Bahler Lab

Search term: YLR214W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name FRE1

SGD link S000004204

Alternative ID YLR214W

Description Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels

Synonyms YLR214W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0039 ACDHYP-

KOGs classification KOGs description

METABOLISMMETABOLISM Ferric reductase, NADH/NADPH oxidase and related proteins

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
IDA
Sce S000003974

GO:0005624 membrane fraction C
IDA
Sce S000004204

GO:0005739 mitochondrion C
IDA
Ath At5g50160
Sce S000005911

GO:0005773 vacuole C
IDA
Ath At4g25090

GO:0005774 vacuolar membrane C
IDA
Sce S000003974

GO:0005783 endoplasmic reticulum C
IDA
Spo SPBC1683.09c
SPBC947.05c

GO:0005840 ribosome C
IDA
Sce S000003128

GO:0005882 intermediate filament C
IDA
Cel WBGene00000253

GO:0005886 plasma membrane C
IDA
Ath At1g01580
At1g64060
At5g47910
At5g49730
At5g50160
Sce S000005908
S000005512
S000001703
S000004204
IMP
Sce S000005343
ISS
Sce S000005343
Spo SPBC1683.09c
SPBC947.05c

GO:0005887 integral to plasma membrane C
IDA
Ath At5g51060
Hsa CYBB
IMP
Ath At1g64060

GO:0009507 chloroplast C
IDA
Ath At5g49740

GO:0016020 membrane C
IDA
Ath At3g45810
ISS
Ath At1g23020
At1g01580
At1g01590
At5g23980
At5g23990
At5g49740
At5g49730
At5g50160
Sce S000003128
S000004037

GO:0016021 integral to membrane C
ISS
Sce S000005908
Spo SPBC947.05c
SPBC1683.09c
TAS
Hsa NOX4

GO:0016324 apical plasma membrane C
NAS
Hsa DUOX1

GO:0022626 cytosolic ribosome C
IDA
Ath At4g25090

GO:0031226 intrinsic to plasma membrane C
IDA
Ath At5g07390

GO:0043020 NADPH oxidase complex C
IDA
Hsa CYBB
TAS
Hsa CYBB

GO:0000166 nucleotide binding F
TAS
Hsa NOX4

GO:0000293 ferric-chelate reductase activity F
IDA
Ath At1g01580
At1g23020
At5g23980
At5g23990
At5g49740
At5g50160
At5g49730
Sce S000001703
S000004204
IGI
Sce S000005512
IMP
Ath At1g01580
At1g01590
At5g49740
Sce S000003974
S000005343
ISS
Ath At5g23990
At1g01590
At1g01580
At1g23020
Sce S000005908
S000003974
S000005343
S000005911
Spo SPBC947.05c
RCA
Sce S000003128
TAS
Spo SPBC1683.09c

GO:0003674 molecular_function F
ND
Ath At1g33640

GO:0005506 iron ion binding F
ISS
Spo SPBC1683.09c
SPBC947.05c

GO:0005509 calcium ion binding F
IDA
Ath At5g07390

GO:0005515 protein binding F
IPI
Hsa CYBB

GO:0009055 electron carrier activity F
IDA
Hsa CYBB
TAS
Hsa NOX4

GO:0015252 hydrogen ion channel activity F
IDA
Hsa NOX5

GO:0016174 NAD(P)H oxidase activity F
IMP
Ath At1g09090
At1g64060
At5g47910
At5g51060
NAS
Hsa DUOX1
TAS
Ath At1g64060
At5g47910
Hsa NOX4

GO:0016175 superoxide-generating NADPH oxidase
activity F
IDA
Hsa CYBB
NOX5
ISS
Ath At3g45810
At5g60010
TAS
Hsa CYBB

GO:0016491 oxidoreductase activity F
ISS
Ath At5g49740
At5g49730
At5g50160

GO:0016722 oxidoreductase activity, oxidizing metal
ions F
IMP
Sce S000004037
ISS
Sce S000003128
S000004037

GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD
or NADP as acceptor F
RCA
Sce S000003128

GO:0019826 oxygen sensor activity F
TAS
Hsa NOX4

GO:0020037 heme binding F
IMP
Hsa CYBB
NAS
Hsa NOX5
TAS
Hsa NOX4

GO:0046982 protein heterodimerization activity F
IPI
Hsa CYBB

GO:0050660 FAD binding F
IMP
Hsa CYBB
ISS
Spo SPBC1683.09c
SPBC947.05c
NAS
Hsa NOX5
TAS
Hsa NOX4

GO:0050661 NADP or NADPH binding F
NAS
Hsa DUOX1
NOX5

GO:0000902 cell morphogenesis P
ISS
Hsa NOX4

GO:0000910 cytokinesis P
NAS
Hsa NOX5

GO:0002119 nematode larval development P
IGI
Cel WBGene00000253
IMP
Cel WBGene00000253
WBGene00018771

GO:0002679 respiratory burst involved in defense
response P
IMP
Ath At1g64060

GO:0006414 translational elongation P
RCA
Sce S000004204

GO:0006800 oxygen and reactive oxygen species metabolic
process P
IDA
Hsa NOX4
IMP
Ath At1g64060
At5g47910
TAS
Ath At5g47910

GO:0006801 superoxide metabolic process P
IDA
Hsa CYBB
TAS
Hsa CYBB

GO:0006826 iron ion transport P
IDA
Sce S000001703
S000004204
IGI
Sce S000005512

GO:0006875 cellular metal ion homeostasis P
IMP
Sce S000004037

GO:0006879 cellular iron ion homeostasis P
IC
Spo SPBC947.05c
IEP
Sce S000005908
IMP
Sce S000005908

GO:0006880 intracellular sequestering of iron
ion P
IMP
Sce S000003974

GO:0006917 induction of apoptosis P
NAS
Hsa NOX5

GO:0006952 defense response P
IMP
Ath At1g64060
At5g47910
Cel WBGene00000253
TAS
Ath At5g07390
At1g09090
At1g19230
At5g51060

GO:0006954 inflammatory response P
TAS
Hsa NOX4
CYBB

GO:0006979 response to oxidative stress P
IGI
Cel WBGene00000253

GO:0007569 cell aging P
ISS
Hsa NOX4

GO:0008150 biological_process P
ND
Ath At1g33640
Sce S000003128
S000005911

GO:0008283 cell proliferation P
NAS
Hsa NOX5

GO:0008285 negative regulation of cell proliferation P
ISS
Hsa NOX4

GO:0009060 aerobic respiration P
IMP
Ath At5g51060

GO:0009408 response to heat P
IMP
Ath At1g09090
At5g47910

GO:0009416 response to light stimulus P
IEP
Ath At5g49730

GO:0009617 response to bacterium P
IEP
Ath At1g01580

GO:0009636 response to toxin P
RCA
Sce S000005908
S000001703
S000005343

GO:0009723 response to ethylene stimulus P
IMP
Ath At1g64060

GO:0009738 abscisic acid mediated signaling
pathway P
TAS
Ath At1g64060

GO:0009767 photosynthetic electron transport
chain P
IMP
Ath At5g49740

GO:0009792 embryo development ending in birth or egg
hatching P
IMP
Cel WBGene00018771
WBGene00000253

GO:0009845 seed germination P
IMP
Ath At1g09090

GO:0009873 ethylene mediated signaling pathway P
TAS
Ath At1g64060

GO:0010053 root epidermal cell differentiation P
IMP
Ath At5g51060

GO:0010119 regulation of stomatal movement P
IMP
Ath At1g64060

GO:0010155 regulation of proton transport P
NAS
Hsa NOX5

GO:0010171 body morphogenesis P
IMP
Cel WBGene00000253
WBGene00018771

GO:0015677 copper ion import P
IDA
Sce S000001703
S000004204
IGI
Sce S000005512
S000003974
ISS
Spo SPBC1683.09c
SPBC947.05c

GO:0015688 iron chelate transport P
IMP
Ath At1g01580

GO:0015892 siderophore-iron transport P
IMP
Sce S000005908
S000005343
ISS
Spo SPBC947.05c

GO:0018149 peptide cross-linking P
IMP
Cel WBGene00000253

GO:0018996 molting cycle, collagen and cuticulin-based
cuticle P
IMP
Cel WBGene00000253
WBGene00018771

GO:0019221 cytokine-mediated signaling pathway P
IDA
Hsa DUOX1

GO:0033198 response to ATP P
IMP
Ath At5g51060

GO:0033215 iron assimilation by reduction and
transport P
IMP
Spo SPBC1683.09c

GO:0034755 iron ion transmembrane transport P
IMP
Spo SPBC1683.09c
ISS
Spo SPBC947.05c

GO:0040002 collagen and cuticulin-based cuticle
development P
IGI
Cel WBGene00000253
IMP
Cel WBGene00018771
WBGene00000253

GO:0040007 growth P
IMP
Cel WBGene00018771
WBGene00000253

GO:0040011 locomotion P
IMP
Cel WBGene00000253
WBGene00018771

GO:0040032 post-embryonic body morphogenesis P
IGI
Cel WBGene00000253

GO:0042335 cuticle development P
IMP
Hsa DUOX1

GO:0042338 cuticle development involved in collagen and
cuticulin-based cuticle molting
cycle P
IGI
Cel WBGene00000253

GO:0042554 superoxide anion generation P
IDA
Hsa CYBB
NOX5
ISS
Hsa NOX4
NAS
Hsa DUOX1
TAS
Hsa CYBB

GO:0043012 regulation of fusion of sperm to egg plasma
membrane P
NAS
Hsa NOX5

GO:0043069 negative regulation of programmed cell
death P
IGI
Ath At5g47910
IMP
Ath At1g64060

GO:0045087 innate immune response P
IMP
Hsa CYBB
TAS
Hsa CYBB

GO:0045730 respiratory burst P
IMP
Hsa CYBB
TAS
Hsa CYBB

GO:0050663 cytokine secretion P
NAS
Hsa NOX5

GO:0050665 hydrogen peroxide biosynthetic
process P
IMP
Ath At1g64060
NAS
Hsa DUOX1

GO:0050832 defense response to fungus P
IMP
Ath At5g47910

GO:0051591 response to cAMP P
IDA
Hsa DUOX1
ISS
Hsa DUOX1

GO:0052542 defense response by callose deposition P
IMP
Ath At1g64060

GO:0055072 iron ion homeostasis P
IMP
Ath At1g01580

GO:0055114 oxidation reduction P
IDA
Hsa CYBB
NOX4
NOX5
TAS
Hsa CYBB
DUOX1

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

39734

Species Gene ID NCBI link UniProt link

Saccharomyces cerevisiae (Sce) FRE1
(S000004204) GI:6323243 P32791

Kluyveromyces lactis (Kla) KLLA0F04950g GI:50310569

Eremothecium gossypii (Ego) AGOS_ADR080W GI:45187953

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005624 membrane fraction C
IDA
Sce S000004204

GO:0005886 plasma membrane C
IDA
Sce S000004204

GO:0000293 ferric-chelate reductase activity F
IDA
Sce S000004204

GO:0006414 translational elongation P
RCA
Sce S000004204

GO:0006826 iron ion transport P
IDA
Sce S000004204

GO:0015677 copper ion import P
IDA
Sce S000004204

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_20776

Species OrthoMCL
sequence Model organism
protein page UniProt link

Ashbya gossypii (Ago) ago1821 ADR080W

Debaryomyces hansenii (Dha) dha695 DEHA0B00385g

Gallus gallus (Gga) gga15316 ENSGALP00000022177

Kluyveromyces lactis (Kla) kla4304 KLLA0F04950g

Saccharomyces cerevisiae (Sce) sce4314 YLR214W
(S000004204)

Schizosaccharomyces pombe (Spo) spo814 SPBC947.05c O94727

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005624 membrane fraction C
IDA
Sce S000004204

GO:0005783 endoplasmic reticulum C
IDA
Spo SPBC947.05c

GO:0005886 plasma membrane C
IDA
Sce S000004204
ISS
Spo SPBC947.05c

GO:0016021 integral to membrane C
ISS
Spo SPBC947.05c

GO:0000293 ferric-chelate reductase activity F
IDA
Sce S000004204
ISS
Spo SPBC947.05c

GO:0005506 iron ion binding F
ISS
Spo SPBC947.05c

GO:0050660 FAD binding F
ISS
Spo SPBC947.05c

GO:0006414 translational elongation P
RCA
Sce S000004204

GO:0006826 iron ion transport P
IDA
Sce S000004204

GO:0006879 cellular iron ion homeostasis P
IC
Spo SPBC947.05c

GO:0015677 copper ion import P
IDA
Sce S000004204
ISS
Spo SPBC947.05c

GO:0015892 siderophore-iron transport P
ISS
Spo SPBC947.05c

GO:0034755 iron ion transmembrane transport P
ISS
Spo SPBC947.05c

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPBC947.05c
(O94727) YLR214W
(S000004204)

SPBC1683.09c
(Q04800) YLR214W
(S000004204)

GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005624 membrane fraction C
IDA
Sce S000004204

GO:0005783 endoplasmic reticulum C
IDA
Spo SPBC1683.09c
SPBC947.05c

GO:0005886 plasma membrane C
IDA
Sce S000004204
ISS
Spo SPBC1683.09c
SPBC947.05c

GO:0016021 integral to membrane C
ISS
Spo SPBC947.05c
SPBC1683.09c

GO:0000293 ferric-chelate reductase activity F
IDA
Sce S000004204
ISS
Spo SPBC947.05c
TAS
Spo SPBC1683.09c

GO:0005506 iron ion binding F
ISS
Spo SPBC1683.09c
SPBC947.05c

GO:0050660 FAD binding F
ISS
Spo SPBC1683.09c
SPBC947.05c

GO:0006414 translational elongation P
RCA
Sce S000004204

GO:0006826 iron ion transport P
IDA
Sce S000004204

GO:0006879 cellular iron ion homeostasis P
IC
Spo SPBC947.05c

GO:0015677 copper ion import P
IDA
Sce S000004204
ISS
Spo SPBC1683.09c
SPBC947.05c

GO:0015892 siderophore-iron transport P
ISS
Spo SPBC947.05c

GO:0033215 iron assimilation by reduction and
transport P
IMP
Spo SPBC1683.09c

GO:0034755 iron ion transmembrane transport P
IMP
Spo SPBC1683.09c
ISS
Spo SPBC947.05c

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0039	ACDHYP-

KOGs classification	KOGs description
METABOLISMMETABOLISM	Ferric reductase, NADH/NADPH oxidase and related proteins

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g01580	GI:15223434
Arabidopsis thaliana (Ath)	At1g01590	GI:15223435
Arabidopsis thaliana (Ath)	At1g09090	GI:15224036
Arabidopsis thaliana (Ath)	At1g19230	GI:15221979
Arabidopsis thaliana (Ath)	At1g23020	GI:15219995
Arabidopsis thaliana (Ath)	At1g33640	GI:15217603
Arabidopsis thaliana (Ath)	At1g64060	GI:15222610
Arabidopsis thaliana (Ath)	At3g45810	GI:15231249
Arabidopsis thaliana (Ath)	At4g11230	GI:15237094
Arabidopsis thaliana (Ath)	At4g25090	GI:15234909
Arabidopsis thaliana (Ath)	At5g07390	GI:15240778
Arabidopsis thaliana (Ath)	At5g23980	GI:15237865
Arabidopsis thaliana (Ath)	At5g23990	GI:15237866
Arabidopsis thaliana (Ath)	At5g47910	GI:15238842
Arabidopsis thaliana (Ath)	At5g49730	GI:15240540
Arabidopsis thaliana (Ath)	At5g49740	GI:15240541
Arabidopsis thaliana (Ath)	At5g50160	GI:15240624
Arabidopsis thaliana (Ath)	At5g51060	GI:15241361
Arabidopsis thaliana (Ath)	At5g60010	GI:15238591
Caenorhabditis elegans (Cel)	CE24999 (WBGene00018771)	GI:17507545	O01795
Caenorhabditis elegans (Cel)	CE28463 (WBGene00000253)	GI:17507675
Drosophila melanogaster (Dme)	7295902	GI:7295902
Drosophila melanogaster (Dme)	7302945	GI:7302945
Homo sapiens (Hsa)	Hs19923434	GI:19923434
Homo sapiens (Hsa)	Hs8393843 (NOX4)	GI:8393843	Q9NPH5
Homo sapiens (Hsa)	Hs6996021 (CYBB)	GI:6996021	P04839
Homo sapiens (Hsa)	Hs20149640 (DUOX1)	GI:20149640	Q9NT13
Homo sapiens (Hsa)	Hs11136626 (NOX3)	GI:11136626	Q9HBY0
Homo sapiens (Hsa)	Hs20127624 (NOX5)	GI:20127624	Q96PH1
Homo sapiens (Hsa)	Hs5902006	GI:5902006
Homo sapiens (Hsa)	Hs7669508	GI:7669508
Homo sapiens (Hsa)	Hs7669510	GI:7669510	Q9Y5S8
Saccharomyces cerevisiae (Sce)	YGL160w (S000003128)	GI:6321278	P53109
Saccharomyces cerevisiae (Sce)	YKL220c (S000001703)	GI:6322629	P36033
Saccharomyces cerevisiae (Sce)	YLL051c (S000003974)	GI:6322977	Q12473
Saccharomyces cerevisiae (Sce)	YLR047c (S000004037)	GI:6323076	Q12209
Saccharomyces cerevisiae (Sce)	YLR214w (S000004204)	GI:6323243	P32791
Saccharomyces cerevisiae (Sce)	YNR060w (S000005343)	GI:6324388	P53746
Saccharomyces cerevisiae (Sce)	YOL152w (S000005512)	GI:6324420
Saccharomyces cerevisiae (Sce)	YOR381w (S000005908)	GI:6324957	Q08905
Saccharomyces cerevisiae (Sce)	YOR384w (S000005911)	GI:6324960	Q08908
Schizosaccharomyces pombe (Spo)	SPBC1683.09c	GI:19111857	Q04800
Schizosaccharomyces pombe (Spo)	SPBC947.05c	GI:19112063	O94727
Arabidopsis thaliana (Ath)	At1g01580	GI:15223434
Arabidopsis thaliana (Ath)	At1g01590	GI:15223435
Arabidopsis thaliana (Ath)	At1g09090	GI:15224036
Arabidopsis thaliana (Ath)	At1g19230	GI:15221979
Arabidopsis thaliana (Ath)	At1g23020	GI:15219995
Arabidopsis thaliana (Ath)	At1g33640	GI:15217603
Arabidopsis thaliana (Ath)	At1g64060	GI:15222610
Arabidopsis thaliana (Ath)	At3g45810	GI:15231249
Arabidopsis thaliana (Ath)	At4g11230	GI:15237094
Arabidopsis thaliana (Ath)	At4g25090	GI:15234909
Arabidopsis thaliana (Ath)	At5g07390	GI:15240778
Arabidopsis thaliana (Ath)	At5g23980	GI:15237865
Arabidopsis thaliana (Ath)	At5g23990	GI:15237866
Arabidopsis thaliana (Ath)	At5g47910	GI:15238842
Arabidopsis thaliana (Ath)	At5g49730	GI:15240540
Arabidopsis thaliana (Ath)	At5g49740	GI:15240541
Arabidopsis thaliana (Ath)	At5g50160	GI:15240624
Arabidopsis thaliana (Ath)	At5g51060	GI:15241361
Arabidopsis thaliana (Ath)	At5g60010	GI:15238591
Caenorhabditis elegans (Cel)	CE24999 (WBGene00018771)	GI:17507545	O01795
Caenorhabditis elegans (Cel)	CE28463 (WBGene00000253)	GI:17507675
Drosophila melanogaster (Dme)	7295902	GI:7295902
Drosophila melanogaster (Dme)	7302945	GI:7302945
Homo sapiens (Hsa)	Hs19923434	GI:19923434
Homo sapiens (Hsa)	Hs8393843 (NOX4)	GI:8393843	Q9NPH5
Homo sapiens (Hsa)	Hs6996021 (CYBB)	GI:6996021	P04839
Homo sapiens (Hsa)	Hs20149640 (DUOX1)	GI:20149640	Q9NT13
Homo sapiens (Hsa)	Hs11136626 (NOX3)	GI:11136626	Q9HBY0
Homo sapiens (Hsa)	Hs20127624 (NOX5)	GI:20127624	Q96PH1
Homo sapiens (Hsa)	Hs5902006	GI:5902006
Homo sapiens (Hsa)	Hs7669508	GI:7669508
Homo sapiens (Hsa)	Hs7669510	GI:7669510	Q9Y5S8
Saccharomyces cerevisiae (Sce)	YGL160w (S000003128)	GI:6321278	P53109
Saccharomyces cerevisiae (Sce)	YKL220c (S000001703)	GI:6322629	P36033
Saccharomyces cerevisiae (Sce)	YLL051c (S000003974)	GI:6322977	Q12473
Saccharomyces cerevisiae (Sce)	YLR047c (S000004037)	GI:6323076	Q12209
Saccharomyces cerevisiae (Sce)	YLR214w (S000004204)	GI:6323243	P32791
Saccharomyces cerevisiae (Sce)	YNR060w (S000005343)	GI:6324388	P53746
Saccharomyces cerevisiae (Sce)	YOL152w (S000005512)	GI:6324420
Saccharomyces cerevisiae (Sce)	YOR381w (S000005908)	GI:6324957	Q08905
Saccharomyces cerevisiae (Sce)	YOR384w (S000005911)	GI:6324960	Q08908
Schizosaccharomyces pombe (Spo)	SPBC1683.09c	GI:19111857	Q04800
Schizosaccharomyces pombe (Spo)	SPBC947.05c	GI:19112063	O94727
Arabidopsis thaliana (Ath)	At1g01580	GI:15223434
Arabidopsis thaliana (Ath)	At1g01590	GI:15223435
Arabidopsis thaliana (Ath)	At1g09090	GI:15224036
Arabidopsis thaliana (Ath)	At1g19230	GI:15221979
Arabidopsis thaliana (Ath)	At1g23020	GI:15219995
Arabidopsis thaliana (Ath)	At1g33640	GI:15217603
Arabidopsis thaliana (Ath)	At1g64060	GI:15222610
Arabidopsis thaliana (Ath)	At3g45810	GI:15231249
Arabidopsis thaliana (Ath)	At4g11230	GI:15237094
Arabidopsis thaliana (Ath)	At4g25090	GI:15234909
Arabidopsis thaliana (Ath)	At5g07390	GI:15240778
Arabidopsis thaliana (Ath)	At5g23980	GI:15237865
Arabidopsis thaliana (Ath)	At5g23990	GI:15237866
Arabidopsis thaliana (Ath)	At5g47910	GI:15238842
Arabidopsis thaliana (Ath)	At5g49730	GI:15240540
Arabidopsis thaliana (Ath)	At5g49740	GI:15240541
Arabidopsis thaliana (Ath)	At5g50160	GI:15240624
Arabidopsis thaliana (Ath)	At5g51060	GI:15241361
Arabidopsis thaliana (Ath)	At5g60010	GI:15238591
Caenorhabditis elegans (Cel)	CE24999 (WBGene00018771)	GI:17507545	O01795
Caenorhabditis elegans (Cel)	CE28463 (WBGene00000253)	GI:17507675
Drosophila melanogaster (Dme)	7295902	GI:7295902
Drosophila melanogaster (Dme)	7302945	GI:7302945
Homo sapiens (Hsa)	Hs19923434	GI:19923434
Homo sapiens (Hsa)	Hs8393843 (NOX4)	GI:8393843	Q9NPH5
Homo sapiens (Hsa)	Hs6996021 (CYBB)	GI:6996021	P04839
Homo sapiens (Hsa)	Hs20149640 (DUOX1)	GI:20149640	Q9NT13
Homo sapiens (Hsa)	Hs11136626 (NOX3)	GI:11136626	Q9HBY0
Homo sapiens (Hsa)	Hs20127624 (NOX5)	GI:20127624	Q96PH1
Homo sapiens (Hsa)	Hs5902006	GI:5902006
Homo sapiens (Hsa)	Hs7669508	GI:7669508
Homo sapiens (Hsa)	Hs7669510	GI:7669510	Q9Y5S8
Saccharomyces cerevisiae (Sce)	YGL160w (S000003128)	GI:6321278	P53109
Saccharomyces cerevisiae (Sce)	YKL220c (S000001703)	GI:6322629	P36033
Saccharomyces cerevisiae (Sce)	YLL051c (S000003974)	GI:6322977	Q12473
Saccharomyces cerevisiae (Sce)	YLR047c (S000004037)	GI:6323076	Q12209
Saccharomyces cerevisiae (Sce)	YLR214w (S000004204)	GI:6323243	P32791
Saccharomyces cerevisiae (Sce)	YNR060w (S000005343)	GI:6324388	P53746
Saccharomyces cerevisiae (Sce)	YOL152w (S000005512)	GI:6324420
Saccharomyces cerevisiae (Sce)	YOR381w (S000005908)	GI:6324957	Q08905
Saccharomyces cerevisiae (Sce)	YOR384w (S000005911)	GI:6324960	Q08908
Schizosaccharomyces pombe (Spo)	SPBC1683.09c	GI:19111857	Q04800
Schizosaccharomyces pombe (Spo)	SPBC947.05c	GI:19112063	O94727

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	FRE1 (S000004204)	GI:6323243	P32791
Kluyveromyces lactis (Kla)	KLLA0F04950g	GI:50310569
Eremothecium gossypii (Ego)	AGOS_ADR080W	GI:45187953

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago1821	ADR080W
Debaryomyces hansenii (Dha)	dha695	DEHA0B00385g
Gallus gallus (Gga)	gga15316	ENSGALP00000022177
Kluyveromyces lactis (Kla)	kla4304	KLLA0F04950g
Saccharomyces cerevisiae (Sce)	sce4314	YLR214W (S000004204)
Schizosaccharomyces pombe (Spo)	spo814	SPBC947.05c	O94727

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC947.05c (O94727)	YLR214W (S000004204)
SPBC1683.09c (Q04800)	YLR214W (S000004204)