostelium discoideum (Ddi) ddi7726 DDB0186287
Dictyostelium discoideum (Ddi) ddi1017 DDB0190258
Dictyostelium discoideum (Ddi) ddi218 DDB0190259
Debaryomyces hansenii (Dha) dha6033 DEHA0G07447g
Drosophila melanogaster (Dme) dme14066 CG10221-PA
(FBgn0028475)
Danio rerio (Dre) dre12462 ENSDARP00000007196
(si:dkey-177p2.3)		 Q5RIK6
Escherichia coli (Eco) eco633 49176040
Encephalitozoon cuniculi (Ecu) ecu101 19074022
Encephalitozoon cuniculi (Ecu) ecu931 19074843
Takifugu rubripes (Fru) fru26649 SINFRUP00000139770
Takifugu rubripes (Fru) fru2227 SINFRUP00000140353
Gallus gallus (Gga) gga19644 ENSGALP00000017200
Gallus gallus (Gga) gga19645 ENSGALP00000017201
(SEL1L)
Homo sapiens (Hsa) hsa19847 ENSP00000284951
(SEL1L2)		 Q5TEA6
Homo sapiens (Hsa) hsa9911 ENSP00000337053
(SEL1L)		 Q9UBV2-1
Kluyveromyces lactis (Kla) kla1944 KLLA0C16665g
Mus musculus (Mmu) mmu6074 ENSMUSP00000021347
(MGI:1329016)		 Q9Z2G6-1
Mus musculus (Mmu) mmu15599 ENSMUSP00000049990
Mus musculus (Mmu) mmu6075 ENSMUSP00000072444
Neurospora crassa (Ncr) ncr10348 NCU10789.2
Oryza sativa (Osa) osa72307 7218.m00135
Plasmodium falciparum (Pfa) pfa1142 PF14_0462
Plasmodium falciparum (Pfa) pfa2780 PFC0550w
Rattus norvegicus (Rno) rno25497 ENSRNOP00000006143
(RGD:620147)		 Q80Z70
Rattus norvegicus (Rno) rno19833 ENSRNOP00000036379
(RGD:1311278)		 Q5XI05
Rattus norvegicus (Rno) rno25498 ENSRNOP00000043232
(RGD:620147)
Saccharomyces cerevisiae (Sce) sce1833 YER096W
(S000000898)
Saccharomyces cerevisiae (Sce) sce4307 YLR207W
(S000004197)
Schizosaccharomyces pombe (Spo) spo1874 SPAC1B3.10c O13875
Schizosaccharomyces pombe (Spo) spo1290 SPCC417.05c O94486
Yarrowia lipolytica (Yli) yli5410 YALI0F01859g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex C
IDA
SceS000004197
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000004197
GO:0005575 cellular_component C
ND
PfaPF14_0462
SpoSPAC1B3.10c
GO:0005628 prospore membrane C
IDA
SceS000000898
GO:0005634 nucleus C
IDA
SpoSPCC417.05c
GO:0005783 endoplasmic reticulum C
IDA
AthAt1g18260
GO:0005789 endoplasmic reticulum membrane C
IPI
SceS000004197
GO:0005829 cytosol C
IDA
SpoSPCC417.05c
GO:0005886 plasma membrane C
ISS
DmeFBgn0028475
GO:0016020 membrane C
IDA
AthAt1g18260
GO:0016023 cytoplasmic membrane-bounded vesicle C
IDA
CelWBGene00004759
GO:0032153 cell division site C
IDA
SpoSPCC417.05c
GO:0034099 luminal surveillance complex C
IDA
SceS000004197
GO:0046658 anchored to plasma membrane C
RCA
SpoSPCC417.05c
GO:0003674 molecular_function F
ND
SpoSPAC1B3.10c
SPCC417.05c
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004197
GO:0008047 enzyme activator activity F
IGI
SceS000000898
GO:0006031 chitin biosynthetic process P
IGI
SceS000000898
GO:0008150 biological_process P
ND
AthAt1g73570
At1g70590
At1g18260
PfaPF14_0462
SpoSPAC1B3.10c
GO:0030433 ER-associated protein catabolic
process		 P
IDA
SceS000004197
GO:0030437 ascospore formation P
IDA
SceS000000898
GO:0033554 cellular response to stress P
IEP
SpoSPCC417.05c
GO:0045746 negative regulation of Notch signaling
pathway		 P
IGI
CelWBGene00004759
GO:0051278 fungal-type cell wall polysaccharide biosynthetic
process		 P
TAS
SpoSPCC417.05c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC28F2.08c
(Q9USV0)		 YLR207W
(S000004197)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000151 ubiquitin ligase complex C
NAS
SpoSPBC28F2.08c
GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex C
IDA
SceS000004197
GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex C
IDA
SceS000004197
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC28F2.08c
GO:0005789 endoplasmic reticulum membrane C
IPI
SceS000004197
ISS
SpoSPBC28F2.08c
GO:0034099 luminal surveillance complex C
IDA
SceS000004197
GO:0003674 molecular_function F
ND
SpoSPBC28F2.08c
GO:0004842 ubiquitin-protein ligase activity F
IDA
SceS000004197
GO:0016567 protein ubiquitination P
NAS
SpoSPBC28F2.08c
GO:0030433 ER-associated protein catabolic
process		 P
IDA
SceS000004197
ISS
SpoSPBC28F2.08c

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